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Protein

Zinc fingers and homeoboxes protein 1

Gene

ZHX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 93C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri102 – 125C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24
DNA bindingi284 – 346Homeobox 1PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi464 – 526Homeobox 2PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi569 – 630Homeobox 3PROSITE-ProRule annotationCuratedAdd BLAST62
DNA bindingi660 – 722Homeobox 4PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi777 – 832Homeobox 5PROSITE-ProRule annotationCuratedAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 1
Gene namesi
Name:ZHX1
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000165156.14
HGNCiHGNC:12871 ZHX1
MIMi604764 gene
neXtProtiNX_Q9UKY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11244
OpenTargetsiENSG00000165156
PharmGKBiPA37460

Polymorphism and mutation databases

BioMutaiZHX1
DMDMi44888551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493881 – 873Zinc fingers and homeoboxes protein 1Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei202PhosphoserineCombined sources1
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei648PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UKY1
MaxQBiQ9UKY1
PaxDbiQ9UKY1
PeptideAtlasiQ9UKY1
PRIDEiQ9UKY1
ProteomicsDBi84909

PTM databases

iPTMnetiQ9UKY1
PhosphoSitePlusiQ9UKY1

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed in podocytes.2 Publications

Gene expression databases

BgeeiENSG00000165156 Expressed in 216 organ(s), highest expression level in liver
CleanExiHS_ZHX1
ExpressionAtlasiQ9UKY1 baseline and differential
GenevisibleiQ9UKY1 HS

Organism-specific databases

HPAiHPA055357
HPA060251

Interactioni

Subunit structurei

Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116406, 58 interactors
IntActiQ9UKY1, 59 interactors
MINTiQ9UKY1
STRINGi9606.ENSP00000297857

Structurei

Secondary structure

1873
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UKY1
SMRiQ9UKY1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKY1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni272 – 564Required for interaction with NFYAAdd BLAST293
Regioni272 – 432Required for dimerizationAdd BLAST161
Regioni734 – 768Required for nuclear localizationAdd BLAST35
Regioni831 – 873Required for repressor activityAdd BLAST43

Sequence similaritiesi

Belongs to the ZHX family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 93C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri102 – 125C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00530000063149
HOGENOMiHOG000013231
HOVERGENiHBG007920
InParanoidiQ9UKY1
OMAiKIWFSAQ
OrthoDBiEOG091G02WT
PhylomeDBiQ9UKY1
TreeFamiTF333363

Family and domain databases

CDDicd00086 homeodomain, 5 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR024578 Homez_homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeobox, 4 hits
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 5 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 5 hits
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRRKSTTP CMVLASEQDP DLELISDLDE GPPVLTPVEN TRAESISSDE
60 70 80 90 100
EVHESVDSDN QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS
110 120 130 140 150
SYVCVECNFL TKRYDALSEH NLKYHPGEEN FKLTMVKRNN QTIFEQTIND
160 170 180 190 200
LTFDGSFVKE ENAEQAESTE VSSSGISISK TPIMKMMKNK VENKRIAVHH
210 220 230 240 250
NSVEDVPEEK ENEIKPDREE IVENPSSSAS ESNTSTSIVN RIHPSTASTV
260 270 280 290 300
VTPAAVLPGL AQVITAVSAQ QNSNLIPKVL IPVNSIPTYN AALDNNPLLL
310 320 330 340 350
NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE
360 370 380 390 400
ARRKQFNGTV HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ
410 420 430 440 450
VAGTNTLPVT APIALTVAGV PSQNNIQKSQ VPAAQPTAET KPATAAVPTS
460 470 480 490 500
QSVKHETALV NPDSFGIRAK KTKEQLAELK VSYLKNQFPH DSEIIRLMKI
510 520 530 540 550
TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSTTIII DSSDETTESP
560 570 580 590 600
TVGTAQPKQS WNPFPDFTPQ KFKEKTAEQL RVLQASFLNS SVLTDEELNR
610 620 630 640 650
LRAQTKLTRR EIDAWFTEKK KSKALKEEKM EIDESNAGSS KEEAGETSPA
660 670 680 690 700
DESGAPKSGS TGKICKKTPE QLHMLKSAFV RTQWPSPEEY DKLAKESGLA
710 720 730 740 750
RTDIVSWFGD TRYAWKNGNL KWYYYYQSAN SSSMNGLSSL RKRGRGRPKG
760 770 780 790 800
RGRGRPRGRP RGSKRINNWD RGPSLIKFKT GTAILKDYYL KHKFLNEQDL
810 820 830 840 850
DELVNKSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE VIDDQEEDEE
860 870
ETDDSDTWEP PRHVKRKLSK SDD
Length:873
Mass (Da):98,098
Last modified:May 1, 2000 - v1
Checksum:i66CF1CEC5EF824E5
GO
Isoform 2 (identifier: Q96EF9-1) [UniParc]FASTAAdd to basket
Also known as: ZHX1-C8orf76
The sequence of this isoform can be found in the external entry Q96EF9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein. No experimental confirmation available.
Length:292
Mass (Da):33,285
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPX4U3KPX4_HUMAN
Zinc fingers and homeoboxes protein...
ZHX1
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263V → M in AAH40481 (PubMed:15489334).Curated1
Sequence conflicti792H → R in AAH40481 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106862 mRNA Translation: AAD50624.1
AF195766 mRNA Translation: AAF35183.1
BC040481 mRNA Translation: AAH40481.1
CCDSiCCDS6342.1 [Q9UKY1-1]
PIRiJC7079
RefSeqiNP_001017926.1, NM_001017926.2 [Q9UKY1-1]
NP_009153.3, NM_007222.4 [Q9UKY1-1]
UniGeneiHs.521800

Genome annotation databases

EnsembliENST00000297857; ENSP00000297857; ENSG00000165156 [Q9UKY1-1]
ENST00000395571; ENSP00000378938; ENSG00000165156 [Q9UKY1-1]
ENST00000522655; ENSP00000428821; ENSG00000165156 [Q9UKY1-1]
GeneIDi11244
KEGGihsa:11244
UCSCiuc003yqe.4 human [Q9UKY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106862 mRNA Translation: AAD50624.1
AF195766 mRNA Translation: AAF35183.1
BC040481 mRNA Translation: AAH40481.1
CCDSiCCDS6342.1 [Q9UKY1-1]
PIRiJC7079
RefSeqiNP_001017926.1, NM_001017926.2 [Q9UKY1-1]
NP_009153.3, NM_007222.4 [Q9UKY1-1]
UniGeneiHs.521800

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECBNMR-A565-640[»]
2GHFNMR-A60-153[»]
2LY9NMR-A462-532[»]
3NARX-ray2.60A/B655-731[»]
ProteinModelPortaliQ9UKY1
SMRiQ9UKY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116406, 58 interactors
IntActiQ9UKY1, 59 interactors
MINTiQ9UKY1
STRINGi9606.ENSP00000297857

PTM databases

iPTMnetiQ9UKY1
PhosphoSitePlusiQ9UKY1

Polymorphism and mutation databases

BioMutaiZHX1
DMDMi44888551

Proteomic databases

EPDiQ9UKY1
MaxQBiQ9UKY1
PaxDbiQ9UKY1
PeptideAtlasiQ9UKY1
PRIDEiQ9UKY1
ProteomicsDBi84909

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297857; ENSP00000297857; ENSG00000165156 [Q9UKY1-1]
ENST00000395571; ENSP00000378938; ENSG00000165156 [Q9UKY1-1]
ENST00000522655; ENSP00000428821; ENSG00000165156 [Q9UKY1-1]
GeneIDi11244
KEGGihsa:11244
UCSCiuc003yqe.4 human [Q9UKY1-1]

Organism-specific databases

CTDi11244
DisGeNETi11244
EuPathDBiHostDB:ENSG00000165156.14
GeneCardsiZHX1
HGNCiHGNC:12871 ZHX1
HPAiHPA055357
HPA060251
MIMi604764 gene
neXtProtiNX_Q9UKY1
OpenTargetsiENSG00000165156
PharmGKBiPA37460
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00530000063149
HOGENOMiHOG000013231
HOVERGENiHBG007920
InParanoidiQ9UKY1
OMAiKIWFSAQ
OrthoDBiEOG091G02WT
PhylomeDBiQ9UKY1
TreeFamiTF333363

Miscellaneous databases

EvolutionaryTraceiQ9UKY1
GeneWikiiZHX1
GenomeRNAii11244
PROiPR:Q9UKY1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165156 Expressed in 216 organ(s), highest expression level in liver
CleanExiHS_ZHX1
ExpressionAtlasiQ9UKY1 baseline and differential
GenevisibleiQ9UKY1 HS

Family and domain databases

CDDicd00086 homeodomain, 5 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR024578 Homez_homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeobox, 4 hits
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 5 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 5 hits
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZHX1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY1
Secondary accession number(s): Q8IWD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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