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Protein

Cdc42 effector protein 3

Gene

CDC42EP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.2 Publications

GO - Molecular functioni

  • cytoskeletal regulatory protein binding Source: ProtInc
  • GTPase activator activity Source: GO_Central
  • GTP-Rho binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell shape

Enzyme and pathway databases

ReactomeiR-HSA-5687128 MAPK6/MAPK4 signaling
SignaLinkiQ9UKI2

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 3
Alternative name(s):
Binder of Rho GTPases 2
MSE55-related Cdc42-binding protein
Gene namesi
Name:CDC42EP3
Synonyms:BORG2, CEP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163171.7
HGNCiHGNC:16943 CDC42EP3
MIMi606133 gene
neXtProtiNX_Q9UKI2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10602
OpenTargetsiENSG00000163171
PharmGKBiPA38429

Polymorphism and mutation databases

DMDMi71152340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126511 – 254Cdc42 effector protein 3Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphotyrosineBy similarity1
Modified residuei89PhosphoserineCombined sources1
Modified residuei108PhosphoserineBy similarity1
Modified residuei144PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UKI2
MaxQBiQ9UKI2
PaxDbiQ9UKI2
PeptideAtlasiQ9UKI2
PRIDEiQ9UKI2
ProteomicsDBi84789

PTM databases

iPTMnetiQ9UKI2
PhosphoSitePlusiQ9UKI2

Expressioni

Tissue specificityi

Highly expressed in the heart and weakly in the brain.1 Publication

Gene expression databases

BgeeiENSG00000163171
CleanExiHS_CDC42EP3
ExpressionAtlasiQ9UKI2 baseline and differential
GenevisibleiQ9UKI2 HS

Organism-specific databases

HPAiHPA034986
HPA061792

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.2 Publications

GO - Molecular functioni

  • cytoskeletal regulatory protein binding Source: ProtInc
  • GTP-Rho binding Source: GO_Central

Protein-protein interaction databases

BioGridi115849, 10 interactors
IntActiQ9UKI2, 7 interactors
STRINGi9606.ENSP00000295324

Structurei

3D structure databases

ProteinModelPortaliQ9UKI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 45CRIBPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IHT2 Eukaryota
ENOG410Y5G0 LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiQ9UKI2
OMAiFDHPAPC
OrthoDBiEOG091G0MK0
PhylomeDBiQ9UKI2
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH
60 70 80 90 100
DVFGDISFLQ GNYELLPGNQ EKAHLGQFPG HNEFFRANST SDSVFTETPS
110 120 130 140 150
PVLKNAISLP TIGGSQALML PLLSPVTFNS KQESFGPAKL PRLSCEPVME
160 170 180 190 200
EKAQEKSSLL ENGTVHQGDT SWGSSGSASQ SSQGRDSHSS SLSEQYPDWP
210 220 230 240 250
AEDMFDHPTP CELIKGKTKS EESLSDLTGS LLSLQLDLGP SLLDEVLNVM

DKNK
Length:254
Mass (Da):27,678
Last modified:May 1, 2000 - v1
Checksum:iC31CDBE151C161ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56I → N in AAD16888 (PubMed:11035016).Curated1
Sequence conflicti233S → F in AAC71773 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164118 mRNA Translation: AAD48815.1
AF104857 mRNA Translation: AAD16888.1
AF094521 mRNA Translation: AAC71773.1
AL136842 mRNA Translation: CAB66776.1
BT007190 mRNA Translation: AAP35854.1
AK313483 mRNA Translation: BAG36267.1
AC006369 Genomic DNA Translation: AAX93072.1
CH471053 Genomic DNA Translation: EAX00390.1
BC019270 mRNA Translation: AAH19270.1
CCDSiCCDS1791.1
PIRiT46465
RefSeqiNP_001257365.1, NM_001270436.1
NP_001257366.1, NM_001270437.1
NP_001257367.1, NM_001270438.1
NP_006440.2, NM_006449.4
XP_011530784.1, XM_011532482.2
UniGeneiHs.369574

Genome annotation databases

EnsembliENST00000295324; ENSP00000295324; ENSG00000163171
ENST00000611976; ENSP00000480549; ENSG00000163171
GeneIDi10602
KEGGihsa:10602
UCSCiuc002rqi.3 human

Similar proteinsi

Entry informationi

Entry nameiBORG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKI2
Secondary accession number(s): B2R8S0, O95353, Q9UQJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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