PCTP

Functionⁱ

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	72	Phosphatidylcholine	1
Binding siteⁱ	78	Phosphatidylcholine	1
Binding siteⁱ	157	Phosphatidylcholine	1

GO - Molecular functionⁱ

phosphatidylcholine binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12055623
phosphatidylcholine transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12055623

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid transport
Source: UniProtKB
Non-traceable author statementⁱ
- 10542325
phosphatidylcholine biosynthetic process Source: Reactome
phospholipid transport
Source: UniProtKB
Inferred from direct assayⁱ
- 12055623

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483191 Synthesis of PC R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Reactomeⁱ

R-HSA-1483191 Synthesis of PC
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Chemistry databases

SwissLipidsⁱ	SLP:000001541

SwissLipidsⁱ

SLP:000001541

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylcholine transfer protein Short name: PC-TP Alternative name(s): START domain-containing protein 2 Short name: StARD2 StAR-related lipid transfer protein 2
Gene namesⁱ	Name:PCTP Synonyms:STARD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141179.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8752 PCTP
MIMⁱ	606055 gene
neXtProtⁱ	NX_Q9UKL6

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	63	C → A: Reduces activity by 20%. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	58488
Open Targets More...OpenTargetsⁱ	ENSG00000141179
PharmGKBⁱ	PA33098

Chemistry databases

DrugBankⁱ

DB04372 Di-Linoleoyl-3-Sn-Phosphatidylcholine
DB02306 Palmitoyl-Linoleoyl Phosphatidylcholine

Polymorphism and mutation databases

BioMutaⁱ	PCTP
DMDMⁱ	15214192

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220658	1 – 214	Phosphatidylcholine transfer proteinAdd BLAST		214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity		1
Modified residueⁱ	139	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UKL6
PaxDbⁱ	Q9UKL6
PeptideAtlas More...PeptideAtlasⁱ	Q9UKL6
PRIDEⁱ	Q9UKL6
ProteomicsDBⁱ	84818 84819 [Q9UKL6-2]

PTM databases

iPTMnetⁱ	Q9UKL6
PhosphoSitePlusⁱ	Q9UKL6

Expressionⁱ

Tissue specificityⁱ

Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung. No expression detected in thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000141179
CleanExⁱ	HS_PCTP
ExpressionAtlasⁱ	Q9UKL6 baseline and differential
Genevisibleⁱ	Q9UKL6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022979

HPAⁱ

HPA022979

Interactionⁱ

Subunit structureⁱ

Interacts with ACOT13/THEM2.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AGTRAP	Q6RW13	3	EBI-4402391,EBI-741181

With

Entry

#Exp.

IntAct

Notes

AGTRAP

Q6RW13

3

EBI-4402391,EBI-741181

Protein-protein interaction databases

BioGridⁱ	121818, 5 interactors
IntActⁱ	Q9UKL6, 1 interactor
STRINGⁱ	9606.ENSP00000268896

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 15	Combined sources	6
Helixⁱ	18 – 21	Combined sources	4
Turnⁱ	26 – 29	Combined sources	4
Beta strandⁱ	31 – 36	Combined sources	6
Beta strandⁱ	39 – 45	Combined sources	7
Turnⁱ	47 – 49	Combined sources	3
Beta strandⁱ	52 – 60	Combined sources	9
Helixⁱ	65 – 73	Combined sources	9
Helixⁱ	75 – 81	Combined sources	7
Beta strandⁱ	85 – 93	Combined sources	9
Beta strandⁱ	96 – 103	Combined sources	8
Beta strandⁱ	107 – 109	Combined sources	3
Beta strandⁱ	112 – 123	Combined sources	12
Helixⁱ	125 – 127	Combined sources	3
Beta strandⁱ	130 – 137	Combined sources	8
Beta strandⁱ	149 – 152	Combined sources	4
Beta strandⁱ	155 – 163	Combined sources	9
Beta strandⁱ	165 – 177	Combined sources	13
Helixⁱ	185 – 193	Combined sources	9
Helixⁱ	195 – 208	Combined sources	14

3D structure databases

ProteinModelPortalⁱ	Q9UKL6
SMRⁱ	Q9UKL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UKL6

EvolutionaryTraceⁱ

Q9UKL6

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 212	STARTPROSITE-ProRule annotationAdd BLAST		212

Phylogenomic databases

eggNOGⁱ	KOG2761 Eukaryota ENOG4111HC0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063520
HOGENOMⁱ	HOG000261644
HOVERGENⁱ	HBG008237
InParanoidⁱ	Q9UKL6
OMAⁱ	CADVYMD
PhylomeDBⁱ	Q9UKL6
TreeFamⁱ	TF320705

Family and domain databases

Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR023393 START-like_dom_sf IPR002913 START_lipid-bd_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01852 START, 1 hit
SMARTⁱ	View protein in SMART SM00234 START, 1 hit
PROSITEⁱ	View protein in PROSITE PS50848 START, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9UKL6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELAAGSFSE EQFWEACAEL QQPALAGADW QLLVETSGIS IYRLLDKKTG 
        60         70         80         90        100
LYEYKVFGVL EDCSPTLLAD IYMDSDYRKQ WDQYVKELYE QECNGETVVY 
       110        120        130        140        150
WEVKYPFPMS NRDYVYLRQR RDLDMEGRKI HVILARSTSM PQLGERSGVI 
       160        170        180        190        200
RVKQYKQSLA IESDGKKGSK VFMYYFDNPG GQIPSWLINW AAKNGVPNFL 
       210 
KDMARACQNY LKKT

Length:214

Mass (Da):24,843

Last modified:May 1, 2000 - v1

Checksum:ⁱE40204B7C0A9AF83

GO

Isoform 2 (identifier: Q9UKL6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-72: Missing.

« Hide

        10         20         30         40         50
MDSDYRKQWD QYVKELYEQE CNGETVVYWE VKYPFPMSNR DYVYLRQRRD 
        60         70         80         90        100
LDMEGRKIHV ILARSTSMPQ LGERSGVIRV KQYKQSLAIE SDGKKGSKVF 
       110        120        130        140 
MYYFDNPGGQ IPSWLINWAA KNGVPNFLKD MARACQNYLK KT

Show »

Length:142

Mass (Da):16,824

Checksum:ⁱ1BA1CE03358BAB59

GO

Sequence cautionⁱ

The sequence AAH05112 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	52	Y → H in AAF08347 (PubMed:10542325).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052070	10	E → A. Corresponds to variant dbSNP:rs12941739Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041363	1 – 72	Missing in isoform 2. 1 PublicationAdd BLAST		72

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF114436 AF114435 Genomic DNA Translation: AAF08347.1 AF114430 mRNA Translation: AAF08345.1 AF151638 mRNA Translation: AAF02536.1 AC009837 Genomic DNA No translation available. AC091155 Genomic DNA No translation available. BC005112 mRNA Translation: AAH05112.1 Different initiation. BC012084 mRNA Translation: AAH12084.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11588.1 [Q9UKL6-1] CCDS45741.1 [Q9UKL6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001095872.1, NM_001102402.2 [Q9UKL6-2] NP_001317307.1, NM_001330378.1 NP_067036.2, NM_021213.3 [Q9UKL6-1]
UniGeneⁱ	Hs.285218

Genome annotation databases

Ensemblⁱ	ENST00000268896; ENSP00000268896; ENSG00000141179 [Q9UKL6-1] ENST00000325214; ENSP00000325181; ENSG00000141179 [Q9UKL6-2]
GeneIDⁱ	58488
KEGGⁱ	hsa:58488
UCSC genome browser More...UCSCⁱ	uc002iul.5 human [Q9UKL6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9UKL6	Phosphatidylcholine transfer protein, isoform CRA_c		HUMAN		214
PCTP isoform 6		PANTR		142
Q9UKL6-2				142

Protein	Similar proteins		Species	Score	Length
Q9UKL6	Phosphatidylcholine transfer protein, isoform CRA_c		HUMAN		214
PCTP isoform 6		PANTR		142
Phosphatidylcholine transfer protein		GORGO		219
Phosphatidylcholine transfer protein		MACMU		219
Phosphatidylcholine transfer protein		COLAP		219
+38

Protein	Similar proteins		Species	Score	Length
Q9UKL6	Phosphatidylcholine transfer protein, isoform CRA_c		HUMAN		214
PCTP isoform 6		PANTR		142
Phosphatidylcholine transfer protein		GORGO		219
PCTP isoform 3		PONAB		219
Phosphatidylcholine transfer protein		PANPA		219
+238

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF114436 AF114435 Genomic DNA Translation: AAF08347.1 AF114430 mRNA Translation: AAF08345.1 AF151638 mRNA Translation: AAF02536.1 AC009837 Genomic DNA No translation available. AC091155 Genomic DNA No translation available. BC005112 mRNA Translation: AAH05112.1 Different initiation. BC012084 mRNA Translation: AAH12084.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11588.1 [Q9UKL6-1] CCDS45741.1 [Q9UKL6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001095872.1, NM_001102402.2 [Q9UKL6-2] NP_001317307.1, NM_001330378.1 NP_067036.2, NM_021213.3 [Q9UKL6-1]
UniGeneⁱ	Hs.285218

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LN1	X-ray	2.40	A	1-214	[»]
	1LN2	X-ray	2.90	A/B	1-214	[»]
	1LN3	X-ray	2.90	A/B	1-214	[»]
ProteinModelPortalⁱ	Q9UKL6
SMRⁱ	Q9UKL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121818, 5 interactors
IntActⁱ	Q9UKL6, 1 interactor
STRINGⁱ	9606.ENSP00000268896

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB04372 Di-Linoleoyl-3-Sn-Phosphatidylcholine DB02306 Palmitoyl-Linoleoyl Phosphatidylcholine
SwissLipidsⁱ	SLP:000001541

PTM databases

iPTMnetⁱ	Q9UKL6
PhosphoSitePlusⁱ	Q9UKL6

Polymorphism and mutation databases

BioMutaⁱ	PCTP
DMDMⁱ	15214192

Proteomic databases

EPDⁱ	Q9UKL6
PaxDbⁱ	Q9UKL6
PeptideAtlas More...PeptideAtlasⁱ	Q9UKL6
PRIDEⁱ	Q9UKL6
ProteomicsDBⁱ	84818 84819 [Q9UKL6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	58488
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000268896; ENSP00000268896; ENSG00000141179 [Q9UKL6-1] ENST00000325214; ENSP00000325181; ENSG00000141179 [Q9UKL6-2]
GeneIDⁱ	58488
KEGGⁱ	hsa:58488
UCSC genome browser More...UCSCⁱ	uc002iul.5 human [Q9UKL6-1]

Organism-specific databases

CTDⁱ	58488
DisGeNET More...DisGeNETⁱ	58488
EuPathDBⁱ	HostDB:ENSG00000141179.13
GeneCardsⁱ	PCTP
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8752 PCTP
Human Protein Atlas More...HPAⁱ	HPA022979
MIMⁱ	606055 gene
neXtProtⁱ	NX_Q9UKL6
Open Targets More...OpenTargetsⁱ	ENSG00000141179
PharmGKBⁱ	PA33098
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2761 Eukaryota ENOG4111HC0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063520
HOGENOMⁱ	HOG000261644
HOVERGENⁱ	HBG008237
InParanoidⁱ	Q9UKL6
OMAⁱ	CADVYMD
PhylomeDBⁱ	Q9UKL6
TreeFamⁱ	TF320705

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483191 Synthesis of PC R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Reactomeⁱ

R-HSA-1483191 Synthesis of PC
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Miscellaneous databases

ChiTaRSⁱ	PCTP human
EvolutionaryTraceⁱ	Q9UKL6
GeneWikiⁱ	Phosphatidylcholine_transfer_protein
GenomeRNAiⁱ	58488
Protein Ontology More...PROⁱ	PR:Q9UKL6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141179
CleanExⁱ	HS_PCTP
ExpressionAtlasⁱ	Q9UKL6 baseline and differential
Genevisibleⁱ	Q9UKL6 HS

Family and domain databases

Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR023393 START-like_dom_sf IPR002913 START_lipid-bd_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01852 START, 1 hit
SMARTⁱ	View protein in SMART SM00234 START, 1 hit
PROSITEⁱ	View protein in PROSITE PS50848 START, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPCT_HUMAN
Accessionⁱ	Q9UKL6Primary (citable) accession number: Q9UKL6 Secondary accession number(s): Q9BSC9, Q9UIT3, Q9UKW7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
	Last sequence update:	May 1, 2000
	Last modified:	June 20, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9UKL6 (PPCT_HUMAN)

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Phosphatidylcholine transfer protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ