UniProtKB - Q9UKT4 (FBX5_HUMAN)
F-box only protein 5
FBXO5
Functioni
Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029).
During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029).
During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408).
Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408).
As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029).
Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940).
During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity).
Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity).
Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565).
By similarity8 Publications: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 378 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 381 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 396 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 401 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 406 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 409 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 414 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 419 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 374 – 422 | ZBR-typePROSITE-ProRule annotationAdd BLAST | 49 |
GO - Molecular functioni
- anaphase-promoting complex binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein kinase binding Source: UniProtKB
- ubiquitin ligase inhibitor activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- microtubule polymerization Source: Ensembl
- negative regulation of cellular senescence Source: UniProtKB
- negative regulation of DNA endoreduplication Source: UniProtKB
- negative regulation of meiotic nuclear division Source: GO_Central
- negative regulation of mitotic metaphase/anaphase transition Source: UniProtKB
- negative regulation of response to DNA damage stimulus Source: UniProtKB
- negative regulation of ubiquitin protein ligase activity Source: UniProtKB
- negative regulation of ubiquitin-protein transferase activity Source: UniProtKB
- oocyte maturation Source: Ensembl
- positive regulation of biomineral tissue development Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
- positive regulation of mesenchymal stem cell migration Source: UniProtKB
- positive regulation of osteoblast differentiation Source: UniProtKB
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of DNA replication Source: UniProtKB
- regulation of mitotic cell cycle Source: UniProtKB
- regulation of mitotic nuclear division Source: GO_Central
- spindle assembly involved in female meiosis I Source: Ensembl
- vesicle organization Source: Ensembl
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UKT4 |
Reactomei | R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176417, Phosphorylation of Emi1 R-HSA-68881, Mitotic Metaphase/Anaphase Transition R-HSA-69205, G1/S-Specific Transcription |
SignaLinki | Q9UKT4 |
SIGNORi | Q9UKT4 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 5CuratedAlternative name(s): Early mitotic inhibitor 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13584, FBXO5 |
MIMi | 606013, gene |
neXtProti | NX_Q9UKT4 |
VEuPathDBi | HostDB:ENSG00000112029 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- spindle 1 Publication
Note: In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984).2 Publications
Cytoskeleton
- meiotic spindle Source: UniProtKB
- spindle Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 143 | E → A: Delays degradation. 1 Publication | 1 | |
Mutagenesisi | 144 | D → A: Does not affect protein stability. 1 Publication | 1 | |
Mutagenesisi | 145 | S → A: Does not affect protein stability; when associated with A-149. 1 Publication | 1 | |
Mutagenesisi | 145 | S → E: Degraded in similar manner to wild-type. 3 Publications | 1 | |
Mutagenesisi | 145 | S → N: Not mitotically degraded. Shows impaired interaction with BTRC and reduced phosphate incorporation; when associated with N-149. 3 Publications | 1 | |
Mutagenesisi | 146 | G → V: Does not affect protein stability. 1 Publication | 1 | |
Mutagenesisi | 148 | S → A: Degraded in similar manner to wild-type. 1 Publication | 1 | |
Mutagenesisi | 149 | S → A: Does not affect protein stability; when associated with A-145. 1 Publication | 1 | |
Mutagenesisi | 149 | S → E: Degraded in similar manner to wild-type. 3 Publications | 1 | |
Mutagenesisi | 149 | S → N: Not mitotically degraded. Shows impaired interaction with BTRC and reduced phosphate incorporation; when associated with N-145. 3 Publications | 1 | |
Mutagenesisi | 182 | S → A: Shows impaired interaction with BTRC. 1 Publication | 1 | |
Mutagenesisi | 210 – 216 | KRNPKVD → AAAAAAA: Loss of interaction with EVI5. 1 Publication | 7 | |
Mutagenesisi | 322 – 325 | RTPL → ATPA: Does not affect inhibition of UBE2S-catalyzed chain elongation. Efficiently inhibits the degradation of PTTG1 at relatively high concentration. Reduces the competitive ability of FBXO5 to inhibit the association of PTTG1 to APC. Can not compete with the APC substrate for APC binding. Decreases inhibition of CCNB1 ubiquitination by UBE2C. 2 Publications | 4 | |
Mutagenesisi | 339 – 345 | Missing : Impairs CCNB1 ubiquitination by UBE2C; when associated with 356-Y--R-358 del. 1 Publication | 7 | |
Mutagenesisi | 345 | L → A: Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C; when associated with 346-S--T-355 del. 1 Publication | 1 | |
Mutagenesisi | 346 – 355 | Missing : Inhibits CCNB1 ubiquitination by UBE2C. Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C; when associated with A-345; A-356 and A-358. 1 Publication | 10 | |
Mutagenesisi | 356 – 358 | Missing : Impairs CCNB1 ubiquitination by UBE2C; when associated with 339-K--L-345 del. 1 Publication | 3 | |
Mutagenesisi | 356 | Y → A: Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C; when associated with 346-S--T-355 del. 1 Publication | 1 | |
Mutagenesisi | 358 | R → A: Substantially impairs inhibition of CCNB1 ubiquitination by UBE2C; when associated with 346-S--T-355 del. 1 Publication | 1 | |
Mutagenesisi | 375 | L → A: Decreases UBE2C-mediated ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 376 | K → A: Decreases UBE2C-mediated ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 393 | R → A: Decreases UBE2C-mediated ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 401 | C → S: Reduced inhibition of APC. Does not affect the FBXO5-mediated inhibitory activity against ubiquitin chain assembly. Does not affect the FBXO5-mediated inhibitory activity against ubiquitin chain assembly; when associated with S-401. Does not affect inhibition of UBE2S-catalyzed chain elongation. Reduces the competitive ability of FBXO5 to inhibit the association of securin to APC. Can still compete with the APC substrate for APC binding. Fails to inhibit ubiquitin chain assembly by UBE2C or mono-ubiquitination by UBE2D1. Largely abolishes the inhibitory activity against protein degradation. Fails to inactivate APC-FZR1 complex. Allows FBXO5 degradation in the absence of CDK4 inhibitor. 3 Publications | 1 | |
Mutagenesisi | 406 | C → S: Does not affect the inhibitory activity against chain assembly; when associated with S-401. 1 Publication | 1 | |
Mutagenesisi | 409 | C → A: Decreases UBE2C-mediated ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 444 – 445 | LR → AA: Loses inhibitory activity on UBE2S-catalyzed chain elongation. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 26271 |
OpenTargetsi | ENSG00000112029 |
PharmGKBi | PA28045 |
Miscellaneous databases
Pharosi | Q9UKT4, Tbio |
Genetic variation databases
BioMutai | FBXO5 |
DMDMi | 24636847 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119881 | 1 – 447 | F-box only protein 5Add BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 94 | PhosphoserineBy similarity | 1 | |
Modified residuei | 102 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UKT4 |
jPOSTi | Q9UKT4 |
MassIVEi | Q9UKT4 |
MaxQBi | Q9UKT4 |
PaxDbi | Q9UKT4 |
PeptideAtlasi | Q9UKT4 |
PRIDEi | Q9UKT4 |
ProteomicsDBi | 84847 [Q9UKT4-1] 84848 [Q9UKT4-2] |
PTM databases
GlyGeni | Q9UKT4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UKT4 |
PhosphoSitePlusi | Q9UKT4 |
Expressioni
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000112029, Expressed in ventricular zone and 184 other tissues |
Genevisiblei | Q9UKT4, HS |
Organism-specific databases
HPAi | ENSG00000112029, Group enriched (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
Interacts with BTRC; mediates proteolysis by the SCF ubiquitin ligase complex leading to activation of APC in late mitosis and subsequent mitotic progression (PubMed:12791267).
Interacts with FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20; prevents APC activation (PubMed:11988738).
Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation (PubMed:16439210).
Interacts simultaneously with anaphase promoting complex (APC), through at least ANAPC2, CDC23, CDC27, the APC substrate GMNN and the APC activator FZR1 (PubMed:23708001, PubMed:26083744).
Interacts with UBE2S; interferes with the activity of UBE2S mainly by disrupting the dynamic electrostatic association between the C-terminal tail of UBE2S and ANAPC2 (PubMed:23708001).
Interacts with RPS6KA2; cooperates to induce the metaphase arrest of early blastomeres; increases and stabilizes interaction of FBXO5 with CDC20 (By similarity).
By similarity5 PublicationsBinary interactionsi
Q9UKT4
With | #Exp. | IntAct |
---|---|---|
CDC27 [P30260] | 2 | EBI-852298,EBI-994813 |
EVI5 [O60447] | 6 | EBI-852298,EBI-852291 |
SKP1 [P63208] | 5 | EBI-852298,EBI-307486 |
Isoform 1 [Q9UKT4-1]
With | #Exp. | IntAct |
---|---|---|
ANAPC2 [Q9UJX6] | 7 | EBI-16059332,EBI-396211 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117655, 54 interactors |
DIPi | DIP-38023N |
ELMi | Q9UKT4 |
IntActi | Q9UKT4, 26 interactors |
MINTi | Q9UKT4 |
STRINGi | 9606.ENSP00000229758 |
Miscellaneous databases
RNActi | Q9UKT4, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9UKT4 |
SMRi | Q9UKT4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 250 – 296 | F-boxAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 244 | Interaction with EVI51 PublicationAdd BLAST | 110 | |
Regioni | 261 – 409 | Requires for efficient binding to CDC20By similarityAdd BLAST | 149 | |
Regioni | 261 – 339 | Sufficient for interaction with RPS6KA2; Prevents association of CDC20 with RPS6KA2By similarityAdd BLAST | 79 | |
Regioni | 305 – 447 | Inhibits APC ubiquitin ligase activity1 PublicationAdd BLAST | 143 | |
Regioni | 322 – 325 | Competitively blocks access of APC substrates to the D-box coreceptor formed by FZR1 and ANAPC101 Publication | 4 | |
Regioni | 337 – 358 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 378 – 420 | Allows a rapid multiple mono-ubiquitination of the APC substrate, but strongly inhibits the slow ubiquitin chain elongation catalyzed by UBCH101 PublicationAdd BLAST | 43 | |
Regioni | 437 – 447 | Sufficient to suppress UBE2S activity; essential for interaction with UBE2S; competitively inhibits the rapide ubiquitin chain elongation by UBE2D1 which blocks UBE2D1 with APC; indispensable for recruitment and position of FBXO5 to the catalytic site of APC; abrogates the inhibition of ubiquitin chain assembly primarily catalyzed by UBE2S; inhibits the ubiquitination by either UBE2C or UBE2D11 PublicationAdd BLAST | 11 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 374 – 422 | ZBR-typePROSITE-ProRule annotationAdd BLAST | 49 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QPWN, Eukaryota |
GeneTreei | ENSGT00530000063692 |
HOGENOMi | CLU_055946_0_0_1 |
InParanoidi | Q9UKT4 |
OMAi | IKFSPHA |
OrthoDBi | 521317at2759 |
PhylomeDBi | Q9UKT4 |
TreeFami | TF101170 |
Family and domain databases
DisProti | DP01450 |
InterProi | View protein in InterPro IPR001810, F-box_dom IPR044064, ZF_ZBR |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
PROSITEi | View protein in PROSITE PS51872, ZF_ZBR, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRRPCSCAL RPPRCSCSAS PSAVTAAGRP RPSDSCKEES STLSVKMKCD
60 70 80 90 100
FNCNHVHSGL KLVKPDDIGR LVSYTPAYLE GSCKDCIKDY ERLSCIGSPI
110 120 130 140 150
VSPRIVQLET ESKRLHNKEN QHVQQTLNST NEIEALETSR LYEDSGYSSF
160 170 180 190 200
SLQSGLSEHE EGSLLEENFG DSLQSCLLQI QSPDQYPNKN LLPVLHFEKV
210 220 230 240 250
VCSTLKKNAK RNPKVDREML KEIIARGNFR LQNIIGRKMG LECVDILSEL
260 270 280 290 300
FRRGLRHVLA TILAQLSDMD LINVSKVSTT WKKILEDDKG AFQLYSKAIQ
310 320 330 340 350
RVTENNNKFS PHASTREYVM FRTPLASVQK SAAQTSLKKD AQTKLSNQGD
360 370 380 390 400
QKGSTYSRHN EFSEVAKTLK KNESLKACIR CNSPAKYDCY LQRATCKREG
410 420 430 440
CGFDYCTKCL CNYHTTKDCS DGKLLKASCK IGPLPGTKKS KKNLRRL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 212 | N → D in BAG51487 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024440 | 107 | Q → E2 PublicationsCorresponds to variant dbSNP:rs2073260Ensembl. | 1 | |
Natural variantiVAR_049038 | 164 | L → F. Corresponds to variant dbSNP:rs7763565Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041362 | 1 – 46 | Missing in isoform 2. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129535 mRNA Translation: AAF04469.1 AY079515 mRNA Translation: AAL86610.1 AK055221 mRNA Translation: BAG51487.1 AL080276 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47719.1 BC018905 mRNA Translation: AAH18905.1 |
CCDSi | CCDS47501.1 [Q9UKT4-2] CCDS5242.1 [Q9UKT4-1] |
RefSeqi | NP_001135994.1, NM_001142522.2 [Q9UKT4-2] NP_036309.1, NM_012177.4 [Q9UKT4-1] |
Genome annotation databases
Ensembli | ENST00000229758; ENSP00000229758; ENSG00000112029 ENST00000367241; ENSP00000356210; ENSG00000112029 [Q9UKT4-2] |
GeneIDi | 26271 |
KEGGi | hsa:26271 |
MANE-Selecti | ENST00000229758.8; ENSP00000229758.3; NM_012177.5; NP_036309.1 |
UCSCi | uc003qpg.4, human [Q9UKT4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129535 mRNA Translation: AAF04469.1 AY079515 mRNA Translation: AAL86610.1 AK055221 mRNA Translation: BAG51487.1 AL080276 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47719.1 BC018905 mRNA Translation: AAH18905.1 |
CCDSi | CCDS47501.1 [Q9UKT4-2] CCDS5242.1 [Q9UKT4-1] |
RefSeqi | NP_001135994.1, NM_001142522.2 [Q9UKT4-2] NP_036309.1, NM_012177.4 [Q9UKT4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2M6N | NMR | - | A | 364-447 | [»] | |
4UI9 | electron microscopy | 3.60 | S | 1-447 | [»] | |
U | 1-27 | [»] | ||||
BMRBi | Q9UKT4 | |||||
SMRi | Q9UKT4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117655, 54 interactors |
DIPi | DIP-38023N |
ELMi | Q9UKT4 |
IntActi | Q9UKT4, 26 interactors |
MINTi | Q9UKT4 |
STRINGi | 9606.ENSP00000229758 |
PTM databases
GlyGeni | Q9UKT4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UKT4 |
PhosphoSitePlusi | Q9UKT4 |
Genetic variation databases
BioMutai | FBXO5 |
DMDMi | 24636847 |
Proteomic databases
EPDi | Q9UKT4 |
jPOSTi | Q9UKT4 |
MassIVEi | Q9UKT4 |
MaxQBi | Q9UKT4 |
PaxDbi | Q9UKT4 |
PeptideAtlasi | Q9UKT4 |
PRIDEi | Q9UKT4 |
ProteomicsDBi | 84847 [Q9UKT4-1] 84848 [Q9UKT4-2] |
Protocols and materials databases
Antibodypediai | 33385, 243 antibodies from 29 providers |
DNASUi | 26271 |
Genome annotation databases
Ensembli | ENST00000229758; ENSP00000229758; ENSG00000112029 ENST00000367241; ENSP00000356210; ENSG00000112029 [Q9UKT4-2] |
GeneIDi | 26271 |
KEGGi | hsa:26271 |
MANE-Selecti | ENST00000229758.8; ENSP00000229758.3; NM_012177.5; NP_036309.1 |
UCSCi | uc003qpg.4, human [Q9UKT4-1] |
Organism-specific databases
CTDi | 26271 |
DisGeNETi | 26271 |
GeneCardsi | FBXO5 |
HGNCi | HGNC:13584, FBXO5 |
HPAi | ENSG00000112029, Group enriched (bone marrow, lymphoid tissue) |
MIMi | 606013, gene |
neXtProti | NX_Q9UKT4 |
OpenTargetsi | ENSG00000112029 |
PharmGKBi | PA28045 |
VEuPathDBi | HostDB:ENSG00000112029 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPWN, Eukaryota |
GeneTreei | ENSGT00530000063692 |
HOGENOMi | CLU_055946_0_0_1 |
InParanoidi | Q9UKT4 |
OMAi | IKFSPHA |
OrthoDBi | 521317at2759 |
PhylomeDBi | Q9UKT4 |
TreeFami | TF101170 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9UKT4 |
Reactomei | R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176417, Phosphorylation of Emi1 R-HSA-68881, Mitotic Metaphase/Anaphase Transition R-HSA-69205, G1/S-Specific Transcription |
SignaLinki | Q9UKT4 |
SIGNORi | Q9UKT4 |
Miscellaneous databases
BioGRID-ORCSi | 26271, 731 hits in 1095 CRISPR screens |
ChiTaRSi | FBXO5, human |
GeneWikii | FBXO5 |
GenomeRNAii | 26271 |
Pharosi | Q9UKT4, Tbio |
PROi | PR:Q9UKT4 |
RNActi | Q9UKT4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112029, Expressed in ventricular zone and 184 other tissues |
Genevisiblei | Q9UKT4, HS |
Family and domain databases
DisProti | DP01450 |
InterProi | View protein in InterPro IPR001810, F-box_dom IPR044064, ZF_ZBR |
Pfami | View protein in Pfam PF00646, F-box, 1 hit |
PROSITEi | View protein in PROSITE PS51872, ZF_ZBR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX5_HUMAN | |
Accessioni | Q9UKT4Primary (citable) accession number: Q9UKT4 Secondary accession number(s): B3KNX5 Q9UGC8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references