Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kallikrein-12

Gene

KLK12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Charge relay systemBy similarity1
Active sitei108Charge relay systemBy similarity1
Active sitei200Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B43 2681
ReactomeiR-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.020

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-12 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 5
Short name:
KLK-L5
Gene namesi
Name:KLK12
Synonyms:KLKL5
ORF Names:UNQ669/PRO1303
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186474.15
HGNCiHGNC:6360 KLK12
MIMi605539 gene
neXtProtiNX_Q9UKR0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi43849
OpenTargetsiENSG00000186474
PharmGKBiPA30149

Chemistry databases

ChEMBLiCHEMBL4943

Polymorphism and mutation databases

BioMutaiKLK12
DMDMi9296989

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002795618 – 248Kallikrein-12Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi28 ↔ 161PROSITE-ProRule annotation
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi133 ↔ 235PROSITE-ProRule annotation
Disulfide bondi140 ↔ 206PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
Disulfide bondi196 ↔ 222PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKR0
PeptideAtlasiQ9UKR0
PRIDEiQ9UKR0
ProteomicsDBi84837
84838 [Q9UKR0-2]

PTM databases

iPTMnetiQ9UKR0
PhosphoSitePlusiQ9UKR0

Expressioni

Gene expression databases

BgeeiENSG00000186474 Expressed in 119 organ(s), highest expression level in ectocervix
CleanExiHS_KLK12
ExpressionAtlasiQ9UKR0 baseline and differential
GenevisibleiQ9UKR0 HS

Organism-specific databases

HPAiCAB025473

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000250351

Structurei

3D structure databases

ProteinModelPortaliQ9UKR0
SMRiQ9UKR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9UKR0
KOiK09621
OMAiCRAVFPG
OrthoDBiEOG091G0AH5
PhylomeDBiQ9UKR0
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV
60 70 80 90 100
LIDHRWVLTA AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG
110 120 130 140 150
ASTSHEHDLR LLRLRLPVRV TSSVQPLPLP NDCATAGTEC HVSGWGITNH
160 170 180 190 200
PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI TSNMVCAGGV PGQDACQGDS
210 220 230 240
GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW IRMIMRNN
Length:248
Mass (Da):26,734
Last modified:May 1, 2000 - v1
Checksum:iBB473E98F8BAF703
GO
Isoform 2 (identifier: Q9UKR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-248: KYVDWIRMIMRNN → NSTLVGLGTSWNFNSCQPF

Show »
Length:254
Mass (Da):27,067
Checksum:i704A1552D34DF188
GO
Isoform 3 (identifier: Q9UKR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: SRYWVRLGEH...STSHEHDLRL → RPIPGSAPVP...RRPGAGCLPG
     112-248: Missing.

Show »
Length:111
Mass (Da):11,984
Checksum:i3E8EAB4295635D8D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR22E9PR22_HUMAN
Kallikrein-12
KLK12
177Annotation score:
E9PPC6E9PPC6_HUMAN
Kallikrein-12
KLK12
79Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04585166 – 111SRYWV…HDLRL → RPIPGSAPVPQPLHRLPCHL PWCVSRENHEQHGVCRRRPG AGCLPG in isoform 3. CuratedAdd BLAST46
Alternative sequenceiVSP_045852112 – 248Missing in isoform 3. CuratedAdd BLAST137
Alternative sequenceiVSP_005403236 – 248KYVDW…IMRNN → NSTLVGLGTSWNFNSCQPF in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135025 Genomic DNA Translation: AAD26426.2
AF135025 Genomic DNA Translation: AAF06065.1
AF135025 Genomic DNA Translation: AAF06066.1
AF243527 Genomic DNA Translation: AAG33365.1
AY358524 mRNA Translation: AAQ88888.1
AC011473 Genomic DNA Translation: AAG23258.1
CH471135 Genomic DNA Translation: EAW71976.1
CCDSiCCDS12820.1 [Q9UKR0-2]
CCDS12821.1 [Q9UKR0-1]
CCDS54298.1 [Q9UKR0-3]
RefSeqiNP_062544.1, NM_019598.2 [Q9UKR0-2]
NP_665901.1, NM_145894.1 [Q9UKR0-1]
NP_665902.1, NM_145895.1 [Q9UKR0-3]
XP_005259008.1, XM_005258951.3 [Q9UKR0-3]
UniGeneiHs.411572

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474 [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474 [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474 [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474 [Q9UKR0-3]
GeneIDi43849
KEGGihsa:43849
UCSCiuc002pvg.1 human [Q9UKR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135025 Genomic DNA Translation: AAD26426.2
AF135025 Genomic DNA Translation: AAF06065.1
AF135025 Genomic DNA Translation: AAF06066.1
AF243527 Genomic DNA Translation: AAG33365.1
AY358524 mRNA Translation: AAQ88888.1
AC011473 Genomic DNA Translation: AAG23258.1
CH471135 Genomic DNA Translation: EAW71976.1
CCDSiCCDS12820.1 [Q9UKR0-2]
CCDS12821.1 [Q9UKR0-1]
CCDS54298.1 [Q9UKR0-3]
RefSeqiNP_062544.1, NM_019598.2 [Q9UKR0-2]
NP_665901.1, NM_145894.1 [Q9UKR0-1]
NP_665902.1, NM_145895.1 [Q9UKR0-3]
XP_005259008.1, XM_005258951.3 [Q9UKR0-3]
UniGeneiHs.411572

3D structure databases

ProteinModelPortaliQ9UKR0
SMRiQ9UKR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000250351

Chemistry databases

ChEMBLiCHEMBL4943

Protein family/group databases

MEROPSiS01.020

PTM databases

iPTMnetiQ9UKR0
PhosphoSitePlusiQ9UKR0

Polymorphism and mutation databases

BioMutaiKLK12
DMDMi9296989

Proteomic databases

PaxDbiQ9UKR0
PeptideAtlasiQ9UKR0
PRIDEiQ9UKR0
ProteomicsDBi84837
84838 [Q9UKR0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250351; ENSP00000250351; ENSG00000186474 [Q9UKR0-2]
ENST00000319590; ENSP00000324181; ENSG00000186474 [Q9UKR0-1]
ENST00000525263; ENSP00000436458; ENSG00000186474 [Q9UKR0-1]
ENST00000529888; ENSP00000434036; ENSG00000186474 [Q9UKR0-3]
GeneIDi43849
KEGGihsa:43849
UCSCiuc002pvg.1 human [Q9UKR0-1]

Organism-specific databases

CTDi43849
DisGeNETi43849
EuPathDBiHostDB:ENSG00000186474.15
GeneCardsiKLK12
HGNCiHGNC:6360 KLK12
HPAiCAB025473
MIMi605539 gene
neXtProtiNX_Q9UKR0
OpenTargetsiENSG00000186474
PharmGKBiPA30149
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9UKR0
KOiK09621
OMAiCRAVFPG
OrthoDBiEOG091G0AH5
PhylomeDBiQ9UKR0
TreeFamiTF331065

Enzyme and pathway databases

BRENDAi3.4.21.B43 2681
ReactomeiR-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiKLK12 human
GeneWikiiKLK12
GenomeRNAii43849
PROiPR:Q9UKR0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186474 Expressed in 119 organ(s), highest expression level in ectocervix
CleanExiHS_KLK12
ExpressionAtlasiQ9UKR0 baseline and differential
GenevisibleiQ9UKR0 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLK12_HUMAN
AccessioniPrimary (citable) accession number: Q9UKR0
Secondary accession number(s): Q9UKR1, Q9UKR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again