Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Paired immunoglobulin-like type 2 receptor beta

Gene

PILRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

GO - Molecular functioni

  • MHC class I protein binding Source: GO_Central

GO - Biological processi

  • activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
  • regulation of immune response Source: Reactome
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Paired immunoglobulin-like type 2 receptor beta
Alternative name(s):
Activating receptor PILR-beta
Cell surface receptor FDFACT
Gene namesi
Name:PILRB
Synonyms:FDFACT
ORF Names:PP1551
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000121716.18
HGNCiHGNC:18297 PILRB
MIMi605342 gene
neXtProtiNX_Q9UKJ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 191ExtracellularSequence analysisAdd BLAST172
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 227CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121716
PharmGKBiPA134906700

Polymorphism and mutation databases

DMDMi74761987

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000022682220 – 227Paired immunoglobulin-like type 2 receptor betaAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UKJ0
PeptideAtlasiQ9UKJ0
PRIDEiQ9UKJ0
ProteomicsDBi84799
84800 [Q9UKJ0-2]
84801 [Q9UKJ0-3]

PTM databases

iPTMnetiQ9UKJ0
PhosphoSitePlusiQ9UKJ0

Expressioni

Gene expression databases

BgeeiENSG00000121716 Expressed in 89 organ(s), highest expression level in adenohypophysis
CleanExiHS_PILRB
ExpressionAtlasiQ9UKJ0 baseline and differential
GenevisibleiQ9UKJ0 HS

Organism-specific databases

HPAiHPA026750

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119015, 2 interactors
IntActiQ9UKJ0, 3 interactors
STRINGi9606.ENSP00000311153

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UKJ0
SMRiQ9UKJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 143Ig-like V-typeAdd BLAST123

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ9UKJ0
OMAiMRISWRW
PhylomeDBiQ9UKJ0
TreeFamiTF338478

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE
60 70 80 90 100
IPFSFYYPWE LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN
110 120 130 140 150
WTEGQESGFL RISNLRKEDQ SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT
160 170 180 190 200
QAVTTTTTWR PSSTTTIAGL RVTESKGHSE SWHLSLDTAI RVALAVAVLK
210 220
TVILGLLCLL LLWWRRRKGS RAPSSDF
Length:227
Mass (Da):25,542
Last modified:May 1, 2000 - v1
Checksum:i7FF960C60AB7EF09
GO
Isoform 2 (identifier: Q9UKJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Show »
Length:149
Mass (Da):16,355
Checksum:i6C5C5524024D1026
GO
Isoform 3 (identifier: Q9UKJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRASYGGSP...PRPLEKNKAM
     23-227: GSTGSGPSYL...KGSRAPSSDF → LCEPALSELD...PPPVVEEKER

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):29,630
Checksum:i31158B0F8F03B41F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNA4C9JNA4_HUMAN
Paired immunoglobulin-like type 2 r...
PILRB
121Annotation score:
C9J8P3C9J8P3_HUMAN
Paired immunoglobulin-like type 2 r...
PILRB
127Annotation score:
C9JTD2C9JTD2_HUMAN
Paired immunoglobulin-like type 2 r...
PILRB
46Annotation score:
V9GYC2V9GYC2_HUMAN
Paired immunoglobulin-like type 2 r...
PILRB
138Annotation score:
C9JGQ4C9JGQ4_HUMAN
Paired immunoglobulin-like type 2 r...
PILRB
60Annotation score:
C9JPU0C9JPU0_HUMAN
Paired immunoglobulin-like type 2 r...
PILRB
107Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63 – 66IVPN → TAPD in CAC19193 (Ref. 2) Curated4
Sequence conflicti212Missing in CAC19193 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05940663I → T. Corresponds to variant dbSNP:rs11771799Ensembl.1
Natural variantiVAR_05940766N → D. Corresponds to variant dbSNP:rs11761306Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175031M → MGRASYGGSPVGHQSSSDHP RAKTCRSPVRDGPRTLCGVP TVALSLHFLREASSGSRTCG RRTSLCTSAKSSWTYRSGRL SWQSIKGTHLTITQALRQPL HRAPLLPGQLCWSPRPLEKN KAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_01750423 – 227GSTGS…PSSDF → LCEPALSELDRGSGERLPQD LKPAEGGPVCVFLPSRAGHP EIREAAVAVHQGDQTHHHPG CHNHHHLEAQQHNHHSRPQG HRKQRALRIMAPKSGHCHQG CIGCRCAQNCHFGTAVPPPP VVEEKER in isoform 2 and isoform 3. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161081 mRNA Translation: AAD52965.1
AJ400845 mRNA Translation: CAC19193.1
AJ400846 mRNA Translation: CAC19194.1
AF217981 mRNA Translation: AAG17224.1
AL834317 mRNA Translation: CAH10714.1
AL834336 mRNA Translation: CAH10711.1
BC050547 mRNA Translation: AAH50547.1
CCDSiCCDS43622.1 [Q9UKJ0-1]
RefSeqiNP_839956.1, NM_178238.3 [Q9UKJ0-1]
UniGeneiHs.521075
Hs.632314

Genome annotation databases

EnsembliENST00000448382; ENSP00000415775; ENSG00000121716 [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716 [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716 [Q9UKJ0-1]
GeneIDi29990
KEGGihsa:29990
UCSCiuc003uun.4 human [Q9UKJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161081 mRNA Translation: AAD52965.1
AJ400845 mRNA Translation: CAC19193.1
AJ400846 mRNA Translation: CAC19194.1
AF217981 mRNA Translation: AAG17224.1
AL834317 mRNA Translation: CAH10714.1
AL834336 mRNA Translation: CAH10711.1
BC050547 mRNA Translation: AAH50547.1
CCDSiCCDS43622.1 [Q9UKJ0-1]
RefSeqiNP_839956.1, NM_178238.3 [Q9UKJ0-1]
UniGeneiHs.521075
Hs.632314

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NFCX-ray2.20A/B32-150[»]
4NFDX-ray1.71A32-150[»]
ProteinModelPortaliQ9UKJ0
SMRiQ9UKJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119015, 2 interactors
IntActiQ9UKJ0, 3 interactors
STRINGi9606.ENSP00000311153

PTM databases

iPTMnetiQ9UKJ0
PhosphoSitePlusiQ9UKJ0

Polymorphism and mutation databases

DMDMi74761987

Proteomic databases

PaxDbiQ9UKJ0
PeptideAtlasiQ9UKJ0
PRIDEiQ9UKJ0
ProteomicsDBi84799
84800 [Q9UKJ0-2]
84801 [Q9UKJ0-3]

Protocols and materials databases

DNASUi29990
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448382; ENSP00000415775; ENSG00000121716 [Q9UKJ0-3]
ENST00000452089; ENSP00000391748; ENSG00000121716 [Q9UKJ0-1]
ENST00000609309; ENSP00000477365; ENSG00000121716 [Q9UKJ0-1]
GeneIDi29990
KEGGihsa:29990
UCSCiuc003uun.4 human [Q9UKJ0-1]

Organism-specific databases

CTDi29990
EuPathDBiHostDB:ENSG00000121716.18
GeneCardsiPILRB
HGNCiHGNC:18297 PILRB
HPAiHPA026750
MIMi605342 gene
neXtProtiNX_Q9UKJ0
OpenTargetsiENSG00000121716
PharmGKBiPA134906700
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ9UKJ0
OMAiMRISWRW
PhylomeDBiQ9UKJ0
TreeFamiTF338478

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiPILRB human
GeneWikiiPILRB
GenomeRNAii29990
PROiPR:Q9UKJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121716 Expressed in 89 organ(s), highest expression level in adenohypophysis
CleanExiHS_PILRB
ExpressionAtlasiQ9UKJ0 baseline and differential
GenevisibleiQ9UKJ0 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPILRB_HUMAN
AccessioniPrimary (citable) accession number: Q9UKJ0
Secondary accession number(s): Q69YF9, Q9HBS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again