UniProtKB - Q9UKL2 (O52A1_HUMAN)
Protein
Olfactory receptor 52A1
Gene
OR52A1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- sensory perception of smell Source: ProtInc
- signal transduction Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q9UKL2 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 52A1Alternative name(s): HPFH1OR Odorant receptor HOR3'beta4 Olfactory receptor OR11-319 |
Gene namesi | Name:OR52A1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182070.4 |
HGNCi | HGNC:8318, OR52A1 |
neXtProti | NX_Q9UKL2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 56 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 101 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 141 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 199 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 200 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 240 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 241 – 261 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 276 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 277 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 312 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000182070 |
PharmGKBi | PA32392 |
Miscellaneous databases
Pharosi | Q9UKL2, Tdark |
Polymorphism and mutation databases
BioMutai | OR52A1 |
DMDMi | 296439247 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150765 | 1 – 312 | Olfactory receptor 52A1Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 182 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9UKL2 |
PRIDEi | Q9UKL2 |
ProteomicsDBi | 84815 |
PTM databases
GlyGeni | Q9UKL2, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000182070, Expressed in blood and 1 other tissue |
Genevisiblei | Q9UKL2, HS |
Organism-specific databases
HPAi | ENSG00000182070, Tissue enhanced (blood, testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000369725 |
Miscellaneous databases
RNActi | Q9UKL2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SITM, Eukaryota |
GeneTreei | ENSGT01010000222449 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q9UKL2 |
OMAi | VIQIGTV |
OrthoDBi | 912949at2759 |
PhylomeDBi | Q9UKL2 |
TreeFami | TF352744 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UKL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI
60 70 80 90 100
IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL
110 120 130 140 150
LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV
160 170 180 190 200
VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI
210 220 230 240 250
YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT
310
QIRIHVVKMF CS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 272 | S → P in AAD51279 (PubMed:10512676).Curated | 1 | |
Sequence conflicti | 272 | S → P in AAG42367 (PubMed:11121057).Curated | 1 | |
Sequence conflicti | 272 | S → P in AAI11723 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154673 Genomic DNA Translation: AAD51279.1 AF289204 Genomic DNA Translation: AAG42367.1 AC129505 Genomic DNA No translation available. BC111722 mRNA Translation: AAI11723.1 BK004431 Genomic DNA Translation: DAA04829.1 |
CCDSi | CCDS31374.1 |
RefSeqi | NP_036507.2, NM_012375.2 |
Genome annotation databases
Ensembli | ENST00000328942; ENSP00000333684; ENSG00000182070 ENST00000380367; ENSP00000369725; ENSG00000182070 |
GeneIDi | 23538 |
KEGGi | hsa:23538 |
UCSCi | uc010qyy.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154673 Genomic DNA Translation: AAD51279.1 AF289204 Genomic DNA Translation: AAG42367.1 AC129505 Genomic DNA No translation available. BC111722 mRNA Translation: AAI11723.1 BK004431 Genomic DNA Translation: DAA04829.1 |
CCDSi | CCDS31374.1 |
RefSeqi | NP_036507.2, NM_012375.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000369725 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9UKL2, 1 site |
Polymorphism and mutation databases
BioMutai | OR52A1 |
DMDMi | 296439247 |
Proteomic databases
PaxDbi | Q9UKL2 |
PRIDEi | Q9UKL2 |
ProteomicsDBi | 84815 |
Protocols and materials databases
Antibodypediai | 55354, 107 antibodies |
DNASUi | 23538 |
Genome annotation databases
Ensembli | ENST00000328942; ENSP00000333684; ENSG00000182070 ENST00000380367; ENSP00000369725; ENSG00000182070 |
GeneIDi | 23538 |
KEGGi | hsa:23538 |
UCSCi | uc010qyy.2, human |
Organism-specific databases
CTDi | 23538 |
EuPathDBi | HostDB:ENSG00000182070.4 |
GeneCardsi | OR52A1 |
HGNCi | HGNC:8318, OR52A1 |
HPAi | ENSG00000182070, Tissue enhanced (blood, testis) |
neXtProti | NX_Q9UKL2 |
OpenTargetsi | ENSG00000182070 |
PharmGKBi | PA32392 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SITM, Eukaryota |
GeneTreei | ENSGT01010000222449 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q9UKL2 |
OMAi | VIQIGTV |
OrthoDBi | 912949at2759 |
PhylomeDBi | Q9UKL2 |
TreeFami | TF352744 |
Enzyme and pathway databases
PathwayCommonsi | Q9UKL2 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 23538, 1 hit in 481 CRISPR screens |
GeneWikii | OR52A1 |
GenomeRNAii | 23538 |
Pharosi | Q9UKL2, Tdark |
PROi | PR:Q9UKL2 |
RNActi | Q9UKL2, protein |
Gene expression databases
Bgeei | ENSG00000182070, Expressed in blood and 1 other tissue |
Genevisiblei | Q9UKL2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O52A1_HUMAN | |
Accessioni | Q9UKL2Primary (citable) accession number: Q9UKL2 Secondary accession number(s): Q6IF31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries