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UniProtKB - Q9UKZ9 (PCOC2_HUMAN)

Entry version 149 (07 Apr 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Procollagen C-endopeptidase enhancer 2

Gene

PCOLCE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • collagen binding Source: MGI
  • heparin binding Source: MGI
  • peptidase activator activity Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UKZ9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1650814, Collagen biosynthesis and modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 2
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 2
Short name:
PCPE-2
Short name:
Procollagen C-proteinase enhancer 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCOLCE2
Synonyms:PCPE2
ORF Names:UNQ250/PRO287
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8739, PCOLCE2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607064, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UKZ9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163710.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26577

Open Targets

More...OpenTargetsi		ENSG00000163710

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33084

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UKZ9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PCOLCE2

Domain mapping of disease mutations (DMDM)

More...DMDMi		67470587

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002202024 – 415Procollagen C-endopeptidase enhancer 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 59PROSITE-ProRule annotation
Disulfide bondi86 ↔ 107PROSITE-ProRule annotation
Disulfide bondi154 ↔ 181PROSITE-ProRule annotation
Disulfide bondi208 ↔ 231PROSITE-ProRule annotation
Disulfide bondi297 ↔ 364By similarity
Disulfide bondi301 ↔ 367By similarity
Disulfide bondi312 ↔ 415By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains sialic acid.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UKZ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UKZ9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UKZ9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UKZ9

PeptideAtlas

More...PeptideAtlasi		Q9UKZ9

PRoteomics IDEntifications database

More...PRIDEi		Q9UKZ9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84920

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UKZ9, 2 sites, 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UKZ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UKZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163710, Expressed in tendon of biceps brachii and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UKZ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UKZ9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163710, Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with heparin with high affinity, and type I or II collagen.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117746, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q9UKZ9, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295992

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UKZ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UKZ9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 144CUB 1PROSITE-ProRule annotationAdd BLAST112
Domaini154 – 268CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini297 – 415NTRPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRMG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034096_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UKZ9

Identification of Orthologs from Complete Genome Data

More...OMAi		TEVCAQS

Database of Orthologous Groups

More...OrthoDBi		862783at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UKZ9

TreeFam database of animal gene trees

More...TreeFami		TF316506

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 2 hits
cd03576, NTR_PCOLCE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.120, 1 hit
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR035814, NTR_PCOLCE
IPR035914, Sperma_CUB_dom_sf
IPR008993, TIMP-like_OB-fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 2 hits
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00643, C345C, 1 hit
SM00042, CUB, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 2 hits
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 2 hits
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UKZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGANAWAPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP 
        60         70         80         90        100
GVYPPNSKCT WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG 
       110        120        130        140        150
QRIGRFCGTF RPGALVSSGN KMMVQMISDA NTAGNGFMAM FSAAEPNERG 
       160        170        180        190        200
DQYCGGLLDR PSGSFKTPNW PDRDYPAGVT CVWHIVAPKN QLIELKFEKF 
       210        220        230        240        250
DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV SERNELLIQF 
       260        270        280        290        300
LSDLSLTADG FIGHYIFRPK KLPTTTEQPV TTTFPVTTGL KPTVALCQQK 
       310        320        330        340        350
CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ 
       360        370        380        390        400
QAGKNMSARL TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK 
       410 
TKNQKLLDAL KNKQC
Length:415
Mass (Da):45,717
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9AA87FD9AAF7A5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYX9C9JYX9_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITE8A0A3B3ITE8_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5D5H7C5D5_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C520H7C520_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051264280V → A. Corresponds to variant dbSNP:rs35692900Ensembl.1
Natural variantiVAR_022448292P → T. Corresponds to variant dbSNP:rs17554211Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF098269 mRNA Translation: AAF04621.1
AY035400 mRNA Translation: AAK63128.1
AY358557 mRNA Translation: AAQ88921.1
CR536570 mRNA Translation: CAG38807.1
AK315121 mRNA Translation: BAG37576.1
CH471052 Genomic DNA Translation: EAW78961.1
CH471052 Genomic DNA Translation: EAW78962.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3127.1

NCBI Reference Sequences

More...RefSeqi		NP_037495.1, NM_013363.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295992; ENSP00000295992; ENSG00000163710

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26577

UCSC genome browser

More...UCSCi		uc003evd.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098269 mRNA Translation: AAF04621.1
AY035400 mRNA Translation: AAK63128.1
AY358557 mRNA Translation: AAQ88921.1
CR536570 mRNA Translation: CAG38807.1
AK315121 mRNA Translation: BAG37576.1
CH471052 Genomic DNA Translation: EAW78961.1
CH471052 Genomic DNA Translation: EAW78962.1
CCDSiCCDS3127.1
RefSeqiNP_037495.1, NM_013363.3

3D structure databases

SMRiQ9UKZ9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117746, 14 interactors
IntActiQ9UKZ9, 9 interactors
STRINGi9606.ENSP00000295992

PTM databases

GlyGeniQ9UKZ9, 2 sites, 2 O-linked glycans (1 site)
iPTMnetiQ9UKZ9
PhosphoSitePlusiQ9UKZ9

Genetic variation databases

BioMutaiPCOLCE2
DMDMi67470587

Proteomic databases

jPOSTiQ9UKZ9
MassIVEiQ9UKZ9
MaxQBiQ9UKZ9
PaxDbiQ9UKZ9
PeptideAtlasiQ9UKZ9
PRIDEiQ9UKZ9
ProteomicsDBi84920

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2145, 151 antibodies

The DNASU plasmid repository

More...DNASUi		26577

Genome annotation databases

EnsembliENST00000295992; ENSP00000295992; ENSG00000163710
GeneIDi26577
KEGGihsa:26577
UCSCiuc003evd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26577
DisGeNETi26577

GeneCards: human genes, protein and diseases

More...GeneCardsi		PCOLCE2
HGNCiHGNC:8739, PCOLCE2
HPAiENSG00000163710, Tissue enhanced (heart)
MIMi607064, gene
neXtProtiNX_Q9UKZ9
OpenTargetsiENSG00000163710
PharmGKBiPA33084
VEuPathDBiHostDB:ENSG00000163710.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRMG, Eukaryota
GeneTreeiENSGT00940000157649
HOGENOMiCLU_034096_0_0_1
InParanoidiQ9UKZ9
OMAiTEVCAQS
OrthoDBi862783at2759
PhylomeDBiQ9UKZ9
TreeFamiTF316506

Enzyme and pathway databases

PathwayCommonsiQ9UKZ9
ReactomeiR-HSA-1650814, Collagen biosynthesis and modifying enzymes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26577, 7 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PCOLCE2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PCOLCE2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26577
PharosiQ9UKZ9, Tbio

Protein Ontology

More...PROi		PR:Q9UKZ9
RNActiQ9UKZ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163710, Expressed in tendon of biceps brachii and 203 other tissues
ExpressionAtlasiQ9UKZ9, baseline and differential
GenevisibleiQ9UKZ9, HS

Family and domain databases

CDDicd00041, CUB, 2 hits
cd03576, NTR_PCOLCE, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR035814, NTR_PCOLCE
IPR035914, Sperma_CUB_dom_sf
IPR008993, TIMP-like_OB-fold
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00042, CUB, 2 hits
SUPFAMiSSF49854, SSF49854, 2 hits
SSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCOC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKZ9
Secondary accession number(s): B2RCH9, D3DNG4, Q9BRH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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