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Entry version 141 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

CCR4-NOT transcription complex subunit 11

Gene

CNOT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UKZ1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-429947, Deadenylation of mRNA
R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNOT11
Synonyms:C2orf29
ORF Names:C40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25217, CNOT11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKZ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000158435.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000158435

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134899354

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKZ1, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105958

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNOT11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893571 – 510CCR4-NOT transcription complex subunit 11Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKZ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UKZ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKZ1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UKZ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKZ1

PeptideAtlas

More...
PeptideAtlasi
Q9UKZ1

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKZ1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84917

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158435, Expressed in heart and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKZ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKZ1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000158435, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120724, 82 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UKZ1

Protein interaction database and analysis system

More...
IntActi
Q9UKZ1, 47 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000289382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UKZ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKZ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 63DisorderedSequence analysisAdd BLAST63
Regioni232 – 259DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT11 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4508, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006356

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028648_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKZ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVGNMAQ

Database of Orthologous Groups

More...
OrthoDBi
996942at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKZ1

TreeFam database of animal gene trees

More...
TreeFami
TF323711

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019312, CNOT11

The PANTHER Classification System

More...
PANTHERi
PTHR15975, PTHR15975, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10155, CNOT11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UKZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGGGASAAS GRLLTAAEQR GSREAAGSAS RSGFGGSGGG RGGASGPGSG
60 70 80 90 100
SGGPGGPAGR MSLTPKELSS LLSIISEEAG GGSTFEGLST AFHHYFSKAD
110 120 130 140 150
HFRLGSVLVM LLQQPDLLPS AAQRLTALYL LWEMYRTEPL AANPFAASFA
160 170 180 190 200
HLLNPAPPAR GGQEPDRPPL SGFLPPITPP EKFFLSQLML APPRELFKKT
210 220 230 240 250
PRQIALMDVG NMGQSVDISG LQLALAERQS ELPTQSKASF PSILSDPDPD
260 270 280 290 300
SSNSGFDSSV ASQITEALVS GPKPPIESHF RPEFIRPPPP LHICEDELAW
310 320 330 340 350
LNPTEPDHAI QWDKSMCVKN STGVEIKRIM AKAFKSPLSS PQQTQLLGEL
360 370 380 390 400
EKDPKLVYHI GLTPAKLPDL VENNPLVAIE MLLKLMQSSQ ITEYFSVLVN
410 420 430 440 450
MDMSLHSMEV VNRLTTAVDL PPEFIHLYIS NCISTCEQIK DKYMQNRLVR
460 470 480 490 500
LVCVFLQSLI RNKIINVQDL FIEVQAFCIE FSRIREAAGL FRLLKTLDTG
510
ETPSETKMSK
Length:510
Mass (Da):55,215
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE733DA59F1D0F280
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0C7H7C0C7_HUMAN
CCR4-NOT transcription complex subu...
CNOT11
127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti507K → E in AAH64421 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF103798 mRNA Translation: AAF02418.1
AC013722 Genomic DNA Translation: AAY15088.1
BC018664 mRNA Translation: AAH18664.2
BC064421 mRNA Translation: AAH64421.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2050.1

NCBI Reference Sequences

More...
RefSeqi
NP_060016.3, NM_017546.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000289382; ENSP00000289382; ENSG00000158435

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55571

UCSC genome browser

More...
UCSCi
uc002taw.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103798 mRNA Translation: AAF02418.1
AC013722 Genomic DNA Translation: AAY15088.1
BC018664 mRNA Translation: AAH18664.2
BC064421 mRNA Translation: AAH64421.1
CCDSiCCDS2050.1
RefSeqiNP_060016.3, NM_017546.4

3D structure databases

SMRiQ9UKZ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120724, 82 interactors
CORUMiQ9UKZ1
IntActiQ9UKZ1, 47 interactors
STRINGi9606.ENSP00000289382

Chemistry databases

ChEMBLiCHEMBL4105958

PTM databases

iPTMnetiQ9UKZ1
PhosphoSitePlusiQ9UKZ1

Genetic variation databases

BioMutaiCNOT11
DMDMi71152358

Proteomic databases

EPDiQ9UKZ1
jPOSTiQ9UKZ1
MassIVEiQ9UKZ1
MaxQBiQ9UKZ1
PaxDbiQ9UKZ1
PeptideAtlasiQ9UKZ1
PRIDEiQ9UKZ1
ProteomicsDBi84917

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47523, 70 antibodies

The DNASU plasmid repository

More...
DNASUi
55571

Genome annotation databases

EnsembliENST00000289382; ENSP00000289382; ENSG00000158435
GeneIDi55571
KEGGihsa:55571
UCSCiuc002taw.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55571

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CNOT11
HGNCiHGNC:25217, CNOT11
HPAiENSG00000158435, Low tissue specificity
neXtProtiNX_Q9UKZ1
OpenTargetsiENSG00000158435
PharmGKBiPA134899354
VEuPathDBiHostDB:ENSG00000158435.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4508, Eukaryota
GeneTreeiENSGT00390000006356
HOGENOMiCLU_028648_0_1_1
InParanoidiQ9UKZ1
OMAiDVGNMAQ
OrthoDBi996942at2759
PhylomeDBiQ9UKZ1
TreeFamiTF323711

Enzyme and pathway databases

PathwayCommonsiQ9UKZ1
ReactomeiR-HSA-429947, Deadenylation of mRNA
R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55571, 54 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CNOT11, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55571
PharosiQ9UKZ1, Tbio

Protein Ontology

More...
PROi
PR:Q9UKZ1
RNActiQ9UKZ1, protein

Gene expression databases

BgeeiENSG00000158435, Expressed in heart and 215 other tissues
ExpressionAtlasiQ9UKZ1, baseline and differential
GenevisibleiQ9UKZ1, HS

Family and domain databases

InterProiView protein in InterPro
IPR019312, CNOT11
PANTHERiPTHR15975, PTHR15975, 1 hit
PfamiView protein in Pfam
PF10155, CNOT11, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNO11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKZ1
Secondary accession number(s): Q6P2M9, Q8N681
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families
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