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Protein

Integrator complex subunit 6

Gene

INTS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144).1 Publication3 Publications

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • snRNA 3'-end processing Source: GO_Central
  • snRNA processing Source: HGNC
  • snRNA transcription by RNA polymerase II Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 6
Short name:
Int6
Alternative name(s):
DBI-1
Protein DDX26
Protein deleted in cancer 1
Short name:
DICE1
Gene namesi
Name:INTS6
Synonyms:DBI1, DDX26, DDX26A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102786.14
HGNCiHGNC:14879 INTS6
MIMi604331 gene
neXtProtiNX_Q9UL03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26512
OpenTargetsiENSG00000102786
PharmGKBiPA27212

Polymorphism and mutation databases

BioMutaiINTS6
DMDMi74753376

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595431 – 887Integrator complex subunit 6Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei804PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UL03
PaxDbiQ9UL03
PeptideAtlasiQ9UL03
PRIDEiQ9UL03
ProteomicsDBi84922
84923 [Q9UL03-2]
84924 [Q9UL03-3]
TopDownProteomicsiQ9UL03-2 [Q9UL03-2]

PTM databases

iPTMnetiQ9UL03
PhosphoSitePlusiQ9UL03

Expressioni

Tissue specificityi

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Inductioni

Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in prostate cancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear.1 Publication

Gene expression databases

BgeeiENSG00000102786 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_INTS6
ExpressionAtlasiQ9UL03 baseline and differential
GenevisibleiQ9UL03 HS

Organism-specific databases

HPAiHPA001552
HPA001846

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCM7P3399310EBI-1381827,EBI-355924

Protein-protein interaction databases

BioGridi117717, 64 interactors
CORUMiQ9UL03
DIPiDIP-38627N
IntActiQ9UL03, 20 interactors
MINTiQ9UL03
STRINGi9606.ENSP00000310260

Structurei

3D structure databases

ProteinModelPortaliQ9UL03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 227VWFAPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the Integrator subunit 6 family.Curated

Phylogenomic databases

eggNOGiKOG3768 Eukaryota
ENOG410XRER LUCA
GeneTreeiENSGT00390000016655
HOGENOMiHOG000015308
HOVERGENiHBG081468
InParanoidiQ9UL03
KOiK13143
OMAiRQSFENY
OrthoDBiEOG091G03YA
PhylomeDBiQ9UL03
TreeFamiTF323386

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029307 INT_SG_DDX_CT_C
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF15300 INT_SG_DDX_CT_C, 1 hit
PF13519 VWA_2, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UL03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPILLFLIDT SASMNQRSHL GTTYLDTAKG AVETFMKLRA RDPASRGDRY
60 70 80 90 100
MLVTFEEPPY AIKAGWKENH ATFMNELKNL QAEGLTTLGQ SLRTAFDLLN
110 120 130 140 150
LNRLVTGIDN YGQGRNPFFL EPAIIITITD GSKLTTTSGV QDELHLPLNS
160 170 180 190 200
PLPGSELTKE PFRWDQRLFA LVLRLPGTMS VESEQLTGVP LDDSAITPMC
210 220 230 240 250
EVTGGRSYSV CSPRMLNQCL ESLVQKVQSG VVINFEKAGP DPSPVEDGQP
260 270 280 290 300
DISRPFGSQP WHSCHKLIYV RPNPKTGVPI GHWPVPESFW PDQNSPTLPP
310 320 330 340 350
RTSHPVVKFS CTDCEPMVID KLPFDKYELE PSPLTQFILE RKSPQTCWQV
360 370 380 390 400
YVSNSAKYSE LGHPFGYLKA STALNCVNLF VMPYNYPVLL PLLDDLFKVH
410 420 430 440 450
KAKPTLKWRQ SFESYLKTMP PYYLGPLKKA VRMMGAPNLI ADSMEYGLSY
460 470 480 490 500
SVISYLKKLS QQAKIESDRV IGSVGKKVVQ ETGIKVRSRS HGLSMAYRKD
510 520 530 540 550
FQQLLQGISE DVPHRLLDLN MKEYTGFQVA LLNKDLKPQT FRNAYDIPRR
560 570 580 590 600
NLLDHLTRMR SNLLKSTRRF LKGQDEDQVH SVPIAQMGNY QEYLKQVPSP
610 620 630 640 650
LRELDPDQPR RLHTFGNPFK LDKKGMMIDE ADEFVAGPQN KHKRPGEPNM
660 670 680 690 700
QGIPKRRRCM SPLLRGRQQN PVVNNHIGGK GPPAPTTQAQ PDLIKPLPLH
710 720 730 740 750
KISETTNDSI IHDVVENHVA DQLSSDITPN AMDTEFSASS PASLLERPTN
760 770 780 790 800
HMEALGHDHL GTNDLTVGGF LENHEEPRDK EQCAEENIPA SSLNKGKKLM
810 820 830 840 850
HCRSHEEVNT ELKAQIMKEI RKPGRKYERI FTLLKHVQGS LQTRLIFLQN
860 870 880
VIKEASRFKK RMLIEQLENF LDEIHRRANQ INHINSN
Length:887
Mass (Da):100,390
Last modified:May 1, 2000 - v1
Checksum:iFCD3FD61B7767E03
GO
Isoform 2 (identifier: Q9UL03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: GR → VG
     116-887: Missing.

Note: No experimental confirmation available.
Show »
Length:115
Mass (Da):12,854
Checksum:i89C3CC2495007B4A
GO
Isoform 3 (identifier: Q9UL03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:874
Mass (Da):98,987
Checksum:iC1F5FA55ADA2C443
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KQH5B3KQH5_HUMAN
Integrator complex subunit 6, isofo...
INTS6 hCG_29123
709Annotation score:
G5E9X1G5E9X1_HUMAN
Integrator complex subunit 6, isofo...
INTS6 hCG_29123
571Annotation score:
C9K0V7C9K0V7_HUMAN
Integrator complex subunit 6
INTS6
130Annotation score:
F8WAV7F8WAV7_HUMAN
Integrator complex subunit 6
INTS6
151Annotation score:
C9J885C9J885_HUMAN
Integrator complex subunit 6
INTS6
126Annotation score:
C9JAV7C9JAV7_HUMAN
Integrator complex subunit 6
INTS6
154Annotation score:
C9JVX2C9JVX2_HUMAN
Integrator complex subunit 6
INTS6
131Annotation score:
C9JXP6C9JXP6_HUMAN
Integrator complex subunit 6
INTS6
89Annotation score:

Sequence cautioni

The sequence AAH13358 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AL833524 differs from that shown. Reason: Erroneous termination at position 796. Translated as Gly.Curated
The sequence CAB56020 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273N → R in AAD39481 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413561 – 13Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_021457114 – 115GR → VG in isoform 2. 1 Publication2
Alternative sequenceiVSP_021458116 – 887Missing in isoform 2. 1 PublicationAdd BLAST772

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097645 mRNA Translation: AAF03046.1
AL833524 mRNA No translation available.
AL354820 Genomic DNA No translation available.
AL137780 Genomic DNA No translation available.
BC013358 mRNA Translation: AAH13358.1 Sequence problems.
BC018725 mRNA Translation: AAH18725.1
BC032386 mRNA Translation: AAH32386.1
BC039829 mRNA Translation: AAH39829.1
AF141326 mRNA Translation: AAD39481.1
AL117626 mRNA Translation: CAB56020.1 Different initiation.
BK005730 mRNA Translation: DAA05730.1
CCDSiCCDS41890.1 [Q9UL03-3]
CCDS45048.1 [Q9UL03-2]
CCDS9428.1 [Q9UL03-1]
PIRiT17330
RefSeqiNP_001035026.1, NM_001039937.1 [Q9UL03-3]
NP_001035027.1, NM_001039938.1 [Q9UL03-2]
NP_001293020.1, NM_001306091.1
NP_036273.1, NM_012141.2 [Q9UL03-1]
XP_011533342.1, XM_011535040.2 [Q9UL03-1]
UniGeneiHs.439440

Genome annotation databases

EnsembliENST00000311234; ENSP00000310260; ENSG00000102786 [Q9UL03-1]
ENST00000398119; ENSP00000381187; ENSG00000102786 [Q9UL03-3]
ENST00000442263; ENSP00000411245; ENSG00000102786 [Q9UL03-2]
GeneIDi26512
KEGGihsa:26512
UCSCiuc001vfj.4 human [Q9UL03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097645 mRNA Translation: AAF03046.1
AL833524 mRNA No translation available.
AL354820 Genomic DNA No translation available.
AL137780 Genomic DNA No translation available.
BC013358 mRNA Translation: AAH13358.1 Sequence problems.
BC018725 mRNA Translation: AAH18725.1
BC032386 mRNA Translation: AAH32386.1
BC039829 mRNA Translation: AAH39829.1
AF141326 mRNA Translation: AAD39481.1
AL117626 mRNA Translation: CAB56020.1 Different initiation.
BK005730 mRNA Translation: DAA05730.1
CCDSiCCDS41890.1 [Q9UL03-3]
CCDS45048.1 [Q9UL03-2]
CCDS9428.1 [Q9UL03-1]
PIRiT17330
RefSeqiNP_001035026.1, NM_001039937.1 [Q9UL03-3]
NP_001035027.1, NM_001039938.1 [Q9UL03-2]
NP_001293020.1, NM_001306091.1
NP_036273.1, NM_012141.2 [Q9UL03-1]
XP_011533342.1, XM_011535040.2 [Q9UL03-1]
UniGeneiHs.439440

3D structure databases

ProteinModelPortaliQ9UL03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117717, 64 interactors
CORUMiQ9UL03
DIPiDIP-38627N
IntActiQ9UL03, 20 interactors
MINTiQ9UL03
STRINGi9606.ENSP00000310260

PTM databases

iPTMnetiQ9UL03
PhosphoSitePlusiQ9UL03

Polymorphism and mutation databases

BioMutaiINTS6
DMDMi74753376

Proteomic databases

EPDiQ9UL03
PaxDbiQ9UL03
PeptideAtlasiQ9UL03
PRIDEiQ9UL03
ProteomicsDBi84922
84923 [Q9UL03-2]
84924 [Q9UL03-3]
TopDownProteomicsiQ9UL03-2 [Q9UL03-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311234; ENSP00000310260; ENSG00000102786 [Q9UL03-1]
ENST00000398119; ENSP00000381187; ENSG00000102786 [Q9UL03-3]
ENST00000442263; ENSP00000411245; ENSG00000102786 [Q9UL03-2]
GeneIDi26512
KEGGihsa:26512
UCSCiuc001vfj.4 human [Q9UL03-1]

Organism-specific databases

CTDi26512
DisGeNETi26512
EuPathDBiHostDB:ENSG00000102786.14
GeneCardsiINTS6
HGNCiHGNC:14879 INTS6
HPAiHPA001552
HPA001846
MIMi604331 gene
neXtProtiNX_Q9UL03
OpenTargetsiENSG00000102786
PharmGKBiPA27212
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3768 Eukaryota
ENOG410XRER LUCA
GeneTreeiENSGT00390000016655
HOGENOMiHOG000015308
HOVERGENiHBG081468
InParanoidiQ9UL03
KOiK13143
OMAiRQSFENY
OrthoDBiEOG091G03YA
PhylomeDBiQ9UL03
TreeFamiTF323386

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRSiINTS6 human
GeneWikiiINTS6
GenomeRNAii26512
PROiPR:Q9UL03
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102786 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_INTS6
ExpressionAtlasiQ9UL03 baseline and differential
GenevisibleiQ9UL03 HS

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029307 INT_SG_DDX_CT_C
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF15300 INT_SG_DDX_CT_C, 1 hit
PF13519 VWA_2, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT6_HUMAN
AccessioniPrimary (citable) accession number: Q9UL03
Secondary accession number(s): Q0P664
, Q6PJP4, Q9UFK0, Q9Y5M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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