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Entry version 138 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein

Cysteine-rich hydrophobic domain-containing protein 2

Gene

CHIC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UKJ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich hydrophobic domain-containing protein 2
Alternative name(s):
BrX-like translocated in leukemia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHIC2
Synonyms:BTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109220.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1935, CHIC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604332, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKJ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi88 – 95CGCLCCCC → SGSLSSSS: Loss of palmitoylation. Abolishes membrane association. 1 Publication8

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei111 – 112Breakpoint for translocation to form CHIC2-ETV6 in AML2

Organism-specific databases

DisGeNET

More...
DisGeNETi
26511

MalaCards human disease database

More...
MalaCardsi
CHIC2

Open Targets

More...
OpenTargetsi
ENSG00000109220

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26466

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKJ5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHIC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62901505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895561 – 165Cysteine-rich hydrophobic domain-containing protein 2Add BLAST165

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylation in the CHIC motif is required for membrane association.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKJ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKJ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKJ5

PeptideAtlas

More...
PeptideAtlasi
Q9UKJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKJ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84809

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKJ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UKJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109220, Expressed in testis and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKJ5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKJ5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000109220, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UKJ5
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-741528,EBI-10173507
AGXT [P21549]3EBI-741528,EBI-727098
AXIN2 [Q9Y2T1]3EBI-741528,EBI-4400025
C1QTNF2 [Q9BXJ5]3EBI-741528,EBI-2817707
CARD10 [Q9BWT7]3EBI-741528,EBI-3866279
CATSPER1 [Q8NEC5]4EBI-741528,EBI-744545
CBY2 [Q8NA61]3EBI-741528,EBI-741724
CDR2 [Q01850]7EBI-741528,EBI-1181367
CEP44 [Q9C0F1]3EBI-741528,EBI-744115
CYSRT1 [A8MQ03]3EBI-741528,EBI-3867333
DNAL4 [O96015]3EBI-741528,EBI-742362
ENKD1 [Q9H0I2]3EBI-741528,EBI-744099
FBLN1 - isoform C [P23142-4]3EBI-741528,EBI-11956479
FLJ13057 [Q53SE7]3EBI-741528,EBI-10172181
GMCL1 [Q96IK5]3EBI-741528,EBI-2548508
HOXA1 [P49639]4EBI-741528,EBI-740785
KANK2 [Q63ZY3]3EBI-741528,EBI-2556193
KRT40 [Q6A162]3EBI-741528,EBI-10171697
KRTAP1-1 [Q07627]3EBI-741528,EBI-11959885
KRTAP10-7 [P60409]3EBI-741528,EBI-10172290
KRTAP10-8 [P60410]6EBI-741528,EBI-10171774
KRTAP10-9 [P60411]3EBI-741528,EBI-10172052
KRTAP12-3 [P60328]3EBI-741528,EBI-11953334
KRTAP2-4 [Q9BYR9]3EBI-741528,EBI-14065470
KRTAP4-2 [Q9BYR5]3EBI-741528,EBI-10172511
KRTAP5-9 [P26371]6EBI-741528,EBI-3958099
KRTAP6-2 [Q3LI66]3EBI-741528,EBI-11962084
LCE1A [Q5T7P2]3EBI-741528,EBI-11962058
LCE1C [Q5T751]3EBI-741528,EBI-12224199
LCE1F [Q5T754]3EBI-741528,EBI-11958008
LCE2C [Q5TA81]3EBI-741528,EBI-11973993
LCE3A [Q5TA76]3EBI-741528,EBI-9394625
LCE3C [Q5T5A8]6EBI-741528,EBI-10245291
LCE3D [Q9BYE3]3EBI-741528,EBI-6658837
LCE5A [Q5TCM9]3EBI-741528,EBI-11955689
LCN2 [P80188]3EBI-741528,EBI-11911016
LZTS2 [Q9BRK4]3EBI-741528,EBI-741037
MEOX2 [P50222]3EBI-741528,EBI-748397
MEOX2 [Q6FHY5]3EBI-741528,EBI-16439278
MTUS2 - isoform 2 [Q5JR59-3]3EBI-741528,EBI-11522433
MYF5 [P13349]3EBI-741528,EBI-17491620
MYPOP [Q86VE0]3EBI-741528,EBI-2858213
NDUFB7 [P17568]3EBI-741528,EBI-1246238
NOTCH2NLA [Q7Z3S9]3EBI-741528,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-741528,EBI-22310682
OTX1 [P32242]4EBI-741528,EBI-740446
PLEKHF1 [Q96S99]3EBI-741528,EBI-745767
PLEKHF2 [Q9H8W4]3EBI-741528,EBI-742388
PLEKHG4 [Q58EX7]3EBI-741528,EBI-949255
PNMA1 [Q8ND90]3EBI-741528,EBI-302345
POU4F2 [Q12837]3EBI-741528,EBI-17236143
REL - isoform 2 [Q04864-2]3EBI-741528,EBI-10829018
SCNM1 [Q9BWG6]3EBI-741528,EBI-748391
SDCBP [O00560]3EBI-741528,EBI-727004
TCF4 [P15884]3EBI-741528,EBI-533224
ZNF330 [Q9Y3S2]3EBI-741528,EBI-373456
ZNF837 [Q96EG3]3EBI-741528,EBI-11962574

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117716, 69 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UKJ5, 64 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263921

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UKJ5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 26Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi88 – 106CHIC motif (Cys-rich)Add BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 15Poly-Glu7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CHIC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4101, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_100628_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKJ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
INRVNGC

Database of Orthologous Groups

More...
OrthoDBi
1449345at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKJ5

TreeFam database of animal gene trees

More...
TreeFami
TF314908

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039735, CHIC1/2
IPR019383, Golgin_A_7/ERF4

The PANTHER Classification System

More...
PANTHERi
PTHR13005, PTHR13005, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10256, Erf4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UKJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADFDEIYEE EEDEERALEE QLLKYSPDPV VVRGSGHVTV FGLSNKFESE
60 70 80 90 100
FPSSLTGKVA PEEFKASINR VNSCLKKNLP VNVRWLLCGC LCCCCTLGCS
110 120 130 140 150
MWPVICLSKR TRRSIEKLLE WENNRLYHKL CLHWRLSKRK CETNNMMEYV
160
ILIEFLPKTP IFRPD
Length:165
Mass (Da):19,254
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC32A9C58524B55E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDW7D6RDW7_HUMAN
Cysteine-rich hydrophobic domain-co...
CHIC2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8H1H0Y8H1_HUMAN
Cysteine-rich hydrophobic domain-co...
CHIC2
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF159423 mRNA Translation: AAD55981.1
AK312427 mRNA Translation: BAG35336.1
CH471057 Genomic DNA Translation: EAX05453.1
BC034691 mRNA Translation: AAH34691.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3493.1

NCBI Reference Sequences

More...
RefSeqi
NP_036242.1, NM_012110.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263921; ENSP00000263921; ENSG00000109220

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26511

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26511

UCSC genome browser

More...
UCSCi
uc003haj.3, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159423 mRNA Translation: AAD55981.1
AK312427 mRNA Translation: BAG35336.1
CH471057 Genomic DNA Translation: EAX05453.1
BC034691 mRNA Translation: AAH34691.1
CCDSiCCDS3493.1
RefSeqiNP_036242.1, NM_012110.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117716, 69 interactors
IntActiQ9UKJ5, 64 interactors
STRINGi9606.ENSP00000263921

PTM databases

iPTMnetiQ9UKJ5
PhosphoSitePlusiQ9UKJ5
SwissPalmiQ9UKJ5

Polymorphism and mutation databases

BioMutaiCHIC2
DMDMi62901505

Proteomic databases

EPDiQ9UKJ5
MassIVEiQ9UKJ5
PaxDbiQ9UKJ5
PeptideAtlasiQ9UKJ5
PRIDEiQ9UKJ5
ProteomicsDBi84809

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12265, 134 antibodies

The DNASU plasmid repository

More...
DNASUi
26511

Genome annotation databases

EnsembliENST00000263921; ENSP00000263921; ENSG00000109220
GeneIDi26511
KEGGihsa:26511
UCSCiuc003haj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26511
DisGeNETi26511
EuPathDBiHostDB:ENSG00000109220.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHIC2
HGNCiHGNC:1935, CHIC2
HPAiENSG00000109220, Low tissue specificity
MalaCardsiCHIC2
MIMi604332, gene
neXtProtiNX_Q9UKJ5
OpenTargetsiENSG00000109220
PharmGKBiPA26466

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4101, Eukaryota
GeneTreeiENSGT00390000003601
HOGENOMiCLU_100628_1_0_1
InParanoidiQ9UKJ5
OMAiINRVNGC
OrthoDBi1449345at2759
PhylomeDBiQ9UKJ5
TreeFamiTF314908

Enzyme and pathway databases

PathwayCommonsiQ9UKJ5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26511, 16 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHIC2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26511
PharosiQ9UKJ5, Tbio

Protein Ontology

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PROi
PR:Q9UKJ5
RNActiQ9UKJ5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000109220, Expressed in testis and 221 other tissues
ExpressionAtlasiQ9UKJ5, baseline and differential
GenevisibleiQ9UKJ5, HS

Family and domain databases

InterProiView protein in InterPro
IPR039735, CHIC1/2
IPR019383, Golgin_A_7/ERF4
PANTHERiPTHR13005, PTHR13005, 1 hit
PfamiView protein in Pfam
PF10256, Erf4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHIC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKJ5
Secondary accession number(s): B2R639
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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