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Protein

F-box/LRR-repeat protein 3

Gene

FBXL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).3 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiological rhythms, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-400253 Circadian Clock
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 3
Alternative name(s):
F-box and leucine-rich repeat protein 3A
F-box/LRR-repeat protein 3A
Gene namesi
Name:FBXL3
Synonyms:FBL3A, FBXL3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000005812.10
HGNCiHGNC:13599 FBXL3
MIMi605653 gene
neXtProtiNX_Q9UKT7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi358C → A: Loss of binding with CRY1. 1 Publication1
Mutagenesisi358C → S: Decrease in binding efficiency with CRY2 and of CRY2 ubiquitination efficiency, loss of binding with CRY1. 1 Publication1

Organism-specific databases

DisGeNETi26224
OpenTargetsiENSG00000005812
PharmGKBiPA28022

Polymorphism and mutation databases

BioMutaiFBXL3
DMDMi37537866

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198421 – 428F-box/LRR-repeat protein 3Add BLAST428

Proteomic databases

EPDiQ9UKT7
MaxQBiQ9UKT7
PaxDbiQ9UKT7
PeptideAtlasiQ9UKT7
PRIDEiQ9UKT7
ProteomicsDBi84852

PTM databases

iPTMnetiQ9UKT7
PhosphoSitePlusiQ9UKT7

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000005812 Expressed in 207 organ(s), highest expression level in bone marrow
CleanExiHS_FBXL3
ExpressionAtlasiQ9UKT7 baseline and differential
GenevisibleiQ9UKT7 HS

Organism-specific databases

HPAiHPA053283
HPA065626

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1, RBX1 and FBXL3. Interacts with CRY1 and CRY2 (phosphorylated).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Cry2Q9R19412EBI-2557269,EBI-1266619From Mus musculus.

Protein-protein interaction databases

BioGridi117615, 16 interactors
CORUMiQ9UKT7
DIPiDIP-40770N
IntActiQ9UKT7, 9 interactors
MINTiQ9UKT7
STRINGi9606.ENSP00000347834

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UKT7
SMRiQ9UKT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 81F-boxAdd BLAST48
Repeati119 – 146LRR 1Add BLAST28
Repeati181 – 207LRR 2Add BLAST27
Repeati208 – 233LRR 3Add BLAST26
Repeati234 – 259LRR 4Add BLAST26
Repeati316 – 341LRR 5Add BLAST26
Repeati343 – 368LRR 6Add BLAST26
Repeati369 – 394LRR 7Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1T Eukaryota
ENOG410XT8H LUCA
GeneTreeiENSGT00390000007432
HOGENOMiHOG000060185
HOVERGENiHBG051587
InParanoidiQ9UKT7
KOiK10269
OMAiCKYLSAV
OrthoDBiEOG091G0R67
PhylomeDBiQ9UKT7
TreeFamiTF352583

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UKT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRGGRDSDR NSSEEGTAEK SKKLRTTNEH SQTCDWGNLL QDIILQVFKY
60 70 80 90 100
LPLLDRAHAS QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK
110 120 130 140 150
QIIKRHSNHL QYVSFKVDSS KESAEAACDI LSQLVNCSLK TLGLISTARP
160 170 180 190 200
SFMDLPKSHF ISALTVVFVN SKSLSSLKID DTPVDDPSLK VLVANNSDTL
210 220 230 240 250
KLLKMSSCPH VSPAGILCVA DQCHGLRELA LNYHLLSDEL LLALSSEKHV
260 270 280 290 300
RLEHLRIDVV SENPGQTHFH TIQKSSWDAF IRHSPKVNLV MYFFLYEEEF
310 320 330 340 350
DPFFRYEIPA THLYFGRSVS KDVLGRVGMT CPRLVELVVC ANGLRPLDEE
360 370 380 390 400
LIRIAERCKN LSAIGLGECE VSCSAFVEFV KMCGGRLSQL SIMEEVLIPD
410 420
QKYSLEQIHW EVSKHLGRVW FPDMMPTW
Length:428
Mass (Da):48,707
Last modified:May 1, 2000 - v1
Checksum:iAAEAB31BAF0EA5A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0Y7C9J0Y7_HUMAN
F-box/LRR-repeat protein 3
FBXL3
241Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → H in AAF37383 (Ref. 2) Curated1
Sequence conflicti13S → A in AAF37383 (Ref. 2) Curated1
Sequence conflicti353R → A in AAF37383 (Ref. 2) Curated1
Sequence conflicti364I → V in BAG37051 (PubMed:14702039).Curated1
Sequence conflicti412V → A in BAG37051 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129532 mRNA Translation: AAF04466.1
AF126028 mRNA Translation: AAF37383.1
AK314442 mRNA Translation: BAG37051.1
BC072448 mRNA Translation: AAH72448.1
CCDSiCCDS9457.1
RefSeqiNP_036290.1, NM_012158.2
XP_005266393.1, XM_005266336.1
UniGeneiHs.508284

Genome annotation databases

EnsembliENST00000355619; ENSP00000347834; ENSG00000005812
GeneIDi26224
KEGGihsa:26224
UCSCiuc001vkd.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129532 mRNA Translation: AAF04466.1
AF126028 mRNA Translation: AAF37383.1
AK314442 mRNA Translation: BAG37051.1
BC072448 mRNA Translation: AAH72448.1
CCDSiCCDS9457.1
RefSeqiNP_036290.1, NM_012158.2
XP_005266393.1, XM_005266336.1
UniGeneiHs.508284

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I6JX-ray2.70B1-428[»]
ProteinModelPortaliQ9UKT7
SMRiQ9UKT7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117615, 16 interactors
CORUMiQ9UKT7
DIPiDIP-40770N
IntActiQ9UKT7, 9 interactors
MINTiQ9UKT7
STRINGi9606.ENSP00000347834

PTM databases

iPTMnetiQ9UKT7
PhosphoSitePlusiQ9UKT7

Polymorphism and mutation databases

BioMutaiFBXL3
DMDMi37537866

Proteomic databases

EPDiQ9UKT7
MaxQBiQ9UKT7
PaxDbiQ9UKT7
PeptideAtlasiQ9UKT7
PRIDEiQ9UKT7
ProteomicsDBi84852

Protocols and materials databases

DNASUi26224
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355619; ENSP00000347834; ENSG00000005812
GeneIDi26224
KEGGihsa:26224
UCSCiuc001vkd.4 human

Organism-specific databases

CTDi26224
DisGeNETi26224
EuPathDBiHostDB:ENSG00000005812.10
GeneCardsiFBXL3
HGNCiHGNC:13599 FBXL3
HPAiHPA053283
HPA065626
MIMi605653 gene
neXtProtiNX_Q9UKT7
OpenTargetsiENSG00000005812
PharmGKBiPA28022
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT1T Eukaryota
ENOG410XT8H LUCA
GeneTreeiENSGT00390000007432
HOGENOMiHOG000060185
HOVERGENiHBG051587
InParanoidiQ9UKT7
KOiK10269
OMAiCKYLSAV
OrthoDBiEOG091G0R67
PhylomeDBiQ9UKT7
TreeFamiTF352583

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-400253 Circadian Clock
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXL3 human
GeneWikiiFBXL3
GenomeRNAii26224
PROiPR:Q9UKT7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005812 Expressed in 207 organ(s), highest expression level in bone marrow
CleanExiHS_FBXL3
ExpressionAtlasiQ9UKT7 baseline and differential
GenevisibleiQ9UKT7 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKT7
Secondary accession number(s): B2RB04, Q9P122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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