UniProtKB - Q9UKQ9 (KLK9_HUMAN)
Protein
Kallikrein-9
Gene
KLK9
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 63 | Charge relay systemBy similarity | 1 | |
Active sitei | 111 | Charge relay systemBy similarity | 1 | |
Active sitei | 204 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
BRENDAi | 3.4.21.B40, 2681 |
PathwayCommonsi | Q9UKQ9 |
Protein family/group databases
MEROPSi | S01.307 |
Names & Taxonomyi
Protein namesi | Recommended name: Kallikrein-9 (EC:3.4.21.-)Alternative name(s): Kallikrein-like protein 3 Short name: KLK-L3 |
Gene namesi | Name:KLK9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000213022.5 |
HGNCi | HGNC:6370, KLK9 |
MIMi | 605504, gene |
neXtProti | NX_Q9UKQ9 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- secretory granule Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 284366 |
OpenTargetsi | ENSG00000213022 ENSG00000269741 |
PharmGKBi | PA30159 |
Miscellaneous databases
Pharosi | Q9UKQ9, Tbio |
Polymorphism and mutation databases
BioMutai | KLK9 |
DMDMi | 9296988 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_0000027952 | 16 – 250 | Kallikrein-9Add BLAST | 235 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 164 | PROSITE-ProRule annotation | ||
Disulfide bondi | 48 ↔ 64 | PROSITE-ProRule annotation | ||
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 136 ↔ 238 | PROSITE-ProRule annotation | ||
Disulfide bondi | 143 ↔ 210 | PROSITE-ProRule annotation | ||
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 175 ↔ 189 | PROSITE-ProRule annotation | ||
Disulfide bondi | 200 ↔ 225 | PROSITE-ProRule annotation | ||
Glycosylationi | 211 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9UKQ9 |
PaxDbi | Q9UKQ9 |
PeptideAtlasi | Q9UKQ9 |
PRIDEi | Q9UKQ9 |
ProteomicsDBi | 67280 84836 [Q9UKQ9-1] |
PTM databases
GlyGeni | Q9UKQ9, 3 sites |
iPTMneti | Q9UKQ9 |
PhosphoSitePlusi | Q9UKQ9 |
Expressioni
Tissue specificityi
Skin, thymus, trachea, cerebellum and spinal cord.
Gene expression databases
Bgeei | ENSG00000213022, Expressed in ectocervix and 23 other tissues |
ExpressionAtlasi | Q9UKQ9, baseline and differential |
Genevisiblei | Q9UKQ9, HS |
Organism-specific databases
HPAi | ENSG00000213022, Tissue enriched (tongue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129846, 11 interactors |
IntActi | Q9UKQ9, 10 interactors |
MINTi | Q9UKQ9 |
STRINGi | 9606.ENSP00000469417 |
Miscellaneous databases
RNActi | Q9UKQ9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 249 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 227 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000162323 |
HOGENOMi | CLU_006842_1_1_1 |
InParanoidi | Q9UKQ9 |
OMAi | KECRPNS |
PhylomeDBi | Q9UKQ9 |
TreeFami | TF331065 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UKQ9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLGLLCALL SLLAGHGWAD TRAIGAEECR PNSQPWQAGL FHLTRLFCGA
60 70 80 90 100
TLISDRWLLT AAHCRKPYLW VRLGEHHLWK WEGPEQLFRV TDFFPHPGFN
110 120 130 140 150
KDLSANDHND DIMLIRLPRQ ARLSPAVQPL NLSQTCVSPG MQCLISGWGA
160 170 180 190 200
VSSPKALFPV TLQCANISIL ENKLCHWAYP GHISDSMLCA GLWEGGRGSC
210 220 230 240 250
QGDSGGPLVC NGTLAGVVSG GAEPCSRPRR PAVYTSVCHY LDWIQEIMEN
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057044 | 16 – 61 | HGWAD…WLLTA → ICGSALESTTSGNGRVRSSC SGLRTSSPTLASTRTSAPMT TMMTSC in isoform 2. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_057045 | 62 – 250 | Missing in isoform 2. 1 PublicationAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF135026 Genomic DNA Translation: AAD26427.2 AF243527 Genomic DNA Translation: AAG33362.1 AY551001 mRNA Translation: AAS55655.1 AC011473 Genomic DNA Translation: AAG23255.1 AC011483 Genomic DNA No translation available. |
CCDSi | CCDS12816.1 [Q9UKQ9-1] |
RefSeqi | NP_036447.1, NM_012315.1 [Q9UKQ9-1] |
Genome annotation databases
Ensembli | ENST00000544410; ENSP00000443289; ENSG00000213022 [Q9UKQ9-2] ENST00000594211; ENSP00000469417; ENSG00000213022 [Q9UKQ9-1] |
GeneIDi | 284366 |
KEGGi | hsa:284366 |
UCSCi | uc002pux.2, human [Q9UKQ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF135026 Genomic DNA Translation: AAD26427.2 AF243527 Genomic DNA Translation: AAG33362.1 AY551001 mRNA Translation: AAS55655.1 AC011473 Genomic DNA Translation: AAG23255.1 AC011483 Genomic DNA No translation available. |
CCDSi | CCDS12816.1 [Q9UKQ9-1] |
RefSeqi | NP_036447.1, NM_012315.1 [Q9UKQ9-1] |
3D structure databases
SMRi | Q9UKQ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129846, 11 interactors |
IntActi | Q9UKQ9, 10 interactors |
MINTi | Q9UKQ9 |
STRINGi | 9606.ENSP00000469417 |
Protein family/group databases
MEROPSi | S01.307 |
PTM databases
GlyGeni | Q9UKQ9, 3 sites |
iPTMneti | Q9UKQ9 |
PhosphoSitePlusi | Q9UKQ9 |
Polymorphism and mutation databases
BioMutai | KLK9 |
DMDMi | 9296988 |
Proteomic databases
MassIVEi | Q9UKQ9 |
PaxDbi | Q9UKQ9 |
PeptideAtlasi | Q9UKQ9 |
PRIDEi | Q9UKQ9 |
ProteomicsDBi | 67280 84836 [Q9UKQ9-1] |
Protocols and materials databases
Antibodypediai | 18949, 175 antibodies |
DNASUi | 284366 |
Genome annotation databases
Ensembli | ENST00000544410; ENSP00000443289; ENSG00000213022 [Q9UKQ9-2] ENST00000594211; ENSP00000469417; ENSG00000213022 [Q9UKQ9-1] |
GeneIDi | 284366 |
KEGGi | hsa:284366 |
UCSCi | uc002pux.2, human [Q9UKQ9-1] |
Organism-specific databases
CTDi | 284366 |
DisGeNETi | 284366 |
EuPathDBi | HostDB:ENSG00000213022.5 |
GeneCardsi | KLK9 |
HGNCi | HGNC:6370, KLK9 |
HPAi | ENSG00000213022, Tissue enriched (tongue) |
MIMi | 605504, gene |
neXtProti | NX_Q9UKQ9 |
OpenTargetsi | ENSG00000213022 ENSG00000269741 |
PharmGKBi | PA30159 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000162323 |
HOGENOMi | CLU_006842_1_1_1 |
InParanoidi | Q9UKQ9 |
OMAi | KECRPNS |
PhylomeDBi | Q9UKQ9 |
TreeFami | TF331065 |
Enzyme and pathway databases
BRENDAi | 3.4.21.B40, 2681 |
PathwayCommonsi | Q9UKQ9 |
Miscellaneous databases
BioGRID-ORCSi | 284366, 4 hits in 840 CRISPR screens |
ChiTaRSi | KLK9, human |
GeneWikii | KLK9 |
GenomeRNAii | 284366 |
Pharosi | Q9UKQ9, Tbio |
PROi | PR:Q9UKQ9 |
RNActi | Q9UKQ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213022, Expressed in ectocervix and 23 other tissues |
ExpressionAtlasi | Q9UKQ9, baseline and differential |
Genevisiblei | Q9UKQ9, HS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLK9_HUMAN | |
Accessioni | Q9UKQ9Primary (citable) accession number: Q9UKQ9 Secondary accession number(s): Q6QA55 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Peptidase families
Classification of peptidase families and list of entries