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Protein

Integrin beta-1-binding protein 2

Gene

ITGB1BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role during maturation and/or organization of muscles cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Zinc 1PROSITE-ProRule annotation1
Metal bindingi10Zinc 1PROSITE-ProRule annotation1
Metal bindingi24Zinc 1PROSITE-ProRule annotation1
Metal bindingi27Zinc 2PROSITE-ProRule annotation1
Metal bindingi42Zinc 2PROSITE-ProRule annotation1
Metal bindingi43Zinc 2PROSITE-ProRule annotation1
Metal bindingi59Zinc 2PROSITE-ProRule annotation1
Metal bindingi64Zinc 1PROSITE-ProRule annotation1
Metal bindingi149Zinc 3PROSITE-ProRule annotation1
Metal bindingi154Zinc 3PROSITE-ProRule annotation1
Metal bindingi168Zinc 3PROSITE-ProRule annotation1
Metal bindingi171Zinc 4PROSITE-ProRule annotation1
Metal bindingi186Zinc 4PROSITE-ProRule annotation1
Metal bindingi187Zinc 4PROSITE-ProRule annotation1
Metal bindingi203Zinc 4PROSITE-ProRule annotation1
Metal bindingi208Zinc 3PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9UKP3

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-1-binding protein 2
Alternative name(s):
Melusin
Gene namesi
ORF Names:MSTP015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147166.10
HGNCiHGNC:6154 ITGB1BP2
MIMi300332 gene
neXtProtiNX_Q9UKP3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi26548
OpenTargetsiENSG00000147166
PharmGKBiPA29954

Polymorphism and mutation databases

BioMutaiITGB1BP2
DMDMi20138790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000842671 – 347Integrin beta-1-binding protein 2Add BLAST347

Proteomic databases

PaxDbiQ9UKP3
PeptideAtlasiQ9UKP3
PRIDEiQ9UKP3
ProteomicsDBi84827

PTM databases

iPTMnetiQ9UKP3
PhosphoSitePlusiQ9UKP3

Expressioni

Tissue specificityi

Expressed in skeletal and cardiac muscles but not in other tissues.

Gene expression databases

BgeeiENSG00000147166 Expressed in 118 organ(s), highest expression level in heart left ventricle
CleanExiHS_ITGB1BP2
GenevisibleiQ9UKP3 HS

Organism-specific databases

HPAiHPA040721

Interactioni

Subunit structurei

Interacts with beta-1 integrin subunit. This interaction is regulated by divalent cations, and it occurs only in absence of calcium.

Binary interactionsi

WithEntry#Exp.IntActNotes
RARAP102762EBI-5659717,EBI-413374

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117742, 10 interactors
IntActiQ9UKP3, 22 interactors
STRINGi9606.ENSP00000362935

Structurei

3D structure databases

ProteinModelPortaliQ9UKP3
SMRiQ9UKP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 64CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini149 – 208CHORD 2PROSITE-ProRule annotationAdd BLAST60
Domaini215 – 304CSPROSITE-ProRule annotationAdd BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 31SH3-bindingSequence analysis4
Motifi70 – 78SH3-bindingSequence analysis9
Motifi158 – 161SH2-bindingSequence analysis4
Motifi172 – 175SH3-bindingSequence analysis4
Motifi234 – 237SH2-bindingSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 59Cys-richAdd BLAST55
Compositional biasi149 – 203Cys-richAdd BLAST55
Compositional biasi320 – 347Asp/Glu-rich (acidic)Add BLAST28

Domaini

The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca2+ ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein.

Keywords - Domaini

Repeat, SH3-binding

Phylogenomic databases

eggNOGiKOG1667 Eukaryota
ENOG410XPV6 LUCA
GeneTreeiENSGT00390000005180
HOGENOMiHOG000207093
HOVERGENiHBG052156
InParanoidiQ9UKP3
KOiK16735
OMAiWHQTSSQ
OrthoDBiEOG091G0BY9
PhylomeDBiQ9UKP3
TreeFamiTF105394

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007051 CHORD_dom
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
PfamiView protein in Pfam
PF04968 CHORD, 2 hits
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51401 CHORD, 2 hits
PS51203 CS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UKP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLLCRNKGC GQHFDPNTNL PDSCCHHPGV PIFHDALKGW SCCRKRTVDF
60 70 80 90 100
SEFLNIKGCT MGPHCAEKLP EAPQPEGPAT SSSLQEQKPL NVIPKSAETL
110 120 130 140 150
RRERPKSELP LKLLPLNISQ ALEMALEQKE LDQEPGAGLD SLIRTGSSCQ
160 170 180 190 200
NPGCDAVYQG PESDATPCTY HPGAPRFHEG MKSWSCCGIQ TLDFGAFLAQ
210 220 230 240 250
PGCRVGRHDW GKQLPASCRH DWHQTDSLVV VTVYGQIPLP AFNWVKASQT
260 270 280 290 300
ELHVHIVFDG NRVFQAQMKL WGVINVEQSS VFLMPSRVEI SLVKADPGSW
310 320 330 340
AQLEHPDALA KKARAGVVLE MDEEESDDSD DDLSWTEEEE EEEAMGE
Length:347
Mass (Da):38,382
Last modified:May 1, 2000 - v1
Checksum:i1D0A94931821E74D
GO
Isoform 2 (identifier: Q9UKP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: LLCRNKGCGQHFDPNTNLP → T

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,374
Checksum:i90B4A0467B68A404
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563793 – 21LLCRN…NTNLP → T in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140690 mRNA Translation: AAF01676.1
AF110225 mRNA Translation: AAL36913.1
AL590762 Genomic DNA No translation available.
BC108901 mRNA Translation: AAI08902.1
CCDSiCCDS14411.1 [Q9UKP3-1]
RefSeqiNP_036410.1, NM_012278.2 [Q9UKP3-1]
UniGeneiHs.109999

Genome annotation databases

EnsembliENST00000373829; ENSP00000362935; ENSG00000147166 [Q9UKP3-1]
ENST00000538820; ENSP00000440289; ENSG00000147166 [Q9UKP3-2]
GeneIDi26548
KEGGihsa:26548
UCSCiuc004dzr.2 human [Q9UKP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140690 mRNA Translation: AAF01676.1
AF110225 mRNA Translation: AAL36913.1
AL590762 Genomic DNA No translation available.
BC108901 mRNA Translation: AAI08902.1
CCDSiCCDS14411.1 [Q9UKP3-1]
RefSeqiNP_036410.1, NM_012278.2 [Q9UKP3-1]
UniGeneiHs.109999

3D structure databases

ProteinModelPortaliQ9UKP3
SMRiQ9UKP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117742, 10 interactors
IntActiQ9UKP3, 22 interactors
STRINGi9606.ENSP00000362935

PTM databases

iPTMnetiQ9UKP3
PhosphoSitePlusiQ9UKP3

Polymorphism and mutation databases

BioMutaiITGB1BP2
DMDMi20138790

Proteomic databases

PaxDbiQ9UKP3
PeptideAtlasiQ9UKP3
PRIDEiQ9UKP3
ProteomicsDBi84827

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373829; ENSP00000362935; ENSG00000147166 [Q9UKP3-1]
ENST00000538820; ENSP00000440289; ENSG00000147166 [Q9UKP3-2]
GeneIDi26548
KEGGihsa:26548
UCSCiuc004dzr.2 human [Q9UKP3-1]

Organism-specific databases

CTDi26548
DisGeNETi26548
EuPathDBiHostDB:ENSG00000147166.10
GeneCardsiITGB1BP2
HGNCiHGNC:6154 ITGB1BP2
HPAiHPA040721
MIMi300332 gene
neXtProtiNX_Q9UKP3
OpenTargetsiENSG00000147166
PharmGKBiPA29954
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1667 Eukaryota
ENOG410XPV6 LUCA
GeneTreeiENSGT00390000005180
HOGENOMiHOG000207093
HOVERGENiHBG052156
InParanoidiQ9UKP3
KOiK16735
OMAiWHQTSSQ
OrthoDBiEOG091G0BY9
PhylomeDBiQ9UKP3
TreeFamiTF105394

Enzyme and pathway databases

SignaLinkiQ9UKP3

Miscellaneous databases

GenomeRNAii26548
PROiPR:Q9UKP3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147166 Expressed in 118 organ(s), highest expression level in heart left ventricle
CleanExiHS_ITGB1BP2
GenevisibleiQ9UKP3 HS

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007051 CHORD_dom
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
PfamiView protein in Pfam
PF04968 CHORD, 2 hits
PF04969 CS, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51401 CHORD, 2 hits
PS51203 CS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKP3
Secondary accession number(s): Q32N04, Q549J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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