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Entry version 136 (18 Sep 2019)
Sequence version 1 (01 May 2000)
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Protein

CASP8-associated protein 2

Gene

CASP8AP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3899300 SUMOylation of transcription cofactors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UKL3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CASP8-associated protein 2
Alternative name(s):
FLICE-associated huge protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASP8AP2Imported
Synonyms:FLASH, KIAA1315Imported, RIP25Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1510 CASP8AP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606880 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKL3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26093

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASP8AP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74721007

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000761882 – 1982CASP8-associated protein 2Add BLAST1981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1343N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UKL3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UKL3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UKL3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UKL3

PeptideAtlas

More...
PeptideAtlasi
Q9UKL3

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKL3

ProteomicsDB human proteome resource

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ProteomicsDBi
84816

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UKL3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TNF which induces strong nuclear localization.1 Publication

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053573

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS.

Interacts with NCOA2 and NCOA3.

Interacts with SRRT.

Interacts with TRAF2.

Interacts with NPAT.

Interacts (via SIM domains) with SUMO1 and SUMO2.

Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115315, 28 interactors

Database of interacting proteins

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DIPi
DIP-40986N

Protein interaction database and analysis system

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IntActi
Q9UKL3, 18 interactors

Molecular INTeraction database

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MINTi
Q9UKL3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478179

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11982
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UKL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1709 – 1982NCOA2-binding1 PublicationAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1683 – 1687SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substratesBy similarity5
Motifi1737 – 1741SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substratesBy similarity5
Motifi1794 – 1798SUMO interaction motif 3 (SIM); mediates the binding to polysumoylated substratesBy similarity5

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UKL3

Database of Orthologous Groups

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OrthoDBi
31356at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UKL3

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039674 FLASH
IPR009057 Homeobox-like_sf

The PANTHER Classification System

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PANTHERi
PTHR15489 PTHR15489, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UKL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADDDNGDG TSLFDVFSAS PLKNNDEGSL DIYAGLDSAV SDSASKSCVP
60 70 80 90 100
SRNCLDLYEE ILTEEGTAKE ATYNDLQVEY GKCQLQMKEL MKKFKEIQTQ
110 120 130 140 150
NFSLINENQS LKKNISALIK TARVEINRKD EEISNLHQRL SEFPHFRNNH
160 170 180 190 200
KTARTFDTVK TKDLKSRSPH LDDCSKTDHR AKSDVSKDVH HSTSLPNLEK
210 220 230 240 250
EGKPHSDKRS TSHLPTSVEK HCTNGVWSRS HYQVGEGSSN EDSRRGRKDI
260 270 280 290 300
RHSQFNRGTE RVRKDLSTGC GDGEPRILEA SQRLQGHPEK YGKGEPKTES
310 320 330 340 350
KSSKFKSNSD SDYKGERINS SWEKETPGER SHSRVDSQSD KKLERQSERS
360 370 380 390 400
QNINRKEVKS QDKEERKVDQ KPKSVVKDQD HWRRSERASL PHSKNEITFS
410 420 430 440 450
HNSSKYHLEE RRGWEDCKRD KSVNSHSFQD GRCPSSLSNS RTHKNIDSKE
460 470 480 490 500
VDAMHQWENT PLKAERHRTE DKRKREQESK EENRHIRNEK RVPTEHLQKT
510 520 530 540 550
NKETKKTTTD LKKQNEPKTD KGEVLDNGVS EGADNKELAM KAESGPNETK
560 570 580 590 600
NKDLKLSFMK KLNLTLSPAK KQPVSQDNQH KITDIPKSSG VCDSESSMQV
610 620 630 640 650
KTVAYVPSIS EHILGEAAVS EHTMGETKST LLEPKVALLA VTEPRIGISE
660 670 680 690 700
TNKEDENSLL VRSVDNTMHC EEPICGTETS FPSPMEIQQT ESLFPSTGMK
710 720 730 740 750
QTINNGRAAA PVVMDVLQTD VSQNFGLELD TKRNDNSDYC GISEGMEMKV
760 770 780 790 800
ALSTTVSETT ESILQPSIEE ADILPIMLSE DNNPKFEPSV IVTPLVESKS
810 820 830 840 850
CHLEPCLPKE TLDSSLQQTE LMDHRMATGE TNSVYHDDDN SVLSIDLNHL
860 870 880 890 900
RPIPEAISPL NSPVRPVAKV LRNESPPQVP VYNNSHKDVF LPNSAHSTSK
910 920 930 940 950
SQSDLNKENQ KPIYKSDKCT EADTCKNSPL DELEEGEIRS DSETSKPQES
960 970 980 990 1000
FEKNSKRRVS ADVRKSKTIP RRGKSTVCLD KDSRKTHVRI HQTNNKWNKR
1010 1020 1030 1040 1050
PDKSSRSSKT EKKDKVMSTS SLEKIVPIIA VPSSEQEIMH MLRMIRKHVR
1060 1070 1080 1090 1100
KNYMKFKAKF SLIQFHRIIE SAILSFTSLI KHLNLHKISK SVTTLQKNLC
1110 1120 1130 1140 1150
DIIESKLKQV KKNGIVDRLF EQQLPDMKKK LWKFVDDQLD YLFAKLKKIL
1160 1170 1180 1190 1200
VCDSKSFGRD SDEGKLEKTS KQNAQYSNSQ KRSVDNSNRE LLKEKLSKSE
1210 1220 1230 1240 1250
DPVHYKSLVG CKKSEENYQD QNNSSINTVK HDIKKNFNIC FDNIKNSQSE
1260 1270 1280 1290 1300
ERSLEVHCPS TPKSEKNEGS SIEDAQTSQH ATLKPERSFE ILTEQQASSL
1310 1320 1330 1340 1350
TFNLVSDAQM GEIFKSLLQG SDLLDSSVNC TEKSEWELKT PEKQLLETLK
1360 1370 1380 1390 1400
CESIPACTTE ELVSGVASPC PKMISDDNWS LLSSEKGPSL SSGLSLPVHP
1410 1420 1430 1440 1450
DVLDESCMFE VSTNLPLSKD NVCSVEKSKP CVSSILLEDL AVSLTVPSPL
1460 1470 1480 1490 1500
KSDGHLSFLK PDMSSSSTPE EVISAHFSED ALLEEEDASE QDIHLALESD
1510 1520 1530 1540 1550
NSSSKSSCSS SWTSRSVAPG FQYHPNLPMH AVIMEKSNDH FIVKIRRATP
1560 1570 1580 1590 1600
STSSGLKQSM MPDELLTSLP RHGKEADEGP EKEYISCQNT VFKSVEELEN
1610 1620 1630 1640 1650
SNKNVDGSKS THEEQSSMIQ TQVPDIYEFL KDASDKMGHS DEVADECFKL
1660 1670 1680 1690 1700
HQVWETKVPE SIEELPSMEE ISHSVGEHLP NTYVDLTKDP VTETKNLGEF
1710 1720 1730 1740 1750
IEVTVLHIDQ LGCSGGNLNQ SAQILDNSLQ ADTVGAFIDL TQDASSEAKS
1760 1770 1780 1790 1800
EGNHPALAVE DLGCGVIQVD EDNCKEEKAQ VANRPLKCIV EETYIDLTTE
1810 1820 1830 1840 1850
SPSSCEVKKD ELKSEPGSNC DNSELPGTLH NSHKKRRNIS DLNHPHKKQR
1860 1870 1880 1890 1900
KETDLTNKEK TKKPTQDSCE NTEAHQKKAS KKKAPPVTKD PSSLKATPGI
1910 1920 1930 1940 1950
KDSSAALATS TSLSAKNVIK KKGEIIILWT RNDDREILLE CQKRGPSFKT
1960 1970 1980
FAYLAAKLDK NPNQVSERFQ QLMKLFEKSK CR
Length:1,982
Mass (Da):222,658
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF2B1A7798C19E39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTW5A0A087WTW5_HUMAN
CASP8-associated protein 2
CASP8AP2
1,972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LP21A0A096LP21_HUMAN
CASP8-associated protein 2
CASP8AP2
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56685 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 364.Curated
The sequence BAA92067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278L → S in AAD45537 (Ref. 2) Curated1
Sequence conflicti362D → E in AAH56685 (PubMed:15489334).Curated1
Sequence conflicti638L → P in AAD45537 (Ref. 2) Curated1
Sequence conflicti668M → T in AAD45537 (Ref. 2) Curated1
Sequence conflicti861N → S in AAD45537 (Ref. 2) Curated1
Sequence conflicti1713C → Y in AAD45537 (Ref. 2) Curated1
Sequence conflicti1754Missing in BAA92553 (PubMed:10718198).Curated1
Sequence conflicti1832S → P in BAA92067 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0507001659P → S. Corresponds to variant dbSNP:rs3799896Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF154415 mRNA Translation: AAF03367.1
AF164678 mRNA Translation: AAD45537.2
AB037736 mRNA Translation: BAA92553.2
AL353692 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48540.1
CH471051 Genomic DNA Translation: EAW48542.1
CH471051 Genomic DNA Translation: EAW48544.1
BC042577 mRNA Translation: AAH42577.1
BC056685 mRNA Translation: AAH56685.1 Sequence problems.
BC132828 mRNA Translation: AAI32829.1
BC132830 mRNA Translation: AAI32831.1
AK002070 mRNA Translation: BAA92067.1 Different initiation.
AF165161 mRNA Translation: AAD45157.1

NCBI Reference Sequences

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RefSeqi
NP_001131139.1, NM_001137667.1
NP_001131140.1, NM_001137668.1
NP_036247.1, NM_012115.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9994

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154415 mRNA Translation: AAF03367.1
AF164678 mRNA Translation: AAD45537.2
AB037736 mRNA Translation: BAA92553.2
AL353692 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48540.1
CH471051 Genomic DNA Translation: EAW48542.1
CH471051 Genomic DNA Translation: EAW48544.1
BC042577 mRNA Translation: AAH42577.1
BC056685 mRNA Translation: AAH56685.1 Sequence problems.
BC132828 mRNA Translation: AAI32829.1
BC132830 mRNA Translation: AAI32831.1
AK002070 mRNA Translation: BAA92067.1 Different initiation.
AF165161 mRNA Translation: AAD45157.1
RefSeqiNP_001131139.1, NM_001137667.1
NP_001131140.1, NM_001137668.1
NP_036247.1, NM_012115.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LR8NMR-A1916-1982[»]
6ANOX-ray2.61A/B51-137[»]
6AOZX-ray2.10A/B/C/D51-137[»]
6AP0X-ray2.58A/B51-137[»]
SMRiQ9UKL3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115315, 28 interactors
DIPiDIP-40986N
IntActiQ9UKL3, 18 interactors
MINTiQ9UKL3
STRINGi9606.ENSP00000478179

PTM databases

iPTMnetiQ9UKL3
PhosphoSitePlusiQ9UKL3

Polymorphism and mutation databases

BioMutaiCASP8AP2
DMDMi74721007

Proteomic databases

EPDiQ9UKL3
jPOSTiQ9UKL3
MassIVEiQ9UKL3
MaxQBiQ9UKL3
PeptideAtlasiQ9UKL3
PRIDEiQ9UKL3
ProteomicsDBi84816

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9994
KEGGihsa:9994

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9994
DisGeNETi9994

GeneCards: human genes, protein and diseases

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GeneCardsi
CASP8AP2
HGNCiHGNC:1510 CASP8AP2
HPAiHPA053573
MIMi606880 gene
neXtProtiNX_Q9UKL3
PharmGKBiPA26093

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

InParanoidiQ9UKL3
OrthoDBi31356at2759
PhylomeDBiQ9UKL3

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors
SIGNORiQ9UKL3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CASP8AP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CASP8AP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9994

Pharos

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Pharosi
Q9UKL3

Protein Ontology

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PROi
PR:Q9UKL3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

InterProiView protein in InterPro
IPR039674 FLASH
IPR009057 Homeobox-like_sf
PANTHERiPTHR15489 PTHR15489, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC8AP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKL3
Secondary accession number(s): A2RUB7
, E1P553, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 2000
Last modified: September 18, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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