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Protein

POU domain, class 2, transcription factor 3

Gene

POU2F3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi281 – 340HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Octamer-binding protein 11
Short name:
Oct-11
Octamer-binding transcription factor 11
Short name:
OTF-11
Transcription factor PLA-1
Transcription factor Skn-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POU2F3
Synonyms:OTF11, PLA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137709.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19864 POU2F3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607394 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25833

Open Targets

More...
OpenTargetsi
ENSG00000137709

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134963258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POU2F3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033416

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007171 – 436POU domain, class 2, transcription factor 3Add BLAST436

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKI9

PeptideAtlas

More...
PeptideAtlasi
Q9UKI9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKI9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84796
84797 [Q9UKI9-2]
84798 [Q9UKI9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in epidermis and cultured keratinocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137709 Expressed in 110 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...
CleanExi
HS_POU2F3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKI9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKI9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019652

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117361, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UKI9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260264

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UKI9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKI9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 257POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi354 – 425Ser-richAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3802 Eukaryota
ENOG410XQ7X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157627

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220842

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052783

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKI9

KEGG Orthology (KO)

More...
KOi
K09364

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVNLEPM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0U0S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKI9

TreeFam database of animal gene trees

More...
TreeFami
TF316413

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00029 OCTAMER
PR00028 POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKI9-1) [UniParc]FASTAAdd to basket
Also known as: Skn-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVNLESMHTD IKMSGDVADS TDARSTLSQV EPGNDRNGLD FNRQIKTEDL
60 70 80 90 100
SDSLQQTLSH RPCHLSQGPA MMSGNQMSGL NASPCQDMAS LHPLQQLVLV
110 120 130 140 150
PGHLQSVSQF LLSQTQPGQQ GLQPNLLPFP QQQSGLLLPQ TGPGLASQAF
160 170 180 190 200
GHPGLPGSSL EPHLEASQHL PVPKHLPSSG GADEPSDLEE LEKFAKTFKQ
210 220 230 240 250
RRIKLGFTQG DVGLAMGKLY GNDFSQTTIS RFEALNLSFK NMCKLKPLLE
260 270 280 290 300
KWLNDAESSP SDPSVSTPSS YPSLSEVFGR KRKKRTSIET NIRLTLEKRF
310 320 330 340 350
QDNPKPSSEE ISMIAEQLSM EKEVVRVWFC NRRQKEKRIN CPVATPIKPP
360 370 380 390 400
VYNSRLVSPS GSLGPLSVPP VHSTMPGTVT SSCSPGNNSR PSSPGSGLHA
410 420 430
SSPTASQNNS KAAVNSASSF NSSGSWYRWN HSTYLH
Length:436
Mass (Da):47,432
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFF7F0153F0B7589
GO
Isoform 2 (identifier: Q9UKI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MESPRTAKGGR

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):47,560
Checksum:i1630C710251D292B
GO
Isoform 3 (identifier: Q9UKI9-3) [UniParc]FASTAAdd to basket
Also known as: Skn-1n

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVNLESMHT → MNDAK

Note: Specifically expressed in keratinocytes, induced by high calcium concentration.
Show »
Length:432
Mass (Da):46,949
Checksum:iF8E1EFD969CF6BC1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLC5H0YLC5_HUMAN
POU domain, class 2, transcription ...
POU2F3
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIN6E9PIN6_HUMAN
POU domain, class 2, transcription ...
POU2F3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6S → P in CAB45383 (Ref. 3) Curated1
Sequence conflicti37N → K in AAD55245 (Ref. 2) Curated1
Sequence conflicti351V → D in AAF00199 (PubMed:10473598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031618152H → R3 PublicationsCorresponds to variant dbSNP:rs7110845Ensembl.1
Natural variantiVAR_055906390R → K1 PublicationCorresponds to variant dbSNP:rs2282537Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0439001 – 9MVNLESMHT → MESPRTAKGGR in isoform 2. 1 Publication9
Alternative sequenceiVSP_0439011 – 9MVNLESMHT → MNDAK in isoform 3. Curated9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF162278 mRNA Translation: AAF00199.1
AF133895 mRNA Translation: AAD55245.1
AJ012214 mRNA Translation: CAB45383.1
AK291993 mRNA Translation: BAF84682.1
AK302212 mRNA Translation: BAG63569.1
AP000679 Genomic DNA No translation available.
AP001150 Genomic DNA No translation available.
BC101649 mRNA Translation: AAI01650.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58190.1 [Q9UKI9-2]
CCDS8431.1 [Q9UKI9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001231611.1, NM_001244682.1 [Q9UKI9-2]
NP_055167.2, NM_014352.3 [Q9UKI9-1]
XP_011541041.1, XM_011542739.2 [Q9UKI9-3]
XP_011541042.1, XM_011542740.2 [Q9UKI9-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.227115

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260264; ENSP00000260264; ENSG00000137709 [Q9UKI9-2]
ENST00000543440; ENSP00000441687; ENSG00000137709 [Q9UKI9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25833

UCSC genome browser

More...
UCSCi
uc001pxc.4 human [Q9UKI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162278 mRNA Translation: AAF00199.1
AF133895 mRNA Translation: AAD55245.1
AJ012214 mRNA Translation: CAB45383.1
AK291993 mRNA Translation: BAF84682.1
AK302212 mRNA Translation: BAG63569.1
AP000679 Genomic DNA No translation available.
AP001150 Genomic DNA No translation available.
BC101649 mRNA Translation: AAI01650.1
CCDSiCCDS58190.1 [Q9UKI9-2]
CCDS8431.1 [Q9UKI9-1]
RefSeqiNP_001231611.1, NM_001244682.1 [Q9UKI9-2]
NP_055167.2, NM_014352.3 [Q9UKI9-1]
XP_011541041.1, XM_011542739.2 [Q9UKI9-3]
XP_011541042.1, XM_011542740.2 [Q9UKI9-3]
UniGeneiHs.227115

3D structure databases

ProteinModelPortaliQ9UKI9
SMRiQ9UKI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117361, 2 interactors
IntActiQ9UKI9, 1 interactor
STRINGi9606.ENSP00000260264

PTM databases

iPTMnetiQ9UKI9
PhosphoSitePlusiQ9UKI9

Polymorphism and mutation databases

BioMutaiPOU2F3
DMDMi311033416

Proteomic databases

PaxDbiQ9UKI9
PeptideAtlasiQ9UKI9
PRIDEiQ9UKI9
ProteomicsDBi84796
84797 [Q9UKI9-2]
84798 [Q9UKI9-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25833
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260264; ENSP00000260264; ENSG00000137709 [Q9UKI9-2]
ENST00000543440; ENSP00000441687; ENSG00000137709 [Q9UKI9-1]
GeneIDi25833
KEGGihsa:25833
UCSCiuc001pxc.4 human [Q9UKI9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25833
DisGeNETi25833
EuPathDBiHostDB:ENSG00000137709.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POU2F3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010200
HGNCiHGNC:19864 POU2F3
HPAiHPA019652
MIMi607394 gene
neXtProtiNX_Q9UKI9
OpenTargetsiENSG00000137709
PharmGKBiPA134963258

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00940000157627
HOGENOMiHOG000220842
HOVERGENiHBG052783
InParanoidiQ9UKI9
KOiK09364
OMAiMVNLEPM
OrthoDBiEOG091G0U0S
PhylomeDBiQ9UKI9
TreeFamiTF316413

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POU2F3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
POU2F3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25833

Protein Ontology

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PROi
PR:Q9UKI9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000137709 Expressed in 110 organ(s), highest expression level in skin of abdomen
CleanExiHS_POU2F3
ExpressionAtlasiQ9UKI9 baseline and differential
GenevisibleiQ9UKI9 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR000972 TF_octamer
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00029 OCTAMER
PR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO2F3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKI9
Secondary accession number(s): A8K7H8
, B4DY07, F5GWW6, Q3MIY3, Q9UKR7, Q9Y504
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 2, 2010
Last modified: December 5, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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