UniProtKB - Q9UKL6 (PPCT_HUMAN)
Protein
Phosphatidylcholine transfer protein
Gene
PCTP
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 72 | Phosphatidylcholine | 1 | |
Binding sitei | 78 | Phosphatidylcholine | 1 | |
Binding sitei | 157 | Phosphatidylcholine | 1 |
GO - Molecular functioni
- phosphatidylcholine binding Source: UniProtKB
- phosphatidylcholine transporter activity Source: UniProtKB
GO - Biological processi
- lipid transport Source: UniProtKB
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- phosphatidylcholine biosynthetic process Source: Reactome
- phospholipid transport Source: UniProtKB
Keywordsi
Biological process | Lipid transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UKL6 |
Reactomei | R-HSA-1483191, Synthesis of PC R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation |
Chemistry databases
SwissLipidsi | SLP:000001541 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylcholine transfer proteinShort name: PC-TP Alternative name(s): START domain-containing protein 2 Short name: StARD2 StAR-related lipid transfer protein 2 |
Gene namesi | Name:PCTP Synonyms:STARD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141179.13 |
HGNCi | HGNC:8752, PCTP |
MIMi | 606055, gene |
neXtProti | NX_Q9UKL6 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 63 | C → A: Reduces activity by 20%. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 58488 |
OpenTargetsi | ENSG00000141179 |
PharmGKBi | PA33098 |
Miscellaneous databases
Pharosi | Q9UKL6, Tbio |
Chemistry databases
DrugBanki | DB04372, L-Dilinoleoyllecithin DB09568, Omega-3-carboxylic acids DB02306, Palmitoyl-Linoleoyl Phosphatidylcholine |
Polymorphism and mutation databases
BioMutai | PCTP |
DMDMi | 15214192 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220658 | 1 – 214 | Phosphatidylcholine transfer proteinAdd BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UKL6 |
MassIVEi | Q9UKL6 |
PaxDbi | Q9UKL6 |
PeptideAtlasi | Q9UKL6 |
PRIDEi | Q9UKL6 |
ProteomicsDBi | 84818 [Q9UKL6-1] 84819 [Q9UKL6-2] |
PTM databases
iPTMneti | Q9UKL6 |
MetOSitei | Q9UKL6 |
PhosphoSitePlusi | Q9UKL6 |
Expressioni
Tissue specificityi
Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung. No expression detected in thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000141179, Expressed in secondary oocyte and 213 other tissues |
ExpressionAtlasi | Q9UKL6, baseline and differential |
Genevisiblei | Q9UKL6, HS |
Organism-specific databases
HPAi | ENSG00000141179, Tissue enhanced (blood, liver) |
Interactioni
Subunit structurei
Interacts with ACOT13/THEM2.
By similarityBinary interactionsi
Q9UKL6
With | #Exp. | IntAct |
---|---|---|
AGTRAP [Q6RW13] | 3 | EBI-4402391,EBI-741181 |
Protein-protein interaction databases
BioGRIDi | 121818, 6 interactors |
IntActi | Q9UKL6, 2 interactors |
STRINGi | 9606.ENSP00000268896 |
Miscellaneous databases
RNActi | Q9UKL6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UKL6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UKL6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 212 | STARTPROSITE-ProRule annotationAdd BLAST | 212 |
Phylogenomic databases
eggNOGi | KOG2761, Eukaryota |
GeneTreei | ENSGT00940000156843 |
HOGENOMi | CLU_042209_1_0_1 |
InParanoidi | Q9UKL6 |
OMAi | KQWDSYV |
OrthoDBi | 973910at2759 |
PhylomeDBi | Q9UKL6 |
TreeFami | TF320705 |
Family and domain databases
CDDi | cd08910, START_STARD2-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR041950, STARD2_START IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS50848, START, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UKL6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELAAGSFSE EQFWEACAEL QQPALAGADW QLLVETSGIS IYRLLDKKTG
60 70 80 90 100
LYEYKVFGVL EDCSPTLLAD IYMDSDYRKQ WDQYVKELYE QECNGETVVY
110 120 130 140 150
WEVKYPFPMS NRDYVYLRQR RDLDMEGRKI HVILARSTSM PQLGERSGVI
160 170 180 190 200
RVKQYKQSLA IESDGKKGSK VFMYYFDNPG GQIPSWLINW AAKNGVPNFL
210
KDMARACQNY LKKT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L3H0 | I3L3H0_HUMAN | Phosphatidylcholine transfer protei... | PCTP hCG_33147 | 219 | Annotation score: | ||
I3L2M9 | I3L2M9_HUMAN | Phosphatidylcholine transfer protei... | PCTP hCG_33147 | 203 | Annotation score: | ||
I3L4Z8 | I3L4Z8_HUMAN | Phosphatidylcholine transfer protei... | PCTP | 146 | Annotation score: | ||
J3QT99 | J3QT99_HUMAN | Phosphatidylcholine transfer protei... | PCTP | 64 | Annotation score: |
Sequence cautioni
The sequence AAH05112 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | Y → H in AAF08347 (PubMed:10542325).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052070 | 10 | E → A. Corresponds to variant dbSNP:rs12941739Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041363 | 1 – 72 | Missing in isoform 2. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF114436 , AF114431, AF114432, AF114433, AF114434, AF114435 Genomic DNA Translation: AAF08347.1 AF114430 mRNA Translation: AAF08345.1 AF151638 mRNA Translation: AAF02536.1 AC009837 Genomic DNA No translation available. AC091155 Genomic DNA No translation available. BC005112 mRNA Translation: AAH05112.1 Different initiation. BC012084 mRNA Translation: AAH12084.1 |
CCDSi | CCDS11588.1 [Q9UKL6-1] CCDS45741.1 [Q9UKL6-2] |
RefSeqi | NP_001095872.1, NM_001102402.2 [Q9UKL6-2] NP_001317307.1, NM_001330378.1 NP_067036.2, NM_021213.3 [Q9UKL6-1] |
Genome annotation databases
Ensembli | ENST00000268896; ENSP00000268896; ENSG00000141179 [Q9UKL6-1] ENST00000325214; ENSP00000325181; ENSG00000141179 [Q9UKL6-2] |
GeneIDi | 58488 |
KEGGi | hsa:58488 |
UCSCi | uc002iul.5, human [Q9UKL6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF114436 , AF114431, AF114432, AF114433, AF114434, AF114435 Genomic DNA Translation: AAF08347.1 AF114430 mRNA Translation: AAF08345.1 AF151638 mRNA Translation: AAF02536.1 AC009837 Genomic DNA No translation available. AC091155 Genomic DNA No translation available. BC005112 mRNA Translation: AAH05112.1 Different initiation. BC012084 mRNA Translation: AAH12084.1 |
CCDSi | CCDS11588.1 [Q9UKL6-1] CCDS45741.1 [Q9UKL6-2] |
RefSeqi | NP_001095872.1, NM_001102402.2 [Q9UKL6-2] NP_001317307.1, NM_001330378.1 NP_067036.2, NM_021213.3 [Q9UKL6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LN1 | X-ray | 2.40 | A | 1-214 | [»] | |
1LN2 | X-ray | 2.90 | A/B | 1-214 | [»] | |
1LN3 | X-ray | 2.90 | A/B | 1-214 | [»] | |
SMRi | Q9UKL6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121818, 6 interactors |
IntActi | Q9UKL6, 2 interactors |
STRINGi | 9606.ENSP00000268896 |
Chemistry databases
DrugBanki | DB04372, L-Dilinoleoyllecithin DB09568, Omega-3-carboxylic acids DB02306, Palmitoyl-Linoleoyl Phosphatidylcholine |
SwissLipidsi | SLP:000001541 |
PTM databases
iPTMneti | Q9UKL6 |
MetOSitei | Q9UKL6 |
PhosphoSitePlusi | Q9UKL6 |
Polymorphism and mutation databases
BioMutai | PCTP |
DMDMi | 15214192 |
Proteomic databases
EPDi | Q9UKL6 |
MassIVEi | Q9UKL6 |
PaxDbi | Q9UKL6 |
PeptideAtlasi | Q9UKL6 |
PRIDEi | Q9UKL6 |
ProteomicsDBi | 84818 [Q9UKL6-1] 84819 [Q9UKL6-2] |
Protocols and materials databases
Antibodypediai | 30858, 196 antibodies |
DNASUi | 58488 |
Genome annotation databases
Ensembli | ENST00000268896; ENSP00000268896; ENSG00000141179 [Q9UKL6-1] ENST00000325214; ENSP00000325181; ENSG00000141179 [Q9UKL6-2] |
GeneIDi | 58488 |
KEGGi | hsa:58488 |
UCSCi | uc002iul.5, human [Q9UKL6-1] |
Organism-specific databases
CTDi | 58488 |
DisGeNETi | 58488 |
EuPathDBi | HostDB:ENSG00000141179.13 |
GeneCardsi | PCTP |
HGNCi | HGNC:8752, PCTP |
HPAi | ENSG00000141179, Tissue enhanced (blood, liver) |
MIMi | 606055, gene |
neXtProti | NX_Q9UKL6 |
OpenTargetsi | ENSG00000141179 |
PharmGKBi | PA33098 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2761, Eukaryota |
GeneTreei | ENSGT00940000156843 |
HOGENOMi | CLU_042209_1_0_1 |
InParanoidi | Q9UKL6 |
OMAi | KQWDSYV |
OrthoDBi | 973910at2759 |
PhylomeDBi | Q9UKL6 |
TreeFami | TF320705 |
Enzyme and pathway databases
PathwayCommonsi | Q9UKL6 |
Reactomei | R-HSA-1483191, Synthesis of PC R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation |
Miscellaneous databases
BioGRID-ORCSi | 58488, 4 hits in 842 CRISPR screens |
ChiTaRSi | PCTP, human |
EvolutionaryTracei | Q9UKL6 |
GeneWikii | Phosphatidylcholine_transfer_protein |
GenomeRNAii | 58488 |
Pharosi | Q9UKL6, Tbio |
PROi | PR:Q9UKL6 |
RNActi | Q9UKL6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141179, Expressed in secondary oocyte and 213 other tissues |
ExpressionAtlasi | Q9UKL6, baseline and differential |
Genevisiblei | Q9UKL6, HS |
Family and domain databases
CDDi | cd08910, START_STARD2-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR041950, STARD2_START IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS50848, START, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPCT_HUMAN | |
Accessioni | Q9UKL6Primary (citable) accession number: Q9UKL6 Secondary accession number(s): Q9BSC9, Q9UIT3, Q9UKW7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations