Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 177 (07 Oct 2020)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger protein Aiolos

Gene

IKZF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 504C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processB-cell activation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UKT9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UKT9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein Aiolos
Alternative name(s):
Ikaros family zinc finger protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IKZF3
Synonyms:ZNFN1A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000161405.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13178, IKZF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606221, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKT9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22806

MalaCards human disease database

More...
MalaCardsi
IKZF3

Open Targets

More...
OpenTargetsi
ENSG00000161405

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
67038, B-cell chronic lymphocytic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37750

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKT9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IKZF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470901 – 509Zinc finger protein AiolosAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei326PhosphothreonineCombined sources1
Modified residuei378PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKT9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UKT9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKT9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKT9

PeptideAtlas

More...
PeptideAtlasi
Q9UKT9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKT9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84855 [Q9UKT9-1]
84856 [Q9UKT9-10]
84857 [Q9UKT9-11]
84858 [Q9UKT9-12]
84859 [Q9UKT9-13]
84860 [Q9UKT9-14]
84861 [Q9UKT9-15]
84862 [Q9UKT9-2]
84863 [Q9UKT9-3]
84864 [Q9UKT9-4]
84865 [Q9UKT9-5]
84866 [Q9UKT9-6]
84867 [Q9UKT9-7]
84868 [Q9UKT9-8]
84869 [Q9UKT9-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161405, Expressed in tonsil and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKT9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKT9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000161405, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with other IKAROS family members.

Interacts with IKZF4 AND IKZF5.

Interacts with IKZF1.

Interacts with HRAS.

Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg).

Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UKT9
With#Exp.IntAct
ABLIM3 [O94929]4EBI-747204,EBI-351267
ABLIM3 - isoform 2 [O94929-2]3EBI-747204,EBI-11961672
AKAP10 [A0A0S2Z4Y8]3EBI-747204,EBI-16428921
AKAP9 - isoform 2 [Q99996-2]3EBI-747204,EBI-9641546
ANKS1A [Q49AR9]5EBI-747204,EBI-11954519
AQP1 [P29972]6EBI-747204,EBI-745213
ARHGEF6 [Q15052]3EBI-747204,EBI-1642523
ARMC7 [Q9H6L4]9EBI-747204,EBI-742909
ATP6V0D2 [Q8N8Y2]3EBI-747204,EBI-3923949
ATPAF2 [Q8N5M1]10EBI-747204,EBI-1166928
BCAS2 [O75934]5EBI-747204,EBI-1050106
BLK [P51451]3EBI-747204,EBI-2105445
BLZF1 [Q9H2G9]3EBI-747204,EBI-2548012
BYSL [Q13895]3EBI-747204,EBI-358049
C1orf109 [Q9NX04]6EBI-747204,EBI-8643161
C2CD6 [Q53TS8]3EBI-747204,EBI-739879
CABP5 [Q9NP86]5EBI-747204,EBI-10311131
CARD9 - isoform 2 [Q9H257-2]3EBI-747204,EBI-11530605
CATSPER1 [Q8NEC5]3EBI-747204,EBI-744545
CCDC102B [Q68D86]3EBI-747204,EBI-10171570
CCDC24 [Q8N4L8]3EBI-747204,EBI-1104933
CCDC57 - isoform 2 [Q2TAC2-2]5EBI-747204,EBI-10961624
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-747204,EBI-10175300
CDC37 [Q16543]3EBI-747204,EBI-295634
CDC7 [O00311]3EBI-747204,EBI-374980
CDK18 [Q07002]3EBI-747204,EBI-746238
CDK4 [P11802]6EBI-747204,EBI-295644
CDKN1A [P38936]3EBI-747204,EBI-375077
CDKN2D [P55273]5EBI-747204,EBI-745859
CFAP206 [Q8IYR0]3EBI-747204,EBI-749051
CHCHD2 [Q9Y6H1]4EBI-747204,EBI-2321769
CKS1B [P61024]3EBI-747204,EBI-456371
CLCNKA - isoform 3 [P51800-3]3EBI-747204,EBI-11980535
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-747204,EBI-12012272
CRYBA4 [P53673]3EBI-747204,EBI-7519711
CTBP2 - isoform 3 [P56545-3]3EBI-747204,EBI-10171902
DTX2 [Q86UW9]3EBI-747204,EBI-740376
EFHC1 [Q5JVL4]13EBI-747204,EBI-743105
EGLN3 [Q9H6Z9]3EBI-747204,EBI-1175354
EHHADH [Q08426]3EBI-747204,EBI-2339219
EMC2 [Q15006]3EBI-747204,EBI-359031
ENKD1 [Q9H0I2]3EBI-747204,EBI-744099
EPHB6 - isoform 2 [O15197-2]3EBI-747204,EBI-10182490
EXOC8 [Q8IYI6]7EBI-747204,EBI-742102
EXOSC5 [Q9NQT4]7EBI-747204,EBI-371876
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-747204,EBI-11986315
FAM50B [Q9Y247]3EBI-747204,EBI-742802
FANCL [Q9NW38]3EBI-747204,EBI-2339898
FARS2 [O95363]6EBI-747204,EBI-2513774
FBF1 - isoform 6 [Q8TES7-6]3EBI-747204,EBI-10244131
FHL3 [Q13643]4EBI-747204,EBI-741101
FOXP3 [Q9BZS1]2EBI-747204,EBI-983719
FRS3 [O43559]3EBI-747204,EBI-725515
GEM [P55040]8EBI-747204,EBI-744104
GOLGA6A [Q9NYA3]3EBI-747204,EBI-11163335
GRB2 [P62993]8EBI-747204,EBI-401755
hCG_1987119 [A0A024R8L2]3EBI-747204,EBI-14103818
HNRNPF [P52597]3EBI-747204,EBI-352986
HOXC8 [P31273]3EBI-747204,EBI-1752118
HSPB7 [Q9UBY9]3EBI-747204,EBI-739361
itself4EBI-747204,EBI-747204
IKZF5 [Q9H5V7]2EBI-747204,EBI-2685636
ING5 [Q8WYH8]3EBI-747204,EBI-488533
KANK2 [Q63ZY3]3EBI-747204,EBI-2556193
KAT5 [Q92993]6EBI-747204,EBI-399080
KIF9 [Q9HAQ2]3EBI-747204,EBI-8472129
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-747204,EBI-14069005
KLHL38 [Q2WGJ6]3EBI-747204,EBI-6426443
KRT19 [P08727]3EBI-747204,EBI-742756
LENG1 [Q96BZ8]3EBI-747204,EBI-726510
LGALS14 [Q8TCE9]8EBI-747204,EBI-10274069
LMO1 [P25800]4EBI-747204,EBI-8639312
LMO2 [P25791]3EBI-747204,EBI-739696
LMO2 - isoform 3 [P25791-3]3EBI-747204,EBI-11959475
LMO4 [P61968]3EBI-747204,EBI-2798728
LNX1 [Q8TBB1]3EBI-747204,EBI-739832
LONRF1 [Q17RB8]3EBI-747204,EBI-2341787
MAD2L2 [Q9UI95]3EBI-747204,EBI-77889
MAGOHB [Q96A72]7EBI-747204,EBI-746778
MCRS1 [Q96EZ8]3EBI-747204,EBI-348259
MGC50722 [Q8IVT4]5EBI-747204,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]5EBI-747204,EBI-10172526
MIPOL1 [Q8TD10]3EBI-747204,EBI-2548751
MISP [Q8IVT2]5EBI-747204,EBI-2555085
MKRN3 [Q13064]3EBI-747204,EBI-2340269
MORN3 [Q6PF18]7EBI-747204,EBI-9675802
MRPL28 [Q13084]3EBI-747204,EBI-723426
MRPL53 [Q96EL3]3EBI-747204,EBI-2513715
NATD1 [Q8N6N6]3EBI-747204,EBI-8656665
NEK6 [Q9HC98]5EBI-747204,EBI-740364
NEK6 - isoform 4 [Q9HC98-4]3EBI-747204,EBI-11750983
NFKBID [Q8NI38]3EBI-747204,EBI-10271199
NME7 [Q9Y5B8]3EBI-747204,EBI-744782
NOS3 [P29474]3EBI-747204,EBI-1391623
NUDT16L1 [Q9BRJ7]3EBI-747204,EBI-2949792
NXT2 - isoform 3 [Q9NPJ8-3]3EBI-747204,EBI-10698339
OAZ3 [Q9UMX2]3EBI-747204,EBI-10281601
OSGIN1 [Q9UJX0]5EBI-747204,EBI-9057006
PCID2 [Q5JVF3]3EBI-747204,EBI-1051701
PDZD4 [Q17RL8]3EBI-747204,EBI-10239064
PFDN5 [Q99471]7EBI-747204,EBI-357275
PIK3R2 [O00459]4EBI-747204,EBI-346930
PIN1 [Q13526]8EBI-747204,EBI-714158
PKN1 [Q16512]3EBI-747204,EBI-602382
POLM [Q6PIY2]3EBI-747204,EBI-10253863
POLR1C [O15160]9EBI-747204,EBI-1055079
PPP1R16B [Q96T49]7EBI-747204,EBI-10293968
PPP1R18 [Q6NYC8]3EBI-747204,EBI-2557469
PRKAA1 [Q13131]3EBI-747204,EBI-1181405
PRKAA2 [P54646]3EBI-747204,EBI-1383852
PRKAB2 [O43741]11EBI-747204,EBI-1053424
PRPF18 [Q99633]3EBI-747204,EBI-2798416
PSMA1 [P25786]3EBI-747204,EBI-359352
PTK6 [Q13882]3EBI-747204,EBI-1383632
RAD51D [O75771]11EBI-747204,EBI-1055693
RCOR3 [Q9P2K3]4EBI-747204,EBI-743428
RHOA [P61586]3EBI-747204,EBI-446668
RNF6 [A0A0S2Z4G9]3EBI-747204,EBI-16428950
SCNM1 [Q9BWG6]3EBI-747204,EBI-748391
SMARCD1 [Q96GM5]3EBI-747204,EBI-358489
SPG21 [Q9NZD8]6EBI-747204,EBI-742688
STAMBPL1 [Q96FJ0]3EBI-747204,EBI-745021
STK16 [O75716]3EBI-747204,EBI-749295
STX11 [O75558]3EBI-747204,EBI-714135
TBC1D22B [Q9NU19]9EBI-747204,EBI-8787464
TCAF1 [Q9Y4C2]5EBI-747204,EBI-750484
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-747204,EBI-11974855
TCAP [O15273]3EBI-747204,EBI-954089
TCEANC - isoform 2 [Q8N8B7-2]3EBI-747204,EBI-11955057
TCHP [Q9BT92]3EBI-747204,EBI-740781
TEKT3 [Q9BXF9]3EBI-747204,EBI-8644516
TEKT4 [Q8WW24]7EBI-747204,EBI-750487
TFAP2D [Q7Z6R9]3EBI-747204,EBI-11952651
TLE5 [Q08117]3EBI-747204,EBI-717810
TLE5 - isoform 2 [Q08117-2]5EBI-747204,EBI-11741437
TRAPPC6A [O75865]3EBI-747204,EBI-743573
TRAPPC6A - isoform 2 [O75865-2]5EBI-747204,EBI-8451480
TRIM42 [Q8IWZ5]3EBI-747204,EBI-5235829
TSEN15 [Q8WW01]3EBI-747204,EBI-372432
TSGA10IP [Q3SY00]3EBI-747204,EBI-10241197
TSSK3 [Q96PN8]8EBI-747204,EBI-3918381
TSTD2 [Q5T7W7]10EBI-747204,EBI-8994397
USP2 [O75604]3EBI-747204,EBI-743272
VBP1 [P61758]3EBI-747204,EBI-357430
YES1 [P07947]5EBI-747204,EBI-515331
ZGPAT [A0A0S2Z6H0]3EBI-747204,EBI-16428984
ZGPAT [Q8N5A5]3EBI-747204,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-747204,EBI-10183064
ZMYM2 [Q9UBW7]3EBI-747204,EBI-2797576
ZNF417 [Q8TAU3]3EBI-747204,EBI-740727
ZNF587 [Q96SQ5]3EBI-747204,EBI-6427977
ZNF76 [P36508]3EBI-747204,EBI-7254550

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116484, 199 interactors

Database of interacting proteins

More...
DIPi
DIP-56975N

Protein interaction database and analysis system

More...
IntActi
Q9UKT9, 173 interactors

Molecular INTeraction database

More...
MINTi
Q9UKT9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344544

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UKT9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKT9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 504C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160462

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025502_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKT9

KEGG Orthology (KO)

More...
KOi
K09220

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRPYDII

Database of Orthologous Groups

More...
OrthoDBi
385551at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKT9

TreeFam database of animal gene trees

More...
TreeFami
TF331189

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 16 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKT9-1) [UniParc]FASTAAdd to basket
Also known as: Aio-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED
60 70 80 90 100
EDIGDDSMKV KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK
110 120 130 140 150
LERHVVSFDS SRPTSGKMNC DVCGLSCISF NVLMVHKRSH TGERPFQCNQ
160 170 180 190 200
CGASFTQKGN LLRHIKLHTG EKPFKCHLCN YACQRRDALT GHLRTHSVEK
210 220 230 240 250
PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE ARHIKAEMGS
260 270 280 290 300
ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ
310 320 330 340 350
TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE
360 370 380 390 400
MSNGAPQELE KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI
410 420 430 440 450
YQQNHMVLSR ARNGMPLLKE VPRSYELLKP PPICPRDSVK VINKEGEVMD
460 470 480 490 500
VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF ECNMCGYRSH DRYEFSSHIA

RGEHRALLK
Length:509
Mass (Da):58,023
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1BB4A0A9A71B81A
GO
Isoform 2 (identifier: Q9UKT9-2) [UniParc]FASTAAdd to basket
Also known as: Aio-del4

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.

Show »
Length:453
Mass (Da):51,632
Checksum:i85DEFC62034A738F
GO
Isoform 3 (identifier: Q9UKT9-3) [UniParc]FASTAAdd to basket
Also known as: Aio-del5

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.

Show »
Length:470
Mass (Da):53,401
Checksum:i18998C960E99C78A
GO
Isoform 4 (identifier: Q9UKT9-4) [UniParc]FASTAAdd to basket
Also known as: Aio-del6

The sequence of this isoform differs from the canonical sequence as follows:
     237-275: Missing.

Show »
Length:470
Mass (Da):53,743
Checksum:i979F785A6B93BC6E
GO
Isoform 5 (identifier: Q9UKT9-5) [UniParc]FASTAAdd to basket
Also known as: Aio-del4,5

The sequence of this isoform differs from the canonical sequence as follows:
     142-236: Missing.

Show »
Length:414
Mass (Da):47,010
Checksum:iDD4C8159B8417844
GO
Isoform 6 (identifier: Q9UKT9-6) [UniParc]FASTAAdd to basket
Also known as: Aio-del5,6

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Show »
Length:431
Mass (Da):49,121
Checksum:i540F806622DCBB56
GO
Isoform 7 (identifier: Q9UKT9-7) [UniParc]FASTAAdd to basket
Also known as: Aio-del2

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.

Show »
Length:475
Mass (Da):54,417
Checksum:i00694E8BA86FFEC5
GO
Isoform 8 (identifier: Q9UKT9-8) [UniParc]FASTAAdd to basket
Also known as: Aio-del2,5

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
     198-236: Missing.

Show »
Length:436
Mass (Da):49,795
Checksum:i965862E0B68846E0
GO
Isoform 9 (identifier: Q9UKT9-9) [UniParc]FASTAAdd to basket
Also known as: Aio-del3

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.

Show »
Length:422
Mass (Da):47,958
Checksum:i42308DF0B90BA4DF
GO
Isoform 10 (identifier: Q9UKT9-10) [UniParc]FASTAAdd to basket
Also known as: Aio-del3,4

The sequence of this isoform differs from the canonical sequence as follows:
     55-197: Missing.

Show »
Length:366
Mass (Da):41,567
Checksum:iA4E825FDBF860925
GO
Isoform 11 (identifier: Q9UKT9-11) [UniParc]FASTAAdd to basket
Also known as: Aio-del3,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     55-236: Missing.

Show »
Length:327
Mass (Da):36,945
Checksum:iD90D2FFBA757F7B9
GO
Isoform 12 (identifier: Q9UKT9-12) [UniParc]FASTAAdd to basket
Also known as: Aio-del3,4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     55-275: Missing.

Show »
Length:288
Mass (Da):32,665
Checksum:iECA1D13AA6312CAB
GO
Isoform 13 (identifier: Q9UKT9-13) [UniParc]FASTAAdd to basket
Also known as: Aio-del4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     142-275: Missing.

Show »
Length:375
Mass (Da):42,730
Checksum:i7AE6138A9450AAF5
GO
Isoform 14 (identifier: Q9UKT9-14) [UniParc]FASTAAdd to basket
Also known as: Aio-1-5a

The sequence of this isoform differs from the canonical sequence as follows:
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
     264-509: Missing.

Show »
Length:263
Mass (Da):30,029
Checksum:iF12F178DB5F635A3
GO
Isoform 15 (identifier: Q9UKT9-15) [UniParc]FASTAAdd to basket
Also known as: Aio-del4-5a

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH

Show »
Length:453
Mass (Da):51,880
Checksum:i8C2E108E02143972
GO
Isoform 16 (identifier: Q9UKT9-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Show »
Length:262
Mass (Da):29,973
Checksum:i74F8C25D67B30D67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGN9A0A0C4DGN9_HUMAN
Zinc finger protein Aiolos
IKZF3
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti321R → C in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti321R → C in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti361K → R in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti361K → R in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti365H → L in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti365H → L in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti443N → D in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti443N → D in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti487Y → D in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti506A → S in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti506A → S in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80431 (PubMed:11745366).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064724277E → Q Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553531 – 247Missing in isoform 16. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_04127421 – 54Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_04127555 – 275Missing in isoform 12. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_04127655 – 236Missing in isoform 11. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_04127755 – 197Missing in isoform 10. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_04127855 – 141Missing in isoform 9. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_041279142 – 275Missing in isoform 13. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_006841142 – 236Missing in isoform 5. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_006840142 – 197Missing in isoform 2 and isoform 15. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_006843198 – 275Missing in isoform 6. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_006842198 – 236Missing in isoform 3 and isoform 8. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_006844237 – 275Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_041280237 – 263ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_041281264 – 509Missing in isoform 14. 1 PublicationAdd BLAST246

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF129512 mRNA Translation: AAF13493.1
AJ292565 mRNA Translation: CAC80427.1
AJ292566 mRNA Translation: CAC80428.1
AJ292567 mRNA Translation: CAC80429.1
AJ292568 mRNA Translation: CAC80430.1
AJ292569 mRNA Translation: CAC80431.1
AY377973 mRNA Translation: AAR84584.1
AY377975 mRNA Translation: AAR84586.1
AY377976 mRNA Translation: AAR84587.1
AY377977 mRNA Translation: AAR84588.1
AY377978 mRNA Translation: AAR84589.1
AY377979 mRNA Translation: AAR84590.1
AY377980 mRNA Translation: AAR84591.1
AY377981 mRNA Translation: AAR84592.1
AY377982 mRNA Translation: AAR84593.1
AK301250 mRNA Translation: BAG62817.1
AK303495 mRNA Translation: BAG64529.1
AC079199 Genomic DNA No translation available.
AC090844 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60606.1
BC032707 mRNA Translation: AAH32707.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11346.1 [Q9UKT9-1]
CCDS11347.1 [Q9UKT9-2]
CCDS11348.1 [Q9UKT9-3]
CCDS11349.1 [Q9UKT9-4]
CCDS11350.1 [Q9UKT9-5]
CCDS11351.1 [Q9UKT9-6]
CCDS58539.1 [Q9UKT9-8]
CCDS58540.1 [Q9UKT9-7]
CCDS58541.1 [Q9UKT9-12]
CCDS58542.1 [Q9UKT9-11]
CCDS58543.1 [Q9UKT9-10]
CCDS58544.1 [Q9UKT9-9]
CCDS58545.1 [Q9UKT9-13]
CCDS74055.1 [Q9UKT9-16]

NCBI Reference Sequences

More...
RefSeqi
NP_001244337.1, NM_001257408.1 [Q9UKT9-7]
NP_001244338.1, NM_001257409.1 [Q9UKT9-8]
NP_001244339.1, NM_001257410.1 [Q9UKT9-9]
NP_001244340.1, NM_001257411.1 [Q9UKT9-10]
NP_001244341.1, NM_001257412.1 [Q9UKT9-11]
NP_001244342.1, NM_001257413.1 [Q9UKT9-12]
NP_001244343.1, NM_001257414.1 [Q9UKT9-13]
NP_001271443.1, NM_001284514.1 [Q9UKT9-16]
NP_001271444.1, NM_001284515.1 [Q9UKT9-16]
NP_001271445.1, NM_001284516.1 [Q9UKT9-16]
NP_036613.2, NM_012481.4 [Q9UKT9-1]
NP_899051.1, NM_183228.2 [Q9UKT9-2]
NP_899052.1, NM_183229.2 [Q9UKT9-3]
NP_899053.1, NM_183230.2 [Q9UKT9-4]
NP_899054.1, NM_183231.2 [Q9UKT9-5]
NP_899055.1, NM_183232.2 [Q9UKT9-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293068; ENSP00000462791; ENSG00000161405 [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405 [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405 [Q9UKT9-1]
ENST00000350532; ENSP00000344471; ENSG00000161405 [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405 [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405 [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405 [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405 [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405 [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405 [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405 [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405 [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405 [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405 [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405 [Q9UKT9-16]
ENST00000623724; ENSP00000485515; ENSG00000161405 [Q9UKT9-16]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22806

UCSC genome browser

More...
UCSCi
uc002hsu.4, human [Q9UKT9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129512 mRNA Translation: AAF13493.1
AJ292565 mRNA Translation: CAC80427.1
AJ292566 mRNA Translation: CAC80428.1
AJ292567 mRNA Translation: CAC80429.1
AJ292568 mRNA Translation: CAC80430.1
AJ292569 mRNA Translation: CAC80431.1
AY377973 mRNA Translation: AAR84584.1
AY377975 mRNA Translation: AAR84586.1
AY377976 mRNA Translation: AAR84587.1
AY377977 mRNA Translation: AAR84588.1
AY377978 mRNA Translation: AAR84589.1
AY377979 mRNA Translation: AAR84590.1
AY377980 mRNA Translation: AAR84591.1
AY377981 mRNA Translation: AAR84592.1
AY377982 mRNA Translation: AAR84593.1
AK301250 mRNA Translation: BAG62817.1
AK303495 mRNA Translation: BAG64529.1
AC079199 Genomic DNA No translation available.
AC090844 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60606.1
BC032707 mRNA Translation: AAH32707.1
CCDSiCCDS11346.1 [Q9UKT9-1]
CCDS11347.1 [Q9UKT9-2]
CCDS11348.1 [Q9UKT9-3]
CCDS11349.1 [Q9UKT9-4]
CCDS11350.1 [Q9UKT9-5]
CCDS11351.1 [Q9UKT9-6]
CCDS58539.1 [Q9UKT9-8]
CCDS58540.1 [Q9UKT9-7]
CCDS58541.1 [Q9UKT9-12]
CCDS58542.1 [Q9UKT9-11]
CCDS58543.1 [Q9UKT9-10]
CCDS58544.1 [Q9UKT9-9]
CCDS58545.1 [Q9UKT9-13]
CCDS74055.1 [Q9UKT9-16]
RefSeqiNP_001244337.1, NM_001257408.1 [Q9UKT9-7]
NP_001244338.1, NM_001257409.1 [Q9UKT9-8]
NP_001244339.1, NM_001257410.1 [Q9UKT9-9]
NP_001244340.1, NM_001257411.1 [Q9UKT9-10]
NP_001244341.1, NM_001257412.1 [Q9UKT9-11]
NP_001244342.1, NM_001257413.1 [Q9UKT9-12]
NP_001244343.1, NM_001257414.1 [Q9UKT9-13]
NP_001271443.1, NM_001284514.1 [Q9UKT9-16]
NP_001271444.1, NM_001284515.1 [Q9UKT9-16]
NP_001271445.1, NM_001284516.1 [Q9UKT9-16]
NP_036613.2, NM_012481.4 [Q9UKT9-1]
NP_899051.1, NM_183228.2 [Q9UKT9-2]
NP_899052.1, NM_183229.2 [Q9UKT9-3]
NP_899053.1, NM_183230.2 [Q9UKT9-4]
NP_899054.1, NM_183231.2 [Q9UKT9-5]
NP_899055.1, NM_183232.2 [Q9UKT9-6]

3D structure databases

SMRiQ9UKT9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116484, 199 interactors
DIPiDIP-56975N
IntActiQ9UKT9, 173 interactors
MINTiQ9UKT9
STRINGi9606.ENSP00000344544

PTM databases

iPTMnetiQ9UKT9
PhosphoSitePlusiQ9UKT9

Polymorphism and mutation databases

BioMutaiIKZF3
DMDMi212276437

Proteomic databases

EPDiQ9UKT9
jPOSTiQ9UKT9
MassIVEiQ9UKT9
PaxDbiQ9UKT9
PeptideAtlasiQ9UKT9
PRIDEiQ9UKT9
ProteomicsDBi84855 [Q9UKT9-1]
84856 [Q9UKT9-10]
84857 [Q9UKT9-11]
84858 [Q9UKT9-12]
84859 [Q9UKT9-13]
84860 [Q9UKT9-14]
84861 [Q9UKT9-15]
84862 [Q9UKT9-2]
84863 [Q9UKT9-3]
84864 [Q9UKT9-4]
84865 [Q9UKT9-5]
84866 [Q9UKT9-6]
84867 [Q9UKT9-7]
84868 [Q9UKT9-8]
84869 [Q9UKT9-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4475, 460 antibodies

The DNASU plasmid repository

More...
DNASUi
22806

Genome annotation databases

EnsembliENST00000293068; ENSP00000462791; ENSG00000161405 [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405 [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405 [Q9UKT9-1]
ENST00000350532; ENSP00000344471; ENSG00000161405 [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405 [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405 [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405 [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405 [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405 [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405 [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405 [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405 [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405 [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405 [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405 [Q9UKT9-16]
ENST00000623724; ENSP00000485515; ENSG00000161405 [Q9UKT9-16]
GeneIDi22806
KEGGihsa:22806
UCSCiuc002hsu.4, human [Q9UKT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22806
DisGeNETi22806
EuPathDBiHostDB:ENSG00000161405.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IKZF3
HGNCiHGNC:13178, IKZF3
HPAiENSG00000161405, Tissue enhanced (blood, lymphoid tissue)
MalaCardsiIKZF3
MIMi606221, gene
neXtProtiNX_Q9UKT9
OpenTargetsiENSG00000161405
Orphaneti67038, B-cell chronic lymphocytic leukemia
PharmGKBiPA37750

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000160462
HOGENOMiCLU_025502_4_1_1
InParanoidiQ9UKT9
KOiK09220
OMAiPRPYDII
OrthoDBi385551at2759
PhylomeDBiQ9UKT9
TreeFamiTF331189

Enzyme and pathway databases

PathwayCommonsiQ9UKT9
SIGNORiQ9UKT9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22806, 9 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IKZF3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IKZF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22806
PharosiQ9UKT9, Tbio

Protein Ontology

More...
PROi
PR:Q9UKT9
RNActiQ9UKT9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161405, Expressed in tonsil and 122 other tissues
ExpressionAtlasiQ9UKT9, baseline and differential
GenevisibleiQ9UKT9, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKZF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKT9
Secondary accession number(s): B4DVV5
, Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 4, 2008
Last modified: October 7, 2020
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again