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Protein

Procollagen C-endopeptidase enhancer 2

Gene

PCOLCE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.1 Publication

GO - Molecular functioni

  • collagen binding Source: MGI
  • heparin binding Source: MGI
  • peptidase activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 2
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 2
Short name:
PCPE-2
Short name:
Procollagen C-proteinase enhancer 2
Gene namesi
Name:PCOLCE2
Synonyms:PCPE2
ORF Names:UNQ250/PRO287
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163710.7
HGNCiHGNC:8739 PCOLCE2
MIMi607064 gene
neXtProtiNX_Q9UKZ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi26577
OpenTargetsiENSG00000163710
PharmGKBiPA33084

Polymorphism and mutation databases

BioMutaiPCOLCE2
DMDMi67470587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000002202024 – 415Procollagen C-endopeptidase enhancer 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 59PROSITE-ProRule annotation
Disulfide bondi86 ↔ 107PROSITE-ProRule annotation
Disulfide bondi154 ↔ 181PROSITE-ProRule annotation
Disulfide bondi208 ↔ 231PROSITE-ProRule annotation
Disulfide bondi297 ↔ 364By similarity
Disulfide bondi301 ↔ 367By similarity
Disulfide bondi312 ↔ 415By similarity
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated; contains sialic acid.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UKZ9
PaxDbiQ9UKZ9
PeptideAtlasiQ9UKZ9
PRIDEiQ9UKZ9
ProteomicsDBi84920

PTM databases

iPTMnetiQ9UKZ9
PhosphoSitePlusiQ9UKZ9

Expressioni

Tissue specificityi

Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage.3 Publications

Gene expression databases

BgeeiENSG00000163710 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PCOLCE2
ExpressionAtlasiQ9UKZ9 baseline and differential
GenevisibleiQ9UKZ9 HS

Organism-specific databases

HPAiHPA013203

Interactioni

Subunit structurei

Interacts with heparin with high affinity, and type I or II collagen.1 Publication

Protein-protein interaction databases

BioGridi117746, 11 interactors
STRINGi9606.ENSP00000295992

Structurei

3D structure databases

ProteinModelPortaliQ9UKZ9
SMRiQ9UKZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 144CUB 1PROSITE-ProRule annotationAdd BLAST112
Domaini154 – 268CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini297 – 415NTRPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEMJ Eukaryota
ENOG410Y9AW LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000059592
HOVERGENiHBG053528
InParanoidiQ9UKZ9
OMAiSIINVYK
OrthoDBiEOG091G06JY
PhylomeDBiQ9UKZ9
TreeFamiTF316506

Family and domain databases

CDDicd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UKZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGANAWAPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP
60 70 80 90 100
GVYPPNSKCT WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG
110 120 130 140 150
QRIGRFCGTF RPGALVSSGN KMMVQMISDA NTAGNGFMAM FSAAEPNERG
160 170 180 190 200
DQYCGGLLDR PSGSFKTPNW PDRDYPAGVT CVWHIVAPKN QLIELKFEKF
210 220 230 240 250
DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV SERNELLIQF
260 270 280 290 300
LSDLSLTADG FIGHYIFRPK KLPTTTEQPV TTTFPVTTGL KPTVALCQQK
310 320 330 340 350
CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ
360 370 380 390 400
QAGKNMSARL TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK
410
TKNQKLLDAL KNKQC
Length:415
Mass (Da):45,717
Last modified:May 1, 2000 - v1
Checksum:iB9AA87FD9AAF7A5B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYX9C9JYX9_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
303Annotation score:
H7C5D5H7C5D5_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
140Annotation score:
H7C520H7C520_HUMAN
Procollagen C-endopeptidase enhance...
PCOLCE2
101Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051264280V → A. Corresponds to variant dbSNP:rs35692900Ensembl.1
Natural variantiVAR_022448292P → T. Corresponds to variant dbSNP:rs17554211Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098269 mRNA Translation: AAF04621.1
AY035400 mRNA Translation: AAK63128.1
AY358557 mRNA Translation: AAQ88921.1
CR536570 mRNA Translation: CAG38807.1
AK315121 mRNA Translation: BAG37576.1
CH471052 Genomic DNA Translation: EAW78961.1
CH471052 Genomic DNA Translation: EAW78962.1
CCDSiCCDS3127.1
RefSeqiNP_037495.1, NM_013363.3
UniGeneiHs.8944

Genome annotation databases

EnsembliENST00000295992; ENSP00000295992; ENSG00000163710
GeneIDi26577
KEGGihsa:26577
UCSCiuc003evd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098269 mRNA Translation: AAF04621.1
AY035400 mRNA Translation: AAK63128.1
AY358557 mRNA Translation: AAQ88921.1
CR536570 mRNA Translation: CAG38807.1
AK315121 mRNA Translation: BAG37576.1
CH471052 Genomic DNA Translation: EAW78961.1
CH471052 Genomic DNA Translation: EAW78962.1
CCDSiCCDS3127.1
RefSeqiNP_037495.1, NM_013363.3
UniGeneiHs.8944

3D structure databases

ProteinModelPortaliQ9UKZ9
SMRiQ9UKZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117746, 11 interactors
STRINGi9606.ENSP00000295992

PTM databases

iPTMnetiQ9UKZ9
PhosphoSitePlusiQ9UKZ9

Polymorphism and mutation databases

BioMutaiPCOLCE2
DMDMi67470587

Proteomic databases

MaxQBiQ9UKZ9
PaxDbiQ9UKZ9
PeptideAtlasiQ9UKZ9
PRIDEiQ9UKZ9
ProteomicsDBi84920

Protocols and materials databases

DNASUi26577
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295992; ENSP00000295992; ENSG00000163710
GeneIDi26577
KEGGihsa:26577
UCSCiuc003evd.4 human

Organism-specific databases

CTDi26577
DisGeNETi26577
EuPathDBiHostDB:ENSG00000163710.7
GeneCardsiPCOLCE2
HGNCiHGNC:8739 PCOLCE2
HPAiHPA013203
MIMi607064 gene
neXtProtiNX_Q9UKZ9
OpenTargetsiENSG00000163710
PharmGKBiPA33084
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEMJ Eukaryota
ENOG410Y9AW LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000059592
HOVERGENiHBG053528
InParanoidiQ9UKZ9
OMAiSIINVYK
OrthoDBiEOG091G06JY
PhylomeDBiQ9UKZ9
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

ChiTaRSiPCOLCE2 human
GeneWikiiPCOLCE2
GenomeRNAii26577
PROiPR:Q9UKZ9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163710 Expressed in 191 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_PCOLCE2
ExpressionAtlasiQ9UKZ9 baseline and differential
GenevisibleiQ9UKZ9 HS

Family and domain databases

CDDicd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCOC2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKZ9
Secondary accession number(s): B2RCH9, D3DNG4, Q9BRH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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