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Protein

Protein mono-ADP-ribosyltransferase PARP4

Gene

PARP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.1 Publication

Caution

Was initially thought to mediate to mediate poly-ADP-ribosylation of proteins (PubMed:10477748). However, it was later shown to act as a mono-ADP-ribosyltransferase (PubMed:25043379).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: ProtInc
  • enzyme binding Source: MGI
  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cell death Source: UniProtKB
  • cellular protein modification process Source: UniProtKB
  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA repair Source: ProtInc
  • inflammatory response Source: UniProtKB
  • protein ADP-ribosylation Source: UniProtKB
  • regulation of telomerase activity Source: BHF-UCL
  • response to drug Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Ribonucleoprotein, Transferase
LigandNAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.4.2.30 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-197264 Nicotinamide salvaging

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9UKK3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mono-ADP-ribosyltransferase PARP4Curated (EC:2.4.2.-1 Publication)
Alternative name(s):
193 kDa vault protein1 Publication
ADP-ribosyltransferase diphtheria toxin-like 41 Publication
Short name:
ARTD41 Publication
PARP-related/IalphaI-related H5/proline-rich1 Publication
Short name:
PH5P1 Publication
Poly [ADP-ribose] polymerase 41 Publication
Short name:
PARP-41 Publication
Vault poly(ADP-ribose) polymerase1 Publication
Short name:
VPARP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARP41 PublicationImported
Synonyms:ADPRTL11 Publication, KIAA01771 Publication, PARPL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102699.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:271 PARP4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607519 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKK3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
143

Open Targets

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OpenTargetsi
ENSG00000102699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24591

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6142

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153574

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113301 – 1724Protein mono-ADP-ribosyltransferase PARP4Add BLAST1724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei101PhosphothreonineCombined sources1
Modified residuei333PhosphothreonineCombined sources1
Modified residuei1236PhosphoserineCombined sources1
Modified residuei1335PhosphoserineCombined sources1
Modified residuei1476Asymmetric dimethylarginineCombined sources1
Modified residuei1504PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKK3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UKK3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UKK3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UKK3

PeptideAtlas

More...
PeptideAtlasi
Q9UKK3

PRoteomics IDEntifications database

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PRIDEi
Q9UKK3

ProteomicsDB human proteome resource

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ProteomicsDBi
84811

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q9UKK3

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UKK3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UKK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000102699 Expressed in 96 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

More...
CleanExi
HS_PARP4

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UKK3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs) (PubMed:10477748). Interacts with TEP1 (PubMed:10551828, PubMed:15169895).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G43EBI-2623021,EBI-6248094From Human immunodeficiency virus 1.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106653, 12 interactors

Protein interaction database and analysis system

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IntActi
Q9UKK3, 18 interactors

Molecular INTeraction database

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MINTi
Q9UKK3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000371419

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9UKK3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UKK3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 94BRCTPROSITE-ProRule annotationAdd BLAST94
Domaini242 – 370PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST129
Domaini369 – 573PARP catalyticPROSITE-ProRule annotationAdd BLAST205
Domaini607 – 735VITPROSITE-ProRule annotationAdd BLAST129
Domaini876 – 1046VWFAPROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1562 – 1724Interaction with the major vault protein1 PublicationAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi19 – 25Nuclear localization signalSequence analysis7
Motifi1237 – 1249Nuclear localization signalSequence analysisAdd BLAST13

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1037 Eukaryota
ENOG410XP18 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160555

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000139369

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053515

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UKK3

KEGG Orthology (KO)

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KOi
K10798

Identification of Orthologs from Complete Genome Data

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OMAi
PYMSWQE

Database of Orthologous Groups

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OrthoDBi
955432at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKK3

TreeFam database of animal gene trees

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TreeFami
TF329720

Family and domain databases

Conserved Domains Database

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CDDi
cd00027 BRCT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.142.10, 1 hit
3.40.50.10190, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR031273 PARP4
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10338:SF127 PTHR10338:SF127, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00533 BRCT, 1 hit
PF00644 PARP, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00292 BRCT, 1 hit
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47587 SSF47587, 1 hit
SSF52113 SSF52113, 1 hit
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UKK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMGIFANCI FCLKVKYLPQ QQKKKLQTDI KENGGKFSFS LNPQCTHIIL
60 70 80 90 100
DNADVLSQYQ LNSIQKNHVH IANPDFIWKS IREKRLLDVK NYDPYKPLDI
110 120 130 140 150
TPPPDQKASS SEVKTEGLCP DSATEEEDTV ELTEFGMQNV EIPHLPQDFE
160 170 180 190 200
VAKYNTLEKV GMEGGQEAVV VELQCSRDSR DCPFLISSHF LLDDGMETRR
210 220 230 240 250
QFAIKKTSED ASEYFENYIE ELKKQGFLLR EHFTPEATQL ASEQLQALLL
260 270 280 290 300
EEVMNSSTLS QEVSDLVEMI WAEALGHLEH MLLKPVNRIS LNDVSKAEGI
310 320 330 340 350
LLLVKAALKN GETAEQLQKM MTEFYRLIPH KGTMPKEVNL GLLAKKADLC
360 370 380 390 400
QLIRDMVNVC ETNLSKPNPP SLAKYRALRC KIEHVEQNTE EFLRVRKEVL
410 420 430 440 450
QNHHSKSPVD VLQIFRVGRV NETTEFLSKL GNVRPLLHGS PVQNIVGILC
460 470 480 490 500
RGLLLPKVVE DRGVQRTDVG NLGSGIYFSD SLSTSIKYSH PGETDGTRLL
510 520 530 540 550
LICDVALGKC MDLHEKDFSL TEAPPGYDSV HGVSQTASVT TDFEDDEFVV
560 570 580 590 600
YKTNQVKMKY IIKFSMPGDQ IKDFHPSDHT ELEEYRPEFS NFSKVEDYQL
610 620 630 640 650
PDAKTSSSTK AGLQDASGNL VPLEDVHIKG RIIDTVAQVI VFQTYTNKSH
660 670 680 690 700
VPIEAKYIFP LDDKAAVCGF EAFINGKHIV GEIKEKEEAQ QEYLEAVTQG
710 720 730 740 750
HGAYLMSQDA PDVFTVSVGN LPPKAKVLIK ITYITELSIL GTVGVFFMPA
760 770 780 790 800
TVAPWQQDKA LNENLQDTVE KICIKEIGTK QSFSLTMSIE MPYVIEFIFS
810 820 830 840 850
DTHELKQKRT DCKAVISTME GSSLDSSGFS LHIGLSAAYL PRMWVEKHPE
860 870 880 890 900
KESEACMLVF QPDLDVDLPD LASESEVIIC LDCSSSMEGV TFLQAKQIAL
910 920 930 940 950
HALSLVGEKQ KVNIIQFGTG YKELFSYPKH ITSNTMAAEF IMSATPTMGN
960 970 980 990 1000
TDFWKTLRYL SLLYPARGSR NILLVSDGHL QDESLTLQLV KRSRPHTRLF
1010 1020 1030 1040 1050
ACGIGSTANR HVLRILSQCG AGVFEYFNAK SKHSWRKQIE DQMTRLCSPS
1060 1070 1080 1090 1100
CHSVSVKWQQ LNPDVPEALQ APAQVPSLFL NDRLLVYGFI PHCTQATLCA
1110 1120 1130 1140 1150
LIQEKEFRTM VSTTELQKTT GTMIHKLAAR ALIRDYEDGI LHENETSHEM
1160 1170 1180 1190 1200
KKQTLKSLII KLSKENSLIT QFTSFVAVEK RDENESPFPD IPKVSELIAK
1210 1220 1230 1240 1250
EDVDFLPYMS WQGEPQEAVR NQSLLASSEW PELRLSKRKH RKIPFSKRKM
1260 1270 1280 1290 1300
ELSQPEVSED FEEDGLGVLP AFTSNLERGG VEKLLDLSWT ESCKPTATEP
1310 1320 1330 1340 1350
LFKKVSPWET STSSFFPILA PAVGSYLPPT ARAHSPASLS FASYRQVASF
1360 1370 1380 1390 1400
GSAAPPRQFD ASQFSQGPVP GTCADWIPQS ASCPTGPPQN PPSSPYCGIV
1410 1420 1430 1440 1450
FSGSSLSSAQ SAPLQHPGGF TTRPSAGTFP ELDSPQLHFS LPTDPDPIRG
1460 1470 1480 1490 1500
FGSYHPSASS PFHFQPSAAS LTANLRLPMA SALPEALCSQ SRTTPVDLCL
1510 1520 1530 1540 1550
LEESVGSLEG SRCPVFAFQS SDTESDELSE VLQDSCFLQI KCDTKDDSIL
1560 1570 1580 1590 1600
CFLEVKEEDE IVCIQHWQDA VPWTELLSLQ TEDGFWKLTP ELGLILNLNT
1610 1620 1630 1640 1650
NGLHSFLKQK GIQSLGVKGR ECLLDLIATM LVLQFIRTRL EKEGIVFKSL
1660 1670 1680 1690 1700
MKMDDASISR NIPWAFEAIK QASEWVRRTE GQYPSICPRL ELGNDWDSAT
1710 1720
KQLLGLQPIS TVSPLHRVLH YSQG
Length:1,724
Mass (Da):192,595
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCA1DD4C001EA22F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11494 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti519S → P in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti897Q → E in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti897Q → E in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti936M → A in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti936M → A in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti936M → T in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1065V → A in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1065V → A in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1080L → R in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1080L → R in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1080L → R in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1108R → C in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1108R → C in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1108R → C in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1328P → T in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1328P → T in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1328P → T in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1331A → T in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1331A → T in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1331A → T in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1394S → A in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1394S → A in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1394S → A in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1459S → Y in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1459S → Y in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1459S → Y in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1550L → P in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1550L → P in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1550L → P in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1555V → L in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1564I → T in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1564I → T in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1564I → T in BAA11494 (PubMed:8724849).Curated1
Sequence conflicti1656A → P in AAD47250 (PubMed:10477748).Curated1
Sequence conflicti1656A → P in AAC62491 (PubMed:10644454).Curated1
Sequence conflicti1656A → P in BAA11494 (PubMed:8724849).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05664581I → V. Corresponds to variant dbSNP:rs35200240Ensembl.1
Natural variantiVAR_056646122S → N. Corresponds to variant dbSNP:rs9578751Ensembl.1
Natural variantiVAR_056647215F → Y. Corresponds to variant dbSNP:rs9318600Ensembl.1
Natural variantiVAR_056648792P → L. Corresponds to variant dbSNP:rs4986818Ensembl.1
Natural variantiVAR_056649873S → N2 PublicationsCorresponds to variant dbSNP:rs7140044Ensembl.1
Natural variantiVAR_056650899A → T1 PublicationCorresponds to variant dbSNP:rs2275660Ensembl.1
Natural variantiVAR_056651991K → R. Corresponds to variant dbSNP:rs34689435Ensembl.1
Natural variantiVAR_0566521012V → I. Corresponds to variant dbSNP:rs9581043Ensembl.1
Natural variantiVAR_0566531253S → T. Corresponds to variant dbSNP:rs4986822Ensembl.1
Natural variantiVAR_0160901265G → A2 PublicationsCorresponds to variant dbSNP:rs1050110Ensembl.1
Natural variantiVAR_0160911280G → R2 PublicationsCorresponds to variant dbSNP:rs13428Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF158255 mRNA Translation: AAD47250.1
AF057160 mRNA Translation: AAC62491.1
D79999 mRNA Translation: BAA11494.2 Different initiation.
AL359763 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9307.1

NCBI Reference Sequences

More...
RefSeqi
NP_006428.2, NM_006437.3
XP_011533234.1, XM_011534932.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.744855

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381989; ENSP00000371419; ENSG00000102699

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
143

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:143

UCSC genome browser

More...
UCSCi
uc001upl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158255 mRNA Translation: AAD47250.1
AF057160 mRNA Translation: AAC62491.1
D79999 mRNA Translation: BAA11494.2 Different initiation.
AL359763 Genomic DNA No translation available.
CCDSiCCDS9307.1
RefSeqiNP_006428.2, NM_006437.3
XP_011533234.1, XM_011534932.2
UniGeneiHs.744855

3D structure databases

ProteinModelPortaliQ9UKK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106653, 12 interactors
IntActiQ9UKK3, 18 interactors
MINTiQ9UKK3
STRINGi9606.ENSP00000371419

Chemistry databases

BindingDBiQ9UKK3
ChEMBLiCHEMBL6142

PTM databases

CarbonylDBiQ9UKK3
iPTMnetiQ9UKK3
PhosphoSitePlusiQ9UKK3

Polymorphism and mutation databases

BioMutaiPARP4
DMDMi308153574

Proteomic databases

EPDiQ9UKK3
jPOSTiQ9UKK3
MaxQBiQ9UKK3
PaxDbiQ9UKK3
PeptideAtlasiQ9UKK3
PRIDEiQ9UKK3
ProteomicsDBi84811

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
143
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381989; ENSP00000371419; ENSG00000102699
GeneIDi143
KEGGihsa:143
UCSCiuc001upl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
143
DisGeNETi143
EuPathDBiHostDB:ENSG00000102699.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PARP4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0019099
HGNCiHGNC:271 PARP4
HPAiHPA011739
MIMi607519 gene
neXtProtiNX_Q9UKK3
OpenTargetsiENSG00000102699
PharmGKBiPA24591

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
GeneTreeiENSGT00940000160555
HOGENOMiHOG000139369
HOVERGENiHBG053515
InParanoidiQ9UKK3
KOiK10798
OMAiPYMSWQE
OrthoDBi955432at2759
PhylomeDBiQ9UKK3
TreeFamiTF329720

Enzyme and pathway databases

BRENDAi2.4.2.30 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging
SignaLinkiQ9UKK3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PARP4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PARP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
143

Protein Ontology

More...
PROi
PR:Q9UKK3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102699 Expressed in 96 organ(s), highest expression level in intestine
CleanExiHS_PARP4
GenevisibleiQ9UKK3 HS

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.142.10, 1 hit
3.40.50.10190, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR031273 PARP4
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR10338:SF127 PTHR10338:SF127, 1 hit
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF00644 PARP, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF47587 SSF47587, 1 hit
SSF52113 SSF52113, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKK3
Secondary accession number(s): O75903
, Q14682, Q5QNZ9, Q9H1M6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 5, 2010
Last modified: January 16, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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