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Protein

POU domain, class 2, transcription factor 3

Gene

POU2F3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi281 – 340HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Octamer-binding protein 11
Short name:
Oct-11
Octamer-binding transcription factor 11
Short name:
OTF-11
Transcription factor PLA-1
Transcription factor Skn-1
Gene namesi
Name:POU2F3
Synonyms:OTF11, PLA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137709.9
HGNCiHGNC:19864 POU2F3
MIMi607394 gene
neXtProtiNX_Q9UKI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25833
OpenTargetsiENSG00000137709
PharmGKBiPA134963258

Polymorphism and mutation databases

BioMutaiPOU2F3
DMDMi311033416

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007171 – 436POU domain, class 2, transcription factor 3Add BLAST436

Proteomic databases

PaxDbiQ9UKI9
PeptideAtlasiQ9UKI9
PRIDEiQ9UKI9
ProteomicsDBi84796
84797 [Q9UKI9-2]
84798 [Q9UKI9-3]

PTM databases

iPTMnetiQ9UKI9
PhosphoSitePlusiQ9UKI9

Expressioni

Tissue specificityi

Specifically expressed in epidermis and cultured keratinocytes.

Gene expression databases

BgeeiENSG00000137709 Expressed in 110 organ(s), highest expression level in skin of abdomen
CleanExiHS_POU2F3
ExpressionAtlasiQ9UKI9 baseline and differential
GenevisibleiQ9UKI9 HS

Organism-specific databases

HPAiHPA019652

Interactioni

Protein-protein interaction databases

BioGridi117361, 2 interactors
IntActiQ9UKI9, 1 interactor
STRINGi9606.ENSP00000260264

Structurei

3D structure databases

ProteinModelPortaliQ9UKI9
SMRiQ9UKI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 257POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi354 – 425Ser-richAdd BLAST72

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000220842
HOVERGENiHBG052783
InParanoidiQ9UKI9
KOiK09364
OMAiMVNLEPM
OrthoDBiEOG091G0U0S
PhylomeDBiQ9UKI9
TreeFamiTF316413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKI9-1) [UniParc]FASTAAdd to basket
Also known as: Skn-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL
60 70 80 90 100
SDSLQQTLSH RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV
110 120 130 140 150
PGHLQSVSQF LLSQTQPGQQ GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF
160 170 180 190 200
GHPGLPGSSL EPHLEASQHL PVPKHLPSSG GADEPSDLEE LEKFAKTFKQ
210 220 230 240 250
RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK NMCKLKPLLE
260 270 280 290 300
KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF
310 320 330 340 350
QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP
360 370 380 390 400
VYNSRLVSPS GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA
410 420 430
SSPTASQNNS KAAVNSASSF NSSGSWYRWN HSTYLH
Length:436
Mass (Da):47,432
Last modified:November 2, 2010 - v3
Checksum:iCFF7F0153F0B7589
GO
Isoform 2 (identifier: Q9UKI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MESPRTAKGGR

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):47,560
Checksum:i1630C710251D292B
GO
Isoform 3 (identifier: Q9UKI9-3) [UniParc]FASTAAdd to basket
Also known as: Skn-1n

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MNDAK

Note: Specifically expressed in keratinocytes, induced by high calcium concentration.
Show »
Length:432
Mass (Da):46,949
Checksum:iF8E1EFD969CF6BC1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLC5H0YLC5_HUMAN
POU domain, class 2, transcription ...
POU2F3
160Annotation score:
E9PIN6E9PIN6_HUMAN
POU domain, class 2, transcription ...
POU2F3
126Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6S → P in CAB45383 (Ref. 3) Curated1
Sequence conflicti37N → K in AAD55245 (Ref. 2) Curated1
Sequence conflicti351V → D in AAF00199 (PubMed:10473598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031618152H → R3 PublicationsCorresponds to variant dbSNP:rs7110845Ensembl.1
Natural variantiVAR_055906390R → K1 PublicationCorresponds to variant dbSNP:rs2282537Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0439001 – 9MVNLESMHT → MESPRTAKGGR in isoform 2. 1 Publication9
Alternative sequenceiVSP_0439011 – 9MVNLESMHT → MNDAK in isoform 3. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162278 mRNA Translation: AAF00199.1
AF133895 mRNA Translation: AAD55245.1
AJ012214 mRNA Translation: CAB45383.1
AK291993 mRNA Translation: BAF84682.1
AK302212 mRNA Translation: BAG63569.1
AP000679 Genomic DNA No translation available.
AP001150 Genomic DNA No translation available.
BC101649 mRNA Translation: AAI01650.1
CCDSiCCDS58190.1 [Q9UKI9-2]
CCDS8431.1 [Q9UKI9-1]
RefSeqiNP_001231611.1, NM_001244682.1 [Q9UKI9-2]
NP_055167.2, NM_014352.3 [Q9UKI9-1]
XP_011541041.1, XM_011542739.2 [Q9UKI9-3]
XP_011541042.1, XM_011542740.2 [Q9UKI9-3]
UniGeneiHs.227115

Genome annotation databases

EnsembliENST00000260264; ENSP00000260264; ENSG00000137709 [Q9UKI9-2]
ENST00000543440; ENSP00000441687; ENSG00000137709 [Q9UKI9-1]
GeneIDi25833
KEGGihsa:25833
UCSCiuc001pxc.4 human [Q9UKI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162278 mRNA Translation: AAF00199.1
AF133895 mRNA Translation: AAD55245.1
AJ012214 mRNA Translation: CAB45383.1
AK291993 mRNA Translation: BAF84682.1
AK302212 mRNA Translation: BAG63569.1
AP000679 Genomic DNA No translation available.
AP001150 Genomic DNA No translation available.
BC101649 mRNA Translation: AAI01650.1
CCDSiCCDS58190.1 [Q9UKI9-2]
CCDS8431.1 [Q9UKI9-1]
RefSeqiNP_001231611.1, NM_001244682.1 [Q9UKI9-2]
NP_055167.2, NM_014352.3 [Q9UKI9-1]
XP_011541041.1, XM_011542739.2 [Q9UKI9-3]
XP_011541042.1, XM_011542740.2 [Q9UKI9-3]
UniGeneiHs.227115

3D structure databases

ProteinModelPortaliQ9UKI9
SMRiQ9UKI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117361, 2 interactors
IntActiQ9UKI9, 1 interactor
STRINGi9606.ENSP00000260264

PTM databases

iPTMnetiQ9UKI9
PhosphoSitePlusiQ9UKI9

Polymorphism and mutation databases

BioMutaiPOU2F3
DMDMi311033416

Proteomic databases

PaxDbiQ9UKI9
PeptideAtlasiQ9UKI9
PRIDEiQ9UKI9
ProteomicsDBi84796
84797 [Q9UKI9-2]
84798 [Q9UKI9-3]

Protocols and materials databases

DNASUi25833
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260264; ENSP00000260264; ENSG00000137709 [Q9UKI9-2]
ENST00000543440; ENSP00000441687; ENSG00000137709 [Q9UKI9-1]
GeneIDi25833
KEGGihsa:25833
UCSCiuc001pxc.4 human [Q9UKI9-1]

Organism-specific databases

CTDi25833
DisGeNETi25833
EuPathDBiHostDB:ENSG00000137709.9
GeneCardsiPOU2F3
H-InvDBiHIX0010200
HGNCiHGNC:19864 POU2F3
HPAiHPA019652
MIMi607394 gene
neXtProtiNX_Q9UKI9
OpenTargetsiENSG00000137709
PharmGKBiPA134963258
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000220842
HOVERGENiHBG052783
InParanoidiQ9UKI9
KOiK09364
OMAiMVNLEPM
OrthoDBiEOG091G0U0S
PhylomeDBiQ9UKI9
TreeFamiTF316413

Miscellaneous databases

ChiTaRSiPOU2F3 human
GeneWikiiPOU2F3
GenomeRNAii25833
PROiPR:Q9UKI9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137709 Expressed in 110 organ(s), highest expression level in skin of abdomen
CleanExiHS_POU2F3
ExpressionAtlasiQ9UKI9 baseline and differential
GenevisibleiQ9UKI9 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPO2F3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI9
Secondary accession number(s): A8K7H8
, B4DY07, F5GWW6, Q3MIY3, Q9UKR7, Q9Y504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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