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Entry version 123 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Tetraspanin-16

Gene

TSPAN16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetraspanin-16
Short name:
Tspan-16
Alternative name(s):
Tetraspanin TM4-B
Transmembrane 4 superfamily member 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPAN16
Synonyms:TM4SF16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30725 TSPAN16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617580 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKR8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 37ExtracellularSequence analysis3
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59CytoplasmicSequence analysis1
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 94ExtracellularSequence analysisAdd BLAST14
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 245CytoplasmicSequence analysisAdd BLAST130

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26526

Open Targets

More...
OpenTargetsi
ENSG00000130167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134989909

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKR8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSPAN16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
11135364

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192641 – 245Tetraspanin-16Add BLAST245

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKR8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKR8

PeptideAtlas

More...
PeptideAtlasi
Q9UKR8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKR8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72182
84842 [Q9UKR8-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130167 Expressed in 72 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKR8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKR8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041579

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319486

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000148746

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKR8

KEGG Orthology (KO)

More...
KOi
K17357

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPRSCCK

Database of Orthologous Groups

More...
OrthoDBi
1051357at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKR8

TreeFam database of animal gene trees

More...
TreeFami
TF316345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652 SSF48652, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEIHTPYSS LKKLLSLLNG FVAVSGIILV GLGIGGKCGG ASLTNVLGLS
60 70 80 90 100
SAYLLHVGNL CLVMGCITVL LGCAGWYGAT KESRGTLLFC ILSMVIVLIM
110 120 130 140 150
EVTAATVVLL FFPIVGDVAL EHTFVTLRKN YRGYNEPDDY STQWNLVMEK
160 170 180 190 200
LKCCGVNNYT DFSGSSFEMT TGHTYPRSCC KSIGSVSCDG RDVSPNVIHQ
210 220 230 240
KGCFHKLLKI TKTQSFTLSG SSLGAAVIQR WGSRYVAQAG LELLA
Length:245
Mass (Da):26,266
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i064CDE593AB2B48C
GO
Isoform 2 (identifier: Q9UKR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-245: RWGSRYVAQAGLELLA → LPGILATLLLFIKLG

Show »
Length:244
Mass (Da):26,058
Checksum:i181A30E73108AF59
GO
Isoform 3 (identifier: Q9UKR8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-114: Missing.
     230-245: RWGSRYVAQAGLELLA → LPGILATLLLFIKLG

Show »
Length:219
Mass (Da):23,339
Checksum:i6CBC140433B8550A
GO
Isoform 4 (identifier: Q9UKR8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-160: LKCCGVNNYT → GLSKYFFSSL
     161-245: Missing.

Show »
Length:160
Mass (Da):17,205
Checksum:i5FD6572C76DBAB6F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMI8K7EMI8_HUMAN
Tetraspanin-16
TSPAN16
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05232953Y → D. Corresponds to variant dbSNP:rs34162761Ensembl.1
Natural variantiVAR_05233055L → P. Corresponds to variant dbSNP:rs17001344Ensembl.1
Natural variantiVAR_052331233S → C. Corresponds to variant dbSNP:rs318687Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05672390 – 114Missing in isoform 3. CuratedAdd BLAST25
Alternative sequenceiVSP_056724151 – 160LKCCGVNNYT → GLSKYFFSSL in isoform 4. 1 Publication10
Alternative sequenceiVSP_056725161 – 245Missing in isoform 4. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_056726230 – 245RWGSR…LELLA → LPGILATLLLFIKLG in isoform 2 and isoform 3. CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF133424 mRNA Translation: AAF08363.1
AC011472 Genomic DNA No translation available.
AC024575 Genomic DNA No translation available.
AC098777 Genomic DNA No translation available.
BC029908 mRNA Translation: AAH29908.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12256.1 [Q9UKR8-1]
CCDS62549.1 [Q9UKR8-2]
CCDS62550.1 [Q9UKR8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001269438.1, NM_001282509.1 [Q9UKR8-2]
NP_001269439.1, NM_001282510.1 [Q9UKR8-3]
NP_036598.1, NM_012466.3 [Q9UKR8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316737; ENSP00000319486; ENSG00000130167 [Q9UKR8-1]
ENST00000337994; ENSP00000338759; ENSG00000130167 [Q9UKR8-4]
ENST00000590327; ENSP00000467341; ENSG00000130167 [Q9UKR8-2]
ENST00000592955; ENSP00000466751; ENSG00000130167 [Q9UKR8-3]
ENST00000621731; ENSP00000480759; ENSG00000130167 [Q9UKR8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26526

UCSC genome browser

More...
UCSCi
uc002mqv.3 human [Q9UKR8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133424 mRNA Translation: AAF08363.1
AC011472 Genomic DNA No translation available.
AC024575 Genomic DNA No translation available.
AC098777 Genomic DNA No translation available.
BC029908 mRNA Translation: AAH29908.1
CCDSiCCDS12256.1 [Q9UKR8-1]
CCDS62549.1 [Q9UKR8-2]
CCDS62550.1 [Q9UKR8-3]
RefSeqiNP_001269438.1, NM_001282509.1 [Q9UKR8-2]
NP_001269439.1, NM_001282510.1 [Q9UKR8-3]
NP_036598.1, NM_012466.3 [Q9UKR8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000319486

Polymorphism and mutation databases

BioMutaiTSPAN16
DMDMi11135364

Proteomic databases

MassIVEiQ9UKR8
PaxDbiQ9UKR8
PeptideAtlasiQ9UKR8
PRIDEiQ9UKR8
ProteomicsDBi72182
84842 [Q9UKR8-1]

Genome annotation databases

EnsembliENST00000316737; ENSP00000319486; ENSG00000130167 [Q9UKR8-1]
ENST00000337994; ENSP00000338759; ENSG00000130167 [Q9UKR8-4]
ENST00000590327; ENSP00000467341; ENSG00000130167 [Q9UKR8-2]
ENST00000592955; ENSP00000466751; ENSG00000130167 [Q9UKR8-3]
ENST00000621731; ENSP00000480759; ENSG00000130167 [Q9UKR8-4]
GeneIDi26526
KEGGihsa:26526
UCSCiuc002mqv.3 human [Q9UKR8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26526
DisGeNETi26526

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSPAN16
HGNCiHGNC:30725 TSPAN16
HPAiHPA041579
MIMi617580 gene
neXtProtiNX_Q9UKR8
OpenTargetsiENSG00000130167
PharmGKBiPA134989909

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00510000049338
HOGENOMiHOG000148746
InParanoidiQ9UKR8
KOiK17357
OMAiYPRSCCK
OrthoDBi1051357at2759
PhylomeDBiQ9UKR8
TreeFamiTF316345

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSPAN16 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26526
PharosiQ9UKR8

Protein Ontology

More...
PROi
PR:Q9UKR8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130167 Expressed in 72 organ(s), highest expression level in sperm
ExpressionAtlasiQ9UKR8 baseline and differential
GenevisibleiQ9UKR8 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSN16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKR8
Secondary accession number(s): K7EN22, K7EPD8, Q8N6J7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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