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Protein

Zinc finger protein Aiolos

Gene

IKZF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 504C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processB-cell activation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UKT9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein Aiolos
Alternative name(s):
Ikaros family zinc finger protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IKZF3
Synonyms:ZNFN1A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000161405.16

Human Gene Nomenclature Database

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HGNCi
HGNC:13178 IKZF3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606221 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKT9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
22806

MalaCards human disease database

More...
MalaCardsi
IKZF3

Open Targets

More...
OpenTargetsi
ENSG00000161405

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
67038 B-cell chronic lymphocytic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37750

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
IKZF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470901 – 509Zinc finger protein AiolosAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei326PhosphothreonineCombined sources1
Modified residuei378PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UKT9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UKT9

PeptideAtlas

More...
PeptideAtlasi
Q9UKT9

PRoteomics IDEntifications database

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PRIDEi
Q9UKT9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84855
84856 [Q9UKT9-10]
84857 [Q9UKT9-11]
84858 [Q9UKT9-12]
84859 [Q9UKT9-13]
84860 [Q9UKT9-14]
84861 [Q9UKT9-15]
84862 [Q9UKT9-2]
84863 [Q9UKT9-3]
84864 [Q9UKT9-4]
84865 [Q9UKT9-5]
84866 [Q9UKT9-6]
84867 [Q9UKT9-7]
84868 [Q9UKT9-8]
84869 [Q9UKT9-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UKT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000161405 Expressed in 102 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

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CleanExi
HS_IKZF3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UKT9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UKT9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017105
HPA024377

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-747204,EBI-747204
ABLIM3O949293EBI-747204,EBI-351267
AESQ081173EBI-747204,EBI-717810
AESQ08117-24EBI-747204,EBI-11741437
AKAP10A0A0S2Z4Y83EBI-747204,EBI-16428921
AKAP9Q99996-23EBI-747204,EBI-9641546
AQP1P299725EBI-747204,EBI-745213
ARMC7Q9H6L47EBI-747204,EBI-742909
ATPAF2Q8N5M19EBI-747204,EBI-1166928
BCAS2O759343EBI-747204,EBI-1050106
C1orf109Q9NX045EBI-747204,EBI-8643161
CABP5Q9NP864EBI-747204,EBI-10311131
CDK4P118024EBI-747204,EBI-295644
CDKN1AP389363EBI-747204,EBI-375077
CDKN2DP552734EBI-747204,EBI-745859
CHCHD2Q9Y6H13EBI-747204,EBI-2321769
CRYBA4P536733EBI-747204,EBI-7519711
EFHC1Q5JVL410EBI-747204,EBI-743105
EMC2Q150063EBI-747204,EBI-359031
EXOC8Q8IYI65EBI-747204,EBI-742102
EXOSC5Q9NQT45EBI-747204,EBI-371876
FANCLQ9NW383EBI-747204,EBI-2339898
FARS2O953635EBI-747204,EBI-2513774
FBF1Q8TES7-63EBI-747204,EBI-10244131
FHL3Q136434EBI-747204,EBI-741101
FOXP3Q9BZS12EBI-747204,EBI-983719
GEMP550405EBI-747204,EBI-744104
GRB2P629937EBI-747204,EBI-401755
HNRNPFP525973EBI-747204,EBI-352986
ING5Q8WYH83EBI-747204,EBI-488533
KAT5Q929935EBI-747204,EBI-399080
KRT19P087273EBI-747204,EBI-742756
LGALS14Q8TCE95EBI-747204,EBI-10274069
LMO1P258003EBI-747204,EBI-8639312
LMO2P257913EBI-747204,EBI-739696
MAGOHBQ96A726EBI-747204,EBI-746778
MORN3Q6PF183EBI-747204,EBI-9675802
MRPL28Q130843EBI-747204,EBI-723426
MRPL53Q96EL33EBI-747204,EBI-2513715
NATD1Q8N6N63EBI-747204,EBI-8656665
NEK6Q9HC983EBI-747204,EBI-740364
OAZ3Q9UMX23EBI-747204,EBI-10281601
OSGIN1Q9UJX03EBI-747204,EBI-9057006
PCID2Q5JVF33EBI-747204,EBI-1051701
PFDN5Q994715EBI-747204,EBI-357275
PIK3R2O004593EBI-747204,EBI-346930
PIN1Q135265EBI-747204,EBI-714158
POLMQ6PIY23EBI-747204,EBI-10253863
POLR1CO151607EBI-747204,EBI-1055079
PPP1R16BQ96T495EBI-747204,EBI-10293968
PRKAA1Q131313EBI-747204,EBI-1181405
PRKAB2O437418EBI-747204,EBI-1053424
PSMA1P257863EBI-747204,EBI-359352
RAD51DO757718EBI-747204,EBI-1055693
RCOR3Q9P2K34EBI-747204,EBI-743428
RHOAP615863EBI-747204,EBI-446668
RNF6A0A0S2Z4G93EBI-747204,EBI-16428950
SPG21Q9NZD85EBI-747204,EBI-742688
STAMBPL1Q96FJ03EBI-747204,EBI-745021
STK16O757163EBI-747204,EBI-749295
STX11O755583EBI-747204,EBI-714135
TBC1D22BQ9NU195EBI-747204,EBI-8787464
TCAF1Q9Y4C24EBI-747204,EBI-750484
TEKT4Q8WW246EBI-747204,EBI-750487
TRAPPC6AO758653EBI-747204,EBI-743573
TRIM42Q8IWZ53EBI-747204,EBI-5235829
TSSK3Q96PN85EBI-747204,EBI-3918381
TSTD2Q5T7W76EBI-747204,EBI-8994397
ZGPATA0A0S2Z6H03EBI-747204,EBI-16428984
ZGPATQ8N5A53EBI-747204,EBI-3439227
ZGPATQ8N5A5-23EBI-747204,EBI-10183064

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116484, 107 interactors

Database of interacting proteins

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DIPi
DIP-56975N

Protein interaction database and analysis system

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IntActi
Q9UKT9, 156 interactors

Molecular INTeraction database

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MINTi
Q9UKT9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000344544

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UKT9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UKT9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 504C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160462

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049114

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004752

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UKT9

KEGG Orthology (KO)

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KOi
K09220

Identification of Orthologs from Complete Genome Data

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OMAi
PSYMYEK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05E2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKT9

TreeFam database of animal gene trees

More...
TreeFami
TF331189

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 16 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKT9-1) [UniParc]FASTAAdd to basket
Also known as: Aio-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED
60 70 80 90 100
EDIGDDSMKV KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK
110 120 130 140 150
LERHVVSFDS SRPTSGKMNC DVCGLSCISF NVLMVHKRSH TGERPFQCNQ
160 170 180 190 200
CGASFTQKGN LLRHIKLHTG EKPFKCHLCN YACQRRDALT GHLRTHSVEK
210 220 230 240 250
PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE ARHIKAEMGS
260 270 280 290 300
ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ
310 320 330 340 350
TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE
360 370 380 390 400
MSNGAPQELE KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI
410 420 430 440 450
YQQNHMVLSR ARNGMPLLKE VPRSYELLKP PPICPRDSVK VINKEGEVMD
460 470 480 490 500
VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF ECNMCGYRSH DRYEFSSHIA

RGEHRALLK
Length:509
Mass (Da):58,023
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1BB4A0A9A71B81A
GO
Isoform 2 (identifier: Q9UKT9-2) [UniParc]FASTAAdd to basket
Also known as: Aio-del4

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.

Show »
Length:453
Mass (Da):51,632
Checksum:i85DEFC62034A738F
GO
Isoform 3 (identifier: Q9UKT9-3) [UniParc]FASTAAdd to basket
Also known as: Aio-del5

The sequence of this isoform differs from the canonical sequence as follows:
     198-236: Missing.

Show »
Length:470
Mass (Da):53,401
Checksum:i18998C960E99C78A
GO
Isoform 4 (identifier: Q9UKT9-4) [UniParc]FASTAAdd to basket
Also known as: Aio-del6

The sequence of this isoform differs from the canonical sequence as follows:
     237-275: Missing.

Show »
Length:470
Mass (Da):53,743
Checksum:i979F785A6B93BC6E
GO
Isoform 5 (identifier: Q9UKT9-5) [UniParc]FASTAAdd to basket
Also known as: Aio-del4,5

The sequence of this isoform differs from the canonical sequence as follows:
     142-236: Missing.

Show »
Length:414
Mass (Da):47,010
Checksum:iDD4C8159B8417844
GO
Isoform 6 (identifier: Q9UKT9-6) [UniParc]FASTAAdd to basket
Also known as: Aio-del5,6

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Show »
Length:431
Mass (Da):49,121
Checksum:i540F806622DCBB56
GO
Isoform 7 (identifier: Q9UKT9-7) [UniParc]FASTAAdd to basket
Also known as: Aio-del2

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.

Show »
Length:475
Mass (Da):54,417
Checksum:i00694E8BA86FFEC5
GO
Isoform 8 (identifier: Q9UKT9-8) [UniParc]FASTAAdd to basket
Also known as: Aio-del2,5

The sequence of this isoform differs from the canonical sequence as follows:
     21-54: Missing.
     198-236: Missing.

Show »
Length:436
Mass (Da):49,795
Checksum:i965862E0B68846E0
GO
Isoform 9 (identifier: Q9UKT9-9) [UniParc]FASTAAdd to basket
Also known as: Aio-del3

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.

Show »
Length:422
Mass (Da):47,958
Checksum:i42308DF0B90BA4DF
GO
Isoform 10 (identifier: Q9UKT9-10) [UniParc]FASTAAdd to basket
Also known as: Aio-del3,4

The sequence of this isoform differs from the canonical sequence as follows:
     55-197: Missing.

Show »
Length:366
Mass (Da):41,567
Checksum:iA4E825FDBF860925
GO
Isoform 11 (identifier: Q9UKT9-11) [UniParc]FASTAAdd to basket
Also known as: Aio-del3,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     55-236: Missing.

Show »
Length:327
Mass (Da):36,945
Checksum:iD90D2FFBA757F7B9
GO
Isoform 12 (identifier: Q9UKT9-12) [UniParc]FASTAAdd to basket
Also known as: Aio-del3,4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     55-275: Missing.

Show »
Length:288
Mass (Da):32,665
Checksum:iECA1D13AA6312CAB
GO
Isoform 13 (identifier: Q9UKT9-13) [UniParc]FASTAAdd to basket
Also known as: Aio-del4,5,6

The sequence of this isoform differs from the canonical sequence as follows:
     142-275: Missing.

Show »
Length:375
Mass (Da):42,730
Checksum:i7AE6138A9450AAF5
GO
Isoform 14 (identifier: Q9UKT9-14) [UniParc]FASTAAdd to basket
Also known as: Aio-1-5a

The sequence of this isoform differs from the canonical sequence as follows:
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH
     264-509: Missing.

Show »
Length:263
Mass (Da):30,029
Checksum:iF12F178DB5F635A3
GO
Isoform 15 (identifier: Q9UKT9-15) [UniParc]FASTAAdd to basket
Also known as: Aio-del4-5a

The sequence of this isoform differs from the canonical sequence as follows:
     142-197: Missing.
     237-263: ASAEARHIKAEMGSERALVLDRLASNV → GTGWGWVELSHLGIRLQDLNVPWCRLH

Show »
Length:453
Mass (Da):51,880
Checksum:i8C2E108E02143972
GO
Isoform 16 (identifier: Q9UKT9-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,973
Checksum:i74F8C25D67B30D67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGN9A0A0C4DGN9_HUMAN
Zinc finger protein Aiolos
IKZF3
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti321R → C in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti321R → C in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti321R → C in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti361K → R in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti361K → R in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti361K → R in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti365H → L in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti365H → L in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti365H → L in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti443N → D in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti443N → D in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti443N → D in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti487Y → D in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti487Y → D in CAC80431 (PubMed:11745366).Curated1
Sequence conflicti506A → S in AAF13493 (PubMed:10552935).Curated1
Sequence conflicti506A → S in CAC80427 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80428 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80429 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80430 (PubMed:11745366).Curated1
Sequence conflicti506A → S in CAC80431 (PubMed:11745366).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064724277E → Q Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553531 – 247Missing in isoform 16. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_04127421 – 54Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_04127555 – 275Missing in isoform 12. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_04127655 – 236Missing in isoform 11. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_04127755 – 197Missing in isoform 10. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_04127855 – 141Missing in isoform 9. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_041279142 – 275Missing in isoform 13. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_006841142 – 236Missing in isoform 5. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_006840142 – 197Missing in isoform 2 and isoform 15. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_006843198 – 275Missing in isoform 6. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_006842198 – 236Missing in isoform 3 and isoform 8. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_006844237 – 275Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_041280237 – 263ASAEA…LASNV → GTGWGWVELSHLGIRLQDLN VPWCRLH in isoform 14 and isoform 15. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_041281264 – 509Missing in isoform 14. 1 PublicationAdd BLAST246

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF129512 mRNA Translation: AAF13493.1
AJ292565 mRNA Translation: CAC80427.1
AJ292566 mRNA Translation: CAC80428.1
AJ292567 mRNA Translation: CAC80429.1
AJ292568 mRNA Translation: CAC80430.1
AJ292569 mRNA Translation: CAC80431.1
AY377973 mRNA Translation: AAR84584.1
AY377975 mRNA Translation: AAR84586.1
AY377976 mRNA Translation: AAR84587.1
AY377977 mRNA Translation: AAR84588.1
AY377978 mRNA Translation: AAR84589.1
AY377979 mRNA Translation: AAR84590.1
AY377980 mRNA Translation: AAR84591.1
AY377981 mRNA Translation: AAR84592.1
AY377982 mRNA Translation: AAR84593.1
AK301250 mRNA Translation: BAG62817.1
AK303495 mRNA Translation: BAG64529.1
AC079199 Genomic DNA No translation available.
AC090844 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60606.1
BC032707 mRNA Translation: AAH32707.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11346.1 [Q9UKT9-1]
CCDS11347.1 [Q9UKT9-2]
CCDS11348.1 [Q9UKT9-3]
CCDS11349.1 [Q9UKT9-4]
CCDS11350.1 [Q9UKT9-5]
CCDS11351.1 [Q9UKT9-6]
CCDS58539.1 [Q9UKT9-8]
CCDS58540.1 [Q9UKT9-7]
CCDS58541.1 [Q9UKT9-12]
CCDS58542.1 [Q9UKT9-11]
CCDS58543.1 [Q9UKT9-10]
CCDS58544.1 [Q9UKT9-9]
CCDS58545.1 [Q9UKT9-13]
CCDS74055.1 [Q9UKT9-16]

NCBI Reference Sequences

More...
RefSeqi
NP_001244337.1, NM_001257408.1 [Q9UKT9-7]
NP_001244338.1, NM_001257409.1 [Q9UKT9-8]
NP_001244339.1, NM_001257410.1 [Q9UKT9-9]
NP_001244340.1, NM_001257411.1 [Q9UKT9-10]
NP_001244341.1, NM_001257412.1 [Q9UKT9-11]
NP_001244342.1, NM_001257413.1 [Q9UKT9-12]
NP_001244343.1, NM_001257414.1 [Q9UKT9-13]
NP_001271443.1, NM_001284514.1 [Q9UKT9-16]
NP_001271444.1, NM_001284515.1 [Q9UKT9-16]
NP_001271445.1, NM_001284516.1 [Q9UKT9-16]
NP_036613.2, NM_012481.4 [Q9UKT9-1]
NP_899051.1, NM_183228.2 [Q9UKT9-2]
NP_899052.1, NM_183229.2 [Q9UKT9-3]
NP_899053.1, NM_183230.2 [Q9UKT9-4]
NP_899054.1, NM_183231.2 [Q9UKT9-5]
NP_899055.1, NM_183232.2 [Q9UKT9-6]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.371680

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293068; ENSP00000462791; ENSG00000161405 [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405 [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405 [Q9UKT9-1]
ENST00000350532; ENSP00000344471; ENSG00000161405 [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405 [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405 [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405 [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405 [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405 [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405 [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405 [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405 [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405 [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405 [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405 [Q9UKT9-16]
ENST00000623724; ENSP00000485515; ENSG00000161405 [Q9UKT9-16]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22806

UCSC genome browser

More...
UCSCi
uc002hsu.4 human [Q9UKT9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129512 mRNA Translation: AAF13493.1
AJ292565 mRNA Translation: CAC80427.1
AJ292566 mRNA Translation: CAC80428.1
AJ292567 mRNA Translation: CAC80429.1
AJ292568 mRNA Translation: CAC80430.1
AJ292569 mRNA Translation: CAC80431.1
AY377973 mRNA Translation: AAR84584.1
AY377975 mRNA Translation: AAR84586.1
AY377976 mRNA Translation: AAR84587.1
AY377977 mRNA Translation: AAR84588.1
AY377978 mRNA Translation: AAR84589.1
AY377979 mRNA Translation: AAR84590.1
AY377980 mRNA Translation: AAR84591.1
AY377981 mRNA Translation: AAR84592.1
AY377982 mRNA Translation: AAR84593.1
AK301250 mRNA Translation: BAG62817.1
AK303495 mRNA Translation: BAG64529.1
AC079199 Genomic DNA No translation available.
AC090844 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60606.1
BC032707 mRNA Translation: AAH32707.1
CCDSiCCDS11346.1 [Q9UKT9-1]
CCDS11347.1 [Q9UKT9-2]
CCDS11348.1 [Q9UKT9-3]
CCDS11349.1 [Q9UKT9-4]
CCDS11350.1 [Q9UKT9-5]
CCDS11351.1 [Q9UKT9-6]
CCDS58539.1 [Q9UKT9-8]
CCDS58540.1 [Q9UKT9-7]
CCDS58541.1 [Q9UKT9-12]
CCDS58542.1 [Q9UKT9-11]
CCDS58543.1 [Q9UKT9-10]
CCDS58544.1 [Q9UKT9-9]
CCDS58545.1 [Q9UKT9-13]
CCDS74055.1 [Q9UKT9-16]
RefSeqiNP_001244337.1, NM_001257408.1 [Q9UKT9-7]
NP_001244338.1, NM_001257409.1 [Q9UKT9-8]
NP_001244339.1, NM_001257410.1 [Q9UKT9-9]
NP_001244340.1, NM_001257411.1 [Q9UKT9-10]
NP_001244341.1, NM_001257412.1 [Q9UKT9-11]
NP_001244342.1, NM_001257413.1 [Q9UKT9-12]
NP_001244343.1, NM_001257414.1 [Q9UKT9-13]
NP_001271443.1, NM_001284514.1 [Q9UKT9-16]
NP_001271444.1, NM_001284515.1 [Q9UKT9-16]
NP_001271445.1, NM_001284516.1 [Q9UKT9-16]
NP_036613.2, NM_012481.4 [Q9UKT9-1]
NP_899051.1, NM_183228.2 [Q9UKT9-2]
NP_899052.1, NM_183229.2 [Q9UKT9-3]
NP_899053.1, NM_183230.2 [Q9UKT9-4]
NP_899054.1, NM_183231.2 [Q9UKT9-5]
NP_899055.1, NM_183232.2 [Q9UKT9-6]
UniGeneiHs.371680

3D structure databases

ProteinModelPortaliQ9UKT9
SMRiQ9UKT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116484, 107 interactors
DIPiDIP-56975N
IntActiQ9UKT9, 156 interactors
MINTiQ9UKT9
STRINGi9606.ENSP00000344544

PTM databases

iPTMnetiQ9UKT9
PhosphoSitePlusiQ9UKT9

Polymorphism and mutation databases

BioMutaiIKZF3
DMDMi212276437

Proteomic databases

EPDiQ9UKT9
PaxDbiQ9UKT9
PeptideAtlasiQ9UKT9
PRIDEiQ9UKT9
ProteomicsDBi84855
84856 [Q9UKT9-10]
84857 [Q9UKT9-11]
84858 [Q9UKT9-12]
84859 [Q9UKT9-13]
84860 [Q9UKT9-14]
84861 [Q9UKT9-15]
84862 [Q9UKT9-2]
84863 [Q9UKT9-3]
84864 [Q9UKT9-4]
84865 [Q9UKT9-5]
84866 [Q9UKT9-6]
84867 [Q9UKT9-7]
84868 [Q9UKT9-8]
84869 [Q9UKT9-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22806
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293068; ENSP00000462791; ENSG00000161405 [Q9UKT9-14]
ENST00000346243; ENSP00000341977; ENSG00000161405 [Q9UKT9-6]
ENST00000346872; ENSP00000344544; ENSG00000161405 [Q9UKT9-1]
ENST00000350532; ENSP00000344471; ENSG00000161405 [Q9UKT9-4]
ENST00000351680; ENSP00000345622; ENSG00000161405 [Q9UKT9-3]
ENST00000377944; ENSP00000367179; ENSG00000161405 [Q9UKT9-10]
ENST00000377945; ENSP00000367180; ENSG00000161405 [Q9UKT9-13]
ENST00000377952; ENSP00000367188; ENSG00000161405 [Q9UKT9-12]
ENST00000377958; ENSP00000367194; ENSG00000161405 [Q9UKT9-9]
ENST00000394189; ENSP00000377741; ENSG00000161405 [Q9UKT9-11]
ENST00000439016; ENSP00000403027; ENSG00000161405 [Q9UKT9-5]
ENST00000439167; ENSP00000403776; ENSG00000161405 [Q9UKT9-8]
ENST00000467757; ENSP00000420463; ENSG00000161405 [Q9UKT9-2]
ENST00000535189; ENSP00000438972; ENSG00000161405 [Q9UKT9-7]
ENST00000583368; ENSP00000462452; ENSG00000161405 [Q9UKT9-16]
ENST00000623724; ENSP00000485515; ENSG00000161405 [Q9UKT9-16]
GeneIDi22806
KEGGihsa:22806
UCSCiuc002hsu.4 human [Q9UKT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22806
DisGeNETi22806
EuPathDBiHostDB:ENSG00000161405.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IKZF3
HGNCiHGNC:13178 IKZF3
HPAiCAB017105
HPA024377
MalaCardsiIKZF3
MIMi606221 gene
neXtProtiNX_Q9UKT9
OpenTargetsiENSG00000161405
Orphaneti67038 B-cell chronic lymphocytic leukemia
PharmGKBiPA37750

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000160462
HOGENOMiHOG000049114
HOVERGENiHBG004752
InParanoidiQ9UKT9
KOiK09220
OMAiPSYMYEK
OrthoDBiEOG091G05E2
PhylomeDBiQ9UKT9
TreeFamiTF331189

Enzyme and pathway databases

SIGNORiQ9UKT9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IKZF3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IKZF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22806

Protein Ontology

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PROi
PR:Q9UKT9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000161405 Expressed in 102 organ(s), highest expression level in leukocyte
CleanExiHS_IKZF3
ExpressionAtlasiQ9UKT9 baseline and differential
GenevisibleiQ9UKT9 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKZF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKT9
Secondary accession number(s): B4DVV5
, Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1, Q69BM2, Q69BM3, Q69BM5, Q8N574, Q8WWQ9, Q8WWR0, Q8WWR1, Q8WWR2, Q8WWR3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 4, 2008
Last modified: December 5, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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