Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (07 Oct 2020)
Sequence version 3 (08 Nov 2002)
Previous versions | rss
Add a publicationFeedback
Protein

PR domain zinc finger protein 4

Gene

PRDM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor involved in cell differentiation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri545 – 566C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri618 – 640C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri702 – 724C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri730 – 752C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UKN5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193670, p75NTR negatively regulates cell cycle via SC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 4 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM4
Synonyms:PFM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110851.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9348, PRDM4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605780, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11108

Open Targets

More...
OpenTargetsi
ENSG00000110851

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33716

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKN5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25008960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477601 – 801PR domain zinc finger protein 4Add BLAST801

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKN5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UKN5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKN5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UKN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKN5

PeptideAtlas

More...
PeptideAtlasi
Q9UKN5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKN5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84824

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues. Highly expressed in ovary, testis, pancreas, brain, heart and prostate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110851, Expressed in prostate gland and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKN5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKN5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110851, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116288, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UKN5, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9UKN5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228437

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UKN5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1801
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q9UKN5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKN5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UKN5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini412 – 529SETPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri545 – 566C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri618 – 640C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri702 – 724C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri730 – 752C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota
KOG2461, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156443

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019772_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKN5

KEGG Orthology (KO)

More...
KOi
K12463

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYISHYS

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKN5

TreeFam database of animal gene trees

More...
TreeFami
TF332513

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017124, PRDM4
IPR041493, PRDM4_Znf_knuckle
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 2 hits
PF18445, zf_PR_Knuckle, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037161, PRDM4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UKN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHHRMNEMNL SPVGMEQLTS SSVSNALPVS GSHLGLAASP THSAIPAPGL
60 70 80 90 100
PVAIPNLGPS LSSLPSALSL MLPMGIGDRG VMCGLPERNY TLPPPPYPHL
110 120 130 140 150
ESSYFRTILP GILSYLADRP PPQYIHPNSI NVDGNTALSI TNNPSALDPY
160 170 180 190 200
QSNGNVGLEP GIVSIDSRSV NTHGAQSLHP SDGHEVALDT AITMENVSRV
210 220 230 240 250
TSPISTDGMA EELTMDGVAG EHSQIPNGSR SHEPLSVDSV SNNLAADAVG
260 270 280 290 300
HGGVIPMHGN GLELPVVMET DHIASRVNGM SDSALSDSIH TVAMSTNSVS
310 320 330 340 350
VALSTSHNLA SLESVSLHEV GLSLEPVAVS SITQEVAMGT GHVDVSSDSL
360 370 380 390 400
SFVSPSLQME DSNSNKENMA TLFTIWCTLC DRAYPSDCPE HGPVTFVPDT
410 420 430 440 450
PIESRARLSL PKQLVLRQSI VGAEVGVWTG ETIPVRTCFG PLIGQQSHSM
460 470 480 490 500
EVAEWTDKAV NHIWKIYHNG VLEFCIITTD ENECNWMMFV RKARNREEQN
510 520 530 540 550
LVAYPHDGKI FFCTSQDIPP ENELLFYYSR DYAQQIGVPE HPDVHLCNCG
560 570 580 590 600
KECNSYTEFK AHLTSHIHNH LPTQGHSGSH GPSHSKERKW KCSMCPQAFI
610 620 630 640 650
SPSKLHVHFM GHMGMKPHKC DFCSKAFSDP SNLRTHLKIH TGQKNYRCTL
660 670 680 690 700
CDKSFTQKAH LESHMVIHTG EKNLKCDYCD KLFMRRQDLK QHVLIHTQER
710 720 730 740 750
QIKCPKCDKL FLRTNHLKKH LNSHEGKRDY VCEKCTKAYL TKYHLTRHLK
760 770 780 790 800
TCKGPTSSSS APEEEEEDDS EEEDLADSVG TEDCRINSAV YSADESLSAH

K
Length:801
Mass (Da):87,920
Last modified:November 8, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13B9B94F0825D113
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VRG2F8VRG2_HUMAN
PR domain zinc finger protein 4
PRDM4
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIF6H0YIF6_HUMAN
PR domain zinc finger protein 4
PRDM4
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZQ2F8VZQ2_HUMAN
PR domain zinc finger protein 4
PRDM4
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16E → A in AAD55249 (PubMed:10552934).Curated1
Sequence conflicti580H → I in AAD55249 (PubMed:10552934).Curated1
Sequence conflicti608H → Y in AAD55249 (PubMed:10552934).Curated1
Sequence conflicti662 – 663ES → GV in AAD55249 (PubMed:10552934).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF144757 mRNA Translation: AAD55249.2
BC035581 mRNA Translation: AAH35581.1
AL133083 mRNA Translation: CAB61401.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9115.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42688

NCBI Reference Sequences

More...
RefSeqi
NP_036538.3, NM_012406.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228437; ENSP00000228437; ENSG00000110851

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11108

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11108

UCSC genome browser

More...
UCSCi
uc001tmp.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144757 mRNA Translation: AAD55249.2
BC035581 mRNA Translation: AAH35581.1
AL133083 mRNA Translation: CAB61401.1
CCDSiCCDS9115.1
PIRiT42688
RefSeqiNP_036538.3, NM_012406.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L9ZNMR-A366-402[»]
3DB5X-ray2.15A/B390-540[»]
BMRBiQ9UKN5
SMRiQ9UKN5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116288, 12 interactors
IntActiQ9UKN5, 7 interactors
MINTiQ9UKN5
STRINGi9606.ENSP00000228437

PTM databases

iPTMnetiQ9UKN5
PhosphoSitePlusiQ9UKN5

Polymorphism and mutation databases

BioMutaiPRDM4
DMDMi25008960

Proteomic databases

EPDiQ9UKN5
jPOSTiQ9UKN5
MassIVEiQ9UKN5
MaxQBiQ9UKN5
PaxDbiQ9UKN5
PeptideAtlasiQ9UKN5
PRIDEiQ9UKN5
ProteomicsDBi84824

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9UKN5, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18264, 277 antibodies

The DNASU plasmid repository

More...
DNASUi
11108

Genome annotation databases

EnsembliENST00000228437; ENSP00000228437; ENSG00000110851
GeneIDi11108
KEGGihsa:11108
UCSCiuc001tmp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11108
DisGeNETi11108
EuPathDBiHostDB:ENSG00000110851.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRDM4
HGNCiHGNC:9348, PRDM4
HPAiENSG00000110851, Low tissue specificity
MIMi605780, gene
neXtProtiNX_Q9UKN5
OpenTargetsiENSG00000110851
PharmGKBiPA33716

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
KOG2461, Eukaryota
GeneTreeiENSGT00940000156443
HOGENOMiCLU_019772_0_0_1
InParanoidiQ9UKN5
KOiK12463
OMAiHYISHYS
OrthoDBi1318335at2759
PhylomeDBiQ9UKN5
TreeFamiTF332513

Enzyme and pathway databases

PathwayCommonsiQ9UKN5
ReactomeiR-HSA-193670, p75NTR negatively regulates cell cycle via SC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11108, 5 hits in 893 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRDM4, human
EvolutionaryTraceiQ9UKN5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11108
PharosiQ9UKN5, Tbio

Protein Ontology

More...
PROi
PR:Q9UKN5
RNActiQ9UKN5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110851, Expressed in prostate gland and 243 other tissues
ExpressionAtlasiQ9UKN5, baseline and differential
GenevisibleiQ9UKN5, HS

Family and domain databases

InterProiView protein in InterPro
IPR017124, PRDM4
IPR041493, PRDM4_Znf_knuckle
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
PF18445, zf_PR_Knuckle, 1 hit
PIRSFiPIRSF037161, PRDM4, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 7 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDM4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKN5
Secondary accession number(s): Q9UFA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 8, 2002
Last modified: October 7, 2020
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again