Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein kinase C and casein kinase substrate in neurons protein 3

Gene

PACSIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calcium channel inhibitor activity Source: UniProtKB
  • cytoskeletal protein binding Source: UniProtKB
  • lipid binding Source: UniProtKB
  • phospholipid binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processEndocytosis
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C and casein kinase substrate in neurons protein 3
Alternative name(s):
SH3 domain-containing protein 6511
Gene namesi
Name:PACSIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165912.15
HGNCiHGNC:8572 PACSIN3
MIMi606513 gene
neXtProtiNX_Q9UKS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165912
PharmGKBiPA32898

Polymorphism and mutation databases

BioMutaiPACSIN3
DMDMi22256967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001618001 – 424Protein kinase C and casein kinase substrate in neurons protein 3Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276PhosphoserineCombined sources1
Modified residuei303PhosphoserineBy similarity1
Modified residuei319PhosphoserineCombined sources1
Modified residuei324PhosphothreonineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UKS6
MaxQBiQ9UKS6
PaxDbiQ9UKS6
PeptideAtlasiQ9UKS6
PRIDEiQ9UKS6
ProteomicsDBi84843

PTM databases

iPTMnetiQ9UKS6
PhosphoSitePlusiQ9UKS6
SwissPalmiQ9UKS6

Expressioni

Tissue specificityi

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.2 Publications

Gene expression databases

BgeeiENSG00000165912 Expressed in 171 organ(s), highest expression level in heart left ventricle
CleanExiHS_PACSIN3
ExpressionAtlasiQ9UKS6 baseline and differential
GenevisibleiQ9UKS6 HS

Organism-specific databases

HPAiHPA039480
HPA043904

Interactioni

Subunit structurei

Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118896, 77 interactors
IntActiQ9UKS6, 46 interactors
MINTiQ9UKS6
STRINGi9606.ENSP00000298838

Structurei

3D structure databases

ProteinModelPortaliQ9UKS6
SMRiQ9UKS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 280F-BARPROSITE-ProRule annotationAdd BLAST271
Domaini363 – 424SH3PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 272By similarityAdd BLAST250

Domaini

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation.1 Publication

Sequence similaritiesi

Belongs to the PACSIN family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG2856 Eukaryota
ENOG410XRX2 LUCA
GeneTreeiENSGT00510000046376
HOVERGENiHBG053486
InParanoidiQ9UKS6
KOiK20123
OMAiESCQAAE
OrthoDBiEOG091G0AS9
PhylomeDBiQ9UKS6
TreeFamiTF313677

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR028523 PACSIN3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23065:SF18 PTHR23065:SF18, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9UKS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPEEDAGGE ALGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE
60 70 80 90 100
KAYAQQLADW ARKWRGTVEK GPQYGTLEKA WHAFFTAAER LSALHLEVRE
110 120 130 140 150
KLQGQDSERV RAWQRGAFHR PVLGGFRESR AAEDGFRKAQ KPWLKRLKEV
160 170 180 190 200
EASKKSYHAA RKDEKTAQTR ESHAKADSAV SQEQLRKLQE RVERCAKEAE
210 220 230 240 250
KTKAQYEQTL AELHRYTPRY MEDMEQAFET CQAAERQRLL FFKDMLLTLH
260 270 280 290 300
QHLDLSSSEK FHELHRDLHQ GIEAASDEED LRWWRSTHGP GMAMNWPQFE
310 320 330 340 350
EWSLDTQRTI SRKEKGGRSP DEVTLTSIVP TRDGTAPPPQ SPGSPGTGQD
360 370 380 390 400
EEWSDEESPR KAATGVRVRA LYDYAGQEAD ELSFRAGEEL LKMSEEDEQG
410 420
WCQGQLQSGR IGLYPANYVE CVGA
Length:424
Mass (Da):48,487
Last modified:August 13, 2002 - v2
Checksum:i6DBD940AE6D1F352
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGG1A0A0C4DGG1_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
405Annotation score:
E9PIY1E9PIY1_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
320Annotation score:
E9PJ75E9PJ75_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
142Annotation score:
E9PNM9E9PNM9_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
148Annotation score:
E9PJ33E9PJ33_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
69Annotation score:
E9PIZ6E9PIZ6_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
48Annotation score:
E9PQ12E9PQ12_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
36Annotation score:
H0YDM6H0YDM6_HUMAN
Protein kinase C and casein kinase ...
PACSIN3
76Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05355661A → V1 PublicationCorresponds to variant dbSNP:rs7106654Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130979 mRNA Translation: AAF04472.1
AF149825 mRNA Translation: AAG31023.1
AF242530 mRNA Translation: AAK29207.1
AC090589 Genomic DNA No translation available.
BC007914 mRNA Translation: AAH07914.1
BC011889 mRNA Translation: AAH11889.1
AK000577 mRNA Translation: BAA91267.1
CCDSiCCDS31481.1
RefSeqiNP_001171903.1, NM_001184974.1
NP_001171904.1, NM_001184975.1
NP_057307.2, NM_016223.4
UniGeneiHs.334639

Genome annotation databases

EnsembliENST00000298838; ENSP00000298838; ENSG00000165912
ENST00000539589; ENSP00000440945; ENSG00000165912
GeneIDi29763
KEGGihsa:29763
UCSCiuc001ndw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130979 mRNA Translation: AAF04472.1
AF149825 mRNA Translation: AAG31023.1
AF242530 mRNA Translation: AAK29207.1
AC090589 Genomic DNA No translation available.
BC007914 mRNA Translation: AAH07914.1
BC011889 mRNA Translation: AAH11889.1
AK000577 mRNA Translation: BAA91267.1
CCDSiCCDS31481.1
RefSeqiNP_001171903.1, NM_001184974.1
NP_001171904.1, NM_001184975.1
NP_057307.2, NM_016223.4
UniGeneiHs.334639

3D structure databases

ProteinModelPortaliQ9UKS6
SMRiQ9UKS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118896, 77 interactors
IntActiQ9UKS6, 46 interactors
MINTiQ9UKS6
STRINGi9606.ENSP00000298838

PTM databases

iPTMnetiQ9UKS6
PhosphoSitePlusiQ9UKS6
SwissPalmiQ9UKS6

Polymorphism and mutation databases

BioMutaiPACSIN3
DMDMi22256967

Proteomic databases

EPDiQ9UKS6
MaxQBiQ9UKS6
PaxDbiQ9UKS6
PeptideAtlasiQ9UKS6
PRIDEiQ9UKS6
ProteomicsDBi84843

Protocols and materials databases

DNASUi29763
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298838; ENSP00000298838; ENSG00000165912
ENST00000539589; ENSP00000440945; ENSG00000165912
GeneIDi29763
KEGGihsa:29763
UCSCiuc001ndw.4 human

Organism-specific databases

CTDi29763
EuPathDBiHostDB:ENSG00000165912.15
GeneCardsiPACSIN3
HGNCiHGNC:8572 PACSIN3
HPAiHPA039480
HPA043904
MIMi606513 gene
neXtProtiNX_Q9UKS6
OpenTargetsiENSG00000165912
PharmGKBiPA32898
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2856 Eukaryota
ENOG410XRX2 LUCA
GeneTreeiENSGT00510000046376
HOVERGENiHBG053486
InParanoidiQ9UKS6
KOiK20123
OMAiESCQAAE
OrthoDBiEOG091G0AS9
PhylomeDBiQ9UKS6
TreeFamiTF313677

Enzyme and pathway databases

ReactomeiR-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

GeneWikiiPACSIN3
GenomeRNAii29763
PROiPR:Q9UKS6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165912 Expressed in 171 organ(s), highest expression level in heart left ventricle
CleanExiHS_PACSIN3
ExpressionAtlasiQ9UKS6 baseline and differential
GenevisibleiQ9UKS6 HS

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR028523 PACSIN3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23065:SF18 PTHR23065:SF18, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPACN3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKS6
Secondary accession number(s): A6NH84, Q9H331, Q9NWV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again