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Protein

Probable ergosterol biosynthetic protein 28

Gene

ERG28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein binding, bridging Source: GO_Central

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ergosterol biosynthetic protein 28
Gene namesi
Name:ERG28Imported
Synonyms:C14orf1Imported
ORF Names:AD-011, HSPC288, x0006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000133935.6
HGNCiHGNC:1187 ERG28
MIMi604576 gene
neXtProtiNX_Q9UKR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11161
OpenTargetsiENSG00000133935
PharmGKBiPA25513

Polymorphism and mutation databases

BioMutaiC14orf1
DMDMi13431328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001939031 – 140Probable ergosterol biosynthetic protein 28Add BLAST140

Proteomic databases

EPDiQ9UKR5
MaxQBiQ9UKR5
PaxDbiQ9UKR5
PeptideAtlasiQ9UKR5
PRIDEiQ9UKR5
ProteomicsDBi84841
TopDownProteomicsiQ9UKR5

PTM databases

iPTMnetiQ9UKR5
PhosphoSitePlusiQ9UKR5

Expressioni

Tissue specificityi

Ubiquitous; strongly expressed in testis and some cancer cell lines.

Gene expression databases

BgeeiENSG00000133935 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_C14orf1
ExpressionAtlasiQ9UKR5 baseline and differential
GenevisibleiQ9UKR5 HS

Organism-specific databases

HPAiHPA043172
HPA063568

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116332, 68 interactors
IntActiQ9UKR5, 96 interactors
MINTiQ9UKR5
STRINGi9606.ENSP00000256319

Structurei

3D structure databases

ProteinModelPortaliQ9UKR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG28 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3455 Eukaryota
ENOG4111J9X LUCA
GeneTreeiENSGT00390000010925
HOGENOMiHOG000164093
HOVERGENiHBG051505
InParanoidiQ9UKR5
OMAiIIRCACA
OrthoDBiEOG091G16N5
PhylomeDBiQ9UKR5
TreeFamiTF300191

Family and domain databases

InterProiView protein in InterPro
IPR005352 Erg28
PANTHERiPTHR15451 PTHR15451, 1 hit
PfamiView protein in Pfam
PF03694 Erg28, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA
60 70 80 90 100
RTFGIWTLLS SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT
110 120 130 140
AAPTIGVLAP LMVASFSILG MLVGLRYLEV EPVSRQKKRN
Length:140
Mass (Da):15,864
Last modified:May 1, 2000 - v1
Checksum:iBDD089148BC60E50
GO

Sequence cautioni

The sequence AAD51373 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF28966 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134159 mRNA Translation: AAD54079.1
AF161406 mRNA Translation: AAF28966.1 Different initiation.
AL136658 mRNA Translation: CAB66593.1
AF136971 mRNA Translation: AAG49432.1
AC007182 Genomic DNA Translation: AAD51373.1 Sequence problems.
BC002444 mRNA Translation: AAH02444.1
CCDSiCCDS9845.1
RefSeqiNP_009107.1, NM_007176.3
UniGeneiHs.15106

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935
GeneIDi11161
KEGGihsa:11161
UCSCiuc001xrt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134159 mRNA Translation: AAD54079.1
AF161406 mRNA Translation: AAF28966.1 Different initiation.
AL136658 mRNA Translation: CAB66593.1
AF136971 mRNA Translation: AAG49432.1
AC007182 Genomic DNA Translation: AAD51373.1 Sequence problems.
BC002444 mRNA Translation: AAH02444.1
CCDSiCCDS9845.1
RefSeqiNP_009107.1, NM_007176.3
UniGeneiHs.15106

3D structure databases

ProteinModelPortaliQ9UKR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116332, 68 interactors
IntActiQ9UKR5, 96 interactors
MINTiQ9UKR5
STRINGi9606.ENSP00000256319

PTM databases

iPTMnetiQ9UKR5
PhosphoSitePlusiQ9UKR5

Polymorphism and mutation databases

BioMutaiC14orf1
DMDMi13431328

Proteomic databases

EPDiQ9UKR5
MaxQBiQ9UKR5
PaxDbiQ9UKR5
PeptideAtlasiQ9UKR5
PRIDEiQ9UKR5
ProteomicsDBi84841
TopDownProteomicsiQ9UKR5

Protocols and materials databases

DNASUi11161
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256319; ENSP00000256319; ENSG00000133935
GeneIDi11161
KEGGihsa:11161
UCSCiuc001xrt.4 human

Organism-specific databases

CTDi11161
DisGeNETi11161
EuPathDBiHostDB:ENSG00000133935.6
GeneCardsiERG28
HGNCiHGNC:1187 ERG28
HPAiHPA043172
HPA063568
MIMi604576 gene
neXtProtiNX_Q9UKR5
OpenTargetsiENSG00000133935
PharmGKBiPA25513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3455 Eukaryota
ENOG4111J9X LUCA
GeneTreeiENSGT00390000010925
HOGENOMiHOG000164093
HOVERGENiHBG051505
InParanoidiQ9UKR5
OMAiIIRCACA
OrthoDBiEOG091G16N5
PhylomeDBiQ9UKR5
TreeFamiTF300191

Miscellaneous databases

ChiTaRSiC14orf1 human
GeneWikiiC14orf1
GenomeRNAii11161
PROiPR:Q9UKR5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133935 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_C14orf1
ExpressionAtlasiQ9UKR5 baseline and differential
GenevisibleiQ9UKR5 HS

Family and domain databases

InterProiView protein in InterPro
IPR005352 Erg28
PANTHERiPTHR15451 PTHR15451, 1 hit
PfamiView protein in Pfam
PF03694 Erg28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERG28_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR5
Secondary accession number(s): Q9P093, Q9UPI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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