Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NTF2-related export protein 1

Gene

NXT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).4 Publications

GO - Molecular functioni

  • protein transporter activity Source: GO_Central
  • Ran GTPase binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Names & Taxonomyi

Protein namesi
Recommended name:
NTF2-related export protein 1
Alternative name(s):
Protein p15
Gene namesi
Name:NXT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132661.3
HGNCiHGNC:15913 NXT1
MIMi605811 gene
neXtProtiNX_Q9UKK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi114I → R: 70% reduction in mRNA export activity. 1 Publication1
Mutagenesisi134R → D: 57% reduction in mRNA export activity and loss of nuclear rim staining. 1 Publication1

Organism-specific databases

DisGeNETi29107
OpenTargetsiENSG00000132661
PharmGKBiPA31867

Polymorphism and mutation databases

BioMutaiNXT1
DMDMi18203504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001947932 – 140NTF2-related export protein 1Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UKK6
MaxQBiQ9UKK6
PaxDbiQ9UKK6
PeptideAtlasiQ9UKK6
PRIDEiQ9UKK6
ProteomicsDBi84812
TopDownProteomicsiQ9UKK6

PTM databases

iPTMnetiQ9UKK6
PhosphoSitePlusiQ9UKK6

Expressioni

Gene expression databases

BgeeiENSG00000132661 Expressed in 208 organ(s), highest expression level in left coronary artery
CleanExiHS_NXT1
GenevisibleiQ9UKK6 HS

Organism-specific databases

HPAiHPA047471

Interactioni

Subunit structurei

Heterodimer with NXF1 (PubMed:11583626). Forms a complex with RANGAP1, RANBP2/NUP358 and NXF1 (PubMed:14729961). Interacts (via NTF2 domain) with NXF1 (PubMed:11583626). Stabilizes the NTF2 domain of NXF1 by heterodimerization (PubMed:11583626). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (PubMed:11583626). Preferentially binds Ran-GTP (PubMed:10567585). Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1 (PubMed:11583626).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118875, 12 interactors
DIPiDIP-33075N
IntActiQ9UKK6, 15 interactors
MINTiQ9UKK6
STRINGi9606.ENSP00000254998

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UKK6
SMRiQ9UKK6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKK6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 135NTF2PROSITE-ProRule annotationAdd BLAST120

Phylogenomic databases

eggNOGiKOG4353 Eukaryota
ENOG4111TWR LUCA
GeneTreeiENSGT00510000046494
HOGENOMiHOG000231890
HOVERGENiHBG018207
InParanoidiQ9UKK6
KOiK14285
OMAiYYSTMDK
OrthoDBiEOG091G0SMX
PhylomeDBiQ9UKK6
TreeFamiTF318944

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UKK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN
60 70 80 90 100
AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK
110 120 130 140
FEGNKQRDFN QNFILTAQAS PSNTVWKIAS DCFRFQDWAS
Length:140
Mass (Da):15,847
Last modified:May 1, 2000 - v1
Checksum:i358FA86AC3944594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156957 mRNA Translation: AAD54942.1
AL096677 Genomic DNA No translation available.
BC000759 mRNA Translation: AAH00759.1
BC002687 mRNA Translation: AAH02687.1
BC003029 mRNA Translation: AAH03029.1
BC003410 mRNA Translation: AAH03410.1
CCDSiCCDS13150.1
RefSeqiNP_037380.1, NM_013248.2
XP_011527532.1, XM_011529230.2
UniGeneiHs.516933

Genome annotation databases

EnsembliENST00000254998; ENSP00000254998; ENSG00000132661
GeneIDi29107
KEGGihsa:29107
UCSCiuc002wsx.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156957 mRNA Translation: AAD54942.1
AL096677 Genomic DNA No translation available.
BC000759 mRNA Translation: AAH00759.1
BC002687 mRNA Translation: AAH02687.1
BC003029 mRNA Translation: AAH03029.1
BC003410 mRNA Translation: AAH03410.1
CCDSiCCDS13150.1
RefSeqiNP_037380.1, NM_013248.2
XP_011527532.1, XM_011529230.2
UniGeneiHs.516933

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JKGX-ray1.90A1-140[»]
1JN5X-ray2.80A1-140[»]
4WYKX-ray3.40B/D2-140[»]
ProteinModelPortaliQ9UKK6
SMRiQ9UKK6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118875, 12 interactors
DIPiDIP-33075N
IntActiQ9UKK6, 15 interactors
MINTiQ9UKK6
STRINGi9606.ENSP00000254998

PTM databases

iPTMnetiQ9UKK6
PhosphoSitePlusiQ9UKK6

Polymorphism and mutation databases

BioMutaiNXT1
DMDMi18203504

Proteomic databases

EPDiQ9UKK6
MaxQBiQ9UKK6
PaxDbiQ9UKK6
PeptideAtlasiQ9UKK6
PRIDEiQ9UKK6
ProteomicsDBi84812
TopDownProteomicsiQ9UKK6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254998; ENSP00000254998; ENSG00000132661
GeneIDi29107
KEGGihsa:29107
UCSCiuc002wsx.2 human

Organism-specific databases

CTDi29107
DisGeNETi29107
EuPathDBiHostDB:ENSG00000132661.3
GeneCardsiNXT1
HGNCiHGNC:15913 NXT1
HPAiHPA047471
MIMi605811 gene
neXtProtiNX_Q9UKK6
OpenTargetsiENSG00000132661
PharmGKBiPA31867
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4353 Eukaryota
ENOG4111TWR LUCA
GeneTreeiENSGT00510000046494
HOGENOMiHOG000231890
HOVERGENiHBG018207
InParanoidiQ9UKK6
KOiK14285
OMAiYYSTMDK
OrthoDBiEOG091G0SMX
PhylomeDBiQ9UKK6
TreeFamiTF318944

Enzyme and pathway databases

ReactomeiR-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Miscellaneous databases

ChiTaRSiNXT1 human
EvolutionaryTraceiQ9UKK6
GeneWikiiNXT1
GenomeRNAii29107
PROiPR:Q9UKK6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132661 Expressed in 208 organ(s), highest expression level in left coronary artery
CleanExiHS_NXT1
GenevisibleiQ9UKK6 HS

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNXT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again