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UniProtKB - Q9UKV3 (ACINU_HUMAN)

Entry version 197 (02 Jun 2021)
Sequence version 2 (05 Oct 2010)
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Protein

Apoptotic chromatin condensation inducer in the nucleus

Gene

ACIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

5 Publications

Caution

Structural and functional studies of the ASAP complex have been conducted with a chimeric complex involving a conserved fragment of Drosophila melanogaster Acinus/hkl.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processApoptosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UKV3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111465, Apoptotic cleavage of cellular proteins

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UKV3

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.18.1.1, the nuclear mrna exporter (mrna-e) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptotic chromatin condensation inducer in the nucleus
Short name:
Acinus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACIN1
Synonyms:ACINUS, KIAA0670
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17066, ACIN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604562, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UKV3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100813.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1093D → A: Abolishes cleavage by CASP3 and chromatin condensation activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		22985

Open Targets

More...OpenTargetsi		ENSG00000100813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134912489

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UKV3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACIN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153407

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000644361 – 1341Apoptotic chromatin condensation inducer in the nucleusAdd BLAST1341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei254PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei269PhosphothreonineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei326PhosphothreonineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei384PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1
Modified residuei393PhosphothreonineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei414PhosphothreonineCombined sources1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei512PhosphotyrosineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Cross-linki532Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei561PhosphoserineCombined sources1
Modified residuei654N6,N6,N6-trimethyllysine; by EHMT2; alternate1 Publication1
Modified residuei654N6,N6-dimethyllysine; by EHMT2; alternate1 Publication1
Modified residuei655PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei682PhosphothreonineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei717N6-acetyllysineCombined sources1
Modified residuei720PhosphothreonineCombined sources1
Modified residuei729PhosphoserineCombined sources1
Cross-linki732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei825PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei861N6-acetyllysine; alternateBy similarity1
Cross-linki861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei895PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1
Cross-linki970Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei976PhosphothreonineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei990PhosphoserineCombined sources1
Modified residuei1004PhosphoserineCombined sources1
Cross-linki1047Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1180Phosphoserine; by SRPK2 and PKB/AKT11 Publication1
Isoform 4 (identifier: Q9UKV3-5)
Modified residuei825PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.1 Publication
Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1093 – 1094Cleavage; by caspase-32

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1342

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UKV3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UKV3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UKV3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UKV3

PeptideAtlas

More...PeptideAtlasi		Q9UKV3

PRoteomics IDEntifications database

More...PRIDEi		Q9UKV3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84889 [Q9UKV3-1]
84890 [Q9UKV3-2]
84891 [Q9UKV3-3]
84892 [Q9UKV3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UKV3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UKV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UKV3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UKV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100813, Expressed in left lobe of thyroid gland and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UKV3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UKV3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100813, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC).

Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex.

Interacts with API5.

Interacts with SRPK2 in a phosphorylation-dependent manner.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116634, 170 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UKV3

Database of interacting proteins

More...DIPi		DIP-32963N

Protein interaction database and analysis system

More...IntActi		Q9UKV3, 65 interactors

Molecular INTeraction database

More...MINTi		Q9UKV3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262710

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UKV3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UKV3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 106SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni159 – 460DisorderedSequence analysisAdd BLAST302
Regioni475 – 530DisorderedSequence analysisAdd BLAST56
Regioni548 – 865DisorderedSequence analysisAdd BLAST318
Regioni892 – 953DisorderedSequence analysisAdd BLAST62
Regioni1098 – 1341DisorderedSequence analysisAdd BLAST244
Regioni1210 – 1237Sufficient for interaction with RNPS1 and SAP18 and formation of th ASAP complexBy similarityAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi159 – 175Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi193 – 234Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi242 – 269Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi270 – 291Acidic residuesSequence analysisAdd BLAST22
Compositional biasi292 – 380Basic and acidic residuesSequence analysisAdd BLAST89
Compositional biasi387 – 401Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi549 – 563Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi566 – 605Polar residuesSequence analysisAdd BLAST40
Compositional biasi644 – 683Polar residuesSequence analysisAdd BLAST40
Compositional biasi692 – 710Polar residuesSequence analysisAdd BLAST19
Compositional biasi711 – 738Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi756 – 782Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi800 – 819Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi851 – 865Polar residuesSequence analysisAdd BLAST15
Compositional biasi892 – 915Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1098 – 1112Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1114 – 1130Pro residuesSequence analysisAdd BLAST17
Compositional biasi1132 – 1177Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi1178 – 1192Basic residuesSequence analysisAdd BLAST15
Compositional biasi1193 – 1216Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1236 – 1322Basic and acidic residuesSequence analysisAdd BLAST87

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2416, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00710000106790

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_482284_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UKV3

Identification of Orthologs from Complete Genome Data

More...OMAi		KISVVWT

Database of Orthologous Groups

More...OrthoDBi		828911at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UKV3

TreeFam database of animal gene trees

More...TreeFami		TF320727

Family and domain databases

Conserved Domains Database

More...CDDi		cd12432, RRM_ACINU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.30, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034257, Acinus_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032552, RSB_motif
IPR003034, SAP_dom
IPR036361, SAP_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16294, RSB_motif, 1 hit
PF02037, SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00513, SAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit
SSF68906, SSF68906, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50800, SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKV3-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MWRRKHPRTS GGTRGVLSGN RGVEYGSGRG HLGTFEGRWR KLPKMPEAVG 
        60         70         80         90        100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK 
       110        120        130        140        150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ 
       160        170        180        190        200
RLEREAREAA ELEEASAESE DEMIHPEGVA SLLPPDFQSS LERPELELSR 
       210        220        230        240        250
HSPRKSSSIS EEKGDSDDEK PRKGERRSSR VRQARAAKLS EGSQPAEEEE 
       260        270        280        290        300
DQETPSRNLR VRADRNLKTE EEEEEEEEEE EDDEEEEGDD EGQKSREAPI 
       310        320        330        340        350
LKEFKEEGEE IPRVKPEEMM DERPKTRSQE QEVLERGGRF TRSQEEARKS 
       360        370        380        390        400
HLARQQQEKE MKTTSPLEEE EREIKSSQGL KEKSKSPSPP RLTEDRKKAS 
       410        420        430        440        450
LVALPEQTAS EEETPPPLLT KEASSPPPHP QLHSEEEIEP MEGPAPAVLI 
       460        470        480        490        500
QLSPPNTDAD TRELLVSQHT VQLVGGLSPL SSPSDTKAES PAEKVPEESV 
       510        520        530        540        550
LPLVQKSTLA DYSAQKDLEP ESDRSAQPLP LKIEELALAK GITEECLKQP 
       560        570        580        590        600
SLEQKEGRRA SHTLLPSHRL KQSADSSSSR SSSSSSSSSR SRSRSPDSSG 
       610        620        630        640        650
SRSHSPLRSK QRDVAQARTH ANPRGRPKMG SRSTSESRSR SRSRSRSASS 
       660        670        680        690        700
NSRKSLSPGV SRDSSTSYTE TKDPSSGQEV ATPPVPQLQV CEPKERTSTS 
       710        720        730        740        750
SSSVQARRLS QPESAEKHVT QRLQPERGSP KKCEAEEAEP PAATQPQTSE 
       760        770        780        790        800
TQTSHLPESE RIHHTVEEKE EVTMDTSENR PENDVPEPPM PIADQVSNDD 
       810        820        830        840        850
RPEGSVEDEE KKESSLPKSF KRKISVVSAT KGVPAGNSDT EGGQPGRKRR 
       860        870        880        890        900
WGASTATTQK KPSISITTES LKSLIPDIKP LAGQEAVVDL HADDSRISED 
       910        920        930        940        950
ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE EKEPEAEPPV 
       960        970        980        990       1000
PPQVSVEVAL PPPAEHEVKK VTLGDTLTRR SISQQKSGVS ITIDDPVRTA 
      1010       1020       1030       1040       1050
QVPSPPRGKI SNIVHISNLV RPFTLGQLKE LLGRTGTLVE EAFWIDKIKS 
      1060       1070       1080       1090       1100
HCFVTYSTVE EAVATRTALH GVKWPQSNPK FLCADYAEQD ELDYHRGLLV 
      1110       1120       1130       1140       1150
DRPSETKTEE QGIPRPLHPP PPPPVQPPQH PRAEQREQER AVREQWAERE 
      1160       1170       1180       1190       1200
REMERRERTR SEREWDRDKV REGPRSRSRS RDRRRKERAK SKEKKSEKKE 
      1210       1220       1230       1240       1250
KAQEEPPAKL LDDLFRKTKA APCIYWLPLT DSQIVQKEAE RAERAKEREK 
      1260       1270       1280       1290       1300
RRKEQEEEEQ KEREKEAERE RNRQLEREKR REHSRERDRE RERERERDRG 
      1310       1320       1330       1340 
DRDRDRERDR ERGRERDRRD TKRHSRSRSR STPVRDRGGR R
Length:1,341
Mass (Da):151,862
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCCBF310A4680691
GO
Isoform 2 (identifier: Q9UKV3-2) [UniParc]FASTAAdd to basket
Also known as: S'

The sequence of this isoform differs from the canonical sequence as follows:
     1-727: Missing.
     728-766: GSPKKCEAEE...PESERIHHTV → MSPADRCRSA...DQSSRTRGLP

Show »
Length:614
Mass (Da):70,948
Checksum:i2E994FB0FA922F4C
GO
Isoform 3 (identifier: Q9UKV3-3) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     1-758: Missing.
     759-766: SERIHHTV → MLSESKEG

Show »
Length:583
Mass (Da):67,566
Checksum:iF227265F2F6BBF68
GO
Isoform 4 (identifier: Q9UKV3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: Missing.
     873-884: Missing.

Show »
Length:1,328
Mass (Da):150,557
Checksum:i47A3C106859D46DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQT4E7EQT4_HUMAN
Apoptotic chromatin condensation in...
ACIN1
1,301Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3H4S4R3H4_HUMAN
Apoptotic chromatin condensation in...
ACIN1
1,283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3B0G3V3B0_HUMAN
Apoptotic chromatin condensation in...
ACIN1
582Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3T3G3V3T3_HUMAN
Apoptotic chromatin condensation in...
ACIN1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYN3A0A087WYN3_HUMAN
Apoptotic chromatin condensation in...
ACIN1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0D2A0A087X0D2_HUMAN
Apoptotic chromatin condensation in...
ACIN1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139Q → H in BAA31645 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050632257R → K. Corresponds to variant dbSNP:rs11555803Ensembl.1
Natural variantiVAR_022031311I → M. Corresponds to variant dbSNP:rs3811182Ensembl.1
Natural variantiVAR_061547447A → PCombined sources5 PublicationsCorresponds to variant dbSNP:rs941719Ensembl.1
Natural variantiVAR_022032467S → P. Corresponds to variant dbSNP:rs1885097Ensembl.1
Natural variantiVAR_022033478S → F. Corresponds to variant dbSNP:rs3751501Ensembl.1
Natural variantiVAR_0357771160R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754494408Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0040261 – 758Missing in isoform 3. 2 PublicationsAdd BLAST758
Alternative sequenceiVSP_0040251 – 727Missing in isoform 2. 1 PublicationAdd BLAST727
Alternative sequenceiVSP_004028728 – 766GSPKK…IHHTV → MSPADRCRSANTIEPATTSS LALFLLLQRDQSSRTRGLP in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_004029759 – 766SERIHHTV → MLSESKEG in isoform 3. 2 Publications8
Alternative sequenceiVSP_042204829Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_042205873 – 884Missing in isoform 4. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF124726 mRNA Translation: AAD56724.1
AF124727 mRNA Translation: AAD56725.1
AF124728 mRNA Translation: AAD56726.1
BX247975 mRNA Translation: CAD62309.1
AL117258 Genomic DNA No translation available.
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66187.1
CH471078 Genomic DNA Translation: EAW66188.1
BC140805 mRNA Translation: AAI40806.1
AB014570 mRNA Translation: BAA31645.2
AL050382 mRNA Translation: CAB43681.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53887.1 [Q9UKV3-3]
CCDS53888.1 [Q9UKV3-2]
CCDS55905.1 [Q9UKV3-5]
CCDS9587.1 [Q9UKV3-1]

NCBI Reference Sequences

More...RefSeqi		NP_001158286.1, NM_001164814.1
NP_001158287.1, NM_001164815.1
NP_001158288.1, NM_001164816.1 [Q9UKV3-2]
NP_001158289.1, NM_001164817.1 [Q9UKV3-3]
NP_055792.1, NM_014977.3
XP_005267475.1, XM_005267418.1 [Q9UKV3-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262710; ENSP00000262710; ENSG00000100813 [Q9UKV3-1]
ENST00000338631; ENSP00000345541; ENSG00000100813 [Q9UKV3-2]
ENST00000357481; ENSP00000350073; ENSG00000100813 [Q9UKV3-3]
ENST00000397341; ENSP00000380502; ENSG00000100813 [Q9UKV3-3]
ENST00000555053; ENSP00000451328; ENSG00000100813 [Q9UKV3-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22985

UCSC genome browser

More...UCSCi		uc001wip.5, human [Q9UKV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124726 mRNA Translation: AAD56724.1
AF124727 mRNA Translation: AAD56725.1
AF124728 mRNA Translation: AAD56726.1
BX247975 mRNA Translation: CAD62309.1
AL117258 Genomic DNA No translation available.
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66187.1
CH471078 Genomic DNA Translation: EAW66188.1
BC140805 mRNA Translation: AAI40806.1
AB014570 mRNA Translation: BAA31645.2
AL050382 mRNA Translation: CAB43681.2
CCDSiCCDS53887.1 [Q9UKV3-3]
CCDS53888.1 [Q9UKV3-2]
CCDS55905.1 [Q9UKV3-5]
CCDS9587.1 [Q9UKV3-1]
RefSeqiNP_001158286.1, NM_001164814.1
NP_001158287.1, NM_001164815.1
NP_001158288.1, NM_001164816.1 [Q9UKV3-2]
NP_001158289.1, NM_001164817.1 [Q9UKV3-3]
NP_055792.1, NM_014977.3
XP_005267475.1, XM_005267418.1 [Q9UKV3-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G6SX-ray1.65A/B1008-1100[»]
SMRiQ9UKV3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116634, 170 interactors
CORUMiQ9UKV3
DIPiDIP-32963N
IntActiQ9UKV3, 65 interactors
MINTiQ9UKV3
STRINGi9606.ENSP00000262710

Protein family/group databases

TCDBi3.A.18.1.1, the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetiQ9UKV3
MetOSiteiQ9UKV3
PhosphoSitePlusiQ9UKV3
SwissPalmiQ9UKV3

Genetic variation databases

BioMutaiACIN1
DMDMi308153407

Proteomic databases

CPTACiCPTAC-1342
EPDiQ9UKV3
jPOSTiQ9UKV3
MassIVEiQ9UKV3
PaxDbiQ9UKV3
PeptideAtlasiQ9UKV3
PRIDEiQ9UKV3
ProteomicsDBi84889 [Q9UKV3-1]
84890 [Q9UKV3-2]
84891 [Q9UKV3-3]
84892 [Q9UKV3-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		63, 518 antibodies

The DNASU plasmid repository

More...DNASUi		22985

Genome annotation databases

EnsembliENST00000262710; ENSP00000262710; ENSG00000100813 [Q9UKV3-1]
ENST00000338631; ENSP00000345541; ENSG00000100813 [Q9UKV3-2]
ENST00000357481; ENSP00000350073; ENSG00000100813 [Q9UKV3-3]
ENST00000397341; ENSP00000380502; ENSG00000100813 [Q9UKV3-3]
ENST00000555053; ENSP00000451328; ENSG00000100813 [Q9UKV3-5]
GeneIDi22985
KEGGihsa:22985
UCSCiuc001wip.5, human [Q9UKV3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22985
DisGeNETi22985

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACIN1
HGNCiHGNC:17066, ACIN1
HPAiENSG00000100813, Low tissue specificity
MIMi604562, gene
neXtProtiNX_Q9UKV3
OpenTargetsiENSG00000100813
PharmGKBiPA134912489
VEuPathDBiHostDB:ENSG00000100813.14

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2416, Eukaryota
GeneTreeiENSGT00710000106790
HOGENOMiCLU_482284_0_0_1
InParanoidiQ9UKV3
OMAiKISVVWT
OrthoDBi828911at2759
PhylomeDBiQ9UKV3
TreeFamiTF320727

Enzyme and pathway databases

PathwayCommonsiQ9UKV3
ReactomeiR-HSA-111465, Apoptotic cleavage of cellular proteins
SIGNORiQ9UKV3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22985, 506 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACIN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ACIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22985
PharosiQ9UKV3, Tbio

Protein Ontology

More...PROi		PR:Q9UKV3
RNActiQ9UKV3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100813, Expressed in left lobe of thyroid gland and 238 other tissues
ExpressionAtlasiQ9UKV3, baseline and differential
GenevisibleiQ9UKV3, HS

Family and domain databases

CDDicd12432, RRM_ACINU, 1 hit
Gene3Di1.10.720.30, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034257, Acinus_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032552, RSB_motif
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
PfamiView protein in Pfam
PF16294, RSB_motif, 1 hit
PF02037, SAP, 1 hit
SMARTiView protein in SMART
SM00513, SAP, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
SSF68906, SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800, SAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACINU_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKV3
Secondary accession number(s): B2RTT4
, D3DS45, O75158, Q9UG91, Q9UKV1, Q9UKV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 5, 2010
Last modified: June 2, 2021
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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