We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9UL15 (BAG5_HUMAN)
Protein
BAG family molecular chaperone regulator 5
Gene
BAG5
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity).
May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
By similarity1 PublicationGO - Molecular functioni
- adenyl-nucleotide exchange factor activity Source: GO_Central
- chaperone binding Source: BHF-UCL
- protein kinase binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- Golgi organization Source: ParkinsonsUK-UCL
- negative regulation of neuron projection development Source: ParkinsonsUK-UCL
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
- negative regulation of protein refolding Source: BHF-UCL
- negative regulation of protein ubiquitination Source: ARUK-UCL
- negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
- neuron death Source: BHF-UCL
- protein folding Source: ProtInc
- protein stabilization Source: ARUK-UCL
- regulation of inclusion body assembly Source: BHF-UCL
- regulation of ubiquitin-protein transferase activity Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q9UL15 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
SignaLinki | Q9UL15 |
SIGNORi | Q9UL15 |
Names & Taxonomyi
Protein namesi | Recommended name: BAG family molecular chaperone regulator 5Short name: BAG-5 Alternative name(s): Bcl-2-associated athanogene 5 |
Gene namesi | Name:BAG5 Synonyms:KIAA0873 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:941, BAG5 |
MIMi | 603885, gene |
neXtProti | NX_Q9UL15 |
VEuPathDBi | HostDB:ENSG00000166170 |
Subcellular locationi
Cytosol
- cytosol Source: ParkinsonsUK-UCL
Mitochondrion
- mitochondrion Source: ParkinsonsUK-UCL
Nucleus
- nucleus Source: ParkinsonsUK-UCL
Other locations
- cytoplasm Source: GO_Central
- inclusion body Source: BHF-UCL
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: BHF-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9529 |
OpenTargetsi | ENSG00000166170 |
PharmGKBi | PA25241 |
Miscellaneous databases
Pharosi | Q9UL15, Tbio |
Genetic variation databases
BioMutai | BAG5 |
DMDMi | 12643895 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088872 | 1 – 447 | BAG family molecular chaperone regulator 5Add BLAST | 447 |
Proteomic databases
EPDi | Q9UL15 |
jPOSTi | Q9UL15 |
MassIVEi | Q9UL15 |
MaxQBi | Q9UL15 |
PaxDbi | Q9UL15 |
PeptideAtlasi | Q9UL15 |
PRIDEi | Q9UL15 |
ProteomicsDBi | 84927 [Q9UL15-1] 84928 [Q9UL15-2] |
PTM databases
GlyGeni | Q9UL15, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UL15 |
MetOSitei | Q9UL15 |
PhosphoSitePlusi | Q9UL15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166170, Expressed in testis and 247 other tissues |
ExpressionAtlasi | Q9UL15, baseline and differential |
Genevisiblei | Q9UL15, HS |
Organism-specific databases
HPAi | ENSG00000166170, Tissue enriched (testis) |
Interactioni
Subunit structurei
Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PRKN.
1 PublicationBinary interactionsi
Q9UL15
Isoform 1 [Q9UL15-1]
With | #Exp. | IntAct |
---|---|---|
P0DMV9 | 3 | EBI-16247256,EBI-11820565 |
GO - Molecular functioni
- chaperone binding Source: BHF-UCL
- protein kinase binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 114905, 311 interactors |
CORUMi | Q9UL15 |
DIPi | DIP-53428N |
IntActi | Q9UL15, 83 interactors |
MINTi | Q9UL15 |
STRINGi | 9606.ENSP00000338814 |
Miscellaneous databases
RNActi | Q9UL15, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UL15 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UL15 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 86 | BAG 1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 95 – 167 | BAG 2PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 182 – 260 | BAG 3PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 275 – 350 | BAG 4PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 365 – 442 | BAG 5PROSITE-ProRule annotationAdd BLAST | 78 |
Domaini
The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.1 Publication
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4361, Eukaryota |
GeneTreei | ENSGT00940000158888 |
HOGENOMi | CLU_579940_0_0_1 |
InParanoidi | Q9UL15 |
OMAi | VWDVLGN |
OrthoDBi | 902874at2759 |
PhylomeDBi | Q9UL15 |
TreeFami | TF102014 |
Family and domain databases
Gene3Di | 1.20.58.120, 5 hits |
InterProi | View protein in InterPro IPR039773, BAG_chaperone_regulator IPR036533, BAG_dom_sf IPR003103, BAG_domain |
PANTHERi | PTHR12329, PTHR12329, 1 hit |
Pfami | View protein in Pfam PF02179, BAG, 4 hits |
SMARTi | View protein in SMART SM00264, BAG, 4 hits |
SUPFAMi | SSF63491, SSF63491, 4 hits |
PROSITEi | View protein in PROSITE PS51035, BAG, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UL15-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDMGNQHPSI SRLQEIQKEV KSVEQQVIGF SGLSDDKNYK KLERILTKQL
60 70 80 90 100
FEIDSVDTEG KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFEE
110 120 130 140 150
AQSLVREKIV PFYNGGNCVT DEFEEGIQDI ILRLTHVKTG GKISLRKARY
160 170 180 190 200
HTLTKICAVQ EIIEDCMKKQ PSLPLSEDAH PSVAKINFVM CEVNKARGVL
210 220 230 240 250
IALLMGVNNN ETCRHLSCVL SGLIADLDAL DVCGRTEIRN YRREVVEDIN
260 270 280 290 300
KLLKYLDLEE EADTTKAFDL RQNHSILKIE KVLKRMREIK NELLQAQNPS
310 320 330 340 350
ELYLSSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE
360 370 380 390 400
ALEKRKLFAC EEHPSHKAVW NVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE
410 420 430 440
LLTKQLLALD AVDPQGEEKC KAARKQAVRL AQNILSYLDL KSDEWEY
Sequence cautioni
The sequence BAA74896 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058712 | 157 | C → W1 PublicationCorresponds to variant dbSNP:rs17854644Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037996 | 1 | M → MRFHWLPTLSEPFDRNQELE TCIRPLWTPSGSACETEHNK SM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095195 mRNA Translation: AAD16124.2 AB020680 mRNA Translation: BAA74896.1 Different initiation. AL139300 Genomic DNA No translation available. BC044216 mRNA Translation: AAH44216.2 BC050551 mRNA Translation: AAH50551.1 |
CCDSi | CCDS9982.1 [Q9UL15-1] |
RefSeqi | NP_001015048.1, NM_001015048.2 [Q9UL15-1] NP_001015049.1, NM_001015049.2 [Q9UL15-1] NP_004864.1, NM_004873.3 [Q9UL15-1] |
Genome annotation databases
Ensembli | ENST00000299204; ENSP00000299204; ENSG00000166170 ENST00000337322; ENSP00000338814; ENSG00000166170 [Q9UL15-2] ENST00000445922; ENSP00000391713; ENSG00000166170 |
GeneIDi | 9529 |
KEGGi | hsa:9529 |
MANE-Selecti | ENST00000299204.6; ENSP00000299204.4; NM_001015048.3; NP_001015048.1 |
UCSCi | uc001ynh.3, human [Q9UL15-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095195 mRNA Translation: AAD16124.2 AB020680 mRNA Translation: BAA74896.1 Different initiation. AL139300 Genomic DNA No translation available. BC044216 mRNA Translation: AAH44216.2 BC050551 mRNA Translation: AAH50551.1 |
CCDSi | CCDS9982.1 [Q9UL15-1] |
RefSeqi | NP_001015048.1, NM_001015048.2 [Q9UL15-1] NP_001015049.1, NM_001015049.2 [Q9UL15-1] NP_004864.1, NM_004873.3 [Q9UL15-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D9D | NMR | - | A | 275-350 | [»] | |
3A8Y | X-ray | 2.30 | C/D | 341-447 | [»] | |
SMRi | Q9UL15 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114905, 311 interactors |
CORUMi | Q9UL15 |
DIPi | DIP-53428N |
IntActi | Q9UL15, 83 interactors |
MINTi | Q9UL15 |
STRINGi | 9606.ENSP00000338814 |
PTM databases
GlyGeni | Q9UL15, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UL15 |
MetOSitei | Q9UL15 |
PhosphoSitePlusi | Q9UL15 |
Genetic variation databases
BioMutai | BAG5 |
DMDMi | 12643895 |
Proteomic databases
EPDi | Q9UL15 |
jPOSTi | Q9UL15 |
MassIVEi | Q9UL15 |
MaxQBi | Q9UL15 |
PaxDbi | Q9UL15 |
PeptideAtlasi | Q9UL15 |
PRIDEi | Q9UL15 |
ProteomicsDBi | 84927 [Q9UL15-1] 84928 [Q9UL15-2] |
Protocols and materials databases
Antibodypediai | 36, 536 antibodies from 36 providers |
DNASUi | 9529 |
Genome annotation databases
Ensembli | ENST00000299204; ENSP00000299204; ENSG00000166170 ENST00000337322; ENSP00000338814; ENSG00000166170 [Q9UL15-2] ENST00000445922; ENSP00000391713; ENSG00000166170 |
GeneIDi | 9529 |
KEGGi | hsa:9529 |
MANE-Selecti | ENST00000299204.6; ENSP00000299204.4; NM_001015048.3; NP_001015048.1 |
UCSCi | uc001ynh.3, human [Q9UL15-1] |
Organism-specific databases
CTDi | 9529 |
DisGeNETi | 9529 |
GeneCardsi | BAG5 |
HGNCi | HGNC:941, BAG5 |
HPAi | ENSG00000166170, Tissue enriched (testis) |
MIMi | 603885, gene |
neXtProti | NX_Q9UL15 |
OpenTargetsi | ENSG00000166170 |
PharmGKBi | PA25241 |
VEuPathDBi | HostDB:ENSG00000166170 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4361, Eukaryota |
GeneTreei | ENSGT00940000158888 |
HOGENOMi | CLU_579940_0_0_1 |
InParanoidi | Q9UL15 |
OMAi | VWDVLGN |
OrthoDBi | 902874at2759 |
PhylomeDBi | Q9UL15 |
TreeFami | TF102014 |
Enzyme and pathway databases
PathwayCommonsi | Q9UL15 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
SignaLinki | Q9UL15 |
SIGNORi | Q9UL15 |
Miscellaneous databases
BioGRID-ORCSi | 9529, 4 hits in 1047 CRISPR screens |
EvolutionaryTracei | Q9UL15 |
GeneWikii | BAG5 |
GenomeRNAii | 9529 |
Pharosi | Q9UL15, Tbio |
PROi | PR:Q9UL15 |
RNActi | Q9UL15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166170, Expressed in testis and 247 other tissues |
ExpressionAtlasi | Q9UL15, baseline and differential |
Genevisiblei | Q9UL15, HS |
Family and domain databases
Gene3Di | 1.20.58.120, 5 hits |
InterProi | View protein in InterPro IPR039773, BAG_chaperone_regulator IPR036533, BAG_dom_sf IPR003103, BAG_domain |
PANTHERi | PTHR12329, PTHR12329, 1 hit |
Pfami | View protein in Pfam PF02179, BAG, 4 hits |
SMARTi | View protein in SMART SM00264, BAG, 4 hits |
SUPFAMi | SSF63491, SSF63491, 4 hits |
PROSITEi | View protein in PROSITE PS51035, BAG, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BAG5_HUMAN | |
Accessioni | Q9UL15Primary (citable) accession number: Q9UL15 Secondary accession number(s): O94950, Q86W59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references