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Protein

Prion-like protein doppel

Gene

PRND

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu2+ (PubMed:15218028, PubMed:20411530).By similarity2 Publications

GO - Molecular functioni

  • copper ion binding Source: UniProtKB

GO - Biological processi

  • acrosome reaction Source: UniProtKB
  • cellular copper ion homeostasis Source: GO_Central
  • protein homooligomerization Source: InterPro

Keywordsi

Molecular functionPrion
Biological processFertilization
LigandCopper, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Protein family/group databases

TCDBi1.C.48.1.4 the prion peptide (prp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Prion-like protein doppel
Alternative name(s):
PrPLP
Prion protein 2
Gene namesi
Name:PRND
Synonyms:DPL
ORF Names:UNQ1830/PRO3443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171864.4
HGNCiHGNC:15748 PRND
MIMi604263 gene
neXtProtiNX_Q9UKY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23627
OpenTargetsiENSG00000171864
PharmGKBiPA33795

Polymorphism and mutation databases

BioMutaiPRND
DMDMi68067934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000002574526 – 152Prion-like protein doppelAdd BLAST127
PropeptideiPRO_0000025746153 – 176Removed in mature formBy similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi94 ↔ 145Combined sources2 Publications
Glycosylationi98N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi108 ↔ 140Combined sources2 Publications
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi152GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated. N-glycosylated at two distinct sites.1 Publication
O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9UKY0
PeptideAtlasiQ9UKY0
PRIDEiQ9UKY0
ProteomicsDBi84908

Expressioni

Tissue specificityi

Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000171864 Expressed in 73 organ(s), highest expression level in testis
CleanExiHS_PRND
GenevisibleiQ9UKY0 HS

Organism-specific databases

HPAiHPA043373

Interactioni

Protein-protein interaction databases

IntActiQ9UKY0, 1 interactor
STRINGi9606.ENSP00000306900

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UKY0
SMRiQ9UKY0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKY0

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 50Flexible tailAdd BLAST24
Regioni51 – 152GlobularAdd BLAST102
Regioni122 – 139Cu(2+) binding1 PublicationAdd BLAST18

Domaini

A short helical region is required and sufficient for Cu2+ binding.1 Publication

Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J97N Eukaryota
ENOG4111EBU LUCA
GeneTreeiENSGT00390000017668
HOGENOMiHOG000232078
HOVERGENiHBG023907
InParanoidiQ9UKY0
OMAiMRKHLGG
OrthoDBiEOG091G0LQ8
PhylomeDBiQ9UKY0
TreeFamiTF337532

Family and domain databases

Gene3Di1.10.790.10, 1 hit
InterProiView protein in InterPro
IPR021566 Doppel
IPR036924 Prion/Doppel_b-ribbon_dom_sf
IPR022416 Prion/Doppel_prot_b-ribbon_dom
PfamiView protein in Pfam
PF11466 Doppel, 1 hit
PF00377 Prion, 1 hit
SUPFAMiSSF54098 SSF54098, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ
60 70 80 90 100
VAENRPGAFI KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT
110 120 130 140 150
KEAFVTGCIN ATQAANQGEF QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE
160 170
RGAGLRVTMH QPVLLCLLAL IWLTVK
Length:176
Mass (Da):20,293
Last modified:June 21, 2005 - v2
Checksum:iA0F41EB0DFEED236
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → E in AAG43448 (Ref. 2) Curated1
Sequence conflicti143K → E in AAG43449 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0137696S → I1 Publication1
Natural variantiVAR_01377022S → P1 Publication1
Natural variantiVAR_01376526T → P1 Publication1
Natural variantiVAR_01377131H → R1 Publication1
Natural variantiVAR_01376656P → L1 PublicationCorresponds to variant dbSNP:rs35453518Ensembl.1
Natural variantiVAR_01377270F → L1 Publication1
Natural variantiVAR_013773149L → S1 Publication1
Natural variantiVAR_013767174T → M Common polymorphism. 6 PublicationsCorresponds to variant dbSNP:rs2245220Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106918 Genomic DNA Translation: AAF02424.1
AF187843 mRNA Translation: AAG43448.1
AF187844 mRNA Translation: AAG43449.1
EU009729 Genomic DNA Translation: ABU40603.1
AY358985 mRNA Translation: AAQ89344.1
AL133396 Genomic DNA No translation available.
BC043644 mRNA Translation: AAH43644.1
CCDSiCCDS13081.1
RefSeqiNP_036541.2, NM_012409.3
UniGeneiHs.406696

Genome annotation databases

EnsembliENST00000305817; ENSP00000306900; ENSG00000171864
GeneIDi23627
KEGGihsa:23627
UCSCiuc002wkz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106918 Genomic DNA Translation: AAF02424.1
AF187843 mRNA Translation: AAG43448.1
AF187844 mRNA Translation: AAG43449.1
EU009729 Genomic DNA Translation: ABU40603.1
AY358985 mRNA Translation: AAQ89344.1
AL133396 Genomic DNA No translation available.
BC043644 mRNA Translation: AAH43644.1
CCDSiCCDS13081.1
RefSeqiNP_036541.2, NM_012409.3
UniGeneiHs.406696

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LG4NMR-A24-152[»]
ProteinModelPortaliQ9UKY0
SMRiQ9UKY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UKY0, 1 interactor
STRINGi9606.ENSP00000306900

Protein family/group databases

TCDBi1.C.48.1.4 the prion peptide (prp) family

Polymorphism and mutation databases

BioMutaiPRND
DMDMi68067934

Proteomic databases

PaxDbiQ9UKY0
PeptideAtlasiQ9UKY0
PRIDEiQ9UKY0
ProteomicsDBi84908

Protocols and materials databases

DNASUi23627
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305817; ENSP00000306900; ENSG00000171864
GeneIDi23627
KEGGihsa:23627
UCSCiuc002wkz.5 human

Organism-specific databases

CTDi23627
DisGeNETi23627
EuPathDBiHostDB:ENSG00000171864.4
GeneCardsiPRND
H-InvDBiHIX0027662
HGNCiHGNC:15748 PRND
HPAiHPA043373
MIMi604263 gene
neXtProtiNX_Q9UKY0
OpenTargetsiENSG00000171864
PharmGKBiPA33795
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97N Eukaryota
ENOG4111EBU LUCA
GeneTreeiENSGT00390000017668
HOGENOMiHOG000232078
HOVERGENiHBG023907
InParanoidiQ9UKY0
OMAiMRKHLGG
OrthoDBiEOG091G0LQ8
PhylomeDBiQ9UKY0
TreeFamiTF337532

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

EvolutionaryTraceiQ9UKY0
GeneWikiiPRND
GenomeRNAii23627
PROiPR:Q9UKY0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171864 Expressed in 73 organ(s), highest expression level in testis
CleanExiHS_PRND
GenevisibleiQ9UKY0 HS

Family and domain databases

Gene3Di1.10.790.10, 1 hit
InterProiView protein in InterPro
IPR021566 Doppel
IPR036924 Prion/Doppel_b-ribbon_dom_sf
IPR022416 Prion/Doppel_prot_b-ribbon_dom
PfamiView protein in Pfam
PF11466 Doppel, 1 hit
PF00377 Prion, 1 hit
SUPFAMiSSF54098 SSF54098, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRND_HUMAN
AccessioniPrimary (citable) accession number: Q9UKY0
Secondary accession number(s): A7U7M5
, Q9H311, Q9H312, Q9NTM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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