UniProtKB - Q9UKZ9 (PCOC2_HUMAN)
Protein
Procollagen C-endopeptidase enhancer 2
Gene
PCOLCE2
Organism
Homo sapiens (Human)
Status
Functioni
Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.1 Publication
GO - Molecular functioni
- collagen binding Source: MGI
- heparin binding Source: MGI
- peptidase activator activity Source: MGI
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
Keywordsi
Molecular function | Heparin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UKZ9 |
Reactomei | R-HSA-1650814, Collagen biosynthesis and modifying enzymes |
Names & Taxonomyi
Protein namesi | Recommended name: Procollagen C-endopeptidase enhancer 2Alternative name(s): Procollagen COOH-terminal proteinase enhancer 2 Short name: PCPE-2 Short name: Procollagen C-proteinase enhancer 2 |
Gene namesi | Name:PCOLCE2 Synonyms:PCPE2 ORF Names:UNQ250/PRO287 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163710.7 |
HGNCi | HGNC:8739, PCOLCE2 |
MIMi | 607064, gene |
neXtProti | NX_Q9UKZ9 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 26577 |
OpenTargetsi | ENSG00000163710 |
PharmGKBi | PA33084 |
Miscellaneous databases
Pharosi | Q9UKZ9, Tbio |
Polymorphism and mutation databases
BioMutai | PCOLCE2 |
DMDMi | 67470587 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 1 PublicationAdd BLAST | 23 | |
ChainiPRO_0000022020 | 24 – 415 | Procollagen C-endopeptidase enhancer 2Add BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 86 ↔ 107 | PROSITE-ProRule annotation | ||
Disulfide bondi | 154 ↔ 181 | PROSITE-ProRule annotation | ||
Disulfide bondi | 208 ↔ 231 | PROSITE-ProRule annotation | ||
Disulfide bondi | 297 ↔ 364 | By similarity | ||
Disulfide bondi | 301 ↔ 367 | By similarity | ||
Disulfide bondi | 312 ↔ 415 | By similarity | ||
Glycosylationi | 355 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
O-glycosylated; contains sialic acid.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9UKZ9 |
MassIVEi | Q9UKZ9 |
MaxQBi | Q9UKZ9 |
PaxDbi | Q9UKZ9 |
PeptideAtlasi | Q9UKZ9 |
PRIDEi | Q9UKZ9 |
ProteomicsDBi | 84920 |
PTM databases
GlyGeni | Q9UKZ9, 2 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q9UKZ9 |
PhosphoSitePlusi | Q9UKZ9 |
Expressioni
Tissue specificityi
Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage.3 Publications
Gene expression databases
Bgeei | ENSG00000163710, Expressed in tendon of biceps brachii and 203 other tissues |
ExpressionAtlasi | Q9UKZ9, baseline and differential |
Genevisiblei | Q9UKZ9, HS |
Organism-specific databases
HPAi | ENSG00000163710, Tissue enhanced (heart) |
Interactioni
Subunit structurei
Interacts with heparin with high affinity, and type I or II collagen.
1 PublicationProtein-protein interaction databases
BioGRIDi | 117746, 13 interactors |
IntActi | Q9UKZ9, 8 interactors |
STRINGi | 9606.ENSP00000295992 |
Miscellaneous databases
RNActi | Q9UKZ9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 144 | CUB 1PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 154 – 268 | CUB 2PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 297 – 415 | NTRPROSITE-ProRule annotationAdd BLAST | 119 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QRMG, Eukaryota |
GeneTreei | ENSGT00940000157649 |
HOGENOMi | CLU_034096_0_0_1 |
InParanoidi | Q9UKZ9 |
OMAi | TEVCAQS |
OrthoDBi | 862783at2759 |
PhylomeDBi | Q9UKZ9 |
TreeFami | TF316506 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd03576, NTR_PCOLCE, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035814, NTR_PCOLCE IPR035914, Sperma_CUB_dom_sf IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00042, CUB, 2 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS50189, NTR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9UKZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGANAWAPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP
60 70 80 90 100
GVYPPNSKCT WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG
110 120 130 140 150
QRIGRFCGTF RPGALVSSGN KMMVQMISDA NTAGNGFMAM FSAAEPNERG
160 170 180 190 200
DQYCGGLLDR PSGSFKTPNW PDRDYPAGVT CVWHIVAPKN QLIELKFEKF
210 220 230 240 250
DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV SERNELLIQF
260 270 280 290 300
LSDLSLTADG FIGHYIFRPK KLPTTTEQPV TTTFPVTTGL KPTVALCQQK
310 320 330 340 350
CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ
360 370 380 390 400
QAGKNMSARL TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK
410
TKNQKLLDAL KNKQC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JYX9 | C9JYX9_HUMAN | Procollagen C-endopeptidase enhance... | PCOLCE2 | 303 | Annotation score: | ||
A0A3B3ITE8 | A0A3B3ITE8_HUMAN | Procollagen C-endopeptidase enhance... | PCOLCE2 | 401 | Annotation score: | ||
H7C5D5 | H7C5D5_HUMAN | Procollagen C-endopeptidase enhance... | PCOLCE2 | 140 | Annotation score: | ||
H7C520 | H7C520_HUMAN | Procollagen C-endopeptidase enhance... | PCOLCE2 | 101 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051264 | 280 | V → A. Corresponds to variant dbSNP:rs35692900Ensembl. | 1 | |
Natural variantiVAR_022448 | 292 | P → T. Corresponds to variant dbSNP:rs17554211Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF098269 mRNA Translation: AAF04621.1 AY035400 mRNA Translation: AAK63128.1 AY358557 mRNA Translation: AAQ88921.1 CR536570 mRNA Translation: CAG38807.1 AK315121 mRNA Translation: BAG37576.1 CH471052 Genomic DNA Translation: EAW78961.1 CH471052 Genomic DNA Translation: EAW78962.1 |
CCDSi | CCDS3127.1 |
RefSeqi | NP_037495.1, NM_013363.3 |
Genome annotation databases
Ensembli | ENST00000295992; ENSP00000295992; ENSG00000163710 |
GeneIDi | 26577 |
KEGGi | hsa:26577 |
UCSCi | uc003evd.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF098269 mRNA Translation: AAF04621.1 AY035400 mRNA Translation: AAK63128.1 AY358557 mRNA Translation: AAQ88921.1 CR536570 mRNA Translation: CAG38807.1 AK315121 mRNA Translation: BAG37576.1 CH471052 Genomic DNA Translation: EAW78961.1 CH471052 Genomic DNA Translation: EAW78962.1 |
CCDSi | CCDS3127.1 |
RefSeqi | NP_037495.1, NM_013363.3 |
3D structure databases
SMRi | Q9UKZ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117746, 13 interactors |
IntActi | Q9UKZ9, 8 interactors |
STRINGi | 9606.ENSP00000295992 |
PTM databases
GlyGeni | Q9UKZ9, 2 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q9UKZ9 |
PhosphoSitePlusi | Q9UKZ9 |
Polymorphism and mutation databases
BioMutai | PCOLCE2 |
DMDMi | 67470587 |
Proteomic databases
jPOSTi | Q9UKZ9 |
MassIVEi | Q9UKZ9 |
MaxQBi | Q9UKZ9 |
PaxDbi | Q9UKZ9 |
PeptideAtlasi | Q9UKZ9 |
PRIDEi | Q9UKZ9 |
ProteomicsDBi | 84920 |
Protocols and materials databases
Antibodypediai | 2145, 147 antibodies |
DNASUi | 26577 |
Genome annotation databases
Ensembli | ENST00000295992; ENSP00000295992; ENSG00000163710 |
GeneIDi | 26577 |
KEGGi | hsa:26577 |
UCSCi | uc003evd.4, human |
Organism-specific databases
CTDi | 26577 |
DisGeNETi | 26577 |
EuPathDBi | HostDB:ENSG00000163710.7 |
GeneCardsi | PCOLCE2 |
HGNCi | HGNC:8739, PCOLCE2 |
HPAi | ENSG00000163710, Tissue enhanced (heart) |
MIMi | 607064, gene |
neXtProti | NX_Q9UKZ9 |
OpenTargetsi | ENSG00000163710 |
PharmGKBi | PA33084 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRMG, Eukaryota |
GeneTreei | ENSGT00940000157649 |
HOGENOMi | CLU_034096_0_0_1 |
InParanoidi | Q9UKZ9 |
OMAi | TEVCAQS |
OrthoDBi | 862783at2759 |
PhylomeDBi | Q9UKZ9 |
TreeFami | TF316506 |
Enzyme and pathway databases
PathwayCommonsi | Q9UKZ9 |
Reactomei | R-HSA-1650814, Collagen biosynthesis and modifying enzymes |
Miscellaneous databases
BioGRID-ORCSi | 26577, 6 hits in 841 CRISPR screens |
ChiTaRSi | PCOLCE2, human |
GeneWikii | PCOLCE2 |
GenomeRNAii | 26577 |
Pharosi | Q9UKZ9, Tbio |
PROi | PR:Q9UKZ9 |
RNActi | Q9UKZ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163710, Expressed in tendon of biceps brachii and 203 other tissues |
ExpressionAtlasi | Q9UKZ9, baseline and differential |
Genevisiblei | Q9UKZ9, HS |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd03576, NTR_PCOLCE, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035814, NTR_PCOLCE IPR035914, Sperma_CUB_dom_sf IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00042, CUB, 2 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCOC2_HUMAN | |
Accessioni | Q9UKZ9Primary (citable) accession number: Q9UKZ9 Secondary accession number(s): B2RCH9, D3DNG4, Q9BRH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations