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Protein

Integrin alpha-11

Gene

ITGA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-11/beta-1 is a receptor for collagen.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi488 – 496Sequence analysis9
Calcium bindingi551 – 559Sequence analysis9
Calcium bindingi613 – 621Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • collagen receptor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-216083 Integrin cell surface interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9UKX5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UKX5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA11
ORF Names:MSTP018
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137809.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6136 ITGA11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604789 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKX5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 1141ExtracellularSequence analysisAdd BLAST1119
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1142 – 1164HelicalSequence analysisAdd BLAST23
Topological domaini1165 – 1188CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1170R → A: No effect on RAB21-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22801

Open Targets

More...
OpenTargetsi
ENSG00000137809

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29937

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5883

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITGA11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104119

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001631823 – 1188Integrin alpha-11Add BLAST1166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi76 ↔ 83By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 139Sequence analysis
Disulfide bondi129 ↔ 159Sequence analysis
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi659 ↔ 668By similarity
Disulfide bondi674 ↔ 729By similarity
Glycosylationi694N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi781 ↔ 787By similarity
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi881 ↔ 893By similarity
Glycosylationi894N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi973N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1031N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1039N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1059N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKX5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UKX5

PeptideAtlas

More...
PeptideAtlasi
Q9UKX5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKX5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84905

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly up-regulated in differentiating fetal muscle cells (in vitro).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137809 Expressed in 144 organ(s), highest expression level in thoracic aorta

CleanEx database of gene expression profiles

More...
CleanExi
HS_ITGA11

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UKX5 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA051813

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116481, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1818 Integrin alpha11-beta1 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UKX5

Protein interaction database and analysis system

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IntActi
Q9UKX5, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000327290

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UKX5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UKX5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 85FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati91 – 151FG-GAP 2PROSITE-ProRule annotationAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini164 – 345VWFAPROSITE-ProRule annotationAdd BLAST182
Repeati355 – 406FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati411 – 461FG-GAP 4PROSITE-ProRule annotationAdd BLAST51
Repeati462 – 527FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati528 – 586FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati590 – 650FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1153 – 1161Poly-Leu9
Compositional biasi1173 – 1176Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPB8 Eukaryota
ENOG410YTFZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155465

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000059610

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006185

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UKX5

KEGG Orthology (KO)

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KOi
K06587

Identification of Orthologs from Complete Genome Data

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OMAi
QIPIWII

Database of Orthologous Groups

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OrthoDBi
EOG091G00QA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKX5

TreeFam database of animal gene trees

More...
TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UKX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI
60 70 80 90 100
SGNKWLVVGA PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK
110 120 130 140 150
DNMRLGLSLA TNPKDNSFLA CSPLWSHECG SSYYTTGMCS RVNSNFRFSK
160 170 180 190 200
TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE VQHFLINILK KFYIGPGQIQ
210 220 230 240 250
VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET RTAFGIEFAR
260 270 280 290 300
SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL
310 320 330 340 350
GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF
360 370 380 390 400
SLEGTNKNET SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA
410 420 430 440 450
GKVIPLRESY LKEFPEELKN HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH
460 470 480 490 500
TGKVILFTMH NNRSLTIHQA MRGQQIGSYF GSEITSVDID GDGVTDVLLV
510 520 530 540 550
GAPMYFNEGR ERGKVYVYEL RQNLFVYNGT LKDSHSYQNA RFGSSIASVR
560 570 580 590 600
DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG
610 620 630 640 650
LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS
660 670 680 690 700
KINIFHRDCK RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER
710 720 730 740 750
RYTPRAHLDE GGDRFTNRAV LLSSGQELCE RINFHVLDTA DYVKPVTFSV
760 770 780 790 800
EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG CNEDEHCVPD LVLDARSDLP
810 820 830 840 850
TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV EATLENRGEN
860 870 880 890 900
AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF
910 920 930 940 950
RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH
960 970 980 990 1000
LKYEADVLFT RSSSLSHYEV KPNSSLERYD GIGPPFSCIF RIQNLGLFPI
1010 1020 1030 1040 1050
HGMMMKITIP IATRSGNRLL KLRDFLTDEA NTSCNIWGNS TEYRPTPVEE
1060 1070 1080 1090 1100
DLRRAPQLNH SNSDVVSINC NIRLVPNQEI NFHLLGNLWL RSLKALKYKS
1110 1120 1130 1140 1150
MKIMVNAALQ RQFHSPFIFR EEDPSRQIVF EISKQEDWQV PIWIIVGSTL
1160 1170 1180
GGLLLLALLV LALWKLGFFR SARRRREPGL DPTPKVLE
Length:1,188
Mass (Da):133,470
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFD95E57ED5D5849
GO
Isoform 2 (identifier: Q9UKX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1029-1029: E → EV

Show »
Length:1,189
Mass (Da):133,569
Checksum:i8EDBBE2EF6191164
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39001 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009889433V → M. Corresponds to variant dbSNP:rs2306022Ensembl.1
Natural variantiVAR_020038471M → L. Corresponds to variant dbSNP:rs2306024Ensembl.1
Natural variantiVAR_009890524L → R3 PublicationsCorresponds to variant dbSNP:rs7168069Ensembl.1
Natural variantiVAR_020039891Q → K. Corresponds to variant dbSNP:rs2271725Ensembl.1
Natural variantiVAR_009891972P → L3 PublicationsCorresponds to variant dbSNP:rs4777035Ensembl.1
Natural variantiVAR_0098921003M → I1 Publication1
Natural variantiVAR_0098941093L → V. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0534161029E → EV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF109681 mRNA Translation: AAF01258.1
AF137378 mRNA Translation: AAD51919.2
AC021553 Genomic DNA No translation available.
AC100825 Genomic DNA No translation available.
AF111799 mRNA Translation: AAL39001.1 Different initiation.
AL359064 mRNA Translation: CAB94392.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45291.1 [Q9UKX5-1]

NCBI Reference Sequences

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RefSeqi
NP_001004439.1, NM_001004439.1 [Q9UKX5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.436416
Hs.458733

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000315757; ENSP00000327290; ENSG00000137809 [Q9UKX5-1]
ENST00000423218; ENSP00000403392; ENSG00000137809 [Q9UKX5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22801

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22801

UCSC genome browser

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UCSCi
uc002ari.4 human [Q9UKX5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109681 mRNA Translation: AAF01258.1
AF137378 mRNA Translation: AAD51919.2
AC021553 Genomic DNA No translation available.
AC100825 Genomic DNA No translation available.
AF111799 mRNA Translation: AAL39001.1 Different initiation.
AL359064 mRNA Translation: CAB94392.1
CCDSiCCDS45291.1 [Q9UKX5-1]
RefSeqiNP_001004439.1, NM_001004439.1 [Q9UKX5-1]
UniGeneiHs.436416
Hs.458733

3D structure databases

ProteinModelPortaliQ9UKX5
SMRiQ9UKX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116481, 1 interactor
ComplexPortaliCPX-1818 Integrin alpha11-beta1 complex
CORUMiQ9UKX5
IntActiQ9UKX5, 3 interactors
STRINGi9606.ENSP00000327290

Chemistry databases

ChEMBLiCHEMBL5883

PTM databases

iPTMnetiQ9UKX5
PhosphoSitePlusiQ9UKX5

Polymorphism and mutation databases

BioMutaiITGA11
DMDMi313104119

Proteomic databases

EPDiQ9UKX5
PaxDbiQ9UKX5
PeptideAtlasiQ9UKX5
PRIDEiQ9UKX5
ProteomicsDBi84905

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315757; ENSP00000327290; ENSG00000137809 [Q9UKX5-1]
ENST00000423218; ENSP00000403392; ENSG00000137809 [Q9UKX5-2]
GeneIDi22801
KEGGihsa:22801
UCSCiuc002ari.4 human [Q9UKX5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22801
DisGeNETi22801
EuPathDBiHostDB:ENSG00000137809.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ITGA11

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0012380
HGNCiHGNC:6136 ITGA11
HPAiHPA051813
MIMi604789 gene
neXtProtiNX_Q9UKX5
OpenTargetsiENSG00000137809
PharmGKBiPA29937

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPB8 Eukaryota
ENOG410YTFZ LUCA
GeneTreeiENSGT00940000155465
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiQ9UKX5
KOiK06587
OMAiQIPIWII
OrthoDBiEOG091G00QA
PhylomeDBiQ9UKX5
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
SignaLinkiQ9UKX5
SIGNORiQ9UKX5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGA11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22801

Protein Ontology

More...
PROi
PR:Q9UKX5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137809 Expressed in 144 organ(s), highest expression level in thoracic aorta
CleanExiHS_ITGA11
GenevisibleiQ9UKX5 HS

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKX5
Secondary accession number(s): J3KQM2, Q8WYI8, Q9UKQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 30, 2010
Last modified: December 5, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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