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Protein

Paired immunoglobulin-like type 2 receptor alpha

Gene

PILRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.2 Publications
(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.1 Publication

GO - Molecular functioni

  • MHC class I protein binding Source: GO_Central

GO - Biological processi

  • regulation of immune response Source: Reactome
  • signal transduction Source: MGI
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Paired immunoglobulin-like type 2 receptor alpha
Alternative name(s):
Cell surface receptor FDF03
Inhibitory receptor PILR-alpha
Gene namesi
Name:PILRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000085514.15
HGNCiHGNC:20396 PILRA
MIMi605341 gene
neXtProtiNX_Q9UKJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 197ExtracellularSequence analysisAdd BLAST178
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 303CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi269Y → F: Greatly diminishes interaction with PTPN6. 1 Publication1

Organism-specific databases

DisGeNETi29992
OpenTargetsiENSG00000085514
PharmGKBiPA134873007

Polymorphism and mutation databases

BioMutaiPILRA
DMDMi296439272

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000022682120 – 303Paired immunoglobulin-like type 2 receptor alphaAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.3 Publications
Phosphorylated on tyrosine residues.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UKJ1
PeptideAtlasiQ9UKJ1
PRIDEiQ9UKJ1
ProteomicsDBi84802
84803 [Q9UKJ1-2]
84804 [Q9UKJ1-3]
84805 [Q9UKJ1-4]

PTM databases

iPTMnetiQ9UKJ1
PhosphoSitePlusiQ9UKJ1

Expressioni

Tissue specificityi

Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.1 Publication

Gene expression databases

BgeeiENSG00000085514 Expressed in 168 organ(s), highest expression level in leukocyte
CleanExiHS_PILRA
ExpressionAtlasiQ9UKJ1 baseline and differential
GenevisibleiQ9UKJ1 HS

Organism-specific databases

HPAiHPA056132

Interactioni

Subunit structurei

Monomer. Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon tyrosine phosphorylation.2 Publications
(Microbial infection) Interacts with herpes simplex virus 1 glycoprotein B.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119017, 14 interactors
IntActiQ9UKJ1, 5 interactors
STRINGi9606.ENSP00000198536

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UKJ1
SMRiQ9UKJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 150Ig-like V-typeAdd BLAST119

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 272ITIM motif 16
Motifi296 – 301ITIM motif 26

Domaini

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ9UKJ1
KOiK15411
OMAiFWRWKHF
OrthoDBiEOG091G0NZB
PhylomeDBiQ9UKJ1
TreeFamiTF338478

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRPLLLPLL PLLLPPAFLQ PSGSTGSGPS YLYGVTQPKH LSASMGGSVE
60 70 80 90 100
IPFSFYYPWE LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN
110 120 130 140 150
WTEGQKSGFL RISNLQKQDQ SVYFCRVELD TRSSGRQQWQ SIEGTKLSIT
160 170 180 190 200
QAVTTTTQRP SSMTTTWRLS STTTTTGLRV TQGKRRSDSW HISLETAVGV
210 220 230 240 250
AVAVTVLGIM ILGLICLLRW RRRKGQQRTK ATTPAREPFQ NTEEPYENIR
260 270 280 290 300
NEGQNTDPKL NPKDDGIVYA SLALSSSTSP RAPPSHRPLK SPQNETLYSV

LKA
Length:303
Mass (Da):34,005
Last modified:May 18, 2010 - v3
Checksum:i77BD068C63274A40
GO
Isoform 2 (identifier: Q9UKJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-303: DDGIVYASLA...NETLYSVLKA → LHLTQSTSQP...GLTNGQPSQD

Show »
Length:299
Mass (Da):33,646
Checksum:iB93981138065A130
GO
Isoform 3 (identifier: Q9UKJ1-3) [UniParc]FASTAAdd to basket
Also known as: FDF03-deltaTM

The sequence of this isoform differs from the canonical sequence as follows:
     152-224: Missing.

Show »
Length:230
Mass (Da):25,936
Checksum:i0A24E0FDC626C715
GO
Isoform 4 (identifier: Q9UKJ1-4) [UniParc]FASTAAdd to basket
Also known as: FDF03-M14

The sequence of this isoform differs from the canonical sequence as follows:
     152-303: AVTTTTQRPS...NETLYSVLKA → GNPSKTQRSHMRISGMKDKIQIPS

Show »
Length:175
Mass (Da):19,898
Checksum:i0F604AF3464B59EF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJ79C9JJ79_HUMAN
Paired immunoglobulin-like type 2 r...
PILRA
226Annotation score:
C9JGG1C9JGG1_HUMAN
Paired immunoglobulin-like type 2 r...
PILRA
166Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92D → E in CAC01615 (PubMed:10903717).Curated1
Sequence conflicti281R → K in AAD52964 (PubMed:10660620).Curated1
Isoform 4 (identifier: Q9UKJ1-4)
Sequence conflicti168K → R in CAC01615 (PubMed:10903717).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06036178R → G3 PublicationsCorresponds to variant dbSNP:rs1859788Ensembl.1
Natural variantiVAR_056062279S → L. Corresponds to variant dbSNP:rs34266222Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017500152 – 303AVTTT…SVLKA → GNPSKTQRSHMRISGMKDKI QIPS in isoform 4. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_017501152 – 224Missing in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_017502264 – 303DDGIV…SVLKA → LHLTQSTSQPPSPQEPPERD PVLCLKGLTNGQPSQD in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161080 mRNA Translation: AAD52964.1
AJ400841 mRNA Translation: CAC01613.1
AJ400842 mRNA Translation: CAC01614.1
AJ400843 mRNA Translation: CAC01615.1
AC005071 Genomic DNA No translation available.
BC017812 mRNA Translation: AAH17812.1
CCDSiCCDS47660.1 [Q9UKJ1-4]
CCDS5691.1 [Q9UKJ1-1]
CCDS5692.1 [Q9UKJ1-3]
RefSeqiNP_038467.2, NM_013439.2 [Q9UKJ1-1]
NP_840056.1, NM_178272.1 [Q9UKJ1-3]
NP_840057.1, NM_178273.1 [Q9UKJ1-4]
UniGeneiHs.444407

Genome annotation databases

EnsembliENST00000198536; ENSP00000198536; ENSG00000085514 [Q9UKJ1-1]
ENST00000350573; ENSP00000340109; ENSG00000085514 [Q9UKJ1-3]
ENST00000394000; ENSP00000377569; ENSG00000085514 [Q9UKJ1-4]
GeneIDi29992
KEGGihsa:29992
UCSCiuc003uuo.1 human [Q9UKJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161080 mRNA Translation: AAD52964.1
AJ400841 mRNA Translation: CAC01613.1
AJ400842 mRNA Translation: CAC01614.1
AJ400843 mRNA Translation: CAC01615.1
AC005071 Genomic DNA No translation available.
BC017812 mRNA Translation: AAH17812.1
CCDSiCCDS47660.1 [Q9UKJ1-4]
CCDS5691.1 [Q9UKJ1-1]
CCDS5692.1 [Q9UKJ1-3]
RefSeqiNP_038467.2, NM_013439.2 [Q9UKJ1-1]
NP_840056.1, NM_178272.1 [Q9UKJ1-3]
NP_840057.1, NM_178273.1 [Q9UKJ1-4]
UniGeneiHs.444407

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WUZX-ray1.30A32-150[»]
3WV0X-ray2.30A/B32-150[»]
4NFBX-ray1.60A32-150[»]
5XO2X-ray2.20A/B32-150[»]
5XOFX-ray1.96A/B/C/D32-150[»]
ProteinModelPortaliQ9UKJ1
SMRiQ9UKJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119017, 14 interactors
IntActiQ9UKJ1, 5 interactors
STRINGi9606.ENSP00000198536

PTM databases

iPTMnetiQ9UKJ1
PhosphoSitePlusiQ9UKJ1

Polymorphism and mutation databases

BioMutaiPILRA
DMDMi296439272

Proteomic databases

PaxDbiQ9UKJ1
PeptideAtlasiQ9UKJ1
PRIDEiQ9UKJ1
ProteomicsDBi84802
84803 [Q9UKJ1-2]
84804 [Q9UKJ1-3]
84805 [Q9UKJ1-4]

Protocols and materials databases

DNASUi29992
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000198536; ENSP00000198536; ENSG00000085514 [Q9UKJ1-1]
ENST00000350573; ENSP00000340109; ENSG00000085514 [Q9UKJ1-3]
ENST00000394000; ENSP00000377569; ENSG00000085514 [Q9UKJ1-4]
GeneIDi29992
KEGGihsa:29992
UCSCiuc003uuo.1 human [Q9UKJ1-1]

Organism-specific databases

CTDi29992
DisGeNETi29992
EuPathDBiHostDB:ENSG00000085514.15
GeneCardsiPILRA
HGNCiHGNC:20396 PILRA
HPAiHPA056132
MIMi605341 gene
neXtProtiNX_Q9UKJ1
OpenTargetsiENSG00000085514
PharmGKBiPA134873007
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ9UKJ1
KOiK15411
OMAiFWRWKHF
OrthoDBiEOG091G0NZB
PhylomeDBiQ9UKJ1
TreeFamiTF338478

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiPILRA human
GenomeRNAii29992
PROiPR:Q9UKJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085514 Expressed in 168 organ(s), highest expression level in leukocyte
CleanExiHS_PILRA
ExpressionAtlasiQ9UKJ1 baseline and differential
GenevisibleiQ9UKJ1 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPILRA_HUMAN
AccessioniPrimary (citable) accession number: Q9UKJ1
Secondary accession number(s): Q8NHI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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