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Protein

Pre-B lymphocyte protein 3

Gene

VPREB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

GO - Biological processi

  • immune response Source: GO_Central
  • immunoglobulin production Source: GO_Central
  • leukocyte migration Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B lymphocyte protein 3
Alternative name(s):
N27C7-2
Protein VPreB3
Gene namesi
Name:VPREB3
ORF Names:UNQ355/PRO619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128218.7
HGNCiHGNC:12710 VPREB3
MIMi605017 gene
neXtProtiNX_Q9UKI3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi29802
OpenTargetsiENSG00000128218
PharmGKBiPA37325

Polymorphism and mutation databases

BioMutaiVPREB3
DMDMi11387357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001500321 – 123Pre-B lymphocyte protein 3Add BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UKI3
PeptideAtlasiQ9UKI3
PRIDEiQ9UKI3
ProteomicsDBi84790

Expressioni

Tissue specificityi

Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.

Gene expression databases

BgeeiENSG00000128218 Expressed in 104 organ(s), highest expression level in bone marrow
CleanExiHS_VPREB3
ExpressionAtlasiQ9UKI3 baseline and differential
GenevisibleiQ9UKI3 HS

Organism-specific databases

HPAiHPA003041

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000248948

Structurei

3D structure databases

ProteinModelPortaliQ9UKI3
SMRiQ9UKI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 123Ig-likeAdd BLAST103

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IZWB Eukaryota
ENOG41118MJ LUCA
GeneTreeiENSGT00900000140867
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiQ9UKI3
KOiK06553
OMAiDEAHNAC
OrthoDBiEOG091G0TNT
PhylomeDBiQ9UKI3
TreeFamiTF352061

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UKI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR
60 70 80 90 100
DYGVSWYQQR AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL
110 120
TISPVQPEDD ADYYCSVGYG FSP
Length:123
Mass (Da):13,710
Last modified:May 1, 2000 - v1
Checksum:iBF09AC5196059E85
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MX21A8MX21_HUMAN
Pre-B lymphocyte protein 3
VPREB3
107Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0499544R → W. Corresponds to variant dbSNP:rs34372784Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163825 mRNA Translation: AAF09451.1
AB050772 Genomic DNA Translation: BAB83034.1
AY359000 mRNA Translation: AAQ89359.1
CR456610 mRNA Translation: CAG30496.1
AK312098 mRNA Translation: BAG35034.1
CH471095 Genomic DNA Translation: EAW59598.1
BC020666 mRNA Translation: AAH20666.1
CCDSiCCDS13813.1
RefSeqiNP_037510.1, NM_013378.2
UniGeneiHs.136713

Genome annotation databases

EnsembliENST00000248948; ENSP00000248948; ENSG00000128218
GeneIDi29802
KEGGihsa:29802
UCSCiuc002zxt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163825 mRNA Translation: AAF09451.1
AB050772 Genomic DNA Translation: BAB83034.1
AY359000 mRNA Translation: AAQ89359.1
CR456610 mRNA Translation: CAG30496.1
AK312098 mRNA Translation: BAG35034.1
CH471095 Genomic DNA Translation: EAW59598.1
BC020666 mRNA Translation: AAH20666.1
CCDSiCCDS13813.1
RefSeqiNP_037510.1, NM_013378.2
UniGeneiHs.136713

3D structure databases

ProteinModelPortaliQ9UKI3
SMRiQ9UKI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000248948

Polymorphism and mutation databases

BioMutaiVPREB3
DMDMi11387357

Proteomic databases

PaxDbiQ9UKI3
PeptideAtlasiQ9UKI3
PRIDEiQ9UKI3
ProteomicsDBi84790

Protocols and materials databases

DNASUi29802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248948; ENSP00000248948; ENSG00000128218
GeneIDi29802
KEGGihsa:29802
UCSCiuc002zxt.4 human

Organism-specific databases

CTDi29802
DisGeNETi29802
EuPathDBiHostDB:ENSG00000128218.7
GeneCardsiVPREB3
HGNCiHGNC:12710 VPREB3
HPAiHPA003041
MIMi605017 gene
neXtProtiNX_Q9UKI3
OpenTargetsiENSG00000128218
PharmGKBiPA37325
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZWB Eukaryota
ENOG41118MJ LUCA
GeneTreeiENSGT00900000140867
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiQ9UKI3
KOiK06553
OMAiDEAHNAC
OrthoDBiEOG091G0TNT
PhylomeDBiQ9UKI3
TreeFamiTF352061

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSiVPREB3 human
GeneWikiiVPREB3
GenomeRNAii29802
PROiPR:Q9UKI3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128218 Expressed in 104 organ(s), highest expression level in bone marrow
CleanExiHS_VPREB3
ExpressionAtlasiQ9UKI3 baseline and differential
GenevisibleiQ9UKI3 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPRE3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI3
Secondary accession number(s): B2R587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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