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UniProtKB - Q9UKF5 (ADA29_HUMAN)

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Protein

Disintegrin and metalloproteinase domain-containing protein 29

Gene

ADAM29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  • metalloendopeptidase activity Source: InterPro
  • metallopeptidase activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • spermatogenesis Source: ProtInc
View the complete GO annotation on QuickGO ...

Protein family/group databases

MEROPSiM12.981

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name:
ADAM 29
Alternative name(s):
Cancer/testis antigen 73
Short name:
CT73
Gene namesi
Name:ADAM29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168594.15
HGNCiHGNC:207 ADAM29
MIMi604778 gene
neXtProtiNX_Q9UKF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini194 – 674ExtracellularSequence analysisAdd BLAST481
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 820CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.1 Publication

Organism-specific databases

DisGeNETi11086
OpenTargetsiENSG00000168594
PharmGKBiPA24524

Polymorphism and mutation databases

BioMutaiADAM29
DMDMi145559438

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002913419 – 193By similarityAdd BLAST175
ChainiPRO_0000029135194 – 820Disintegrin and metalloproteinase domain-containing protein 29Add BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi307 ↔ 384By similarity
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi347 ↔ 369By similarity
Disulfide bondi349 ↔ 354By similarity
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi455 ↔ 475By similarity
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 636By similarity
Disulfide bondi630 ↔ 642By similarity
Disulfide bondi644 ↔ 653By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKF5
PeptideAtlasiQ9UKF5
PRIDEiQ9UKF5
ProteomicsDBi84779
84780 [Q9UKF5-2]
84781 [Q9UKF5-3]

PTM databases

iPTMnetiQ9UKF5
PhosphoSitePlusiQ9UKF5

Expressioni

Tissue specificityi

Expressed specifically in testes.

Gene expression databases

BgeeiENSG00000168594
CleanExiHS_ADAM29
ExpressionAtlasiQ9UKF5 baseline and differential
GenevisibleiQ9UKF5 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352177

Structurei

3D structure databases

ProteinModelPortaliQ9UKF5
SMRiQ9UKF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 390Peptidase M12BPROSITE-ProRule annotationAdd BLAST193
Domaini397 – 483DisintegrinPROSITE-ProRule annotationAdd BLAST87
Domaini625 – 654EGF-likeAdd BLAST30
Repeati739 – 74719
Repeati748 – 75629
Repeati757 – 76539
Repeati766 – 77449
Repeati775 – 78359
Repeati784 – 79269
Repeati793 – 80179
Repeati802 – 81089
Repeati811 – 81999

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni739 – 8199 X 9 AA approximate repeatsAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi484 – 624Cys-richAdd BLAST141
Compositional biasi669 – 675Poly-Lys7

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144019
HOGENOMiHOG000230883
HOVERGENiHBG006978
InParanoidiQ9UKF5
KOiK16069
OMAiCHCNYLW
OrthoDBiEOG091G03BZ
PhylomeDBiQ9UKF5
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9UKF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG 
        60         70         80         90        100
WLSYILPFGG QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC 
       110        120        130        140        150
YYHGYVEGDP ESLVSLSTCF GGFQGILQIN DFAYEIKPLA FSTTFEHLVY 
       160        170        180        190        200
KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI DNSTQKQSSY VGWWIHFRIV 
       210        220        230        240        250
EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG VKVLLFGLEI 
       260        270        280        290        300
WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 
       310        320        330        340        350
GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS 
       360        370        380        390        400
QPRCIMHEGN PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC 
       410        420        430        440        450
GNGVVEEGEE CDCGPLKHCA KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP 
       460        470        480        490        500
SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY VEDGIPCKER GYCYEKSCHD 
       510        520        530        540        550
RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT YIKCNISDVQ 
       560        570        580        590        600
CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 
       610        620        630        640        650
GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP 
       660        670        680        690        700
PNCLIKGYGG SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK 
       710        720        730        740        750
SKPIKKQQDV QTPSAKEEEK IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS 
       760        770        780        790        800
HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP VMPSQSHPQL TPSQSQPPVT 
       810        820
PSQRQPQLMP SQSQPPVTPS
Length:820
Mass (Da):92,759
Last modified:April 17, 2007 - v3
Checksum:iAA2FB11342A884C9
GO
Isoform Beta (identifier: Q9UKF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.

Show »
Length:766
Mass (Da):86,983
Checksum:iACA4BEDFA700ABA5
GO
Isoform Gamma (identifier: Q9UKF5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

Show »
Length:787
Mass (Da):89,460
Checksum:i2B0E5E7C496B8C9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196H → Y in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti744P → H in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti748S → Y in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti753Q → R in AAF03777 (PubMed:10512762).Curated1
Sequence conflicti764T → M in AAF03777 (PubMed:10512762).Curated1
Sequence conflicti769 – 773QPRVM → HPQLT in AAF03777 (PubMed:10512762).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03614831P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs544557652Ensembl.1
Natural variantiVAR_06632272L → F in a melanoma cell line. 1 Publication1
Natural variantiVAR_06632389I → M in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066324111E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant dbSNP:rs267600087Ensembl.1
Natural variantiVAR_066325112S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066326115S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066327131D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066328176E → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs899870236Ensembl.1
Natural variantiVAR_036149205V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772388824Ensembl.1
Natural variantiVAR_066329234S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs866380131Ensembl.1
Natural variantiVAR_066330257I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant dbSNP:rs140083180Ensembl.1
Natural variantiVAR_066331305G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600089Ensembl.1
Natural variantiVAR_066332345D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600090Ensembl.1
Natural variantiVAR_066333403G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs150047888Ensembl.1
Natural variantiVAR_066334434G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant dbSNP:rs267600091Ensembl.1
Natural variantiVAR_066335503E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066336533H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600093Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005491750 – 803Missing in isoform Beta. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_005492763 – 787VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_005493788 – 820Missing in isoform Gamma. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171929 mRNA Translation: AAF03777.1
AF171930 mRNA Translation: AAF03778.1
AF171931 mRNA Translation: AAF03779.1
AF134708 mRNA Translation: AAF22163.1
AK292410 mRNA Translation: BAF85099.1
AC105914 Genomic DNA Translation: AAY41055.1
CH471056 Genomic DNA Translation: EAX04727.1
CH471056 Genomic DNA Translation: EAX04728.1
CCDSiCCDS3823.1 [Q9UKF5-1]
RefSeqiNP_001124175.1, NM_001130703.1 [Q9UKF5-1]
NP_001124176.1, NM_001130704.1 [Q9UKF5-1]
NP_001124177.1, NM_001130705.1 [Q9UKF5-1]
NP_001265054.1, NM_001278125.1 [Q9UKF5-1]
NP_001265055.1, NM_001278126.1 [Q9UKF5-1]
NP_001265056.1, NM_001278127.1 [Q9UKF5-1]
NP_055084.3, NM_014269.4 [Q9UKF5-1]
XP_011529858.1, XM_011531556.1 [Q9UKF5-1]
XP_011529859.1, XM_011531557.1 [Q9UKF5-1]
XP_011529861.1, XM_011531559.1 [Q9UKF5-1]
XP_011529862.1, XM_011531560.1 [Q9UKF5-1]
XP_011529863.1, XM_011531561.1 [Q9UKF5-1]
UniGeneiHs.126838

Genome annotation databases

EnsembliENST00000359240; ENSP00000352177; ENSG00000168594 [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594 [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594 [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594 [Q9UKF5-1]
ENST00000615367; ENSP00000484862; ENSG00000168594 [Q9UKF5-1]
ENST00000618444; ENSP00000478469; ENSG00000168594 [Q9UKF5-1]
GeneIDi11086
KEGGihsa:11086
UCSCiuc003iuc.3 human [Q9UKF5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADA29_HUMAN
AccessioniPrimary (citable) accession number: Q9UKF5
Secondary accession number(s): Q4W5F3
, Q9UHP1, Q9UKF3, Q9UKF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 17, 2007
Last modified: June 20, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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