UniProtKB - Q9UKM7 (MA1B1_HUMAN)
Protein
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Gene
MAN1B1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2.2 Publications
Caution
It is uncertain whether Met-1 or Met-37 is the initiator.Curated
Catalytic activityi
- 4 H2O + N4-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 β-D-mannose + N4-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)3 PublicationsEC:3.2.1.1133 Publications
- 3 H2O + N4-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 β-D-mannose + N4-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)3 PublicationsEC:3.2.1.1133 Publications
Cofactori
Ca2+By similarity
Activity regulationi
Inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine.1 Publication
Kineticsi
- KM=0.4 mM for Man9GlcNAc21 Publication
pH dependencei
Optimum pH is between 6.5 and 6.9.1 Publication
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarityView all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 330 | Proton donorCurated | 1 | |
Active sitei | 463 | Curated | 1 | |
Active sitei | 570 | Proton donorBy similarity | 1 | |
Active sitei | 599 | Curated | 1 | |
Metal bindingi | 688 | CalciumBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB
GO - Biological processi
- endoplasmic reticulum mannose trimming Source: ParkinsonsUK-UCL
- mannose trimming involved in glycoprotein ERAD pathway Source: ParkinsonsUK-UCL
- N-glycan processing Source: GO_Central
- oligosaccharide metabolic process Source: ProtInc
- protein alpha-1,2-demannosylation Source: ParkinsonsUK-UCL
- protein glycosylation Source: UniProtKB-UniPathway
- trimming of first mannose on A branch Source: Reactome
- trimming of second mannose on A branch Source: Reactome
- trimming of terminal mannose on B branch Source: ParkinsonsUK-UCL
- trimming of terminal mannose on C branch Source: Reactome
- ubiquitin-dependent ERAD pathway Source: UniProtKB
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS11144-MONOMER |
BRENDAi | 3.2.1.113, 2681 |
PathwayCommonsi | Q9UKM7 |
Reactomei | R-HSA-4793950, Defective MAN1B1 causes MRT15 R-HSA-901032, ER Quality Control Compartment (ERQC) |
SABIO-RKi | Q9UKM7 |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GH47, Glycoside Hydrolase Family 47 |
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC:3.2.1.1133 Publications)Alternative name(s): ER alpha-1,2-mannosidase ER mannosidase 1 Short name: ERMan1 Man9GlcNAc2-specific-processing alpha-mannosidase Mannosidase alpha class 1B member 1 |
Gene namesi | Name:MAN1B1 ORF Names:UNQ747/PRO1477 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177239.14 |
HGNCi | HGNC:6823, MAN1B1 |
MIMi | 604346, gene |
neXtProti | NX_Q9UKM7 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- endoplasmic reticulum quality control compartment Source: ParkinsonsUK-UCL
Extracellular region or secreted
- extracellular vesicle Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: ParkinsonsUK-UCL
Other locations
- integral component of membrane Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 84 | CytoplasmicSequence analysisAdd BLAST | 84 | |
Transmembranei | 85 – 105 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 699 | LumenalSequence analysisAdd BLAST | 594 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Mental retardation, autosomal recessive 15 (MRT15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066592 | 334 | R → C in MRT15; results in about 1300-fold decrease in activity. 1 PublicationCorresponds to variant dbSNP:rs387906886EnsemblClinVar. | 1 | |
Natural variantiVAR_066593 | 397 | E → K in MRT15; disrupts stable protein expression. 1 PublicationCorresponds to variant dbSNP:rs387906885EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 330 | E → Q: About 44-fold reduction in K(cat), slight reduction in K(m), about 100-fold increase in binding affinity for Man(9)GlcnAc(2) but no change in binding affinity for the inhibitor, dMNJ. Even further greater reduction in K(cat) and increase in K(m); when associated with Q-599. 1 Publication | 1 | |
Mutagenesisi | 463 | D → N: Some reduction in K(cat) but no change in K(m), abolishes almost all binding to Man(9)GlcnAc(2) but reduced binding to the inhibitor dMNJ by about 73-fold. Further reduction in K(m) but slight increase in K(m); when associated with Q-599. 1 Publication | 1 | |
Mutagenesisi | 524 | H → A: About 4-fold reduction in K(cat). 1 Publication | 1 | |
Mutagenesisi | 599 | E → Q: Very significant reduction in K(cat), 4-fold weaker binding affinity for Man(9)GlcnAc(2) but about 1000-fold reduction in binding affinity for the inhibitor, dMNJ. Significant reductions in K(cat) and slight increase in K(m); when associated with E-330 or N-463. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 11253 |
MalaCardsi | MAN1B1 |
MIMi | 614202, phenotype |
OpenTargetsi | ENSG00000177239 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability 397941, MAN1B1-CDG |
PharmGKBi | PA30572 |
Miscellaneous databases
Pharosi | Q9UKM7, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2308 |
DrugBanki | DB01955, 1,4-Butanediol DB03206, Duvoglustat DB02742, Kifunensine DB02422, Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside |
Polymorphism and mutation databases
BioMutai | MAN1B1 |
DMDMi | 93195043 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210314 | 1 – 699 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseAdd BLAST | 699 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 527 ↔ 556 | 1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | Q9UKM7 |
jPOSTi | Q9UKM7 |
MassIVEi | Q9UKM7 |
MaxQBi | Q9UKM7 |
PaxDbi | Q9UKM7 |
PeptideAtlasi | Q9UKM7 |
PRIDEi | Q9UKM7 |
ProteomicsDBi | 84820 |
PTM databases
GlyGeni | Q9UKM7, 4 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q9UKM7 |
PhosphoSitePlusi | Q9UKM7 |
SwissPalmi | Q9UKM7 |
Expressioni
Tissue specificityi
Widely expressed.2 Publications
Gene expression databases
Bgeei | ENSG00000177239, Expressed in stromal cell of endometrium and 226 other tissues |
ExpressionAtlasi | Q9UKM7, baseline and differential |
Genevisiblei | Q9UKM7, HS |
Organism-specific databases
HPAi | ENSG00000177239, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116414, 49 interactors |
IntActi | Q9UKM7, 10 interactors |
MINTi | Q9UKM7 |
STRINGi | 9606.ENSP00000360645 |
Chemistry databases
BindingDBi | Q9UKM7 |
Miscellaneous databases
RNActi | Q9UKM7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UKM7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UKM7 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 45 | Poly-Pro | 7 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 47 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2431, Eukaryota |
GeneTreei | ENSGT00940000155422 |
HOGENOMi | CLU_003818_3_3_1 |
InParanoidi | Q9UKM7 |
OMAi | RKHLVTY |
OrthoDBi | 693882at2759 |
PhylomeDBi | Q9UKM7 |
TreeFami | TF354274 |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases |
Pfami | View protein in Pfam PF01532, Glyco_hydro_47, 1 hit |
PRINTSi | PR00747, GLYHDRLASE47 |
SUPFAMi | SSF48225, SSF48225, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9UKM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAACEGRRSG ALGSSQSDFL TPPVGGAPWA VATTVVMYPP PPPPPHRDFI
60 70 80 90 100
SVTLSFGENY DNSKSWRRRS CWRKWKQLSR LQRNMILFLL AFLLFCGLLF
110 120 130 140 150
YINLADHWKA LAFRLEEEQK MRPEIAGLKP ANPPVLPAPQ KADTDPENLP
160 170 180 190 200
EISSQKTQRH IQRGPPHLQI RPPSQDLKDG TQEEATKRQE APVDPRPEGD
210 220 230 240 250
PQRTVISWRG AVIEPEQGTE LPSRRAEVPT KPPLPPARTQ GTPVHLNYRQ
260 270 280 290 300
KGVIDVFLHA WKGYRKFAWG HDELKPVSRS FSEWFGLGLT LIDALDTMWI
310 320 330 340 350
LGLRKEFEEA RKWVSKKLHF EKDVDVNLFE STIRILGGLL SAYHLSGDSL
360 370 380 390 400
FLRKAEDFGN RLMPAFRTPS KIPYSDVNIG TGVAHPPRWT SDSTVAEVTS
410 420 430 440 450
IQLEFRELSR LTGDKKFQEA VEKVTQHIHG LSGKKDGLVP MFINTHSGLF
460 470 480 490 500
THLGVFTLGA RADSYYEYLL KQWIQGGKQE TQLLEDYVEA IEGVRTHLLR
510 520 530 540 550
HSEPSKLTFV GELAHGRFSA KMDHLVCFLP GTLALGVYHG LPASHMELAQ
560 570 580 590 600
ELMETCYQMN RQMETGLSPE IVHFNLYPQP GRRDVEVKPA DRHNLLRPET
610 620 630 640 650
VESLFYLYRV TGDRKYQDWG WEILQSFSRF TRVPSGGYSS INNVQDPQKP
660 670 680 690
EPRDKMESFF LGETLKYLFL LFSDDPNLLS LDAYVFNTEA HPLPIWTPA
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YG20 | H0YG20_HUMAN | alpha-1,2-Mannosidase | MAN1B1 | 695 | Annotation score: | ||
H0YGV7 | H0YGV7_HUMAN | alpha-1,2-Mannosidase | MAN1B1 | 550 | Annotation score: | ||
H0YIU0 | H0YIU0_HUMAN | Endoplasmic reticulum mannosyl-olig... | MAN1B1 | 124 | Annotation score: | ||
H0YI64 | H0YI64_HUMAN | Endoplasmic reticulum mannosyl-olig... | MAN1B1 | 270 | Annotation score: | ||
H0YGQ1 | H0YGQ1_HUMAN | Endoplasmic reticulum mannosyl-olig... | MAN1B1 | 182 | Annotation score: | ||
A0A087X064 | A0A087X064_HUMAN | Endoplasmic reticulum mannosyl-olig... | MAN1B1 | 115 | Annotation score: | ||
H0YFU3 | H0YFU3_HUMAN | Endoplasmic reticulum mannosyl-olig... | MAN1B1 | 52 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | T → A in AAD45504 (PubMed:10409699).Curated | 1 | |
Sequence conflicti | 223 | S → P in AAD45504 (PubMed:10409699).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055841 | 59 | N → S4 PublicationsCorresponds to variant dbSNP:rs968733EnsemblClinVar. | 1 | |
Natural variantiVAR_066592 | 334 | R → C in MRT15; results in about 1300-fold decrease in activity. 1 PublicationCorresponds to variant dbSNP:rs387906886EnsemblClinVar. | 1 | |
Natural variantiVAR_066593 | 397 | E → K in MRT15; disrupts stable protein expression. 1 PublicationCorresponds to variant dbSNP:rs387906885EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148509 mRNA Translation: AAF03215.1 AF145732 mRNA Translation: AAD45504.1 AY358465 mRNA Translation: AAQ88830.1 AL929554 Genomic DNA No translation available. AL807752 Genomic DNA No translation available. BC002953 mRNA Translation: AAH02953.1 BC006079 mRNA Translation: AAH06079.1 |
CCDSi | CCDS7029.1 |
RefSeqi | NP_057303.2, NM_016219.4 |
Genome annotation databases
Ensembli | ENST00000371589; ENSP00000360645; ENSG00000177239 |
GeneIDi | 11253 |
KEGGi | hsa:11253 |
UCSCi | uc004cld.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148509 mRNA Translation: AAF03215.1 AF145732 mRNA Translation: AAD45504.1 AY358465 mRNA Translation: AAQ88830.1 AL929554 Genomic DNA No translation available. AL807752 Genomic DNA No translation available. BC002953 mRNA Translation: AAH02953.1 BC006079 mRNA Translation: AAH06079.1 |
CCDSi | CCDS7029.1 |
RefSeqi | NP_057303.2, NM_016219.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FMI | X-ray | 1.90 | A | 243-697 | [»] | |
1FO2 | X-ray | 2.38 | A | 243-699 | [»] | |
1FO3 | X-ray | 1.75 | A | 243-699 | [»] | |
1X9D | X-ray | 1.41 | A | 172-699 | [»] | |
5KIJ | X-ray | 1.65 | A | 245-696 | [»] | |
5KK7 | X-ray | 1.73 | A/B | 245-699 | [»] | |
SMRi | Q9UKM7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116414, 49 interactors |
IntActi | Q9UKM7, 10 interactors |
MINTi | Q9UKM7 |
STRINGi | 9606.ENSP00000360645 |
Chemistry databases
BindingDBi | Q9UKM7 |
ChEMBLi | CHEMBL2308 |
DrugBanki | DB01955, 1,4-Butanediol DB03206, Duvoglustat DB02742, Kifunensine DB02422, Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-Mannopyranoside |
Protein family/group databases
CAZyi | GH47, Glycoside Hydrolase Family 47 |
PTM databases
GlyGeni | Q9UKM7, 4 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q9UKM7 |
PhosphoSitePlusi | Q9UKM7 |
SwissPalmi | Q9UKM7 |
Polymorphism and mutation databases
BioMutai | MAN1B1 |
DMDMi | 93195043 |
Proteomic databases
EPDi | Q9UKM7 |
jPOSTi | Q9UKM7 |
MassIVEi | Q9UKM7 |
MaxQBi | Q9UKM7 |
PaxDbi | Q9UKM7 |
PeptideAtlasi | Q9UKM7 |
PRIDEi | Q9UKM7 |
ProteomicsDBi | 84820 |
Protocols and materials databases
Antibodypediai | 32359, 139 antibodies |
DNASUi | 11253 |
Genome annotation databases
Ensembli | ENST00000371589; ENSP00000360645; ENSG00000177239 |
GeneIDi | 11253 |
KEGGi | hsa:11253 |
UCSCi | uc004cld.3, human |
Organism-specific databases
CTDi | 11253 |
DisGeNETi | 11253 |
EuPathDBi | HostDB:ENSG00000177239.14 |
GeneCardsi | MAN1B1 |
HGNCi | HGNC:6823, MAN1B1 |
HPAi | ENSG00000177239, Low tissue specificity |
MalaCardsi | MAN1B1 |
MIMi | 604346, gene 614202, phenotype |
neXtProti | NX_Q9UKM7 |
OpenTargetsi | ENSG00000177239 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability 397941, MAN1B1-CDG |
PharmGKBi | PA30572 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2431, Eukaryota |
GeneTreei | ENSGT00940000155422 |
HOGENOMi | CLU_003818_3_3_1 |
InParanoidi | Q9UKM7 |
OMAi | RKHLVTY |
OrthoDBi | 693882at2759 |
PhylomeDBi | Q9UKM7 |
TreeFami | TF354274 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
BioCyci | MetaCyc:HS11144-MONOMER |
BRENDAi | 3.2.1.113, 2681 |
PathwayCommonsi | Q9UKM7 |
Reactomei | R-HSA-4793950, Defective MAN1B1 causes MRT15 R-HSA-901032, ER Quality Control Compartment (ERQC) |
SABIO-RKi | Q9UKM7 |
Miscellaneous databases
BioGRID-ORCSi | 11253, 5 hits in 841 CRISPR screens |
ChiTaRSi | MAN1B1, human |
EvolutionaryTracei | Q9UKM7 |
GeneWikii | MAN1B1 |
GenomeRNAii | 11253 |
Pharosi | Q9UKM7, Tchem |
PROi | PR:Q9UKM7 |
RNActi | Q9UKM7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177239, Expressed in stromal cell of endometrium and 226 other tissues |
ExpressionAtlasi | Q9UKM7, baseline and differential |
Genevisiblei | Q9UKM7, HS |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases |
Pfami | View protein in Pfam PF01532, Glyco_hydro_47, 1 hit |
PRINTSi | PR00747, GLYHDRLASE47 |
SUPFAMi | SSF48225, SSF48225, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MA1B1_HUMAN | |
Accessioni | Q9UKM7Primary (citable) accession number: Q9UKM7 Secondary accession number(s): Q5VSG3, Q9BRS9, Q9Y5K7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries