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Protein

Angiopoietin-related protein 2

Gene

ANGPTL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces sprouting in endothelial cells through an autocrine and paracrine action.

GO - Molecular functioni

  • signaling receptor binding Source: ProtInc

GO - Biological processi

  • multicellular organism development Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 2
Alternative name(s):
Angiopoietin-like protein 2
Gene namesi
Name:ANGPTL2
Synonyms:ARP2
ORF Names:UNQ170/PRO196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136859.9
HGNCiHGNC:490 ANGPTL2
MIMi605001 gene
neXtProtiNX_Q9UKU9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi23452
OpenTargetsiENSG00000136859
PharmGKBiPA24795

Polymorphism and mutation databases

BioMutaiANGPTL2
DMDMi13626119

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000912023 – 493Angiopoietin-related protein 2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi278 ↔ 307PROSITE-ProRule annotation
Disulfide bondi430 ↔ 443PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UKU9
PaxDbiQ9UKU9
PeptideAtlasiQ9UKU9
PRIDEiQ9UKU9
ProteomicsDBi84880

PTM databases

iPTMnetiQ9UKU9
PhosphoSitePlusiQ9UKU9

Expressioni

Tissue specificityi

Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.

Gene expression databases

BgeeiENSG00000136859
CleanExiHS_ANGPTL2
ExpressionAtlasiQ9UKU9 baseline and differential
GenevisibleiQ9UKU9 HS

Organism-specific databases

HPAiHPA040933
HPA041299

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LILRB2Q8N4235EBI-15485893,EBI-2816428

GO - Molecular functioni

  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi117018, 2 interactors
DIPiDIP-59886N
IntActiQ9UKU9, 2 interactors
STRINGi9606.ENSP00000362524

Structurei

3D structure databases

ProteinModelPortaliQ9UKU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 489Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 115Sequence analysisAdd BLAST40
Coiled coili152 – 206Sequence analysisAdd BLAST55

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148944
HOGENOMiHOG000037127
HOVERGENiHBG103336
InParanoidiQ9UKU9
OMAiTPPRVYQ
OrthoDBiEOG091G03M1
PhylomeDBiQ9UKU9
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLCVTCWW LGLLAAMGAV AGQEDGFEGT EEGSPREFIY LNRYKRAGES
60 70 80 90 100
QDKCTYTFIV PQQRVTGAIC VNSKEPEVLL ENRVHKQELE LLNNELLKQK
110 120 130 140 150
RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD
160 170 180 190 200
NALELSQLEN RILNQTADML QLASKYKDLE HKYQHLATLA HNQSEIIAQL
210 220 230 240 250
EEHCQRVPSA RPVPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV
260 270 280 290 300
LPPPLPTMPT LTSLPSSTDK PSGPWRDCLQ ALEDGHDTSS IYLVKPENTN
310 320 330 340 350
RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG
360 370 380 390 400
LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY
410 420 430 440 450
HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG
460 470 480 490
VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH
Length:493
Mass (Da):57,104
Last modified:May 1, 2000 - v1
Checksum:i0F2ADECE53D185CA
GO
Isoform 2 (identifier: Q9UKU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-302: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):22,717
Checksum:iD050F4E25A571F6A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569341 – 302Missing in isoform 2. 1 PublicationAdd BLAST302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125175 mRNA Translation: AAD55357.1
AY358274 mRNA Translation: AAQ88641.1
AK074726 mRNA Translation: BAC11164.1
AL356862 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87651.1
BC012368 mRNA Translation: AAH12368.1
CCDSiCCDS6868.1 [Q9UKU9-1]
RefSeqiNP_036230.1, NM_012098.2 [Q9UKU9-1]
UniGeneiHs.653262

Genome annotation databases

EnsembliENST00000373417; ENSP00000362516; ENSG00000136859 [Q9UKU9-2]
ENST00000373425; ENSP00000362524; ENSG00000136859 [Q9UKU9-1]
GeneIDi23452
KEGGihsa:23452
UCSCiuc004bqr.2 human [Q9UKU9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANGL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKU9
Secondary accession number(s): Q5JT58, Q8NCH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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