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Entry version 182 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Myosin-2

Gene

MYH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Muscle contraction. Required for cytoskeleton organization (By similarity).By similarity

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-2 (MYO2).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi179 – 186ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  • muscle contraction Source: BHF-UCL
  • muscle filament sliding Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UKX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-2
Alternative name(s):
Myosin heavy chain 2
Myosin heavy chain 2a
Short name:
MyHC-2a
Myosin heavy chain IIa
Short name:
MyHC-IIa
Myosin heavy chain, skeletal muscle, adult 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH2
Synonyms:MYHSA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7572 MYH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
160740 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, proximal, and ophthalmoplegia (MYPOP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA muscular disorder characterized by mild-to-moderate muscle weakness, ophthalmoplegia, and contractures at birth in some patients. Muscle biopsies from patients show predominance of type 1 fibers and small or absent type 2A fibers. The disease is non-progressive or it progresses very slowly. Inheritance is autosomal dominant or recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032630706E → K in MYPOP. 1 PublicationCorresponds to variant dbSNP:rs121434589EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4620

MalaCards human disease database

More...
MalaCardsi
MYH2
MIMi605637 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000125414

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
363677 Childhood-onset autosomal recessive myopathy with external ophthalmoplegia
79091 Hereditary inclusion body myopathy-joint contractures-ophthalmoplegia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31369

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYH2

Domain mapping of disease mutations (DMDM)

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DMDMi
13431716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001233931 – 1941Myosin-2Add BLAST1941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei130N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei625PhosphoserineBy similarity1
Modified residuei759Pros-methylhistidineBy similarity1
Modified residuei1094PhosphoserineBy similarity1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1164PhosphoserineBy similarity1
Modified residuei1239PhosphoserineBy similarity1
Modified residuei1243PhosphothreonineBy similarity1
Modified residuei1245PhosphoserineBy similarity1
Modified residuei1257PhosphothreonineBy similarity1
Modified residuei1263PhosphoserineBy similarity1
Modified residuei1288PhosphothreonineBy similarity1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1308PhosphoserineBy similarity1
Modified residuei1469PhosphothreonineBy similarity1
Modified residuei1476PhosphoserineBy similarity1
Modified residuei1494PhosphotyrosineBy similarity1
Modified residuei1497PhosphoserineBy similarity1
Modified residuei1503PhosphothreonineBy similarity1
Modified residuei1516PhosphoserineBy similarity1
Modified residuei1519PhosphothreonineBy similarity1
Modified residuei1556PhosphoserineBy similarity1
Modified residuei1576PhosphoserineBy similarity1
Modified residuei1602PhosphoserineBy similarity1
Modified residuei1605PhosphoserineBy similarity1
Modified residuei1716PhosphoserineBy similarity1
Modified residuei1728PhosphoserineBy similarity1
Modified residuei1732PhosphothreonineBy similarity1
Modified residuei1738PhosphothreonineBy similarity1
Modified residuei1741PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKX2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UKX2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UKX2

PeptideAtlas

More...
PeptideAtlasi
Q9UKX2

PRoteomics IDEntifications database

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PRIDEi
Q9UKX2

ProteomicsDB human proteome resource

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ProteomicsDBi
84903

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
Q9UKX2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UKX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000125414 Expressed in 112 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UKX2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UKX2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010760
HPA001349

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110705, 19 interactors

Protein interaction database and analysis system

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IntActi
Q9UKX2, 9 interactors

Molecular INTeraction database

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MINTi
Q9UKX2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000245503

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UKX2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 82Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini86 – 784Myosin motorPROSITE-ProRule annotationAdd BLAST699
Domaini787 – 816IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni661 – 683Actin-bindingBy similarityAdd BLAST23
Regioni763 – 777Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili845 – 1941Sequence analysisAdd BLAST1097

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161336

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000173959

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UKX2

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

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OMAi
YERNFGW

Database of Orthologous Groups

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OrthoDBi
1612133at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UKX2

TreeFam database of animal gene trees

More...
TreeFami
TF314375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSDSELAVF GEAAPFLRKS ERERIEAQNR PFDAKTSVFV AEPKESFVKG
60 70 80 90 100
TIQSREGGKV TVKTEGGATL TVKDDQVFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYKPEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEI TSGKIQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVVFQL KAERSYHIFY QITSNKKPEL
310 320 330 340 350
IEMLLITTNP YDYPFVSQGE ISVASIDDQE ELMATDSAID ILGFTNEEKV
360 370 380 390 400
SIYKLTGAVM HYGNLKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV EQVSNAVGAL AKAVYEKMFL WMVARINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYDQHL GKSANFQKPK VVKGKAEAHF ALIHYAGVVD YNITGWLEKN
610 620 630 640 650
KDPLNETVVG LYQKSAMKTL AQLFSGAQTA EGEGAGGGAK KGGKKKGSSF
660 670 680 690 700
QTVSALFREN LNKLMTNLRS THPHFVRCII PNETKTPGAM EHELVLHQLR
710 720 730 740 750
CNGVLEGIRI CRKGFPSRIL YADFKQRYKV LNASAIPEGQ FIDSKKASEK
760 770 780 790 800
LLASIDIDHT QYKFGHTKVF FKAGLLGLLE EMRDDKLAQL ITRTQARCRG
810 820 830 840 850
FLARVEYQRM VERREAIFCI QYNIRSFMNV KHWPWMKLFF KIKPLLKSAE
860 870 880 890 900
TEKEMATMKE EFQKIKDELA KSEAKRKELE EKMVTLLKEK NDLQLQVQAE
910 920 930 940 950
AEGLADAEER CDQLIKTKIQ LEAKIKEVTE RAEDEEEINA ELTAKKRKLE
960 970 980 990 1000
DECSELKKDI DDLELTLAKV EKEKHATENK VKNLTEEMAG LDETIAKLTK
1010 1020 1030 1040 1050
EKKALQEAHQ QTLDDLQAEE DKVNTLTKAK IKLEQQVDDL EGSLEQEKKL
1060 1070 1080 1090 1100
RMDLERAKRK LEGDLKLAQE SIMDIENEKQ QLDEKLKKKE FEISNLQSKI
1110 1120 1130 1140 1150
EDEQALGIQL QKKIKELQAR IEELEEEIEA ERASRAKAEK QRSDLSRELE
1160 1170 1180 1190 1200
EISERLEEAG GATSAQIEMN KKREAEFQKM RRDLEEATLQ HEATAATLRK
1210 1220 1230 1240 1250
KHADSVAELG EQIDNLQRVK QKLEKEKSEM KMEIDDLASN VETVSKAKGN
1260 1270 1280 1290 1300
LEKMCRTLED QLSELKSKEE EQQRLINDLT AQRGRLQTES GEFSRQLDEK
1310 1320 1330 1340 1350
EALVSQLSRG KQAFTQQIEE LKRQLEEEIK AKNALAHALQ SSRHDCDLLR
1360 1370 1380 1390 1400
EQYEEEQESK AELQRALSKA NTEVAQWRTK YETDAIQRTE ELEEAKKKLA
1410 1420 1430 1440 1450
QRLQAAEEHV EAVNAKCASL EKTKQRLQNE VEDLMLDVER TNAACAALDK
1460 1470 1480 1490 1500
KQRNFDKILA EWKQKCEETH AELEASQKEA RSLGTELFKI KNAYEESLDQ
1510 1520 1530 1540 1550
LETLKRENKN LQQEISDLTE QIAEGGKRIH ELEKIKKQVE QEKCELQAAL
1560 1570 1580 1590 1600
EEAEASLEHE EGKILRIQLE LNQVKSEVDR KIAEKDEEID QLKRNHIRIV
1610 1620 1630 1640 1650
ESMQSTLDAE IRSRNDAIRL KKKMEGDLNE MEIQLNHANR MAAEALRNYR
1660 1670 1680 1690 1700
NTQGILKDTQ IHLDDALRSQ EDLKEQLAMV ERRANLLQAE IEELRATLEQ
1710 1720 1730 1740 1750
TERSRKIAEQ ELLDASERVQ LLHTQNTSLI NTKKKLETDI SQMQGEMEDI
1760 1770 1780 1790 1800
LQEARNAEEK AKKAITDAAM MAEELKKEQD TSAHLERMKK NMEQTVKDLQ
1810 1820 1830 1840 1850
LRLDEAEQLA LKGGKKQIQK LEARVRELEG EVESEQKRNA EAVKGLRKHE
1860 1870 1880 1890 1900
RRVKELTYQT EEDRKNILRL QDLVDKLQAK VKSYKRQAEE AEEQSNTNLA
1910 1920 1930 1940
KFRKLQHELE EAEERADIAE SQVNKLRVKS REVHTKVISE E
Length:1,941
Mass (Da):223,044
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i681E866F83AEA83F
GO
Isoform 2 (identifier: Q9UKX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     659-1891: Missing.

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):79,880
Checksum:i44FD901775553881
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLR0J3QLR0_HUMAN
Myosin-2
MYH2
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX84E7EX84_HUMAN
Myosin-2
MYH2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150E → G in CAD91136 (PubMed:17974005).Curated1
Sequence conflicti1844K → R in CAA83687 (PubMed:7751403).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032630706E → K in MYPOP. 1 PublicationCorresponds to variant dbSNP:rs121434589EnsemblClinVar.1
Natural variantiVAR_032631970V → I in one patient with familial myopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143872329EnsemblClinVar.1
Natural variantiVAR_0326321061L → V1 PublicationCorresponds to variant dbSNP:rs142586585EnsemblClinVar.1
Natural variantiVAR_0326331927R → Q. Corresponds to variant dbSNP:rs34161789EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056291659 – 1891Missing in isoform 2. 1 PublicationAdd BLAST1233

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF111784 mRNA Translation: AAD29950.1
BX510904 mRNA Translation: CAD91136.1
AC005323 Genomic DNA No translation available.
BC093082 mRNA Translation: AAH93082.1
BC126409 mRNA Translation: AAI26410.1
S73840 mRNA Translation: AAC13916.1
Z32858 mRNA Translation: CAA83687.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11156.1 [Q9UKX2-1]

Protein sequence database of the Protein Information Resource

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PIRi
I51912

NCBI Reference Sequences

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RefSeqi
NP_001093582.1, NM_001100112.1 [Q9UKX2-1]
NP_060004.3, NM_017534.5 [Q9UKX2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000245503; ENSP00000245503; ENSG00000125414 [Q9UKX2-1]
ENST00000397183; ENSP00000380367; ENSG00000125414 [Q9UKX2-1]
ENST00000532183; ENSP00000433944; ENSG00000125414 [Q9UKX2-2]
ENST00000622564; ENSP00000482463; ENSG00000125414 [Q9UKX2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4620

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4620

UCSC genome browser

More...
UCSCi
uc002gmp.5 human [Q9UKX2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111784 mRNA Translation: AAD29950.1
BX510904 mRNA Translation: CAD91136.1
AC005323 Genomic DNA No translation available.
BC093082 mRNA Translation: AAH93082.1
BC126409 mRNA Translation: AAI26410.1
S73840 mRNA Translation: AAC13916.1
Z32858 mRNA Translation: CAA83687.1
CCDSiCCDS11156.1 [Q9UKX2-1]
PIRiI51912
RefSeqiNP_001093582.1, NM_001100112.1 [Q9UKX2-1]
NP_060004.3, NM_017534.5 [Q9UKX2-1]

3D structure databases

SMRiQ9UKX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110705, 19 interactors
IntActiQ9UKX2, 9 interactors
MINTiQ9UKX2
STRINGi9606.ENSP00000245503

PTM databases

iPTMnetiQ9UKX2
PhosphoSitePlusiQ9UKX2

Polymorphism and mutation databases

BioMutaiMYH2
DMDMi13431716

2D gel databases

UCD-2DPAGEiQ9UKX2

Proteomic databases

EPDiQ9UKX2
jPOSTiQ9UKX2
PaxDbiQ9UKX2
PeptideAtlasiQ9UKX2
PRIDEiQ9UKX2
ProteomicsDBi84903

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245503; ENSP00000245503; ENSG00000125414 [Q9UKX2-1]
ENST00000397183; ENSP00000380367; ENSG00000125414 [Q9UKX2-1]
ENST00000532183; ENSP00000433944; ENSG00000125414 [Q9UKX2-2]
ENST00000622564; ENSP00000482463; ENSG00000125414 [Q9UKX2-2]
GeneIDi4620
KEGGihsa:4620
UCSCiuc002gmp.5 human [Q9UKX2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4620
DisGeNETi4620

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYH2
HGNCiHGNC:7572 MYH2
HPAiCAB010760
HPA001349
MalaCardsiMYH2
MIMi160740 gene
605637 phenotype
neXtProtiNX_Q9UKX2
OpenTargetsiENSG00000125414
Orphaneti363677 Childhood-onset autosomal recessive myopathy with external ophthalmoplegia
79091 Hereditary inclusion body myopathy-joint contractures-ophthalmoplegia syndrome
PharmGKBiPA31369

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000161336
HOGENOMiHOG000173959
InParanoidiQ9UKX2
KOiK10352
OMAiYERNFGW
OrthoDBi1612133at2759
PhylomeDBiQ9UKX2
TreeFamiTF314375

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
SIGNORiQ9UKX2

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYH2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4620

Protein Ontology

More...
PROi
PR:Q9UKX2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125414 Expressed in 112 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
ExpressionAtlasiQ9UKX2 baseline and differential
GenevisibleiQ9UKX2 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKX2
Secondary accession number(s): A0AVL4
, Q14322, Q16229, Q567P6, Q86T56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: May 8, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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