UniProtKB - Q9UKG1 (DP13A_HUMAN)

BLAST

>sp|Q9UKG1|DP13A_HUMAN DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHL
TSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKE
RDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMH
YFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREM
DSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQ
FYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESK
KDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRP
PTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTN
PFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRM
TESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLS
SVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIE
KDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA

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History
Entry version 158 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

DCC-interacting protein 13-alpha

Gene

APPL1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.3 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 15016378
extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
insulin receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26073777
regulation of glucose import
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17848569
regulation of protein localization to plasma membrane
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17848569
signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: UniProtKB
Traceable author statementⁱ
- 10490823

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle

Biological process

Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418889 via Dependence Receptors in the absence of ligand
SignaLinkⁱ	Q9UKG1
SIGNORⁱ	Q9UKG1

Protein family/group databases

MoonDBⁱ	Q9UKG1 Curated

MoonDBⁱ

Q9UKG1 Curated

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DCC-interacting protein 13-alpha Short name: Dip13-alpha Alternative name(s): Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
Gene namesⁱ	Name:APPL1 Synonyms:APPLImported, DIP13A, KIAA1428Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157500.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24035 APPL1
MIMⁱ	604299 gene
neXtProtⁱ	NX_Q9UKG1

Keywords - Cellular componentⁱ

Endosome, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Maturity-onset diabetes of the young 14 (MODY14)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	410	S → D: Decreased interaction with OCRL. 1 Publication		1

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26060
MalaCards human disease database More...MalaCardsⁱ	APPL1
MIMⁱ	616511 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000157500
Orphanetⁱ	552 MODY
PharmGKBⁱ	PA162376755

Polymorphism and mutation databases

BioMutaⁱ	APPL1
DMDMⁱ	61213025

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079985	1 – 709	DCC-interacting protein 13-alphaAdd BLAST		709

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	399	PhosphothreonineCombined sources	1
Modified residueⁱ	401	PhosphoserineCombined sources	1
Modified residueⁱ	410	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	693	PhosphoserineBy similarity	1
Modified residueⁱ	696	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UKG1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UKG1
PaxDbⁱ	Q9UKG1
PeptideAtlas More...PeptideAtlasⁱ	Q9UKG1
PRIDEⁱ	Q9UKG1
ProteomicsDBⁱ	84785

PTM databases

iPTMnetⁱ	Q9UKG1
PhosphoSitePlusⁱ	Q9UKG1

Expressionⁱ

Tissue specificityⁱ

High levels in heart, ovary, pancreas and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000157500 Expressed in 219 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_APPL1
ExpressionAtlasⁱ	Q9UKG1 baseline and differential
Genevisibleⁱ	Q9UKG1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011138 HPA073477

HPAⁱ

HPA011138
HPA073477

Interactionⁱ

Subunit structureⁱ

Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Interacts with OCRL and INPP5B. Interacts with NTRK2 (By similarity).By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		10	EBI-741243,EBI-741243
ACTN2	P35609	2	EBI-741243,EBI-77797
ADIPOR1	Q96A54	6	EBI-741243,EBI-1632076
Adipor1	Q91VH1	3	EBI-741243,EBI-992398	From Mus musculus.
ADIPOR2	Q86V24	3	EBI-741243,EBI-1769445
AKT1	P31749	2	EBI-741243,EBI-296087
APPL2	Q8NEU8	9	EBI-741243,EBI-741261
DST	Q03001	3	EBI-741243,EBI-310758
DYSF	O75923	2	EBI-741243,EBI-2799016
EGFR	P00533	2	EBI-741243,EBI-297353
FARS2	O95363	5	EBI-741243,EBI-2513774
HDAC1	Q13547	2	EBI-741243,EBI-301834
HDAC3	O15379	2	EBI-741243,EBI-607682
MAGEA9B	P43362	3	EBI-741243,EBI-10209139
MEOX1	P50221	3	EBI-741243,EBI-2864512
RAB21	Q9UL25	10	EBI-741243,EBI-1056039
RAB5A	P20339	20	EBI-741243,EBI-399437
RHEBL1	Q8TAI7	3	EBI-741243,EBI-746555
RTCB	Q9Y3I0	3	EBI-741243,EBI-2107208
SYNE2	Q8WXH0	3	EBI-741243,EBI-2372294
TRAF2	Q12933	2	EBI-741243,EBI-355744
UBE2O	Q9C0C9	5	EBI-741243,EBI-2339946

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117522, 74 interactors
CORUMⁱ	Q9UKG1
Database of interacting proteins More...DIPⁱ	DIP-29322N
ELMⁱ	Q9UKG1
IntActⁱ	Q9UKG1, 88 interactors
Molecular INTeraction database More...MINTⁱ	Q9UKG1
STRINGⁱ	9606.ENSP00000288266

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 11	Combined sources	3
Turnⁱ	12 – 14	Combined sources	3
Helixⁱ	16 – 66	Combined sources	51
Helixⁱ	67 – 70	Combined sources	4
Helixⁱ	81 – 110	Combined sources	30
Helixⁱ	112 – 120	Combined sources	9
Helixⁱ	122 – 151	Combined sources	30
Beta strandⁱ	152 – 154	Combined sources	3
Helixⁱ	157 – 217	Combined sources	61
Helixⁱ	220 – 257	Combined sources	38
Helixⁱ	259 – 261	Combined sources	3
Beta strandⁱ	262 – 265	Combined sources	4
Turnⁱ	268 – 270	Combined sources	3
Beta strandⁱ	281 – 286	Combined sources	6
Beta strandⁱ	298 – 305	Combined sources	8
Beta strandⁱ	308 – 312	Combined sources	5
Beta strandⁱ	320 – 324	Combined sources	5
Beta strandⁱ	329 – 333	Combined sources	5
Beta strandⁱ	339 – 345	Combined sources	7
Beta strandⁱ	348 – 350	Combined sources	3
Beta strandⁱ	354 – 356	Combined sources	3
Helixⁱ	360 – 374	Combined sources	15
Beta strandⁱ	499 – 512	Combined sources	14
Helixⁱ	519 – 534	Combined sources	16
Beta strandⁱ	542 – 555	Combined sources	14
Turnⁱ	557 – 559	Combined sources	3
Beta strandⁱ	562 – 567	Combined sources	6
Helixⁱ	568 – 570	Combined sources	3
Beta strandⁱ	571 – 577	Combined sources	7
Beta strandⁱ	580 – 590	Combined sources	11
Beta strandⁱ	600 – 610	Combined sources	11
Helixⁱ	612 – 629	Combined sources	18
Helixⁱ	634 – 643	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UKG1
SMRⁱ	Q9UKG1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UKG1

EvolutionaryTraceⁱ

Q9UKG1

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	277 – 375	PHPROSITE-ProRule annotationAdd BLAST		99
Domainⁱ	496 – 656	PIDPROSITE-ProRule annotationAdd BLAST		161

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 428	Required for RAB5A bindingAdd BLAST		428

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	215 – 259	Sequence analysisAdd BLAST		45
Coiled coilⁱ	621 – 673	Sequence analysisAdd BLAST		53

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	403 – 414	F&HAdd BLAST		12

Domainⁱ

Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.1 Publication

The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.1 Publication

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0521 Eukaryota KOG3536 Eukaryota ENOG410ZWZQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106752
HOGENOMⁱ	HOG000285988
HOVERGENⁱ	HBG051394
InParanoidⁱ	Q9UKG1
KEGG Orthology (KO) More...KOⁱ	K08733
OMAⁱ	SDVETMQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08AV
PhylomeDBⁱ	Q9UKG1
TreeFamⁱ	TF328669

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07631 BAR_APPL1, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR037929 APPL1_BAR IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR006020 PTB/PI_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00462 PTB, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit PS01179 PID, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9UKG1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGIDKLPIE ETLEDSPQTR SLLGVFEEDA TAISNYMNQL YQAMHRIYDA 
        60         70         80         90        100
QNELSAATHL TSKLLKEYEK QRFPLGGDDE VMSSTLQQFS KVIDELSSCH 
       110        120        130        140        150
AVLSTQLADA MMFPITQFKE RDLKEILTLK EVFQIASNDH DAAINRYSRL 
       160        170        180        190        200
SKKRENDKVK YEVTEDVYTS RKKQHQTMMH YFCALNTLQY KKKIALLEPL 
       210        220        230        240        250
LGYMQAQISF FKMGSENLNE QLEEFLANIG TSVQNVRREM DSDIETMQQT 
       260        270        280        290        300
IEDLEVASDP LYVPDPDPTK FPVNRNLTRK AGYLNARNKT GLVSSTWDRQ 
       310        320        330        340        350
FYFTQGGNLM SQARGDVAGG LAMDIDNCSV MAVDCEDRRY CFQITSFDGK 
       360        370        380        390        400
KSSILQAESK KDHEEWICTI NNISKQIYLS ENPEETAARV NQSALEAVTP 
       410        420        430        440        450
SPSFQQRHES LRPAAGQSRP PTARTSSSGS LGSESTNLAA LSLDSLVAPD 
       460        470        480        490        500
TPIQFDIISP VCEDQPGQAK AFGQGGRRTN PFGESGGSTK SETEDSILHQ 
       510        520        530        540        550
LFIVRFLGSM EVKSDDHPDV VYETMRQILA ARAIHNIFRM TESHLLVTCD 
       560        570        580        590        600
CLKLIDPQTQ VTRLTFPLPC VVLYATHQEN KRLFGFVLRT SSGRSESNLS 
       610        620        630        640        650
SVCYIFESNN EGEKICDSVG LAKQIALHAE LDRRASEKQK EIERVKEKQQ 
       660        670        680        690        700
KELNKQKQIE KDLEEQSRLI AASSRPNQAS SEGQFVVLSS SQSEESDLGE 

GGKKRESEA

Length:709

Mass (Da):79,663

Last modified:May 1, 2000 - v1

Checksum:ⁱ4CABECFCF4BB110D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JAB0	C9JAB0_HUMAN	DCC-interacting protein 13-alpha DCC-interacting protein 13-alpha	APPL1	133	Annotation score:
C9K0C4	C9K0C4_HUMAN	DCC-interacting protein 13-alpha DCC-interacting protein 13-alpha	APPL1	114	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_075857	94	D → N in MODY14; no effect on protein abundance; loss of function in insulin receptor signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs796065047EnsemblClinVar.	1
Natural variantⁱVAR_050958	108	A → V. Corresponds to variant dbSNP:rs4381906Ensembl.	1
Natural variantⁱVAR_035909	643	E → Q in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_050959	700	E → G. Corresponds to variant dbSNP:rs11544593Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF169797 mRNA Translation: AAF04012.1 AF424738 mRNA Translation: AAL17835.1 AB037849 mRNA Translation: BAA92666.2 BC028599 mRNA Translation: AAH28599.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2882.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036228.1, NM_012096.2
UniGeneⁱ	Hs.476415

Genome annotation databases

Ensemblⁱ	ENST00000288266; ENSP00000288266; ENSG00000157500
GeneIDⁱ	26060
KEGGⁱ	hsa:26060
UCSC genome browser More...UCSCⁱ	uc003dio.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UKG1	APPL1 isoform 1		PANTR		709	UniRef100_Q9UKG1

Protein	Similar proteins		Species	Score	Length	Source
Q9UKG1	DCC-interacting protein 13-alpha		MOUSE		707	UniRef90_Q9UKG1
APPL1 isoform 1		PANTR		709
Uncharacterized protein		CHICK		839
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1		RABIT		711
Uncharacterized protein		COLVI		710
+193

Protein	Similar proteins		Species	Score	Length	Source
Q9UKG1	DCC-interacting protein 13-alpha		MOUSE		707	UniRef50_Q9UKG1
APPL1 isoform 1		PANTR		709
Uncharacterized protein		CHICK		839
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1		RABIT		711
Uncharacterized protein		MONDO		710
+255

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF169797 mRNA Translation: AAF04012.1 AF424738 mRNA Translation: AAL17835.1 AB037849 mRNA Translation: BAA92666.2 BC028599 mRNA Translation: AAH28599.1
CCDSⁱ	CCDS2882.1
RefSeqⁱ	NP_036228.1, NM_012096.2
UniGeneⁱ	Hs.476415

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EJ8	X-ray	1.84	A/B	492-644	[»]
	2ELA	X-ray	2.00	A/B	493-646	[»]
	2ELB	X-ray	2.60	A	1-376	[»]
	2Q12	X-ray	1.79	A	5-265	[»]
	2Q13	X-ray	2.05	A	5-385	[»]
	2Z0N	X-ray	1.95	A	1-275	[»]
	2Z0O	X-ray	2.58	A	1-385	[»]
	5C5B	X-ray	2.90	A/C	5-375	[»]
ProteinModelPortalⁱ	Q9UKG1
SMRⁱ	Q9UKG1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117522, 74 interactors
CORUMⁱ	Q9UKG1
DIPⁱ	DIP-29322N
ELMⁱ	Q9UKG1
IntActⁱ	Q9UKG1, 88 interactors
MINTⁱ	Q9UKG1
STRINGⁱ	9606.ENSP00000288266

Protein family/group databases

MoonDBⁱ	Q9UKG1 Curated

MoonDBⁱ

Q9UKG1 Curated

PTM databases

iPTMnetⁱ	Q9UKG1
PhosphoSitePlusⁱ	Q9UKG1

Polymorphism and mutation databases

BioMutaⁱ	APPL1
DMDMⁱ	61213025

Proteomic databases

EPDⁱ	Q9UKG1
MaxQBⁱ	Q9UKG1
PaxDbⁱ	Q9UKG1
PeptideAtlasⁱ	Q9UKG1
PRIDEⁱ	Q9UKG1
ProteomicsDBⁱ	84785

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000288266; ENSP00000288266; ENSG00000157500
GeneIDⁱ	26060
KEGGⁱ	hsa:26060
UCSCⁱ	uc003dio.4 human

Organism-specific databases

CTDⁱ	26060
DisGeNETⁱ	26060
EuPathDBⁱ	HostDB:ENSG00000157500.10
GeneCardsⁱ	APPL1
HGNCⁱ	HGNC:24035 APPL1
HPAⁱ	HPA011138 HPA073477
MalaCardsⁱ	APPL1
MIMⁱ	604299 gene 616511 phenotype
neXtProtⁱ	NX_Q9UKG1
OpenTargetsⁱ	ENSG00000157500
Orphanetⁱ	552 MODY
PharmGKBⁱ	PA162376755
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0521 Eukaryota KOG3536 Eukaryota ENOG410ZWZQ LUCA
GeneTreeⁱ	ENSGT00710000106752
HOGENOMⁱ	HOG000285988
HOVERGENⁱ	HBG051394
InParanoidⁱ	Q9UKG1
KOⁱ	K08733
OMAⁱ	SDVETMQ
OrthoDBⁱ	EOG091G08AV
PhylomeDBⁱ	Q9UKG1
TreeFamⁱ	TF328669

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418889 via Dependence Receptors in the absence of ligand
SignaLinkⁱ	Q9UKG1
SIGNORⁱ	Q9UKG1

Miscellaneous databases

ChiTaRSⁱ	APPL1 human
EvolutionaryTraceⁱ	Q9UKG1
GeneWikiⁱ	APPL1
GenomeRNAiⁱ	26060
Protein Ontology More...PROⁱ	PR:Q9UKG1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157500 Expressed in 219 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_APPL1
ExpressionAtlasⁱ	Q9UKG1 baseline and differential
Genevisibleⁱ	Q9UKG1 HS

Family and domain databases

CDDⁱ	cd07631 BAR_APPL1, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 2.30.29.30, 2 hits
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR037929 APPL1_BAR IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR006020 PTB/PI_dom
Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00462 PTB, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit PS01179 PID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DP13A_HUMAN
Accessionⁱ	Q9UKG1Primary (citable) accession number: Q9UKG1 Secondary accession number(s): Q9P2B9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q9UKG1 (DP13A_HUMAN)

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DCC-interacting protein 13-alpha

APPL1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Nucleus

Cytosol

Endosome

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ