Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 182 (11 Dec 2019)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger protein Helios

Gene

IKZF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with Ikaros at centromeric heterochromatin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UKS7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein Helios
Alternative name(s):
Ikaros family zinc finger protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IKZF2
Synonyms:HELIOS, ZNFN1A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000030419.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13177 IKZF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606234 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKS7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22807

Open Targets

More...
OpenTargetsi
ENSG00000030419

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391927

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKS7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IKZF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470921 – 526Zinc finger protein HeliosAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei288N6-acetyllysineCombined sources1
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 2 (identifier: Q9UKS7-2)
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 4 (identifier: Q9UKS7-4)
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 7 (identifier: Q9UKS7-7)
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKS7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UKS7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKS7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKS7

PeptideAtlas

More...
PeptideAtlasi
Q9UKS7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKS7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84844 [Q9UKS7-1]
84845 [Q9UKS7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKS7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000030419 Expressed in 187 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKS7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKS7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059142

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IKZF4 AND IKZF5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116485, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UKS7, 12 interactors

Molecular INTeraction database

More...
MINTi
Q9UKS7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412869

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UKS7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKS7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049114

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKS7

KEGG Orthology (KO)

More...
KOi
K09220

Database of Orthologous Groups

More...
OrthoDBi
385551at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKS7

TreeFam database of animal gene trees

More...
TreeFami
TF331189

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METEAIDGYI TCDNELSPER EHSNMAIDLT SSTPNGQHAS PSHMTSTNSV
60 70 80 90 100
KLEMQSDEEC DRKPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQELQ
110 120 130 140 150
GEGGIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT
160 170 180 190 200
QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY
210 220 230 240 250
CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP MEDCKEQEPI
260 270 280 290 300
MDNNISLVPF ERPAVIEKLT GNMGKRKSST PQKFVGEKLM RFSYPDIHFD
310 320 330 340 350
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHP PSTIAEVAPV
360 370 380 390 400
ISSAYSQVYH PNRIERPISR ETADSHENNM DGPISLIRPK SRPQEREASP
410 420 430 440 450
SNSCLDSTDS ESSHDDHQSY QGHPALNPKR KQSPAYMKED VKALDTTKAP
460 470 480 490 500
KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF LDHVMYTIHM GCHGYRDPLE
510 520
CNICGYRSQD RYEFSSHIVR GEHTFH
Length:526
Mass (Da):59,574
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i949BE60E242BA8E8
GO
Isoform 2 (identifier: Q9UKS7-2) [UniParc]FASTAAdd to basket
Also known as: Helios 1v

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.

Show »
Length:500
Mass (Da):56,765
Checksum:i544DCEABB3FA6B54
GO
Isoform 3 (identifier: Q9UKS7-3) [UniParc]FASTAAdd to basket
Also known as: Helios del(Ex3,4)

The sequence of this isoform differs from the canonical sequence as follows:
     137-148: ERPFHCNQCGAS → VAVVKTTFSEFC
     149-526: Missing.

Show »
Length:148
Mass (Da):16,247
Checksum:iAD853102487B5D43
GO
Isoform 4 (identifier: Q9UKS7-4) [UniParc]FASTAAdd to basket
Also known as: Helios del(Ex6)v

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.
     238-285: Missing.

Show »
Length:452
Mass (Da):51,353
Checksum:i8FC57AD8EDEE1C03
GO
Isoform 5 (identifier: Q9UKS7-5) [UniParc]FASTAAdd to basket
Also known as: Helios 1+2a,2b, Helios 1v+2a, Helios del(Ex3)+2a

The sequence of this isoform differs from the canonical sequence as follows:
     47-52: TNSVKL → RSFSKI
     53-526: Missing.

Show »
Length:52
Mass (Da):5,725
Checksum:iB38751A5F5596CC3
GO
Isoform 6 (identifier: Q9UKS7-6) [UniParc]FASTAAdd to basket
Also known as: Helios 1+5a, Helios 1+5a,5b

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: VP → DS
     240-526: Missing.

Show »
Length:239
Mass (Da):26,802
Checksum:i4BC57CA088E5E06E
GO
Isoform 7 (identifier: Q9UKS7-7) [UniParc]FASTAAdd to basket
Also known as: Helios del(Ex5)v

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.
     192-237: Missing.

Show »
Length:454
Mass (Da):51,424
Checksum:i5F535D03AAC3758D
GO
Isoform 8 (identifier: Q9UKS7-8) [UniParc]FASTAAdd to basket
Also known as: Helios S

The sequence of this isoform differs from the canonical sequence as follows:
     46-341: Missing.

Show »
Length:230
Mass (Da):25,979
Checksum:i887F78570777EE1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DWF2B4DWF2_HUMAN
Zinc finger protein Helios
IKZF2 ZNFN1A2, hCG_14830
532Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSL2A0A0A0MSL2_HUMAN
Zinc finger protein Helios
IKZF2
409Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT14A0A0A0MT14_HUMAN
Zinc finger protein Helios
IKZF2
411Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPU0E7EPU0_HUMAN
Zinc finger protein Helios
IKZF2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUI1E7EUI1_HUMAN
Zinc finger protein Helios
IKZF2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ES26E7ES26_HUMAN
Zinc finger protein Helios
IKZF2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4E → D in AAF09441 (PubMed:10541817).Curated1
Sequence conflicti4E → D in AAS99855 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99857 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99858 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99859 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99860 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99861 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99862 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99863 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99864 (Ref. 2) Curated1
Sequence conflicti4E → D in AAS99865 (Ref. 2) Curated1
Sequence conflicti69D → N in AAF09441 (PubMed:10541817).Curated1
Sequence conflicti69D → N in AAS99857 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99859 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99861 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99862 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99863 (Ref. 2) Curated1
Sequence conflicti69D → N in AAS99864 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02822793N → S. Corresponds to variant dbSNP:rs16849611Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05534446 – 341Missing in isoform 8. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_05534547 – 52TNSVKL → RSFSKI in isoform 5. 1 Publication6
Alternative sequenceiVSP_05534653 – 526Missing in isoform 5. 1 PublicationAdd BLAST474
Alternative sequenceiVSP_006845111 – 136Missing in isoform 2, isoform 4 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_055347137 – 148ERPFH…QCGAS → VAVVKTTFSEFC in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_055348149 – 526Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_055349192 – 237Missing in isoform 7. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_055350238 – 285Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_055351238 – 239VP → DS in isoform 6. 1 Publication2
Alternative sequenceiVSP_055352240 – 526Missing in isoform 6. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF130863 mRNA Translation: AAF09441.1
AY587062 mRNA Translation: AAS99855.1
AY587064 mRNA Translation: AAS99857.1
AY587065 mRNA Translation: AAS99858.1
AY587066 mRNA Translation: AAS99859.1
AY587067 mRNA Translation: AAS99860.1
AY587068 mRNA Translation: AAS99861.1
AY587069 mRNA Translation: AAS99862.1
AY587070 mRNA Translation: AAS99863.1
AY587071 mRNA Translation: AAS99864.1
AY587072 mRNA Translation: AAS99865.1
BC028936 mRNA Translation: AAH28936.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2395.1 [Q9UKS7-1]
CCDS46507.1 [Q9UKS7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001072994.1, NM_001079526.1 [Q9UKS7-2]
NP_057344.2, NM_016260.2 [Q9UKS7-1]
XP_005246441.1, XM_005246384.4 [Q9UKS7-1]
XP_005246442.1, XM_005246385.3 [Q9UKS7-1]
XP_011509116.1, XM_011510814.2
XP_016859078.1, XM_017003589.1
XP_016859079.1, XM_017003590.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374319; ENSP00000363439; ENSG00000030419 [Q9UKS7-2]
ENST00000374326; ENSP00000363446; ENSG00000030419 [Q9UKS7-5]
ENST00000412444; ENSP00000413680; ENSG00000030419 [Q9UKS7-5]
ENST00000431520; ENSP00000396253; ENSG00000030419 [Q9UKS7-6]
ENST00000434687; ENSP00000412869; ENSG00000030419 [Q9UKS7-1]
ENST00000439848; ENSP00000389548; ENSG00000030419 [Q9UKS7-3]
ENST00000453575; ENSP00000411444; ENSG00000030419 [Q9UKS7-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22807

UCSC genome browser

More...
UCSCi
uc002ven.5 human [Q9UKS7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130863 mRNA Translation: AAF09441.1
AY587062 mRNA Translation: AAS99855.1
AY587064 mRNA Translation: AAS99857.1
AY587065 mRNA Translation: AAS99858.1
AY587066 mRNA Translation: AAS99859.1
AY587067 mRNA Translation: AAS99860.1
AY587068 mRNA Translation: AAS99861.1
AY587069 mRNA Translation: AAS99862.1
AY587070 mRNA Translation: AAS99863.1
AY587071 mRNA Translation: AAS99864.1
AY587072 mRNA Translation: AAS99865.1
BC028936 mRNA Translation: AAH28936.1
CCDSiCCDS2395.1 [Q9UKS7-1]
CCDS46507.1 [Q9UKS7-2]
RefSeqiNP_001072994.1, NM_001079526.1 [Q9UKS7-2]
NP_057344.2, NM_016260.2 [Q9UKS7-1]
XP_005246441.1, XM_005246384.4 [Q9UKS7-1]
XP_005246442.1, XM_005246385.3 [Q9UKS7-1]
XP_011509116.1, XM_011510814.2
XP_016859078.1, XM_017003589.1
XP_016859079.1, XM_017003590.1

3D structure databases

SMRiQ9UKS7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116485, 20 interactors
IntActiQ9UKS7, 12 interactors
MINTiQ9UKS7
STRINGi9606.ENSP00000412869

PTM databases

iPTMnetiQ9UKS7
PhosphoSitePlusiQ9UKS7

Polymorphism and mutation databases

BioMutaiIKZF2
DMDMi116242509

Proteomic databases

EPDiQ9UKS7
jPOSTiQ9UKS7
MassIVEiQ9UKS7
PaxDbiQ9UKS7
PeptideAtlasiQ9UKS7
PRIDEiQ9UKS7
ProteomicsDBi84844 [Q9UKS7-1]
84845 [Q9UKS7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22807

Genome annotation databases

EnsembliENST00000374319; ENSP00000363439; ENSG00000030419 [Q9UKS7-2]
ENST00000374326; ENSP00000363446; ENSG00000030419 [Q9UKS7-5]
ENST00000412444; ENSP00000413680; ENSG00000030419 [Q9UKS7-5]
ENST00000431520; ENSP00000396253; ENSG00000030419 [Q9UKS7-6]
ENST00000434687; ENSP00000412869; ENSG00000030419 [Q9UKS7-1]
ENST00000439848; ENSP00000389548; ENSG00000030419 [Q9UKS7-3]
ENST00000453575; ENSP00000411444; ENSG00000030419 [Q9UKS7-5]
GeneIDi22807
KEGGihsa:22807
UCSCiuc002ven.5 human [Q9UKS7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22807
DisGeNETi22807
EuPathDBiHostDB:ENSG00000030419.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IKZF2
HGNCiHGNC:13177 IKZF2
HPAiHPA059142
MIMi606234 gene
neXtProtiNX_Q9UKS7
OpenTargetsiENSG00000030419
PharmGKBiPA162391927

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000157137
HOGENOMiHOG000049114
InParanoidiQ9UKS7
KOiK09220
OrthoDBi385551at2759
PhylomeDBiQ9UKS7
TreeFamiTF331189

Enzyme and pathway databases

SIGNORiQ9UKS7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IKZF2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IKZF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22807
PharosiQ9UKS7 Tbio

Protein Ontology

More...
PROi
PR:Q9UKS7
RNActiQ9UKS7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000030419 Expressed in 187 organ(s), highest expression level in thymus
ExpressionAtlasiQ9UKS7 baseline and differential
GenevisibleiQ9UKS7 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKZF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKS7
Secondary accession number(s): Q53YJ5
, Q6PQC5, Q6PQC6, Q6PQC7, Q6PQC8, Q6PQD0, Q6PQD1, Q8N6S1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 17, 2006
Last modified: December 11, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again