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Entry version 177 (10 Apr 2019)
Sequence version 2 (15 Feb 2017)
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Protein

REST corepressor 1

Gene

RCOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214815 HDACs deacetylate histones
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UKL0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
REST corepressor 1
Alternative name(s):
Protein CoREST
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCOR1
Synonyms:KIAA0071, RCOR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000089902.9

Human Gene Nomenclature Database

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HGNCi
HGNC:17441 RCOR1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607675 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKL0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23186

Open Targets

More...
OpenTargetsi
ENSG00000089902

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34305

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3137262

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RCOR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762776

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002267731 – 485REST corepressor 1Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei460PhosphoserineCombined sources1
Cross-linki466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by HSV-1 protein kinases in case of infection.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKL0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UKL0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UKL0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UKL0

PeptideAtlas

More...
PeptideAtlasi
Q9UKL0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKL0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84814

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKL0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKL0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089902 Expressed in 226 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UKL0 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049327
HPA054241

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex may recruit the ATP-dependent chromatin-remodeling SWI-SNF complex.By similarity11 Publications
(Microbial infection) Interacts with herpes virus HSV-1 ICP0 protein; the interaction leads to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116796, 103 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UKL0

Database of interacting proteins

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DIPi
DIP-35263N

Protein interaction database and analysis system

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IntActi
Q9UKL0, 31 interactors

Molecular INTeraction database

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MINTi
Q9UKL0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IW5X-ray2.57B289-485[»]
2UXNX-ray2.72B289-485[»]
2UXXX-ray2.74B289-485[»]
2V1DX-ray3.10B308-485[»]
2X0LX-ray3.00B311-443[»]
2XAFX-ray3.25B4-485[»]
2XAGX-ray3.10B4-485[»]
2XAHX-ray3.10B4-485[»]
2XAJX-ray3.30B4-485[»]
2XAQX-ray3.20B4-485[»]
2XASX-ray3.20B4-485[»]
2Y48X-ray3.00B308-485[»]
3ZMSX-ray2.96B4-485[»]
3ZMTX-ray3.10B4-485[»]
3ZMUX-ray3.20B4-485[»]
3ZMVX-ray3.00B4-485[»]
3ZMZX-ray3.00B4-485[»]
3ZN0X-ray2.80B4-485[»]
3ZN1X-ray3.10B4-485[»]
4BAYX-ray3.10B311-443[»]
4KUMX-ray3.05B289-485[»]
4UV8X-ray2.80B4-485[»]
4UV9X-ray3.00B4-485[»]
4UVAX-ray2.90B4-485[»]
4UVBX-ray2.80B4-485[»]
4UVCX-ray3.10B4-485[»]
4UXNX-ray2.85B4-485[»]
4XBFX-ray2.80B311-443[»]
5H6QX-ray2.53B311-443[»]
5H6RX-ray2.60B311-443[»]
5L3BX-ray3.30B4-485[»]
5L3CX-ray3.31B4-485[»]
5L3DX-ray2.60B4-485[»]
5L3EX-ray2.80B308-485[»]
5L3FX-ray3.50B308-485[»]
5L3GX-ray3.10B308-485[»]
5LBQX-ray3.30B308-485[»]
5LGNX-ray3.20B311-443[»]
5LGTX-ray3.00B308-485[»]
5LGUX-ray3.20B308-485[»]
5LHGX-ray3.34B4-485[»]
5LHHX-ray3.05B4-485[»]
5LHIX-ray3.40B4-485[»]
5X60X-ray2.69B311-443[»]
5YJBX-ray2.96B311-443[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UKL0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKL0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UKL0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 189ELM2PROSITE-ProRule annotationAdd BLAST87
Domaini190 – 241SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini381 – 432SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 257Interaction with HDAC11 PublicationAdd BLAST180
Regioni296 – 384Interaction with KDM1A1 PublicationAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili244 – 273Sequence analysisAdd BLAST30
Coiled coili334 – 369Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 77Ala-richAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CoREST family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1194 Eukaryota
ENOG410XSIS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065784

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079800

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKL0

KEGG Orthology (KO)

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KOi
K11829

Identification of Orthologs from Complete Genome Data

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OMAi
WSVEDKV

Database of Orthologous Groups

More...
OrthoDBi
641792at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKL0

TreeFam database of animal gene trees

More...
TreeFami
TF106450

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UKL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAMVEKGPE VSGKRRGRNN AAASASAAAA SAAASAACAS PAATAASGAA
60 70 80 90 100
ASSASAAAAS AAAAPNNGQN KSLAAAAPNG NSSSNSWEEG SSGSSSDEEH
110 120 130 140 150
GGGGMRVGPQ YQAVVPDFDP AKLARRSQER DNLGMLVWSP NQNLSEAKLD
160 170 180 190 200
EYIAIAKEKH GYNMEQALGM LFWHKHNIEK SLADLPNFTP FPDEWTVEDK
210 220 230 240 250
VLFEQAFSFH GKTFHRIQQM LPDKSIASLV KFYYSWKKTR TKTSVMDRHA
260 270 280 290 300
RKQKREREES EDELEEANGN NPIDIEVDQN KESKKEVPPT ETVPQVKKEK
310 320 330 340 350
HSTQAKNRAK RKPPKGMFLS QEDVEAVSAN ATAATTVLRQ LDMELVSVKR
360 370 380 390 400
QIQNIKQTNS ALKEKLDGGI EPYRLPEVIQ KCNARWTTEE QLLAVQAIRK
410 420 430 440 450
YGRDFQAISD VIGNKSVVQV KNFFVNYRRR FNIDEVLQEW EAEHGKEETN
460 470 480
GPSNQKPVKS PDNSIKMPEE EDEAPVLDVR YASAS
Length:485
Mass (Da):53,327
Last modified:February 15, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77E90FB0EFD514B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNY4H0YNY4_HUMAN
REST corepressor 1
RCOR1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH51003 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH64495 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL132801 Genomic DNA No translation available.
AL136293 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81793.1
BC051003 mRNA Translation: AAH51003.1 Different initiation.
BC064495 mRNA Translation: AAH64495.1 Sequence problems.
AF155595 mRNA Translation: AAF01498.1
D31888 mRNA Translation: BAA06686.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9974.2

NCBI Reference Sequences

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RefSeqi
NP_055971.2, NM_015156.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.510521

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262241; ENSP00000262241; ENSG00000089902

Database of genes from NCBI RefSeq genomes

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GeneIDi
23186

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23186

UCSC genome browser

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UCSCi
uc001ymb.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132801 Genomic DNA No translation available.
AL136293 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81793.1
BC051003 mRNA Translation: AAH51003.1 Different initiation.
BC064495 mRNA Translation: AAH64495.1 Sequence problems.
AF155595 mRNA Translation: AAF01498.1
D31888 mRNA Translation: BAA06686.1
CCDSiCCDS9974.2
RefSeqiNP_055971.2, NM_015156.3
UniGeneiHs.510521

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IW5X-ray2.57B289-485[»]
2UXNX-ray2.72B289-485[»]
2UXXX-ray2.74B289-485[»]
2V1DX-ray3.10B308-485[»]
2X0LX-ray3.00B311-443[»]
2XAFX-ray3.25B4-485[»]
2XAGX-ray3.10B4-485[»]
2XAHX-ray3.10B4-485[»]
2XAJX-ray3.30B4-485[»]
2XAQX-ray3.20B4-485[»]
2XASX-ray3.20B4-485[»]
2Y48X-ray3.00B308-485[»]
3ZMSX-ray2.96B4-485[»]
3ZMTX-ray3.10B4-485[»]
3ZMUX-ray3.20B4-485[»]
3ZMVX-ray3.00B4-485[»]
3ZMZX-ray3.00B4-485[»]
3ZN0X-ray2.80B4-485[»]
3ZN1X-ray3.10B4-485[»]
4BAYX-ray3.10B311-443[»]
4KUMX-ray3.05B289-485[»]
4UV8X-ray2.80B4-485[»]
4UV9X-ray3.00B4-485[»]
4UVAX-ray2.90B4-485[»]
4UVBX-ray2.80B4-485[»]
4UVCX-ray3.10B4-485[»]
4UXNX-ray2.85B4-485[»]
4XBFX-ray2.80B311-443[»]
5H6QX-ray2.53B311-443[»]
5H6RX-ray2.60B311-443[»]
5L3BX-ray3.30B4-485[»]
5L3CX-ray3.31B4-485[»]
5L3DX-ray2.60B4-485[»]
5L3EX-ray2.80B308-485[»]
5L3FX-ray3.50B308-485[»]
5L3GX-ray3.10B308-485[»]
5LBQX-ray3.30B308-485[»]
5LGNX-ray3.20B311-443[»]
5LGTX-ray3.00B308-485[»]
5LGUX-ray3.20B308-485[»]
5LHGX-ray3.34B4-485[»]
5LHHX-ray3.05B4-485[»]
5LHIX-ray3.40B4-485[»]
5X60X-ray2.69B311-443[»]
5YJBX-ray2.96B311-443[»]
ProteinModelPortaliQ9UKL0
SMRiQ9UKL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116796, 103 interactors
CORUMiQ9UKL0
DIPiDIP-35263N
IntActiQ9UKL0, 31 interactors
MINTiQ9UKL0
STRINGi9606.ENSP00000262241

Chemistry databases

ChEMBLiCHEMBL3137262

PTM databases

iPTMnetiQ9UKL0
PhosphoSitePlusiQ9UKL0

Polymorphism and mutation databases

BioMutaiRCOR1
DMDMi74762776

Proteomic databases

EPDiQ9UKL0
jPOSTiQ9UKL0
MaxQBiQ9UKL0
PaxDbiQ9UKL0
PeptideAtlasiQ9UKL0
PRIDEiQ9UKL0
ProteomicsDBi84814

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23186
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262241; ENSP00000262241; ENSG00000089902
GeneIDi23186
KEGGihsa:23186
UCSCiuc001ymb.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23186
DisGeNETi23186
EuPathDBiHostDB:ENSG00000089902.9

GeneCards: human genes, protein and diseases

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GeneCardsi
RCOR1
HGNCiHGNC:17441 RCOR1
HPAiHPA049327
HPA054241
MIMi607675 gene
neXtProtiNX_Q9UKL0
OpenTargetsiENSG00000089902
PharmGKBiPA34305

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1194 Eukaryota
ENOG410XSIS LUCA
GeneTreeiENSGT00940000155654
HOGENOMiHOG000065784
HOVERGENiHBG079800
InParanoidiQ9UKL0
KOiK11829
OMAiWSVEDKV
OrthoDBi641792at2759
PhylomeDBiQ9UKL0
TreeFamiTF106450

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiQ9UKL0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RCOR1 human
EvolutionaryTraceiQ9UKL0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RCOR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23186

Protein Ontology

More...
PROi
PR:Q9UKL0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089902 Expressed in 226 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9UKL0 baseline and differential

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCOR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKL0
Secondary accession number(s): J3KN32
, Q15044, Q6P2I9, Q86VG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2017
Last modified: April 10, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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