UniProtKB - Q9UKZ9 (PCOC2_HUMAN)

BLAST

>sp|Q9UKZ9|PCOC2_HUMAN Procollagen C-endopeptidase enhancer 2 OS=Homo sapiens OX=9606 GN=PCOLCE2 PE=1 SV=1
MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCT
WKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGN
KMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVT
CVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIV
SERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQK
CRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARL
TVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC

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History
Entry version 133 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

Procollagen C-endopeptidase enhancer 2

Gene

PCOLCE2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.1 Publication

GO - Molecular functionⁱ

collagen binding
Source: MGI
Inferred from direct assayⁱ
- 12393877
heparin binding
Source: MGI
Inferred from direct assayⁱ
- 12393877
peptidase activator activity
Source: MGI
Inferred from direct assayⁱ
- 12393877

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to leukemia inhibitory factor Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding

Molecular function

Heparin-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1650814 Collagen biosynthesis and modifying enzymes

Reactomeⁱ

R-HSA-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Procollagen C-endopeptidase enhancer 2 Alternative name(s): Procollagen COOH-terminal proteinase enhancer 2 Short name: PCPE-2 Short name: Procollagen C-proteinase enhancer 2
Gene namesⁱ	Name:PCOLCE2 Synonyms:PCPE2 ORF Names:UNQ250/PRO287
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163710.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8739 PCOLCE2
MIMⁱ	607064 gene
neXtProtⁱ	NX_Q9UKZ9

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26577
Open Targets More...OpenTargetsⁱ	ENSG00000163710
PharmGKBⁱ	PA33084

Polymorphism and mutation databases

BioMutaⁱ	PCOLCE2
DMDMⁱ	67470587

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000022020	24 – 415	Procollagen C-endopeptidase enhancer 2Add BLAST		392

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	33 ↔ 59	PROSITE-ProRule annotation
Disulfide bondⁱ	86 ↔ 107	PROSITE-ProRule annotation
Disulfide bondⁱ	154 ↔ 181	PROSITE-ProRule annotation
Disulfide bondⁱ	208 ↔ 231	PROSITE-ProRule annotation
Disulfide bondⁱ	297 ↔ 364	By similarity
Disulfide bondⁱ	301 ↔ 367	By similarity
Disulfide bondⁱ	312 ↔ 415	By similarity
Glycosylationⁱ	355	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

O-glycosylated; contains sialic acid.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UKZ9
PaxDbⁱ	Q9UKZ9
PeptideAtlas More...PeptideAtlasⁱ	Q9UKZ9
PRIDEⁱ	Q9UKZ9
ProteomicsDBⁱ	84920

PTM databases

iPTMnetⁱ	Q9UKZ9
PhosphoSitePlusⁱ	Q9UKZ9

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000163710 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_PCOLCE2
ExpressionAtlasⁱ	Q9UKZ9 baseline and differential
Genevisibleⁱ	Q9UKZ9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013203

HPAⁱ

HPA013203

Interactionⁱ

Subunit structureⁱ

Interacts with heparin with high affinity, and type I or II collagen.1 Publication

Protein-protein interaction databases

BioGridⁱ	117746, 11 interactors
STRINGⁱ	9606.ENSP00000295992

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UKZ9
SMRⁱ	Q9UKZ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	33 – 144	CUB 1PROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	154 – 268	CUB 2PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	297 – 415	NTRPROSITE-ProRule annotationAdd BLAST	119

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IEMJ Eukaryota ENOG410Y9AW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119018
HOGENOMⁱ	HOG000059592
HOVERGENⁱ	HBG053528
InParanoidⁱ	Q9UKZ9
OMAⁱ	SIINVYK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06JY
PhylomeDBⁱ	Q9UKZ9
TreeFamⁱ	TF316506

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 2 hits cd03576 NTR_PCOLCE, 1 hit
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR001134 Netrin_domain IPR018933 Netrin_module_non-TIMP IPR035814 NTR_PCOLCE IPR035914 Sperma_CUB_dom_sf IPR008993 TIMP-like_OB-fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 2 hits PF01759 NTR, 1 hit
SMARTⁱ	View protein in SMART SM00643 C345C, 1 hit SM00042 CUB, 2 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF50242 SSF50242, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 2 hits PS50189 NTR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9UKZ9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MRGANAWAPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP 
        60         70         80         90        100
GVYPPNSKCT WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG 
       110        120        130        140        150
QRIGRFCGTF RPGALVSSGN KMMVQMISDA NTAGNGFMAM FSAAEPNERG 
       160        170        180        190        200
DQYCGGLLDR PSGSFKTPNW PDRDYPAGVT CVWHIVAPKN QLIELKFEKF 
       210        220        230        240        250
DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV SERNELLIQF 
       260        270        280        290        300
LSDLSLTADG FIGHYIFRPK KLPTTTEQPV TTTFPVTTGL KPTVALCQQK 
       310        320        330        340        350
CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ 
       360        370        380        390        400
QAGKNMSARL TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK 
       410 
TKNQKLLDAL KNKQC

Length:415

Mass (Da):45,717

Last modified:May 1, 2000 - v1

Checksum:ⁱB9AA87FD9AAF7A5B

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JYX9	C9JYX9_HUMAN	Procollagen C-endopeptidase enhance... Procollagen C-endopeptidase enhancer 2	PCOLCE2	303	Annotation score:
H7C5D5	H7C5D5_HUMAN	Procollagen C-endopeptidase enhance... Procollagen C-endopeptidase enhancer 2	PCOLCE2	140	Annotation score:
H7C520	H7C520_HUMAN	Procollagen C-endopeptidase enhance... Procollagen C-endopeptidase enhancer 2	PCOLCE2	101	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051264	280	V → A. Corresponds to variant dbSNP:rs35692900Ensembl.		1
Natural variantⁱVAR_022448	292	P → T. Corresponds to variant dbSNP:rs17554211Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF098269 mRNA Translation: AAF04621.1 AY035400 mRNA Translation: AAK63128.1 AY358557 mRNA Translation: AAQ88921.1 CR536570 mRNA Translation: CAG38807.1 AK315121 mRNA Translation: BAG37576.1 CH471052 Genomic DNA Translation: EAW78961.1 CH471052 Genomic DNA Translation: EAW78962.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3127.1
NCBI Reference Sequences More...RefSeqⁱ	NP_037495.1, NM_013363.3
UniGeneⁱ	Hs.8944

Genome annotation databases

Ensemblⁱ	ENST00000295992; ENSP00000295992; ENSG00000163710
GeneIDⁱ	26577
KEGGⁱ	hsa:26577
UCSC genome browser More...UCSCⁱ	uc003evd.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UKZ9	Uncharacterized protein		RABIT		417	UniRef90_Q9UKZ9
procollagen C-endopeptidase enhancer 2 isoform X1		Yangtze finless porpoise		416
Uncharacterized protein		AOTNA		415
Procollagen C-endopeptidase enhancer 2 variant (Fragment)		HUMAN		415
Uncharacterized protein		COLAP		415
+24

Protein	Similar proteins		Species	Score	Length	Source
Q9UKZ9	Uncharacterized protein		RABIT		417	UniRef50_Q9UKZ9
procollagen C-endopeptidase enhancer 2 isoform X1		Yangtze finless porpoise		416
Uncharacterized protein		AOTNA		415
Procollagen C-endopeptidase enhancer 2		CALJA		415
procollagen C-endopeptidase enhancer 2		TURTR		415
+85

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF098269 mRNA Translation: AAF04621.1 AY035400 mRNA Translation: AAK63128.1 AY358557 mRNA Translation: AAQ88921.1 CR536570 mRNA Translation: CAG38807.1 AK315121 mRNA Translation: BAG37576.1 CH471052 Genomic DNA Translation: EAW78961.1 CH471052 Genomic DNA Translation: EAW78962.1
CCDSⁱ	CCDS3127.1
RefSeqⁱ	NP_037495.1, NM_013363.3
UniGeneⁱ	Hs.8944

3D structure databases

ProteinModelPortalⁱ	Q9UKZ9
SMRⁱ	Q9UKZ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117746, 11 interactors
STRINGⁱ	9606.ENSP00000295992

PTM databases

iPTMnetⁱ	Q9UKZ9
PhosphoSitePlusⁱ	Q9UKZ9

Polymorphism and mutation databases

BioMutaⁱ	PCOLCE2
DMDMⁱ	67470587

Proteomic databases

MaxQBⁱ	Q9UKZ9
PaxDbⁱ	Q9UKZ9
PeptideAtlasⁱ	Q9UKZ9
PRIDEⁱ	Q9UKZ9
ProteomicsDBⁱ	84920

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26577
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295992; ENSP00000295992; ENSG00000163710
GeneIDⁱ	26577
KEGGⁱ	hsa:26577
UCSCⁱ	uc003evd.4 human

Organism-specific databases

CTDⁱ	26577
DisGeNETⁱ	26577
EuPathDBⁱ	HostDB:ENSG00000163710.7
GeneCardsⁱ	PCOLCE2
HGNCⁱ	HGNC:8739 PCOLCE2
HPAⁱ	HPA013203
MIMⁱ	607064 gene
neXtProtⁱ	NX_Q9UKZ9
OpenTargetsⁱ	ENSG00000163710
PharmGKBⁱ	PA33084
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEMJ Eukaryota ENOG410Y9AW LUCA
GeneTreeⁱ	ENSGT00760000119018
HOGENOMⁱ	HOG000059592
HOVERGENⁱ	HBG053528
InParanoidⁱ	Q9UKZ9
OMAⁱ	SIINVYK
OrthoDBⁱ	EOG091G06JY
PhylomeDBⁱ	Q9UKZ9
TreeFamⁱ	TF316506

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1650814 Collagen biosynthesis and modifying enzymes

Reactomeⁱ

R-HSA-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

ChiTaRSⁱ	PCOLCE2 human
GeneWikiⁱ	PCOLCE2
GenomeRNAiⁱ	26577
Protein Ontology More...PROⁱ	PR:Q9UKZ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163710 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_PCOLCE2
ExpressionAtlasⁱ	Q9UKZ9 baseline and differential
Genevisibleⁱ	Q9UKZ9 HS

Family and domain databases

CDDⁱ	cd00041 CUB, 2 hits cd03576 NTR_PCOLCE, 1 hit
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR001134 Netrin_domain IPR018933 Netrin_module_non-TIMP IPR035814 NTR_PCOLCE IPR035914 Sperma_CUB_dom_sf IPR008993 TIMP-like_OB-fold
Pfamⁱ	View protein in Pfam PF00431 CUB, 2 hits PF01759 NTR, 1 hit
SMARTⁱ	View protein in SMART SM00643 C345C, 1 hit SM00042 CUB, 2 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF50242 SSF50242, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 2 hits PS50189 NTR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCOC2_HUMAN
Accessionⁱ	Q9UKZ9Primary (citable) accession number: Q9UKZ9 Secondary accession number(s): B2RCH9, D3DNG4, Q9BRH3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UKZ9 (PCOC2_HUMAN)

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Procollagen C-endopeptidase enhancer 2

PCOLCE2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ