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Protein

General transcription factor 3C polypeptide 4

Gene

GTF3C4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • enzyme activator activity Source: ProtInc
  • histone acetyltransferase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, DNA-binding, Transferase
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 4 (EC:2.3.1.48)
Alternative name(s):
TF3C-delta
Transcription factor IIIC 90 kDa subunit
Short name:
TFIIIC 90 kDa subunit
Short name:
TFIIIC90
Transcription factor IIIC subunit delta
Gene namesi
Name:GTF3C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000125484.11
HGNCiHGNC:4667 GTF3C4
MIMi604892 gene
neXtProtiNX_Q9UKN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125484
PharmGKBiPA29055

Polymorphism and mutation databases

BioMutaiGTF3C4
DMDMi212276467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097131 – 822General transcription factor 3C polypeptide 4Add BLAST822

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei604PhosphoserineCombined sources1
Modified residuei611PhosphoserineCombined sources1
Cross-linki629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei652PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UKN8
MaxQBiQ9UKN8
PaxDbiQ9UKN8
PeptideAtlasiQ9UKN8
PRIDEiQ9UKN8
ProteomicsDBi84826

PTM databases

iPTMnetiQ9UKN8
PhosphoSitePlusiQ9UKN8

Expressioni

Gene expression databases

BgeeiENSG00000125484 Expressed in 201 organ(s), highest expression level in forebrain
CleanExiHS_GTF3C4
ExpressionAtlasiQ9UKN8 baseline and differential
GenevisibleiQ9UKN8 HS

Organism-specific databases

HPAiHPA069369

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.2 Publications

Protein-protein interaction databases

BioGridi114738, 95 interactors
CORUMiQ9UKN8
IntActiQ9UKN8, 25 interactors
MINTiQ9UKN8
STRINGi9606.ENSP00000361219

Structurei

3D structure databases

ProteinModelPortaliQ9UKN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIIC subunit 4 family.Curated

Phylogenomic databases

eggNOGiENOG410IDZI Eukaryota
ENOG410YTGT LUCA
GeneTreeiENSGT00390000011873
HOGENOMiHOG000121774
HOVERGENiHBG059337
InParanoidiQ9UKN8
KOiK11310
OMAiWSPLGCD
OrthoDBiEOG091G060P
PhylomeDBiQ9UKN8
TreeFamiTF328412

Family and domain databases

InterProiView protein in InterPro
IPR024761 TFIIIC_delta_N
IPR024764 TFIIIC_Znf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12657 TFIIIC_delta, 1 hit
PF12660 zf-TFIIIC, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UKN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTADQARVG PADDGPAPSG EEEGEGGGEA GGKEPAADAA PGPSAAFRLM
60 70 80 90 100
VTRREPAVKL QYAVSGLEPL AWSEDHRVSV STARSIAVLE LICDVHNPGQ
110 120 130 140 150
DLVIHRTSVP APLNSCLLKV GSKTEVAECK EKFAASKDPT VSQTFMLDRV
160 170 180 190 200
FNPEGKALPP MRGFKYTSWS PMGCDANGRC LLAALTMDNR LTIQANLNRL
210 220 230 240 250
QWVQLVDLTE IYGERLYETS YRLSKNEAPE GNLGDFAEFQ RRHSMQTPVR
260 270 280 290 300
MEWSGICTTQ QVKHNNECRD VGSVLLAVLF ENGNIAVWQF QLPFVGKESI
310 320 330 340 350
SSCNTIESGI TSPSVLFWWE YEHNNRKMSG LIVGSAFGPI KILPVNLKAV
360 370 380 390 400
KGYFTLRQPV ILWKEMDQLP VHSIKCVPLY HPYQKCSCSL VVAARGSYVF
410 420 430 440 450
WCLLLISKAG LNVHNSHVTG LHSLPIVSMT ADKQNGTVYT CSSDGKVRQL
460 470 480 490 500
IPIFTDVALK FEHQLIKLSD VFGSVRTHGI AVSPCGAYLA IITTEGMING
510 520 530 540 550
LHPVNKNYQV QFVTLKTFEE AAAQLLESSV QNLFKQVDLI DLVRWKILKD
560 570 580 590 600
KHIPQFLQEA LEKKIESSGV TYFWRFKLFL LRILYQSMQK TPSEALWKPT
610 620 630 640 650
HEDSKILLVD SPGMGNADDE QQEEGTSSKQ VVKQGLQERS KEGDVEEPTD
660 670 680 690 700
DSLPTTGDAG GREPMEEKLL EIQGKIEAVE MHLTREHMKR VLGEVYLHTW
710 720 730 740 750
ITENTSIPTR GLCNFLMSDE EYDDRTARVL IGHISKKMNK QTFPEHCSLC
760 770 780 790 800
KEILPFTDRK QAVCSNGHIW LRCFLTYQSC QSLIYRRCLL HDSIARHPAP
810 820
EDPDWIKRLL QSPCPFCDSP VF
Length:822
Mass (Da):91,982
Last modified:November 4, 2008 - v2
Checksum:i2546A1E7D87F563C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z356F2Z356_HUMAN
General transcription factor 3C pol...
GTF3C4
149Annotation score:

Sequence cautioni

The sequence AAH11619 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268C → S in AAF05087 (PubMed:10523658).Curated1
Sequence conflicti402C → R in AAF05087 (PubMed:10523658).Curated1
Sequence conflicti413V → L in AAF05087 (PubMed:10523658).Curated1
Sequence conflicti450L → V in AAF05087 (PubMed:10523658).Curated1
Sequence conflicti483S → K in AAF05087 (PubMed:10523658).Curated1
Sequence conflicti690R → P in AAF05087 (PubMed:10523658).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142328 mRNA Translation: AAF05087.1
AL160165 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88011.1
BC011619 mRNA Translation: AAH11619.1 Sequence problems.
BC094774 mRNA Translation: AAH94774.1
BC104755 mRNA Translation: AAI04756.1
BC112245 mRNA Translation: AAI12246.1
CCDSiCCDS6953.1
RefSeqiNP_036336.2, NM_012204.3
UniGeneiHs.22302
Hs.656646

Genome annotation databases

EnsembliENST00000372146; ENSP00000361219; ENSG00000125484
GeneIDi9329
KEGGihsa:9329
UCSCiuc010mzv.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142328 mRNA Translation: AAF05087.1
AL160165 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88011.1
BC011619 mRNA Translation: AAH11619.1 Sequence problems.
BC094774 mRNA Translation: AAH94774.1
BC104755 mRNA Translation: AAI04756.1
BC112245 mRNA Translation: AAI12246.1
CCDSiCCDS6953.1
RefSeqiNP_036336.2, NM_012204.3
UniGeneiHs.22302
Hs.656646

3D structure databases

ProteinModelPortaliQ9UKN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114738, 95 interactors
CORUMiQ9UKN8
IntActiQ9UKN8, 25 interactors
MINTiQ9UKN8
STRINGi9606.ENSP00000361219

PTM databases

iPTMnetiQ9UKN8
PhosphoSitePlusiQ9UKN8

Polymorphism and mutation databases

BioMutaiGTF3C4
DMDMi212276467

Proteomic databases

EPDiQ9UKN8
MaxQBiQ9UKN8
PaxDbiQ9UKN8
PeptideAtlasiQ9UKN8
PRIDEiQ9UKN8
ProteomicsDBi84826

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372146; ENSP00000361219; ENSG00000125484
GeneIDi9329
KEGGihsa:9329
UCSCiuc010mzv.4 human

Organism-specific databases

CTDi9329
EuPathDBiHostDB:ENSG00000125484.11
GeneCardsiGTF3C4
HGNCiHGNC:4667 GTF3C4
HPAiHPA069369
MIMi604892 gene
neXtProtiNX_Q9UKN8
OpenTargetsiENSG00000125484
PharmGKBiPA29055
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDZI Eukaryota
ENOG410YTGT LUCA
GeneTreeiENSGT00390000011873
HOGENOMiHOG000121774
HOVERGENiHBG059337
InParanoidiQ9UKN8
KOiK11310
OMAiWSPLGCD
OrthoDBiEOG091G060P
PhylomeDBiQ9UKN8
TreeFamiTF328412

Enzyme and pathway databases

ReactomeiR-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

ChiTaRSiGTF3C4 human
GeneWikiiGTF3C4
GenomeRNAii9329
PROiPR:Q9UKN8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125484 Expressed in 201 organ(s), highest expression level in forebrain
CleanExiHS_GTF3C4
ExpressionAtlasiQ9UKN8 baseline and differential
GenevisibleiQ9UKN8 HS

Family and domain databases

InterProiView protein in InterPro
IPR024761 TFIIIC_delta_N
IPR024764 TFIIIC_Znf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12657 TFIIIC_delta, 1 hit
PF12660 zf-TFIIIC, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C4_HUMAN
AccessioniPrimary (citable) accession number: Q9UKN8
Secondary accession number(s): Q5VZJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 4, 2008
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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