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UniProtKB - Q9UKF5 (ADA29_HUMAN)

Entry version 181 (10 Feb 2021)
Sequence version 3 (17 Apr 2007)
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Protein

Disintegrin and metalloproteinase domain-containing protein 29

Gene

ADAM29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UKF5

Protein family/group databases

MEROPS protease database

More...MEROPSi		M12.981

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name:
ADAM 29
Alternative name(s):
Cancer/testis antigen 73
Short name:
CT73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAM29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:207, ADAM29

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604778, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UKF5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168594.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini194 – 674ExtracellularSequence analysisAdd BLAST481
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 820CytoplasmicSequence analysisAdd BLAST125

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		11086

Open Targets

More...OpenTargetsi		ENSG00000168594

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24524

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UKF5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADAM29

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002913419 – 193By similarityAdd BLAST175
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029135194 – 820Disintegrin and metalloproteinase domain-containing protein 29Add BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi307 ↔ 384By similarity
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi347 ↔ 369By similarity
Disulfide bondi349 ↔ 354By similarity
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi455 ↔ 475By similarity
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 636By similarity
Disulfide bondi630 ↔ 642By similarity
Disulfide bondi644 ↔ 653By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UKF5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UKF5

PeptideAtlas

More...PeptideAtlasi		Q9UKF5

PRoteomics IDEntifications database

More...PRIDEi		Q9UKF5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84779 [Q9UKF5-1]
84780 [Q9UKF5-2]
84781 [Q9UKF5-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UKF5, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UKF5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UKF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in testes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168594, Expressed in testis and 83 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UKF5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UKF5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168594, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000484862

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UKF5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UKF5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 390Peptidase M12BPROSITE-ProRule annotationAdd BLAST193
Domaini397 – 483DisintegrinPROSITE-ProRule annotationAdd BLAST87
Domaini625 – 654EGF-likeAdd BLAST30
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati739 – 74719
Repeati748 – 75629
Repeati757 – 76539
Repeati766 – 77449
Repeati775 – 78359
Repeati784 – 79269
Repeati793 – 80179
Repeati802 – 81089
Repeati811 – 81999

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni739 – 8199 X 9 AA approximate repeatsAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi484 – 624Cys-richAdd BLAST141
Compositional biasi669 – 675Poly-Lys7

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3607, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012714_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UKF5

Identification of Orthologs from Complete Genome Data

More...OMAi		CHCNYLW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UKF5

TreeFam database of animal gene trees

More...TreeFami		TF314733

Family and domain databases

Conserved Domains Database

More...CDDi		cd04269, ZnMc_adamalysin_II_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.390.10, 1 hit
4.10.70.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006586, ADAM_Cys-rich
IPR018358, Disintegrin_CS
IPR001762, Disintegrin_dom
IPR036436, Disintegrin_dom_sf
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR034027, Reprolysin_adamalysin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08516, ADAM_CR, 1 hit
PF00200, Disintegrin, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00289, DISINTEGRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00608, ACR, 1 hit
SM00050, DISIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57552, SSF57552, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS00427, DISINTEGRIN_1, 1 hit
PS50214, DISINTEGRIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q9UKF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG 
        60         70         80         90        100
WLSYILPFGG QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC 
       110        120        130        140        150
YYHGYVEGDP ESLVSLSTCF GGFQGILQIN DFAYEIKPLA FSTTFEHLVY 
       160        170        180        190        200
KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI DNSTQKQSSY VGWWIHFRIV 
       210        220        230        240        250
EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG VKVLLFGLEI 
       260        270        280        290        300
WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 
       310        320        330        340        350
GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS 
       360        370        380        390        400
QPRCIMHEGN PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC 
       410        420        430        440        450
GNGVVEEGEE CDCGPLKHCA KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP 
       460        470        480        490        500
SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY VEDGIPCKER GYCYEKSCHD 
       510        520        530        540        550
RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT YIKCNISDVQ 
       560        570        580        590        600
CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 
       610        620        630        640        650
GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP 
       660        670        680        690        700
PNCLIKGYGG SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK 
       710        720        730        740        750
SKPIKKQQDV QTPSAKEEEK IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS 
       760        770        780        790        800
HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP VMPSQSHPQL TPSQSQPPVT 
       810        820
PSQRQPQLMP SQSQPPVTPS
Length:820
Mass (Da):92,759
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA2FB11342A884C9
GO
Isoform Beta (identifier: Q9UKF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.

Show »
Length:766
Mass (Da):86,983
Checksum:iACA4BEDFA700ABA5
GO
Isoform Gamma (identifier: Q9UKF5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

Show »
Length:787
Mass (Da):89,460
Checksum:i2B0E5E7C496B8C9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBU0D6RBU0_HUMAN
Disintegrin and metalloproteinase d...
ADAM29
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHU0D6RHU0_HUMAN
Disintegrin and metalloproteinase d...
ADAM29
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIU9D6RIU9_HUMAN
Disintegrin and metalloproteinase d...
ADAM29
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti196H → Y in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti744P → H in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti748S → Y in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti753Q → R in AAF03777 (PubMed:10512762).Curated1
Sequence conflicti764T → M in AAF03777 (PubMed:10512762).Curated1
Sequence conflicti769 – 773QPRVM → HPQLT in AAF03777 (PubMed:10512762).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03614831P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs544557652Ensembl.1
Natural variantiVAR_06632272L → F in a melanoma cell line. 1 Publication1
Natural variantiVAR_06632389I → M in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066324111E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant dbSNP:rs267600087Ensembl.1
Natural variantiVAR_066325112S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066326115S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066327131D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066328176E → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs899870236Ensembl.1
Natural variantiVAR_036149205V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772388824Ensembl.1
Natural variantiVAR_066329234S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs866380131Ensembl.1
Natural variantiVAR_066330257I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant dbSNP:rs140083180Ensembl.1
Natural variantiVAR_066331305G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600089Ensembl.1
Natural variantiVAR_066332345D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600090Ensembl.1
Natural variantiVAR_066333403G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs150047888Ensembl.1
Natural variantiVAR_066334434G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant dbSNP:rs267600091Ensembl.1
Natural variantiVAR_066335503E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066336533H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267600093Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005491750 – 803Missing in isoform Beta. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_005492763 – 787VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_005493788 – 820Missing in isoform Gamma. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF171929 mRNA Translation: AAF03777.1
AF171930 mRNA Translation: AAF03778.1
AF171931 mRNA Translation: AAF03779.1
AF134708 mRNA Translation: AAF22163.1
AK292410 mRNA Translation: BAF85099.1
AC105914 Genomic DNA Translation: AAY41055.1
CH471056 Genomic DNA Translation: EAX04727.1
CH471056 Genomic DNA Translation: EAX04728.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3823.1 [Q9UKF5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001124175.1, NM_001130703.1 [Q9UKF5-1]
NP_001124176.1, NM_001130704.1 [Q9UKF5-1]
NP_001124177.1, NM_001130705.1 [Q9UKF5-1]
NP_001265054.1, NM_001278125.1 [Q9UKF5-1]
NP_001265055.1, NM_001278126.1 [Q9UKF5-1]
NP_001265056.1, NM_001278127.1 [Q9UKF5-1]
NP_055084.3, NM_014269.4 [Q9UKF5-1]
XP_011529858.1, XM_011531556.1 [Q9UKF5-1]
XP_011529859.1, XM_011531557.1 [Q9UKF5-1]
XP_011529861.1, XM_011531559.1 [Q9UKF5-1]
XP_011529862.1, XM_011531560.1 [Q9UKF5-1]
XP_011529863.1, XM_011531561.1 [Q9UKF5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359240; ENSP00000352177; ENSG00000168594 [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594 [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594 [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594 [Q9UKF5-1]
ENST00000615367; ENSP00000484862; ENSG00000168594 [Q9UKF5-1]
ENST00000618444; ENSP00000478469; ENSG00000168594 [Q9UKF5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11086

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11086

UCSC genome browser

More...UCSCi		uc003iuc.3, human [Q9UKF5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171929 mRNA Translation: AAF03777.1
AF171930 mRNA Translation: AAF03778.1
AF171931 mRNA Translation: AAF03779.1
AF134708 mRNA Translation: AAF22163.1
AK292410 mRNA Translation: BAF85099.1
AC105914 Genomic DNA Translation: AAY41055.1
CH471056 Genomic DNA Translation: EAX04727.1
CH471056 Genomic DNA Translation: EAX04728.1
CCDSiCCDS3823.1 [Q9UKF5-1]
RefSeqiNP_001124175.1, NM_001130703.1 [Q9UKF5-1]
NP_001124176.1, NM_001130704.1 [Q9UKF5-1]
NP_001124177.1, NM_001130705.1 [Q9UKF5-1]
NP_001265054.1, NM_001278125.1 [Q9UKF5-1]
NP_001265055.1, NM_001278126.1 [Q9UKF5-1]
NP_001265056.1, NM_001278127.1 [Q9UKF5-1]
NP_055084.3, NM_014269.4 [Q9UKF5-1]
XP_011529858.1, XM_011531556.1 [Q9UKF5-1]
XP_011529859.1, XM_011531557.1 [Q9UKF5-1]
XP_011529861.1, XM_011531559.1 [Q9UKF5-1]
XP_011529862.1, XM_011531560.1 [Q9UKF5-1]
XP_011529863.1, XM_011531561.1 [Q9UKF5-1]

3D structure databases

SMRiQ9UKF5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000484862

Protein family/group databases

MEROPSiM12.981

PTM databases

GlyGeniQ9UKF5, 9 sites
iPTMnetiQ9UKF5
PhosphoSitePlusiQ9UKF5

Genetic variation databases

BioMutaiADAM29
DMDMi145559438

Proteomic databases

MassIVEiQ9UKF5
PaxDbiQ9UKF5
PeptideAtlasiQ9UKF5
PRIDEiQ9UKF5
ProteomicsDBi84779 [Q9UKF5-1]
84780 [Q9UKF5-2]
84781 [Q9UKF5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2608, 83 antibodies

The DNASU plasmid repository

More...DNASUi		11086

Genome annotation databases

EnsembliENST00000359240; ENSP00000352177; ENSG00000168594 [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594 [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594 [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594 [Q9UKF5-1]
ENST00000615367; ENSP00000484862; ENSG00000168594 [Q9UKF5-1]
ENST00000618444; ENSP00000478469; ENSG00000168594 [Q9UKF5-1]
GeneIDi11086
KEGGihsa:11086
UCSCiuc003iuc.3, human [Q9UKF5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11086
DisGeNETi11086

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADAM29
HGNCiHGNC:207, ADAM29
HPAiENSG00000168594, Tissue enriched (testis)
MIMi604778, gene
neXtProtiNX_Q9UKF5
OpenTargetsiENSG00000168594
PharmGKBiPA24524
VEuPathDBiHostDB:ENSG00000168594.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3607, Eukaryota
GeneTreeiENSGT00940000163394
HOGENOMiCLU_012714_4_0_1
InParanoidiQ9UKF5
OMAiCHCNYLW
PhylomeDBiQ9UKF5
TreeFamiTF314733

Enzyme and pathway databases

PathwayCommonsiQ9UKF5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11086, 5 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADAM29, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11086
PharosiQ9UKF5, Tbio

Protein Ontology

More...PROi		PR:Q9UKF5
RNActiQ9UKF5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168594, Expressed in testis and 83 other tissues
ExpressionAtlasiQ9UKF5, baseline and differential
GenevisibleiQ9UKF5, HS

Family and domain databases

CDDicd04269, ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586, ADAM_Cys-rich
IPR018358, Disintegrin_CS
IPR001762, Disintegrin_dom
IPR036436, Disintegrin_dom_sf
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR034027, Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516, ADAM_CR, 1 hit
PF00200, Disintegrin, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PRINTSiPR00289, DISINTEGRIN
SMARTiView protein in SMART
SM00608, ACR, 1 hit
SM00050, DISIN, 1 hit
SUPFAMiSSF57552, SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS00427, DISINTEGRIN_1, 1 hit
PS50214, DISINTEGRIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA29_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKF5
Secondary accession number(s): Q4W5F3
, Q9UHP1, Q9UKF3, Q9UKF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 17, 2007
Last modified: February 10, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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