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Protein

Unconventional myosin-XV

Gene

MYO15A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1315 – 1322ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • inner ear morphogenesis Source: Ensembl
  • locomotory behavior Source: Ensembl
  • sensory perception of sound Source: ProtInc

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processHearing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XV
Alternative name(s):
Unconventional myosin-15
Gene namesi
Name:MYO15A
Synonyms:MYO15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000091536.16
HGNCiHGNC:7594 MYO15A
MIMi602666 gene
neXtProtiNX_Q9UKN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 3 (DFNB3)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:600316
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0716481806L → P in DFNB3. 1 Publication1
Natural variantiVAR_0103032111N → Y in DFNB3; family from Bengkala. 1 PublicationCorresponds to variant dbSNP:rs121908966EnsemblClinVar.1
Natural variantiVAR_0103042113I → F in DFNB3; Indian family. 1 PublicationCorresponds to variant dbSNP:rs121908965EnsemblClinVar.1
Natural variantiVAR_0379642716Q → H in DFNB3. 1 PublicationCorresponds to variant dbSNP:rs121908969EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi51168
GeneReviewsiMYO15A
MalaCardsiMYO15A
MIMi600316 phenotype
OpenTargetsiENSG00000091536
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA31395

Polymorphism and mutation databases

BioMutaiMYO15A
DMDMi296439233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234741 – 3530Unconventional myosin-XVAdd BLAST3530

Proteomic databases

EPDiQ9UKN7
PaxDbiQ9UKN7
PeptideAtlasiQ9UKN7
PRIDEiQ9UKN7
ProteomicsDBi84825

PTM databases

iPTMnetiQ9UKN7
PhosphoSitePlusiQ9UKN7

Expressioni

Tissue specificityi

Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.1 Publication

Gene expression databases

BgeeiENSG00000091536 Expressed in 110 organ(s), highest expression level in adenohypophysis
CleanExiHS_MYO15A
ExpressionAtlasiQ9UKN7 baseline and differential
GenevisibleiQ9UKN7 HS

Organism-specific databases

HPAiHPA078501

Interactioni

Subunit structurei

Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with EPS8 (By similarity). Interacts with FASLG.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119348, 4 interactors
IntActiQ9UKN7, 4 interactors
STRINGi9606.ENSP00000205890

Structurei

3D structure databases

ProteinModelPortaliQ9UKN7
SMRiQ9UKN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1222 – 1899Myosin motorPROSITE-ProRule annotationAdd BLAST678
Domaini1902 – 1924IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini1925 – 1954IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini1955 – 1976IQ 3PROSITE-ProRule annotationAdd BLAST22
Domaini2065 – 2217MyTH4 1PROSITE-ProRule annotationAdd BLAST153
Domaini2867 – 2953SH3PROSITE-ProRule annotationAdd BLAST87
Domaini3050 – 3204MyTH4 2PROSITE-ProRule annotationAdd BLAST155
Domaini3209 – 3530FERMPROSITE-ProRule annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1792 – 1799Actin-bindingSequence analysis8
Regioni1888 – 2029Neck or regulatory domainAdd BLAST142
Regioni2030 – 3530TailAdd BLAST1501

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1323 – 1350Sequence analysisAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000113705
HOVERGENiHBG052554
InParanoidiQ9UKN7
KOiK10361
OMAiQAMGRAQ
PhylomeDBiQ9UKN7
TreeFamiTF316834

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd01387 MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR035487 MYO15A
IPR001609 Myosin_head_motor_dom
IPR036057 MYSc_Myo15
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR13140:SF379 PTHR13140:SF379, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKEEDEEKK AKKGKKGKKA PEPEKPKRSL KGTSRLFMGF RDRTPKISKK
60 70 80 90 100
GQFRSASAFF WGLHTGPQKT KRKRKARTVL KSTSKLMTQM RMGKKKRAMK
110 120 130 140 150
GKKPSFMVIR FPGRRGYGRL RPRARSLSKA STAINWLTKK FLLKKAEESG
160 170 180 190 200
SEQATVDAWL QRSSSRMGSR KLPFPSGAEI LRPGGRLRRF PRSRSIYASG
210 220 230 240 250
EPLGFLPFED EAPFHHSGSR KSLYGLEGFQ DLGEYYDYHR DGDDYYDRQS
260 270 280 290 300
LHRYEEQEPY LAGLGPYSPA WPPYGDHYYG YPPEDPYDYY HPDYYGGPFD
310 320 330 340 350
PGYTYGYGYD DYEPPYAPPS GYSSPYSYHD GYEGEAHPYG YYLDPYAPYD
360 370 380 390 400
APYPPYDLPY HTPYDVPYFD PYGVHYTVPY AEGVYGGGDE AIYPPEVPYF
410 420 430 440 450
YPEESASAFV YPWVPPPIPS PHNPYAHAMD DIAELEEPED AGVERQGTSF
460 470 480 490 500
RLPSAAFFEQ QGMDKPARSK LSLIRKFRLF PRPQVKLFGK EKLEVPLPPS
510 520 530 540 550
LDIPLPLGDA DEEEDEEELP PVSAVPYGHP FWGFLTPRQR NLQRALSAFG
560 570 580 590 600
AHRGLGFGPE FGRPVPRPAT SLARFLKKTL SEKKPIARLR GSQKARAGGP
610 620 630 640 650
AVREAAYKRF GYKLAGMDPE KPGTPIVLRR AQPRARSSND ARRPPAPQPA
660 670 680 690 700
PRTLSHWSAL LSPPVPPRPP SSGPPPAPPL SPALSGLPRP ASPYGSLRRH
710 720 730 740 750
PPPWAAPAHV PPAPQASWWA FVEPPAVSPE VPPDLLAFPG PRPSFRGSRR
760 770 780 790 800
RGAAFGFPGA SPRASRRRAW SPLASPQPSL RSSPGLGYCS PLAPPSPQLS
810 820 830 840 850
LRTGPFQPPF LPPARRPRSL QESPAPRRAA GRLGPPGSPL PGSPRPPSPP
860 870 880 890 900
LGLCHSPRRS SLNLPSRLPH TWRRLSEPPT RAVKPQVRLP FHRPPRAGAW
910 920 930 940 950
RAPLEHRESP REPEDSETPW TVPPLAPSWD VDMPPTQRPP SPWPGGAGSR
960 970 980 990 1000
RGFSRPPPVP ENPFLQLLGP VPSPTLQPED PAADMTRVFL GRHHEPGPGQ
1010 1020 1030 1040 1050
LTKSAGPTPE KPEEEATLGD PQLPAETKPP TPAPPKDVTP PKDITPPKDV
1060 1070 1080 1090 1100
LPEQKTLRPS LSYPLAACDQ TRATWPPWHR WGTLPQAAAP LAPIRAPEPL
1110 1120 1130 1140 1150
PKGGERRQAA PGRFAVVMPR VQKLSSFQRV GPATLKPQVQ PIQDPKPRAC
1160 1170 1180 1190 1200
SLRWSCLWLR ADAYGPWPRV HTHPQSCHLG PGAACLSLRG SWEEVGPPSW
1210 1220 1230 1240 1250
RNKMHSIRNL PSMRFREQHG EDGVEDMTQL EDLQETTVLS NLKIRFERNL
1260 1270 1280 1290 1300
IYTYIGSILV SVNPYQMFGI YGPEQVQQYN GRALGENPPH LFAVANLAFA
1310 1320 1330 1340 1350
KMLDAKQNQC IIISGESGSG KTEATKLILR YLAAMNQKRE VMQQIKILEA
1360 1370 1380 1390 1400
TPLLESFGNA KTVRNDNSSR FGKFVEIFLE GGVISGAITS QYLLEKSRIV
1410 1420 1430 1440 1450
FQAKNERNYH IFYELLAGLP AQLRQAFSLQ EAETYYYLNQ GGNCEIAGKS
1460 1470 1480 1490 1500
DADDFRRLLA AMEVLGFSSE DQDSIFRILA SILHLGNVYF EKYETDAQEV
1510 1520 1530 1540 1550
ASVVSAREIQ AVAELLQISP EGLQKAITFK VTETMREKIF TPLTVESAVD
1560 1570 1580 1590 1600
ARDAIAKVLY ALLFSWLITR VNALVSPRQD TLSIAILDIY GFEDLSFNSF
1610 1620 1630 1640 1650
EQLCINYANE NLQYLFNKIV FQEEQEEYIR EQIDWQEITF ADNQPCINLI
1660 1670 1680 1690 1700
SLKPYGILRI LDDQCCFPQA TDHTFLQKCH YHHGANPLYS KPKMPLPEFT
1710 1720 1730 1740 1750
IKHYAGKVTY QVHKFLDKNH DQVRQDVLDL FVRSRTRVVA HLFSSHAPQA
1760 1770 1780 1790 1800
APQRLGKSSS VTRLYKAHTV AAKFQQSLLD LVEKMERCNP LFMRCLKPNH
1810 1820 1830 1840 1850
KKEPGLFEPD VVMAQLRYSG VLETVRIRKE GFPVRLPFQG FIDRYCCLVA
1860 1870 1880 1890 1900
LKHDLPANGD MCVSVLSRLC KVMPNMYRVG VSKLFLKEHL YQLLESMREH
1910 1920 1930 1940 1950
VLNLAALTLQ RCLRGFFIKR RFRSLRHKII LLQSRARGYL ARQRYQQMRR
1960 1970 1980 1990 2000
SLVKFRSLVH AYVSRRRYLK LRAEWRCQVE GALLWEQEEL SKREVVAVGH
2010 2020 2030 2040 2050
LEVPAELAGL LQAVAGLGLA QVPQVAPVRT PRLQAEPRVT LPLDINNYPM
2060 2070 2080 2090 2100
AKFVQCHFKE PAFGMLTVPL RTPLTQLPAE HHAEAVSIFK LILRFMGDPH
2110 2120 2130 2140 2150
LHGARENIFG NYIVQKGLAV PELRDEILAQ LANQVWHNHN AHNAERGWLL
2160 2170 2180 2190 2200
LAACLSGFAP SPCFNKYLLK FVSDYGRNGF QAVCQHRLMQ AMGRAQQQGS
2210 2220 2230 2240 2250
GAARTLPPTQ LEWTATYEKA SMALDVGCFN GDQFSCPVHS WSTGEEVAGD
2260 2270 2280 2290 2300
ILRHRGLADG WRGWTVAMKN GVQWAELAGH DYVLDLVSDL ELLRDFPRQK
2310 2320 2330 2340 2350
SYFIVGTEGP AASRGGPKVV FGNSWDSDED MSTRPQPQEH MPKVLDSDGY
2360 2370 2380 2390 2400
SSHNQDGTNG ETEAQRGTAT HQESDSLGEP AVPHKGLDCY LDSLFDPVLS
2410 2420 2430 2440 2450
YGDADLEKPT AIAYRMKGGG QPGGGSSSGT EDTPRRPPEP KPIPGLDAST
2460 2470 2480 2490 2500
LALQQAFIHK QAVLLAREMT LQATALQQQP LSAALRSLPA EKPPAPEAQP
2510 2520 2530 2540 2550
TSVGTGPPAK PVLLRATPKP LAPAPLAKAP RLPIKPVAAP VLAQDQASPE
2560 2570 2580 2590 2600
TTSPSPELVR YSTLNSEHFP QPTQQIKNIV RQYQQPFRGG RPEALRKDGG
2610 2620 2630 2640 2650
KVFMKRPDPH EEALMILKGQ MTHLAAAPGT QVSREAVALV KPVTSAPRPS
2660 2670 2680 2690 2700
MAPTSALPSR SLEPPEELTQ TRLHRLINPN FYGYQDAPWK IFLRKEVFYP
2710 2720 2730 2740 2750
KDSYSHPVQL DLLFRQILHD TLSEACLRIS EDERLRMKAL FAQNQLDTQK
2760 2770 2780 2790 2800
PLVTESVKRA VVSTARDTWE VYFSRIFPAT GSVGTGVQLL AVSHVGIKLL
2810 2820 2830 2840 2850
RMVKGGQEAG GQLRVLRAYS FADILFVTMP SQNMLEFNLA SEKVILFSAR
2860 2870 2880 2890 2900
AHQVKTLVDD FILELKKDSD YVVAVRNFLP EDPALLAFHK GDIIHLQPLE
2910 2920 2930 2940 2950
PPRVGYSAGC VVRRKVVYLE ELRRRGPDFG WRFGTIHGRV GRFPSELVQP
2960 2970 2980 2990 3000
AAAPDFLQLP TEPGRGRAAA VAAAVASAAA AQEVGRRREG PPVRARSADH
3010 3020 3030 3040 3050
GEDALALPPY TMLEFAQKYF RDPQRRPQDG LRLKSKEPRE SRTLEDMLCF
3060 3070 3080 3090 3100
TKTPLQESLI ELSDSSLSKM ATDMFLAVMR FMGDAPLKGQ SDLDVLCNLL
3110 3120 3130 3140 3150
KLCGDHEVMR DECYCQVVKQ ITDNTSSKQD SCQRGWRLLY IVTAYHSCSE
3160 3170 3180 3190 3200
VLHPHLTRFL QDVSRTPGLP FQGIAKACEQ NLQKTLRFGG RLELPSSIEL
3210 3220 3230 3240 3250
RAMLAGRSSK RQLFLLPGGL ERHLKIKTCT VALDVVEEIC AEMALTRPEA
3260 3270 3280 3290 3300
FNEYVIFVVT NRGQHVCPLS RRAYILDVAS EMEQVDGGYM LWFRRVLWDQ
3310 3320 3330 3340 3350
PLKFENELYV TMHYNQVLPD YLKGLFSSVP ASRPSEQLLQ QVSKLASLQH
3360 3370 3380 3390 3400
RAKDHFYLPS VREVQEYIPA QLYRTTAGST WLNLVSQHRQ QTQALSPHQA
3410 3420 3430 3440 3450
RAQFLGLLSA LPMFGSSFFF IQSCSNIAVP APCILAINHN GLNFLSTETH
3460 3470 3480 3490 3500
ELMVKFPLKE IQSTRTQRPT ANSSYPYVEI ALGDVAAQRT LQLQLEQGLE
3510 3520 3530
LCRVVAVHVE NLLSAHEKRL TLPPSEITLL
Length:3,530
Mass (Da):395,293
Last modified:May 18, 2010 - v2
Checksum:iDCCFBAD37BEA6309
GO
Isoform 2 (identifier: Q9UKN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2736: Missing.
     3498-3530: GLELCRVVAVHVENLLSAHEKRLTLPPSEITLL → VRAGEVLDGRGLSLSPAGTGTVSCGGRARGEPAQCP

Note: No experimental confirmation available.
Show »
Length:797
Mass (Da):88,988
Checksum:i4B5A442322774C73
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYA1A0A087WYA1_HUMAN
Unconventional myosin-XV
MYO15A
3,530Annotation score:
A0A2R8Y712A0A2R8Y712_HUMAN
Unconventional myosin-XV
MYO15A
716Annotation score:
K7EL45K7EL45_HUMAN
Unconventional myosin-XV
MYO15A
257Annotation score:
K7EQV1K7EQV1_HUMAN
Unconventional myosin-XV
MYO15A
123Annotation score:
G3V4G3G3V4G3_HUMAN
Unconventional myosin-XV
MYO15A
153Annotation score:
K7EMS7K7EMS7_HUMAN
Unconventional myosin-XV
MYO15A
120Annotation score:
G3V4Q3G3V4Q3_HUMAN
Unconventional myosin-XV
MYO15A
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti595A → T in AAF05903 (PubMed:10552926).Curated1
Sequence conflicti595A → T in AF051976 (PubMed:10552926).Curated1
Sequence conflicti718W → G in AAF05903 (PubMed:10552926).Curated1
Sequence conflicti718W → G in AF051976 (PubMed:10552926).Curated1
Sequence conflicti1646C → R in AAF05903 (PubMed:10552926).Curated1
Sequence conflicti2468E → G in AAF05903 (PubMed:10552926).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0716481806L → P in DFNB3. 1 Publication1
Natural variantiVAR_0379591977C → R. Corresponds to variant dbSNP:rs854777EnsemblClinVar.1
Natural variantiVAR_0379602018G → R. Corresponds to variant dbSNP:rs2272571EnsemblClinVar.1
Natural variantiVAR_0103032111N → Y in DFNB3; family from Bengkala. 1 PublicationCorresponds to variant dbSNP:rs121908966EnsemblClinVar.1
Natural variantiVAR_0103042113I → F in DFNB3; Indian family. 1 PublicationCorresponds to variant dbSNP:rs121908965EnsemblClinVar.1
Natural variantiVAR_0379612205T → I Associated with moderately severe sensorineural hearing loss (DFNB3) in a Smith-Magenis syndrome patient. 1 PublicationCorresponds to variant dbSNP:rs121908970EnsemblClinVar.1
Natural variantiVAR_0379622490A → T. Corresponds to variant dbSNP:rs16960959EnsemblClinVar.1
Natural variantiVAR_0379632682Y → F. Corresponds to variant dbSNP:rs712270EnsemblClinVar.1
Natural variantiVAR_0379642716Q → H in DFNB3. 1 PublicationCorresponds to variant dbSNP:rs121908969EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566551 – 2736Missing in isoform 2. 1 PublicationAdd BLAST2736
Alternative sequenceiVSP_0566563498 – 3530GLELC…EITLL → VRAGEVLDGRGLSLSPAGTG TVSCGGRARGEPAQCP in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051976 Genomic DNA No translation available.
AF144094 mRNA Translation: AAF05903.1
AK294036 mRNA Translation: BAG57388.1
AC087164 Genomic DNA No translation available.
CCDSiCCDS42271.1 [Q9UKN7-1]
PIRiA59266
RefSeqiNP_057323.3, NM_016239.3 [Q9UKN7-1]
UniGeneiHs.462390

Genome annotation databases

EnsembliENST00000205890; ENSP00000205890; ENSG00000091536 [Q9UKN7-1]
ENST00000418233; ENSP00000408800; ENSG00000091536 [Q9UKN7-2]
ENST00000647165; ENSP00000495481; ENSG00000091536 [Q9UKN7-1]
GeneIDi51168
KEGGihsa:51168
UCSCiuc010vxi.3 human [Q9UKN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051976 Genomic DNA No translation available.
AF144094 mRNA Translation: AAF05903.1
AK294036 mRNA Translation: BAG57388.1
AC087164 Genomic DNA No translation available.
CCDSiCCDS42271.1 [Q9UKN7-1]
PIRiA59266
RefSeqiNP_057323.3, NM_016239.3 [Q9UKN7-1]
UniGeneiHs.462390

3D structure databases

ProteinModelPortaliQ9UKN7
SMRiQ9UKN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119348, 4 interactors
IntActiQ9UKN7, 4 interactors
STRINGi9606.ENSP00000205890

PTM databases

iPTMnetiQ9UKN7
PhosphoSitePlusiQ9UKN7

Polymorphism and mutation databases

BioMutaiMYO15A
DMDMi296439233

Proteomic databases

EPDiQ9UKN7
PaxDbiQ9UKN7
PeptideAtlasiQ9UKN7
PRIDEiQ9UKN7
ProteomicsDBi84825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000205890; ENSP00000205890; ENSG00000091536 [Q9UKN7-1]
ENST00000418233; ENSP00000408800; ENSG00000091536 [Q9UKN7-2]
ENST00000647165; ENSP00000495481; ENSG00000091536 [Q9UKN7-1]
GeneIDi51168
KEGGihsa:51168
UCSCiuc010vxi.3 human [Q9UKN7-1]

Organism-specific databases

CTDi51168
DisGeNETi51168
EuPathDBiHostDB:ENSG00000091536.16
GeneCardsiMYO15A
GeneReviewsiMYO15A
H-InvDBiHIX0013595
HGNCiHGNC:7594 MYO15A
HPAiHPA078501
MalaCardsiMYO15A
MIMi600316 phenotype
602666 gene
neXtProtiNX_Q9UKN7
OpenTargetsiENSG00000091536
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA31395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000113705
HOVERGENiHBG052554
InParanoidiQ9UKN7
KOiK10361
OMAiQAMGRAQ
PhylomeDBiQ9UKN7
TreeFamiTF316834

Miscellaneous databases

ChiTaRSiMYO15A human
GeneWikiiMYO15A
GenomeRNAii51168
PROiPR:Q9UKN7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091536 Expressed in 110 organ(s), highest expression level in adenohypophysis
CleanExiHS_MYO15A
ExpressionAtlasiQ9UKN7 baseline and differential
GenevisibleiQ9UKN7 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd01387 MYSc_Myo15, 1 hit
Gene3Di1.25.40.530, 2 hits
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR035487 MYO15A
IPR001609 Myosin_head_motor_dom
IPR036057 MYSc_Myo15
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR13140:SF379 PTHR13140:SF379, 1 hit
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO15_HUMAN
AccessioniPrimary (citable) accession number: Q9UKN7
Secondary accession number(s): B4DFC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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