UniProtKB - Q9UKE5 (TNIK_HUMAN)
TRAF2 and NCK-interacting protein kinase
TNIK
Functioni
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
6 PublicationsCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 153 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 39 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- cytoskeleton organization Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- MAPK cascade Source: GO_Central
- microvillus assembly Source: UniProtKB
- neuron projection morphogenesis Source: GO_Central
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of dendrite morphogenesis Source: UniProtKB
- regulation of MAPK cascade Source: GO_Central
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Neurogenesis, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UKE5 |
Reactomei | R-HSA-2559580, Oxidative Stress Induced Senescence |
SignaLinki | Q9UKE5 |
SIGNORi | Q9UKE5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TNIK Synonyms:KIAA0551 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30765, TNIK |
MIMi | 610005, gene |
neXtProti | NX_Q9UKE5 |
VEuPathDBi | HostDB:ENSG00000154310 |
Subcellular locationi
Nucleus
Cytoskeleton
Endosome
Cytoplasm and Cytosol
Note: Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Cytoskeleton
- cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: HPA
Endosome
- recycling endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- postsynaptic density, intracellular component Source: Ensembl
- presynapse Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Endosome, NucleusPathology & Biotechi
Involvement in diseasei
Mental retardation, autosomal recessive 54 (MRT54)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 54 | K → A: Kinase dead. Loss of autophosphorylation and loss of function in cytoskeleton regulation. 2 Publications | 1 | |
Mutagenesisi | 152 – 153 | RD → AA: Loss of autophosphorylation. 1 Publication | 2 | |
Mutagenesisi | 171 – 172 | DF → AA: Loss of autophosphorylation. 1 Publication | 2 |
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 23043 |
MalaCardsi | TNIK |
MIMi | 617028, phenotype |
OpenTargetsi | ENSG00000154310 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability |
PharmGKBi | PA134893180 |
Miscellaneous databases
Pharosi | Q9UKE5, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4527 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UKE5 |
GuidetoPHARMACOLOGYi | 2244 |
Genetic variation databases
BioMutai | TNIK |
DMDMi | 29840818 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086761 | 1 – 1360 | TRAF2 and NCK-interacting protein kinaseAdd BLAST | 1360 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 187 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 324 | PhosphoserineBy similarity | 1 | |
Modified residuei | 326 | PhosphoserineCombined sources | 1 | |
Modified residuei | 560 | PhosphoserineCombined sources | 1 | |
Modified residuei | 570 | PhosphoserineCombined sources | 1 | |
Modified residuei | 581 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 600 | PhosphoserineCombined sources | 1 | |
Modified residuei | 608 | PhosphoserineCombined sources | 1 | |
Modified residuei | 610 | PhosphoserineCombined sources | 1 | |
Modified residuei | 640 | PhosphoserineCombined sources | 1 | |
Modified residuei | 678 | PhosphoserineCombined sources | 1 | |
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 688 | PhosphoserineCombined sources | 1 | |
Modified residuei | 701 | PhosphoserineCombined sources | 1 | |
Modified residuei | 707 | PhosphoserineCombined sources | 1 | |
Modified residuei | 720 | PhosphoserineCombined sources | 1 | |
Modified residuei | 764 | PhosphoserineCombined sources | 1 | |
Modified residuei | 766 | PhosphoserineCombined sources | 1 | |
Modified residuei | 769 | PhosphoserineCombined sources | 1 | |
Modified residuei | 959 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UKE5 |
jPOSTi | Q9UKE5 |
MassIVEi | Q9UKE5 |
MaxQBi | Q9UKE5 |
PaxDbi | Q9UKE5 |
PeptideAtlasi | Q9UKE5 |
PRIDEi | Q9UKE5 |
ProteomicsDBi | 84769 [Q9UKE5-1] 84770 [Q9UKE5-2] 84771 [Q9UKE5-3] 84772 [Q9UKE5-4] 84773 [Q9UKE5-5] 84774 [Q9UKE5-6] 84775 [Q9UKE5-7] 84776 [Q9UKE5-8] |
PTM databases
GlyGeni | Q9UKE5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UKE5 |
PhosphoSitePlusi | Q9UKE5 |
SwissPalmi | Q9UKE5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154310, Expressed in corpus callosum and 223 other tissues |
ExpressionAtlasi | Q9UKE5, baseline and differential |
Genevisiblei | Q9UKE5, HS |
Organism-specific databases
HPAi | ENSG00000154310, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A.
Interacts with NEDD4; recruits RAP2A to NEDD4.
Interacts with TRAF2 and NCK.
Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct.
Interacts with TANC1.
5 PublicationsBinary interactionsi
Q9UKE5
Protein-protein interaction databases
BioGRIDi | 116682, 111 interactors |
DIPi | DIP-37562N |
IntActi | Q9UKE5, 122 interactors |
MINTi | Q9UKE5 |
STRINGi | 9606.ENSP00000399511 |
Chemistry databases
BindingDBi | Q9UKE5 |
Miscellaneous databases
RNActi | Q9UKE5, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UKE5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UKE5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 289 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 265 | |
Domaini | 1047 – 1334 | CNHPROSITE-ProRule annotationAdd BLAST | 288 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 284 – 347 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 290 – 1047 | Mediates interaction with NEDD41 PublicationAdd BLAST | 758 | |
Regioni | 398 – 440 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 539 – 589 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 601 – 801 | DisorderedSequence analysisAdd BLAST | 201 | |
Regioni | 814 – 878 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 908 – 927 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 933 – 998 | DisorderedSequence analysisAdd BLAST | 66 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 288 – 320 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 321 – 336 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 563 – 577 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 602 – 647 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 656 – 670 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 671 – 687 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 719 – 759 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 776 – 801 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 814 – 831 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 834 – 849 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 933 – 981 | Polar residuesSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0587, Eukaryota |
GeneTreei | ENSGT00950000183196 |
InParanoidi | Q9UKE5 |
OMAi | FKIVRYE |
OrthoDBi | 533537at2759 |
PhylomeDBi | Q9UKE5 |
TreeFami | TF105138 |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTG DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ
110 120 130 140 150
LWLVMEFCGA GSVTDLIKNT KGNTLKEEWI AYICREILRG LSHLHQHKVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPA
260 270 280 290 300
PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL
360 370 380 390 400
RRDFLRLQLA NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE
410 420 430 440 450
QRRRLEEQQR REKELRKQQE REQRRHYEEQ MRREEERRRA EHEQEYIRRQ
460 470 480 490 500
LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL EEQRQAERLQ RQLKQERDYL
510 520 530 540 550
VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER SRLNRQSSPA
560 570 580 590 600
MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS
610 620 630 640 650
QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP
660 670 680 690 700
TRIEKFDRSS WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG
710 720 730 740 750
SQPIRASNPD LRRTEPILES PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS
760 770 780 790 800
QAGSSERTRV RANSKSEGSP VLPHEPAKVK PEESRDITRP SRPASYKKAI
810 820 830 840 850
DEDLTALAKE LRELRIEETN RPMKKVTDYS SSSEESESSE EEEEDGESET
860 870 880 890 900
HDGTVAVSDI PRLIPTGAPG SNEQYNVGMV GTHGLETSHA DSFSGSISRE
910 920 930 940 950
GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV
960 970 980 990 1000
STHSQEMDSG TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA
1010 1020 1030 1040 1050
LFTSELLRQE QAKLNEARKI SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI
1060 1070 1080 1090 1100
LCAALWGVNL LVGTENGLML LDRSGQGKVY NLINRRRFQQ MDVLEGLNVL
1110 1120 1130 1140 1150
VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD LEGCIHYKVV
1160 1170 1180 1190 1200
KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE
1210 1220 1230 1240 1250
EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD
1260 1270 1280 1290 1300
GMEMLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK
1310 1320 1330 1340 1350
AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR SGGSSQVFFM
1360
TLNRNSMMNW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J338 | C9J338_HUMAN | TRAF2 and NCK-interacting protein k... | TNIK | 350 | Annotation score: | ||
C9JVV1 | C9JVV1_HUMAN | TRAF2 and NCK-interacting protein k... | TNIK | 45 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041231 | 778 | K → E1 PublicationCorresponds to variant dbSNP:rs55778284Ensembl. | 1 | |
Natural variantiVAR_041232 | 910 | G → E1 PublicationCorresponds to variant dbSNP:rs35090763EnsemblClinVar. | 1 | |
Natural variantiVAR_041233 | 999 | A → T1 PublicationCorresponds to variant dbSNP:rs17857452Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004889 | 445 – 473 | Missing in isoform 2, isoform 5, isoform 6 and isoform 8. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_004890 | 537 – 591 | Missing in isoform 3, isoform 5, isoform 7 and isoform 8. 2 PublicationsAdd BLAST | 55 | |
Alternative sequenceiVSP_004891 | 795 – 802 | Missing in isoform 4, isoform 6, isoform 7 and isoform 8. 1 Publication | 8 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000284483; ENSP00000284483; ENSG00000154310 [Q9UKE5-4] ENST00000341852; ENSP00000345352; ENSG00000154310 [Q9UKE5-5] ENST00000357327; ENSP00000349880; ENSG00000154310 [Q9UKE5-2] ENST00000436636; ENSP00000399511; ENSG00000154310 ENST00000460047; ENSP00000418916; ENSG00000154310 [Q9UKE5-7] ENST00000470834; ENSP00000419990; ENSG00000154310 [Q9UKE5-6] ENST00000475336; ENSP00000418156; ENSG00000154310 [Q9UKE5-8] ENST00000488470; ENSP00000418378; ENSG00000154310 [Q9UKE5-3] |
GeneIDi | 23043 |
KEGGi | hsa:23043 |
MANE-Selecti | ENST00000436636.7; ENSP00000399511.2; NM_015028.4; NP_055843.1 |
UCSCi | uc003fhh.3, human [Q9UKE5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2X7F | X-ray | 2.80 | A/B/C/D/E | 1-325 | [»] | |
5AX9 | X-ray | 2.40 | A/B/C | 11-314 | [»] | |
5CWZ | X-ray | 2.90 | A/B/C | 11-314 | [»] | |
5D7A | X-ray | 2.90 | A/B/C | 11-314 | [»] | |
6RA5 | X-ray | 2.90 | A/B | 11-314 | [»] | |
6RA7 | X-ray | 1.20 | A | 11-314 | [»] | |
SMRi | Q9UKE5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116682, 111 interactors |
DIPi | DIP-37562N |
IntActi | Q9UKE5, 122 interactors |
MINTi | Q9UKE5 |
STRINGi | 9606.ENSP00000399511 |
Chemistry databases
BindingDBi | Q9UKE5 |
ChEMBLi | CHEMBL4527 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UKE5 |
GuidetoPHARMACOLOGYi | 2244 |
PTM databases
GlyGeni | Q9UKE5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UKE5 |
PhosphoSitePlusi | Q9UKE5 |
SwissPalmi | Q9UKE5 |
Genetic variation databases
BioMutai | TNIK |
DMDMi | 29840818 |
Proteomic databases
EPDi | Q9UKE5 |
jPOSTi | Q9UKE5 |
MassIVEi | Q9UKE5 |
MaxQBi | Q9UKE5 |
PaxDbi | Q9UKE5 |
PeptideAtlasi | Q9UKE5 |
PRIDEi | Q9UKE5 |
ProteomicsDBi | 84769 [Q9UKE5-1] 84770 [Q9UKE5-2] 84771 [Q9UKE5-3] 84772 [Q9UKE5-4] 84773 [Q9UKE5-5] 84774 [Q9UKE5-6] 84775 [Q9UKE5-7] 84776 [Q9UKE5-8] |
Protocols and materials databases
Antibodypediai | 2086, 551 antibodies from 32 providers |
DNASUi | 23043 |
Genome annotation databases
Ensembli | ENST00000284483; ENSP00000284483; ENSG00000154310 [Q9UKE5-4] ENST00000341852; ENSP00000345352; ENSG00000154310 [Q9UKE5-5] ENST00000357327; ENSP00000349880; ENSG00000154310 [Q9UKE5-2] ENST00000436636; ENSP00000399511; ENSG00000154310 ENST00000460047; ENSP00000418916; ENSG00000154310 [Q9UKE5-7] ENST00000470834; ENSP00000419990; ENSG00000154310 [Q9UKE5-6] ENST00000475336; ENSP00000418156; ENSG00000154310 [Q9UKE5-8] ENST00000488470; ENSP00000418378; ENSG00000154310 [Q9UKE5-3] |
GeneIDi | 23043 |
KEGGi | hsa:23043 |
MANE-Selecti | ENST00000436636.7; ENSP00000399511.2; NM_015028.4; NP_055843.1 |
UCSCi | uc003fhh.3, human [Q9UKE5-1] |
Organism-specific databases
CTDi | 23043 |
DisGeNETi | 23043 |
GeneCardsi | TNIK |
HGNCi | HGNC:30765, TNIK |
HPAi | ENSG00000154310, Tissue enhanced (brain) |
MalaCardsi | TNIK |
MIMi | 610005, gene 617028, phenotype |
neXtProti | NX_Q9UKE5 |
OpenTargetsi | ENSG00000154310 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability |
PharmGKBi | PA134893180 |
VEuPathDBi | HostDB:ENSG00000154310 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0587, Eukaryota |
GeneTreei | ENSGT00950000183196 |
InParanoidi | Q9UKE5 |
OMAi | FKIVRYE |
OrthoDBi | 533537at2759 |
PhylomeDBi | Q9UKE5 |
TreeFami | TF105138 |
Enzyme and pathway databases
PathwayCommonsi | Q9UKE5 |
Reactomei | R-HSA-2559580, Oxidative Stress Induced Senescence |
SignaLinki | Q9UKE5 |
SIGNORi | Q9UKE5 |
Miscellaneous databases
BioGRID-ORCSi | 23043, 7 hits in 1078 CRISPR screens |
ChiTaRSi | TNIK, human |
EvolutionaryTracei | Q9UKE5 |
GeneWikii | TNIK |
GenomeRNAii | 23043 |
Pharosi | Q9UKE5, Tchem |
PROi | PR:Q9UKE5 |
RNActi | Q9UKE5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154310, Expressed in corpus callosum and 223 other tissues |
ExpressionAtlasi | Q9UKE5, baseline and differential |
Genevisiblei | Q9UKE5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TNIK_HUMAN | |
Accessioni | Q9UKE5Primary (citable) accession number: Q9UKE5 Secondary accession number(s): A7E2A3 Q9UKE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families