UniProtKB - Q9UKS6 (PACN3_HUMAN)

BLAST

>sp|Q9UKS6|PACN3_HUMAN Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2
MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW
ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR
PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV
SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL
FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE
EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPR
KAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE
CVGA

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History
Entry version 159 (07 Nov 2018)
Sequence version 2 (13 Aug 2002)
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Protein

Protein kinase C and casein kinase substrate in neurons protein 3

Gene

PACSIN3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

calcium channel inhibitor activity Source: UniProtKB
cytoskeletal protein binding Source: UniProtKB
lipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23236520
phospholipid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoskeleton organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
endocytosis Source: UniProtKB-KW
negative regulation of calcium ion transport Source: UniProtKB
negative regulation of endocytosis Source: UniProtKB
plasma membrane tubulation
Source: UniProtKB
Inferred from direct assayⁱ
- 23236520
positive regulation of membrane protein ectodomain proteolysis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15280379

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein kinase C and casein kinase substrate in neurons protein 3 Alternative name(s): SH3 domain-containing protein 6511
Gene namesⁱ	Name:PACSIN3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165912.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8572 PACSIN3
MIMⁱ	606513 gene
neXtProtⁱ	NX_Q9UKS6

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000165912
PharmGKBⁱ	PA32898

Polymorphism and mutation databases

BioMutaⁱ	PACSIN3
DMDMⁱ	22256967

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000161800	1 – 424	Protein kinase C and casein kinase substrate in neurons protein 3Add BLAST		424

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	276	PhosphoserineCombined sources	1
Modified residueⁱ	303	PhosphoserineBy similarity	1
Modified residueⁱ	319	PhosphoserineCombined sources	1
Modified residueⁱ	324	PhosphothreonineCombined sources	1
Modified residueⁱ	327	PhosphoserineCombined sources	1
Modified residueⁱ	354	PhosphoserineCombined sources	1
Modified residueⁱ	383	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UKS6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UKS6
PaxDbⁱ	Q9UKS6
PeptideAtlas More...PeptideAtlasⁱ	Q9UKS6
PRIDEⁱ	Q9UKS6
ProteomicsDBⁱ	84843

PTM databases

iPTMnetⁱ	Q9UKS6
PhosphoSitePlusⁱ	Q9UKS6
SwissPalmⁱ	Q9UKS6

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000165912 Expressed in 171 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_PACSIN3
ExpressionAtlasⁱ	Q9UKS6 baseline and differential
Genevisibleⁱ	Q9UKS6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039480 HPA043904

HPAⁱ

HPA039480
HPA043904

Interactionⁱ

Subunit structureⁱ

Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ADAM15	Q13444	3	EBI-77926,EBI-77818
ADAM9	Q13443	2	EBI-77926,EBI-77903
FASLG	P48023	4	EBI-77926,EBI-495538
LGALS13	Q9UHV8	3	EBI-77926,EBI-3957707
PACSIN1	Q9BY11	5	EBI-77926,EBI-721769
SOS1	Q07889	2	EBI-77926,EBI-297487
SOS2	Q07890	2	EBI-77926,EBI-298181
SPRY2	O43597	3	EBI-77926,EBI-742487

GO - Molecular functionⁱ

cytoskeletal protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118896, 77 interactors
IntActⁱ	Q9UKS6, 46 interactors
Molecular INTeraction database More...MINTⁱ	Q9UKS6
STRINGⁱ	9606.ENSP00000298838

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UKS6
SMRⁱ	Q9UKS6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 280	F-BARPROSITE-ProRule annotationAdd BLAST		271
Domainⁱ	363 – 424	SH3PROSITE-ProRule annotationAdd BLAST		62

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	23 – 272	By similarityAdd BLAST		250

Domainⁱ

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.1 Publication

Sequence similaritiesⁱ

Belongs to the PACSIN family.Curated

Keywords - Domainⁱ

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG2856 Eukaryota ENOG410XRX2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046376
HOVERGENⁱ	HBG053486
InParanoidⁱ	Q9UKS6
KEGG Orthology (KO) More...KOⁱ	K20123
OMAⁱ	ESCQAAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AS9
PhylomeDBⁱ	Q9UKS6
TreeFamⁱ	TF313677

Family and domain databases

Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR028523 PACSIN3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR23065:SF18 PTHR23065:SF18, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit PF14604 SH3_9, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q9UKS6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE 
        60         70         80         90        100
KAYAQQLADW ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE 
       110        120        130        140        150
KLQGQDSERV RAWQRGAFHR PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV 
       160        170        180        190        200
EASKKSYHAA RKDEKTAQTR ESHAKADSAV SQEQLRKLQE RVERCAKEAE 
       210        220        230        240        250
KTKAQYEQTL AELHRYTPRY MEDMEQAFET CQAAERQRLL FFKDMLLTLH 
       260        270        280        290        300
QHLDLSSSEK FHELHRDLHQ GIEAASDEED LRWWRSTHGP GMAMNWPQFE 
       310        320        330        340        350
EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPGSPGTGQD 
       360        370        380        390        400
EEWSDEESPR KAATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG 
       410        420 
WCQGQLQSGR IGLYPANYVE CVGA

Length:424

Mass (Da):48,487

Last modified:August 13, 2002 - v2

Checksum:ⁱ6DBD940AE6D1F352

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DGG1	A0A0C4DGG1_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	405	Annotation score:
E9PIY1	E9PIY1_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	320	Annotation score:
E9PJ75	E9PJ75_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	142	Annotation score:
E9PNM9	E9PNM9_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	148	Annotation score:
E9PJ33	E9PJ33_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	69	Annotation score:
E9PIZ6	E9PIZ6_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	48	Annotation score:
E9PQ12	E9PQ12_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	36	Annotation score:
H0YDM6	H0YDM6_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 3	PACSIN3	76	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053556	61	A → V1 PublicationCorresponds to variant dbSNP:rs7106654Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF130979 mRNA Translation: AAF04472.1 AF149825 mRNA Translation: AAG31023.1 AF242530 mRNA Translation: AAK29207.1 AC090589 Genomic DNA No translation available. BC007914 mRNA Translation: AAH07914.1 BC011889 mRNA Translation: AAH11889.1 AK000577 mRNA Translation: BAA91267.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31481.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001171903.1, NM_001184974.1 NP_001171904.1, NM_001184975.1 NP_057307.2, NM_016223.4
UniGeneⁱ	Hs.334639

Genome annotation databases

Ensemblⁱ	ENST00000298838; ENSP00000298838; ENSG00000165912 ENST00000539589; ENSP00000440945; ENSG00000165912
GeneIDⁱ	29763
KEGGⁱ	hsa:29763
UCSC genome browser More...UCSCⁱ	uc001ndw.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UKS6	Protein kinase C and casein kinase substrate in neurons 3		MACMU		424	UniRef100_Q9UKS6
PACSIN3 isoform 6		PANTR		424
Protein kinase C and casein kinase substrate in neurons 3		MACFA		424
PACSIN3 isoform 6		PONAB		424
Uncharacterized protein		CERAT		424
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9UKS6	Protein kinase C and casein kinase substrate in neurons 3		MACMU		424	UniRef90_Q9UKS6
PACSIN3 isoform 6		PANTR		424
Protein kinase C and casein kinase substrate in neurons 3		MACFA		424
PACSIN3 isoform 6		PONAB		424
Uncharacterized protein		CERAT		424
+71

Protein	Similar proteins		Species	Score	Length	Source
Q9UKS6	Isoform 2 of Protein kinase C and casein kinase substrate in neurons 2 protein		RAT		447	UniRef50_Q9QY17-2
Protein kinase C and casein kinase II substrate protein 3	)	MOUSE		424
protein kinase C and casein kinase substrate in neurons protein 2 isoform X3		ERIEU		447
protein kinase C and casein kinase substrate in neurons protein 2 isoform X3		TARSY		447
Uncharacterized protein DKFZp459J1025		PONAB		447
+411

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF130979 mRNA Translation: AAF04472.1 AF149825 mRNA Translation: AAG31023.1 AF242530 mRNA Translation: AAK29207.1 AC090589 Genomic DNA No translation available. BC007914 mRNA Translation: AAH07914.1 BC011889 mRNA Translation: AAH11889.1 AK000577 mRNA Translation: BAA91267.1
CCDSⁱ	CCDS31481.1
RefSeqⁱ	NP_001171903.1, NM_001184974.1 NP_001171904.1, NM_001184975.1 NP_057307.2, NM_016223.4
UniGeneⁱ	Hs.334639

3D structure databases

ProteinModelPortalⁱ	Q9UKS6
SMRⁱ	Q9UKS6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118896, 77 interactors
IntActⁱ	Q9UKS6, 46 interactors
MINTⁱ	Q9UKS6
STRINGⁱ	9606.ENSP00000298838

PTM databases

iPTMnetⁱ	Q9UKS6
PhosphoSitePlusⁱ	Q9UKS6
SwissPalmⁱ	Q9UKS6

Polymorphism and mutation databases

BioMutaⁱ	PACSIN3
DMDMⁱ	22256967

Proteomic databases

EPDⁱ	Q9UKS6
MaxQBⁱ	Q9UKS6
PaxDbⁱ	Q9UKS6
PeptideAtlasⁱ	Q9UKS6
PRIDEⁱ	Q9UKS6
ProteomicsDBⁱ	84843

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	29763
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000298838; ENSP00000298838; ENSG00000165912 ENST00000539589; ENSP00000440945; ENSG00000165912
GeneIDⁱ	29763
KEGGⁱ	hsa:29763
UCSCⁱ	uc001ndw.4 human

Organism-specific databases

CTDⁱ	29763
EuPathDBⁱ	HostDB:ENSG00000165912.15
GeneCardsⁱ	PACSIN3
HGNCⁱ	HGNC:8572 PACSIN3
HPAⁱ	HPA039480 HPA043904
MIMⁱ	606513 gene
neXtProtⁱ	NX_Q9UKS6
OpenTargetsⁱ	ENSG00000165912
PharmGKBⁱ	PA32898
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2856 Eukaryota ENOG410XRX2 LUCA
GeneTreeⁱ	ENSGT00510000046376
HOVERGENⁱ	HBG053486
InParanoidⁱ	Q9UKS6
KOⁱ	K20123
OMAⁱ	ESCQAAE
OrthoDBⁱ	EOG091G0AS9
PhylomeDBⁱ	Q9UKS6
TreeFamⁱ	TF313677

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

GeneWikiⁱ	PACSIN3
GenomeRNAiⁱ	29763
Protein Ontology More...PROⁱ	PR:Q9UKS6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165912 Expressed in 171 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_PACSIN3
ExpressionAtlasⁱ	Q9UKS6 baseline and differential
Genevisibleⁱ	Q9UKS6 HS

Family and domain databases

Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR028523 PACSIN3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR23065:SF18 PTHR23065:SF18, 1 hit
Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit PF14604 SH3_9, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PACN3_HUMAN
Accessionⁱ	Q9UKS6Primary (citable) accession number: Q9UKS6 Secondary accession number(s): A6NH84, Q9H331, Q9NWV9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
	Last sequence update:	August 13, 2002
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q9UKS6 (PACN3_HUMAN)

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Protein kinase C and casein kinase substrate in neurons protein 3

PACSIN3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ