UniProtKB - Q9UKV3 (ACINU_HUMAN)

BLAST

>sp|Q9UKV3|ACINU_HUMAN Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2
MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMA
ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA
FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA
SLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS
EGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI
LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE
MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT
KEASSPPPHPQLHSEEEIEPMEGPAPAVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL
SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK
GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG
SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGV
SRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT
QRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR
PENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT
EGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED
ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVAL
PPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLV
RPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK
FLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER
AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE
KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ
KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD
TKRHSRSRSRSTPVRDRGGRR

Align

Format
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History
Entry version 180 (07 Nov 2018)
Sequence version 2 (05 Oct 2010)
Previous versions | rss
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Protein

Apoptotic chromatin condensation inducer in the nucleus

Gene

ACIN1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.5 Publications

Caution

Structural and functional studies of the ASAP complex have been conducted with a chimeric complex involving a conserved fragment of Drosophila melanogaster Acinus/hkl.1 Publication

GO - Molecular functionⁱ

ATPase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10490026
enzyme binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10490026
nucleic acid binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10490026
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic chromosome condensation
Source: UniProtKB
Inferred from direct assayⁱ
- 10490026
erythrocyte differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 11208865
mRNA processing Source: UniProtKB-KW
negative regulation of mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 12665594
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12665594
positive regulation of monocyte differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 12393560
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Apoptosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111465 Apoptotic cleavage of cellular proteins
SIGNORⁱ	Q9UKV3

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apoptotic chromatin condensation inducer in the nucleus Short name: Acinus
Gene namesⁱ	Name:ACIN1 Synonyms:ACINUS, KIAA0670
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100813.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17066 ACIN1
MIMⁱ	604562 gene
neXtProtⁱ	NX_Q9UKV3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1093	D → A: Abolishes cleavage by CASP3 and chromatin condensation activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22985
Open Targets More...OpenTargetsⁱ	ENSG00000100813
PharmGKBⁱ	PA134912489

Polymorphism and mutation databases

BioMutaⁱ	ACIN1
DMDMⁱ	308153407

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064436	1 – 1341	Apoptotic chromatin condensation inducer in the nucleusAdd BLAST		1341

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	132	PhosphoserineCombined sources	1
Modified residueⁱ	166	PhosphoserineCombined sources	1
Modified residueⁱ	169	PhosphoserineCombined sources	1
Modified residueⁱ	208	PhosphoserineCombined sources	1
Modified residueⁱ	210	PhosphoserineCombined sources	1
Modified residueⁱ	216	PhosphoserineCombined sources	1
Modified residueⁱ	240	PhosphoserineCombined sources	1
Modified residueⁱ	243	PhosphoserineCombined sources	1
Modified residueⁱ	254	PhosphothreonineCombined sources	1
Cross-linkⁱ	268	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residueⁱ	269	PhosphothreonineCombined sources	1
Modified residueⁱ	295	PhosphoserineCombined sources	1
Cross-linkⁱ	305	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	315	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	326	PhosphothreonineCombined sources	1
Modified residueⁱ	328	PhosphoserineCombined sources	1
Modified residueⁱ	365	PhosphoserineCombined sources	1
Cross-linkⁱ	375	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	384	PhosphoserineCombined sources	1
Modified residueⁱ	386	PhosphoserineCombined sources	1
Modified residueⁱ	388	PhosphoserineCombined sources	1
Modified residueⁱ	393	PhosphothreonineCombined sources	1
Modified residueⁱ	400	PhosphoserineCombined sources	1
Modified residueⁱ	410	PhosphoserineCombined sources	1
Modified residueⁱ	414	PhosphothreonineCombined sources	1
Modified residueⁱ	420	PhosphothreonineCombined sources	1
Modified residueⁱ	434	PhosphoserineCombined sources	1
Modified residueⁱ	453	PhosphoserineCombined sources	1
Modified residueⁱ	478	PhosphoserineCombined sources	1
Modified residueⁱ	490	PhosphoserineCombined sources	1
Modified residueⁱ	512	PhosphotyrosineCombined sources	1
Modified residueⁱ	522	PhosphoserineCombined sources	1
Cross-linkⁱ	532	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	561	PhosphoserineCombined sources	1
Modified residueⁱ	654	N6,N6,N6-trimethyllysine; by EHMT2; alternate1 Publication	1
Modified residueⁱ	654	N6,N6-dimethyllysine; by EHMT2; alternate1 Publication	1
Modified residueⁱ	655	PhosphoserineCombined sources	1
Modified residueⁱ	657	PhosphoserineCombined sources	1
Modified residueⁱ	682	PhosphothreonineCombined sources	1
Modified residueⁱ	710	PhosphoserineCombined sources	1
Modified residueⁱ	714	PhosphoserineCombined sources	1
Modified residueⁱ	717	N6-acetyllysineCombined sources	1
Modified residueⁱ	720	PhosphothreonineCombined sources	1
Modified residueⁱ	729	PhosphoserineCombined sources	1
Cross-linkⁱ	732	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	825	PhosphoserineCombined sources	1
Modified residueⁱ	838	PhosphoserineCombined sources	1
Modified residueⁱ	861	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	861	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	879	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	895	PhosphoserineCombined sources	1
Modified residueⁱ	898	PhosphoserineCombined sources	1
Cross-linkⁱ	970	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	976	PhosphothreonineCombined sources	1
Modified residueⁱ	987	PhosphoserineCombined sources	1
Modified residueⁱ	990	PhosphoserineCombined sources	1
Modified residueⁱ	1004	PhosphoserineCombined sources	1
Cross-linkⁱ	1047	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1107	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1180	Phosphoserine; by SRPK2 and PKB/AKT11 Publication	1
Isoform 4 (identifier: Q9UKV3-5)
Modified residueⁱ	825	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.1 Publication

Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	1093 – 1094	Cleavage; by caspase-3		2

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UKV3
PaxDbⁱ	Q9UKV3
PeptideAtlas More...PeptideAtlasⁱ	Q9UKV3
PRIDEⁱ	Q9UKV3
ProteomicsDBⁱ	84889 84890 [Q9UKV3-2] 84891 [Q9UKV3-3] 84892 [Q9UKV3-5]

PTM databases

iPTMnetⁱ	Q9UKV3
PhosphoSitePlusⁱ	Q9UKV3
SwissPalmⁱ	Q9UKV3

Miscellaneous databases

PMAP-CutDBⁱ	Q9UKV3

PMAP-CutDBⁱ

Q9UKV3

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Gene expression databases

Bgeeⁱ	ENSG00000100813 Expressed in 227 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_ACIN1
ExpressionAtlasⁱ	Q9UKV3 baseline and differential
Genevisibleⁱ	Q9UKV3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000657

HPAⁱ

HPA000657

Interactionⁱ

Subunit structureⁱ

Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
API5	Q9BZZ5	2	EBI-6976596,EBI-1048422
PCBD1	P61457	2	EBI-396258,EBI-740475
RNPS1	Q15287-1	4	EBI-5279966,EBI-15972541

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10490026

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116634, 122 interactors
CORUMⁱ	Q9UKV3
Database of interacting proteins More...DIPⁱ	DIP-32963N
IntActⁱ	Q9UKV3, 34 interactors
Molecular INTeraction database More...MINTⁱ	Q9UKV3
STRINGⁱ	9606.ENSP00000262710

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	1012 – 1017	Combined sources	6
Helixⁱ	1025 – 1032	Combined sources	8
Helixⁱ	1040 – 1042	Combined sources	3
Beta strandⁱ	1049 – 1058	Combined sources	10
Helixⁱ	1059 – 1069	Combined sources	11
Beta strandⁱ	1083 – 1087	Combined sources	5
Helixⁱ	1089 – 1095	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UKV3
SMRⁱ	Q9UKV3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	72 – 106	SAPPROSITE-ProRule annotationAdd BLAST		35

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1210 – 1237	Sufficient for interaction with RNPS1 and SAP18 and formation of th ASAP complexBy similarityAdd BLAST		28

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	142 – 442	Glu-richAdd BLAST	301
Compositional biasⁱ	573 – 676	Ser-richAdd BLAST	104
Compositional biasⁱ	1114 – 1131	Pro-richAdd BLAST	18
Compositional biasⁱ	1132 – 1341	Arg/Asp/Glu/Lys-richAdd BLAST	210

Phylogenomic databases

eggNOGⁱ	KOG2416 Eukaryota ENOG4111HR1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106790
HOGENOMⁱ	HOG000088615
HOVERGENⁱ	HBG050449
InParanoidⁱ	Q9UKV3
KEGG Orthology (KO) More...KOⁱ	K12875
OMAⁱ	LSECSQA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MO8
PhylomeDBⁱ	Q9UKV3
TreeFamⁱ	TF320727

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12432 RRM_ACINU, 1 hit
Gene3Dⁱ	1.10.720.30, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR034257 Acinus_RRM IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR032552 RSB_motif IPR003034 SAP_dom IPR036361 SAP_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16294 RSB_motif, 1 hit PF02037 SAP, 1 hit
SMARTⁱ	View protein in SMART SM00513 SAP, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF68906 SSF68906, 1 hit
PROSITEⁱ	View protein in PROSITE PS50800 SAP, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UKV3-1) [UniParc]FASTA Add to basket

Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MWRRKHPRTS GGTRGVLSGN RGVEYGSGRG HLGTFEGRWR KLPKMPEAVG 
        60         70         80         90        100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK 
       110        120        130        140        150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ 
       160        170        180        190        200
RLEREAREAA ELEEASAESE DEMIHPEGVA SLLPPDFQSS LERPELELSR 
       210        220        230        240        250
HSPRKSSSIS EEKGDSDDEK PRKGERRSSR VRQARAAKLS EGSQPAEEEE 
       260        270        280        290        300
DQETPSRNLR VRADRNLKTE EEEEEEEEEE EDDEEEEGDD EGQKSREAPI 
       310        320        330        340        350
LKEFKEEGEE IPRVKPEEMM DERPKTRSQE QEVLERGGRF TRSQEEARKS 
       360        370        380        390        400
HLARQQQEKE MKTTSPLEEE EREIKSSQGL KEKSKSPSPP RLTEDRKKAS 
       410        420        430        440        450
LVALPEQTAS EEETPPPLLT KEASSPPPHP QLHSEEEIEP MEGPAPAVLI 
       460        470        480        490        500
QLSPPNTDAD TRELLVSQHT VQLVGGLSPL SSPSDTKAES PAEKVPEESV 
       510        520        530        540        550
LPLVQKSTLA DYSAQKDLEP ESDRSAQPLP LKIEELALAK GITEECLKQP 
       560        570        580        590        600
SLEQKEGRRA SHTLLPSHRL KQSADSSSSR SSSSSSSSSR SRSRSPDSSG 
       610        620        630        640        650
SRSHSPLRSK QRDVAQARTH ANPRGRPKMG SRSTSESRSR SRSRSRSASS 
       660        670        680        690        700
NSRKSLSPGV SRDSSTSYTE TKDPSSGQEV ATPPVPQLQV CEPKERTSTS 
       710        720        730        740        750
SSSVQARRLS QPESAEKHVT QRLQPERGSP KKCEAEEAEP PAATQPQTSE 
       760        770        780        790        800
TQTSHLPESE RIHHTVEEKE EVTMDTSENR PENDVPEPPM PIADQVSNDD 
       810        820        830        840        850
RPEGSVEDEE KKESSLPKSF KRKISVVSAT KGVPAGNSDT EGGQPGRKRR 
       860        870        880        890        900
WGASTATTQK KPSISITTES LKSLIPDIKP LAGQEAVVDL HADDSRISED 
       910        920        930        940        950
ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE EKEPEAEPPV 
       960        970        980        990       1000
PPQVSVEVAL PPPAEHEVKK VTLGDTLTRR SISQQKSGVS ITIDDPVRTA 
      1010       1020       1030       1040       1050
QVPSPPRGKI SNIVHISNLV RPFTLGQLKE LLGRTGTLVE EAFWIDKIKS 
      1060       1070       1080       1090       1100
HCFVTYSTVE EAVATRTALH GVKWPQSNPK FLCADYAEQD ELDYHRGLLV 
      1110       1120       1130       1140       1150
DRPSETKTEE QGIPRPLHPP PPPPVQPPQH PRAEQREQER AVREQWAERE 
      1160       1170       1180       1190       1200
REMERRERTR SEREWDRDKV REGPRSRSRS RDRRRKERAK SKEKKSEKKE 
      1210       1220       1230       1240       1250
KAQEEPPAKL LDDLFRKTKA APCIYWLPLT DSQIVQKEAE RAERAKEREK 
      1260       1270       1280       1290       1300
RRKEQEEEEQ KEREKEAERE RNRQLEREKR REHSRERDRE RERERERDRG 
      1310       1320       1330       1340 
DRDRDRERDR ERGRERDRRD TKRHSRSRSR STPVRDRGGR R

Length:1,341

Mass (Da):151,862

Last modified:October 5, 2010 - v2

Checksum:ⁱDCCBF310A4680691

Isoform 2 (identifier: Q9UKV3-2) [UniParc]FASTA Add to basket

Also known as: S'

The sequence of this isoform differs from the canonical sequence as follows:
1-727: Missing.
728-766: GSPKKCEAEE...PESERIHHTV → MSPADRCRSA...DQSSRTRGLP

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        10         20         30         40         50
MSPADRCRSA NTIEPATTSS LALFLLLQRD QSSRTRGLPE EKEEVTMDTS 
        60         70         80         90        100
ENRPENDVPE PPMPIADQVS NDDRPEGSVE DEEKKESSLP KSFKRKISVV 
       110        120        130        140        150
SATKGVPAGN SDTEGGQPGR KRRWGASTAT TQKKPSISIT TESLKSLIPD 
       160        170        180        190        200
IKPLAGQEAV VDLHADDSRI SEDETERNGD DGTHDKGLKI CRTVTQVVPA 
       210        220        230        240        250
EGQENGQREE EEEEKEPEAE PPVPPQVSVE VALPPPAEHE VKKVTLGDTL 
       260        270        280        290        300
TRRSISQQKS GVSITIDDPV RTAQVPSPPR GKISNIVHIS NLVRPFTLGQ 
       310        320        330        340        350
LKELLGRTGT LVEEAFWIDK IKSHCFVTYS TVEEAVATRT ALHGVKWPQS 
       360        370        380        390        400
NPKFLCADYA EQDELDYHRG LLVDRPSETK TEEQGIPRPL HPPPPPPVQP 
       410        420        430        440        450
PQHPRAEQRE QERAVREQWA EREREMERRE RTRSEREWDR DKVREGPRSR 
       460        470        480        490        500
SRSRDRRRKE RAKSKEKKSE KKEKAQEEPP AKLLDDLFRK TKAAPCIYWL 
       510        520        530        540        550
PLTDSQIVQK EAERAERAKE REKRRKEQEE EEQKEREKEA ERERNRQLER 
       560        570        580        590        600
EKRREHSRER DRERERERER DRGDRDRDRE RDRERGRERD RRDTKRHSRS 
       610 
RSRSTPVRDR GGRR

Show »

Length:614

Mass (Da):70,948

Checksum:ⁱ2E994FB0FA922F4C

Isoform 3 (identifier: Q9UKV3-3) [UniParc]FASTA Add to basket

Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
1-758: Missing.
759-766: SERIHHTV → MLSESKEG

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        10         20         30         40         50
MLSESKEGEE KEEVTMDTSE NRPENDVPEP PMPIADQVSN DDRPEGSVED 
        60         70         80         90        100
EEKKESSLPK SFKRKISVVS ATKGVPAGNS DTEGGQPGRK RRWGASTATT 
       110        120        130        140        150
QKKPSISITT ESLKSLIPDI KPLAGQEAVV DLHADDSRIS EDETERNGDD 
       160        170        180        190        200
GTHDKGLKIC RTVTQVVPAE GQENGQREEE EEEKEPEAEP PVPPQVSVEV 
       210        220        230        240        250
ALPPPAEHEV KKVTLGDTLT RRSISQQKSG VSITIDDPVR TAQVPSPPRG 
       260        270        280        290        300
KISNIVHISN LVRPFTLGQL KELLGRTGTL VEEAFWIDKI KSHCFVTYST 
       310        320        330        340        350
VEEAVATRTA LHGVKWPQSN PKFLCADYAE QDELDYHRGL LVDRPSETKT 
       360        370        380        390        400
EEQGIPRPLH PPPPPPVQPP QHPRAEQREQ ERAVREQWAE REREMERRER 
       410        420        430        440        450
TRSEREWDRD KVREGPRSRS RSRDRRRKER AKSKEKKSEK KEKAQEEPPA 
       460        470        480        490        500
KLLDDLFRKT KAAPCIYWLP LTDSQIVQKE AERAERAKER EKRRKEQEEE 
       510        520        530        540        550
EQKEREKEAE RERNRQLERE KRREHSRERD RERERERERD RGDRDRDRER 
       560        570        580 
DRERGRERDR RDTKRHSRSR SRSTPVRDRG GRR

Show »

Length:583

Mass (Da):67,566

Checksum:ⁱF227265F2F6BBF68

Isoform 4 (identifier: Q9UKV3-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
829-829: Missing.
873-884: Missing.

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        10         20         30         40         50
MWRRKHPRTS GGTRGVLSGN RGVEYGSGRG HLGTFEGRWR KLPKMPEAVG 
        60         70         80         90        100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK 
       110        120        130        140        150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ 
       160        170        180        190        200
RLEREAREAA ELEEASAESE DEMIHPEGVA SLLPPDFQSS LERPELELSR 
       210        220        230        240        250
HSPRKSSSIS EEKGDSDDEK PRKGERRSSR VRQARAAKLS EGSQPAEEEE 
       260        270        280        290        300
DQETPSRNLR VRADRNLKTE EEEEEEEEEE EDDEEEEGDD EGQKSREAPI 
       310        320        330        340        350
LKEFKEEGEE IPRVKPEEMM DERPKTRSQE QEVLERGGRF TRSQEEARKS 
       360        370        380        390        400
HLARQQQEKE MKTTSPLEEE EREIKSSQGL KEKSKSPSPP RLTEDRKKAS 
       410        420        430        440        450
LVALPEQTAS EEETPPPLLT KEASSPPPHP QLHSEEEIEP MEGPAPAVLI 
       460        470        480        490        500
QLSPPNTDAD TRELLVSQHT VQLVGGLSPL SSPSDTKAES PAEKVPEESV 
       510        520        530        540        550
LPLVQKSTLA DYSAQKDLEP ESDRSAQPLP LKIEELALAK GITEECLKQP 
       560        570        580        590        600
SLEQKEGRRA SHTLLPSHRL KQSADSSSSR SSSSSSSSSR SRSRSPDSSG 
       610        620        630        640        650
SRSHSPLRSK QRDVAQARTH ANPRGRPKMG SRSTSESRSR SRSRSRSASS 
       660        670        680        690        700
NSRKSLSPGV SRDSSTSYTE TKDPSSGQEV ATPPVPQLQV CEPKERTSTS 
       710        720        730        740        750
SSSVQARRLS QPESAEKHVT QRLQPERGSP KKCEAEEAEP PAATQPQTSE 
       760        770        780        790        800
TQTSHLPESE RIHHTVEEKE EVTMDTSENR PENDVPEPPM PIADQVSNDD 
       810        820        830        840        850
RPEGSVEDEE KKESSLPKSF KRKISVVSTK GVPAGNSDTE GGQPGRKRRW 
       860        870        880        890        900
GASTATTQKK PSISITTESL KEAVVDLHAD DSRISEDETE RNGDDGTHDK 
       910        920        930        940        950
GLKICRTVTQ VVPAEGQENG QREEEEEEKE PEAEPPVPPQ VSVEVALPPP 
       960        970        980        990       1000
AEHEVKKVTL GDTLTRRSIS QQKSGVSITI DDPVRTAQVP SPPRGKISNI 
      1010       1020       1030       1040       1050
VHISNLVRPF TLGQLKELLG RTGTLVEEAF WIDKIKSHCF VTYSTVEEAV 
      1060       1070       1080       1090       1100
ATRTALHGVK WPQSNPKFLC ADYAEQDELD YHRGLLVDRP SETKTEEQGI 
      1110       1120       1130       1140       1150
PRPLHPPPPP PVQPPQHPRA EQREQERAVR EQWAEREREM ERRERTRSER 
      1160       1170       1180       1190       1200
EWDRDKVREG PRSRSRSRDR RRKERAKSKE KKSEKKEKAQ EEPPAKLLDD 
      1210       1220       1230       1240       1250
LFRKTKAAPC IYWLPLTDSQ IVQKEAERAE RAKEREKRRK EQEEEEQKER 
      1260       1270       1280       1290       1300
EKEAERERNR QLEREKRREH SRERDRERER ERERDRGDRD RDRERDRERG 
      1310       1320 
RERDRRDTKR HSRSRSRSTP VRDRGGRR

Show »

Length:1,328

Mass (Da):150,557

Checksum:ⁱ47A3C106859D46DB

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EQT4	E7EQT4_HUMAN	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	ACIN1	1,301	Annotation score:
S4R3H4	S4R3H4_HUMAN	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	ACIN1	1,283	Annotation score:
G3V3B0	G3V3B0_HUMAN	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	ACIN1	582	Annotation score:
G3V3T3	G3V3T3_HUMAN	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	ACIN1	194	Annotation score:
A0A087WYN3	A0A087WYN3_HUMAN	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	ACIN1	82	Annotation score:
A0A087X0D2	A0A087X0D2_HUMAN	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	ACIN1	36	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	139	Q → H in BAA31645 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050632	257	R → K. Corresponds to variant dbSNP:rs11555803Ensembl.	1
Natural variantⁱVAR_022031	311	I → M. Corresponds to variant dbSNP:rs3811182Ensembl.	1
Natural variantⁱVAR_061547	447	A → PCombined sources5 PublicationsCorresponds to variant dbSNP:rs941719Ensembl.	1
Natural variantⁱVAR_022032	467	S → P. Corresponds to variant dbSNP:rs1885097Ensembl.	1
Natural variantⁱVAR_022033	478	S → F. Corresponds to variant dbSNP:rs3751501Ensembl.	1
Natural variantⁱVAR_035777	1160	R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754494408Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004026	1 – 758	Missing in isoform 3. 2 PublicationsAdd BLAST	758
Alternative sequenceⁱVSP_004025	1 – 727	Missing in isoform 2. 1 PublicationAdd BLAST	727
Alternative sequenceⁱVSP_004028	728 – 766	GSPKK…IHHTV → MSPADRCRSANTIEPATTSS LALFLLLQRDQSSRTRGLP in isoform 2. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_004029	759 – 766	SERIHHTV → MLSESKEG in isoform 3. 2 Publications	8
Alternative sequenceⁱVSP_042204	829	Missing in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_042205	873 – 884	Missing in isoform 4. 1 PublicationAdd BLAST	12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124726 mRNA Translation: AAD56724.1 AF124727 mRNA Translation: AAD56725.1 AF124728 mRNA Translation: AAD56726.1 BX247975 mRNA Translation: CAD62309.1 AL117258 Genomic DNA No translation available. AL132780 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66187.1 CH471078 Genomic DNA Translation: EAW66188.1 BC140805 mRNA Translation: AAI40806.1 AB014570 mRNA Translation: BAA31645.2 AL050382 mRNA Translation: CAB43681.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53887.1 [Q9UKV3-3] CCDS53888.1 [Q9UKV3-2] CCDS55905.1 [Q9UKV3-5] CCDS9587.1 [Q9UKV3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001158286.1, NM_001164814.1 NP_001158287.1, NM_001164815.1 NP_001158288.1, NM_001164816.1 [Q9UKV3-2] NP_001158289.1, NM_001164817.1 [Q9UKV3-3] NP_055792.1, NM_014977.3 XP_005267475.1, XM_005267418.1 [Q9UKV3-3]
UniGeneⁱ	Hs.124490

Genome annotation databases

Ensemblⁱ	ENST00000262710; ENSP00000262710; ENSG00000100813 [Q9UKV3-1] ENST00000338631; ENSP00000345541; ENSG00000100813 [Q9UKV3-2] ENST00000357481; ENSP00000350073; ENSG00000100813 [Q9UKV3-3] ENST00000397341; ENSP00000380502; ENSG00000100813 [Q9UKV3-3] ENST00000555053; ENSP00000451328; ENSG00000100813 [Q9UKV3-5]
GeneIDⁱ	22985
KEGGⁱ	hsa:22985
UCSC genome browser More...UCSCⁱ	uc001wip.5 human [Q9UKV3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus		HUMAN		1283	UniRef100_Q9UKV3
Q9UKV3-2	Apoptotic chromatin condensation inducer in the nucleus isoform 4		MACMU		614	UniRef100_H9Z6L0
ACIN1 isoform 4		PANTR		614
ACIN1 isoform 12		PONAB		614
Uncharacterized protein		PAPAN		614
Uncharacterized protein		PANPA		614
+4
Q9UKV3-3	ACIN1 isoform 11		PANTR		1352	UniRef100_A0A2J8QK52
ACIN1 isoform 10		PONAB		583
Apoptotic chromatin condensation inducer in the nucleus isoform 5		MACMU		583
Uncharacterized protein		PAPAN		583
Uncharacterized protein		PANPA		583
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus		HUMAN		1283	UniRef90_Q9UKV3
Apoptotic chromatin condensation inducer 1		SAIBB		1353
apoptotic chromatin condensation inducer in the nucleus		TARSY		1352
Uncharacterized protein		AOTNA		1351
Uncharacterized protein		Cebus capucinus imitator		1349
+245
Q9UKV3-2	Apoptotic chromatin condensation inducer in the nucleus		MOUSE		580	UniRef90_B8JJ92
Uncharacterized protein		AOTNA		618
Apoptotic chromatin condensation inducer 1		ICTTR		615
apoptotic chromatin condensation inducer in the nucleus isoform X3		NEOSC		615
Uncharacterized protein		MACMU		615
+117
Q9UKV3-3	Apoptotic chromatin condensation inducer in the nucleus		HUMAN		582	UniRef90_G3V3B0
ACIN1 isoform 10		PANTR		1351
Uncharacterized protein		COLAP		583
Uncharacterized protein		MACMU		582
ACIN1 isoform 11		PONAB		582
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus		MOUSE		1338	UniRef50_Q9UKV3
Apoptotic chromatin condensation inducer in the nucleus		HUMAN		1283
Apoptotic chromatin condensation inducer 1		SAIBB		1353
apoptotic chromatin condensation inducer in the nucleus		TARSY		1352
Uncharacterized protein		AOTNA		1351
+454
Q9UKV3-2	Isoform 2 of Apoptotic chromatin condensation inducer in the nucleus		MOUSE		581	UniRef50_Q9JIX8-2
Uncharacterized protein		CAVPO		635
Uncharacterized protein		CERAT		631
MGC132201 protein		XENLA		639
Apoptotic chromatin condensation inducer 1		XENTR		568
+143

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124726 mRNA Translation: AAD56724.1 AF124727 mRNA Translation: AAD56725.1 AF124728 mRNA Translation: AAD56726.1 BX247975 mRNA Translation: CAD62309.1 AL117258 Genomic DNA No translation available. AL132780 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66187.1 CH471078 Genomic DNA Translation: EAW66188.1 BC140805 mRNA Translation: AAI40806.1 AB014570 mRNA Translation: BAA31645.2 AL050382 mRNA Translation: CAB43681.2
CCDSⁱ	CCDS53887.1 [Q9UKV3-3] CCDS53888.1 [Q9UKV3-2] CCDS55905.1 [Q9UKV3-5] CCDS9587.1 [Q9UKV3-1]
RefSeqⁱ	NP_001158286.1, NM_001164814.1 NP_001158287.1, NM_001164815.1 NP_001158288.1, NM_001164816.1 [Q9UKV3-2] NP_001158289.1, NM_001164817.1 [Q9UKV3-3] NP_055792.1, NM_014977.3 XP_005267475.1, XM_005267418.1 [Q9UKV3-3]
UniGeneⁱ	Hs.124490

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6G6S	X-ray	1.65	A/B	1008-1100	[»]
ProteinModelPortalⁱ	Q9UKV3
SMRⁱ	Q9UKV3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116634, 122 interactors
CORUMⁱ	Q9UKV3
DIPⁱ	DIP-32963N
IntActⁱ	Q9UKV3, 34 interactors
MINTⁱ	Q9UKV3
STRINGⁱ	9606.ENSP00000262710

Protein family/group databases

TCDBⁱ	3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetⁱ	Q9UKV3
PhosphoSitePlusⁱ	Q9UKV3
SwissPalmⁱ	Q9UKV3

Polymorphism and mutation databases

BioMutaⁱ	ACIN1
DMDMⁱ	308153407

Proteomic databases

EPDⁱ	Q9UKV3
PaxDbⁱ	Q9UKV3
PeptideAtlasⁱ	Q9UKV3
PRIDEⁱ	Q9UKV3
ProteomicsDBⁱ	84889 84890 [Q9UKV3-2] 84891 [Q9UKV3-3] 84892 [Q9UKV3-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262710; ENSP00000262710; ENSG00000100813 [Q9UKV3-1] ENST00000338631; ENSP00000345541; ENSG00000100813 [Q9UKV3-2] ENST00000357481; ENSP00000350073; ENSG00000100813 [Q9UKV3-3] ENST00000397341; ENSP00000380502; ENSG00000100813 [Q9UKV3-3] ENST00000555053; ENSP00000451328; ENSG00000100813 [Q9UKV3-5]
GeneIDⁱ	22985
KEGGⁱ	hsa:22985
UCSCⁱ	uc001wip.5 human [Q9UKV3-1]

Organism-specific databases

CTDⁱ	22985
DisGeNETⁱ	22985
EuPathDBⁱ	HostDB:ENSG00000100813.14
GeneCardsⁱ	ACIN1
HGNCⁱ	HGNC:17066 ACIN1
HPAⁱ	HPA000657
MIMⁱ	604562 gene
neXtProtⁱ	NX_Q9UKV3
OpenTargetsⁱ	ENSG00000100813
PharmGKBⁱ	PA134912489
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2416 Eukaryota ENOG4111HR1 LUCA
GeneTreeⁱ	ENSGT00710000106790
HOGENOMⁱ	HOG000088615
HOVERGENⁱ	HBG050449
InParanoidⁱ	Q9UKV3
KOⁱ	K12875
OMAⁱ	LSECSQA
OrthoDBⁱ	EOG091G0MO8
PhylomeDBⁱ	Q9UKV3
TreeFamⁱ	TF320727

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111465 Apoptotic cleavage of cellular proteins
SIGNORⁱ	Q9UKV3

Miscellaneous databases

ChiTaRSⁱ	ACIN1 human
GeneWikiⁱ	ACIN1
GenomeRNAiⁱ	22985
PMAP-CutDBⁱ	Q9UKV3
Protein Ontology More...PROⁱ	PR:Q9UKV3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100813 Expressed in 227 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_ACIN1
ExpressionAtlasⁱ	Q9UKV3 baseline and differential
Genevisibleⁱ	Q9UKV3 HS

Family and domain databases

CDDⁱ	cd12432 RRM_ACINU, 1 hit
Gene3Dⁱ	1.10.720.30, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR034257 Acinus_RRM IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR032552 RSB_motif IPR003034 SAP_dom IPR036361 SAP_dom_sf
Pfamⁱ	View protein in Pfam PF16294 RSB_motif, 1 hit PF02037 SAP, 1 hit
SMARTⁱ	View protein in SMART SM00513 SAP, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF68906 SSF68906, 1 hit
PROSITEⁱ	View protein in PROSITE PS50800 SAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACINU_HUMAN
Accessionⁱ	Q9UKV3Primary (citable) accession number: Q9UKV3 Secondary accession number(s): B2RTT4 , D3DS45, O75158, Q9UG91, Q9UKV1, Q9UKV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	October 5, 2010
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q9UKV3 (ACINU_HUMAN)

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Apoptotic chromatin condensation inducer in the nucleus

ACIN1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ