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UniProtKB - Q9UKE5 (TNIK_HUMAN)

Entry version 197 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

TRAF2 and NCK-interacting protein kinase

Gene

TNIK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei54ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processNeurogenesis, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UKE5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2559580, Oxidative Stress Induced Senescence

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UKE5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UKE5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TRAF2 and NCK-interacting protein kinase (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNIK
Synonyms:KIAA0551
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000154310.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:30765, TNIK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610005, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UKE5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 54 (MRT54)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT54 patients manifest intellectual disability, delayed speech and hyperactivity.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54K → A: Kinase dead. Loss of autophosphorylation and loss of function in cytoskeleton regulation. 2 Publications1
Mutagenesisi152 – 153RD → AA: Loss of autophosphorylation. 1 Publication2
Mutagenesisi171 – 172DF → AA: Loss of autophosphorylation. 1 Publication2

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		23043

MalaCards human disease database

More...MalaCardsi		TNIK
MIMi617028, phenotype

Open Targets

More...OpenTargetsi		ENSG00000154310

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		88616, Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134893180

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UKE5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4527

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		Q9UKE5

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2244

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNIK

Domain mapping of disease mutations (DMDM)

More...DMDMi		29840818

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867611 – 1360TRAF2 and NCK-interacting protein kinaseAdd BLAST1360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei187PhosphothreonineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei581PhosphothreonineBy similarity1
Modified residuei600PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei766PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UKE5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UKE5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UKE5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UKE5

PeptideAtlas

More...PeptideAtlasi		Q9UKE5

PRoteomics IDEntifications database

More...PRIDEi		Q9UKE5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84769 [Q9UKE5-1]
84770 [Q9UKE5-2]
84771 [Q9UKE5-3]
84772 [Q9UKE5-4]
84773 [Q9UKE5-5]
84774 [Q9UKE5-6]
84775 [Q9UKE5-7]
84776 [Q9UKE5-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UKE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UKE5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UKE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154310, Expressed in corpus callosum and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UKE5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UKE5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154310, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A.

Interacts with NEDD4; recruits RAP2A to NEDD4.

Interacts with TRAF2 and NCK.

Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct.

Interacts with TANC1.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116682, 63 interactors

Database of interacting proteins

More...DIPi		DIP-37562N

Protein interaction database and analysis system

More...IntActi		Q9UKE5, 120 interactors

Molecular INTeraction database

More...MINTi		Q9UKE5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000399511

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UKE5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UKE5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UKE5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UKE5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini1047 – 1334CNHPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni290 – 1047Mediates interaction with NEDD41 PublicationAdd BLAST758

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0587, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183196

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UKE5

KEGG Orthology (KO)

More...KOi		K08840

Identification of Orthologs from Complete Genome Data

More...OMAi		FKIVRYE

Database of Orthologous Groups

More...OrthoDBi		533537at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UKE5

TreeFam database of animal gene trees

More...TreeFami		TF105138

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001180, CNH_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00036, CNH, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50219, CNH, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTG DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ 
       110        120        130        140        150
LWLVMEFCGA GSVTDLIKNT KGNTLKEEWI AYICREILRG LSHLHQHKVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPA 
       260        270        280        290        300
PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL 
       360        370        380        390        400
RRDFLRLQLA NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE 
       410        420        430        440        450
QRRRLEEQQR REKELRKQQE REQRRHYEEQ MRREEERRRA EHEQEYIRRQ 
       460        470        480        490        500
LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL EEQRQAERLQ RQLKQERDYL 
       510        520        530        540        550
VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER SRLNRQSSPA 
       560        570        580        590        600
MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS 
       610        620        630        640        650
QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP 
       660        670        680        690        700
TRIEKFDRSS WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG 
       710        720        730        740        750
SQPIRASNPD LRRTEPILES PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS 
       760        770        780        790        800
QAGSSERTRV RANSKSEGSP VLPHEPAKVK PEESRDITRP SRPASYKKAI 
       810        820        830        840        850
DEDLTALAKE LRELRIEETN RPMKKVTDYS SSSEESESSE EEEEDGESET 
       860        870        880        890        900
HDGTVAVSDI PRLIPTGAPG SNEQYNVGMV GTHGLETSHA DSFSGSISRE 
       910        920        930        940        950
GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV 
       960        970        980        990       1000
STHSQEMDSG TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA 
      1010       1020       1030       1040       1050
LFTSELLRQE QAKLNEARKI SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI 
      1060       1070       1080       1090       1100
LCAALWGVNL LVGTENGLML LDRSGQGKVY NLINRRRFQQ MDVLEGLNVL 
      1110       1120       1130       1140       1150
VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD LEGCIHYKVV 
      1160       1170       1180       1190       1200
KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE 
      1210       1220       1230       1240       1250
EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD 
      1260       1270       1280       1290       1300
GMEMLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK 
      1310       1320       1330       1340       1350
AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR SGGSSQVFFM 
      1360
TLNRNSMMNW
Length:1,360
Mass (Da):154,943
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3590BC2905A72C3D
GO
Isoform 2 (identifier: Q9UKE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.

Show »
Length:1,331
Mass (Da):151,300
Checksum:i85378CBC98631411
GO
Isoform 3 (identifier: Q9UKE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-591: Missing.

Show »
Length:1,305
Mass (Da):148,829
Checksum:i209230BB15712DFC
GO
Isoform 4 (identifier: Q9UKE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-802: Missing.

Show »
Length:1,352
Mass (Da):154,008
Checksum:iF4708A71FF26C54F
GO
Isoform 5 (identifier: Q9UKE5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     537-591: Missing.

Show »
Length:1,276
Mass (Da):145,186
Checksum:i9B85E462E4FAE9F0
GO
Isoform 6 (identifier: Q9UKE5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     795-802: Missing.

Show »
Length:1,323
Mass (Da):150,365
Checksum:i93B2E73EF75034B9
GO
Isoform 7 (identifier: Q9UKE5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-591: Missing.
     795-802: Missing.

Show »
Length:1,297
Mass (Da):147,894
Checksum:iEED944B571948D3F
GO
Isoform 8 (identifier: Q9UKE5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     537-591: Missing.
     795-802: Missing.

Show »
Length:1,268
Mass (Da):144,251
Checksum:i55AD5F59B7A08A2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J338C9J338_HUMAN
TRAF2 and NCK-interacting protein k...
TNIK
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVV1C9JVV1_HUMAN
TRAF2 and NCK-interacting protein k...
TNIK
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25477 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041231778K → E1 PublicationCorresponds to variant dbSNP:rs55778284Ensembl.1
Natural variantiVAR_041232910G → E1 PublicationCorresponds to variant dbSNP:rs35090763Ensembl.1
Natural variantiVAR_041233999A → T1 PublicationCorresponds to variant dbSNP:rs17857452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004889445 – 473Missing in isoform 2, isoform 5, isoform 6 and isoform 8. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_004890537 – 591Missing in isoform 3, isoform 5, isoform 7 and isoform 8. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_004891795 – 802Missing in isoform 4, isoform 6, isoform 7 and isoform 8. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF172264 mRNA Translation: AAF03782.1
AF172268 mRNA Translation: AAF03786.1
AF172267 mRNA Translation: AAF03785.1
AF172266 mRNA Translation: AAF03784.1
AF172265 mRNA Translation: AAF03783.1
AF172270 mRNA Translation: AAF03788.1
AF172271 mRNA Translation: AAF03789.1
AF172269 mRNA Translation: AAF03787.1
AB011123 mRNA Translation: BAA25477.2 Different initiation.
AK291056 mRNA Translation: BAF83745.1
AC026315 Genomic DNA No translation available.
AC078793 Genomic DNA No translation available.
AC092919 Genomic DNA No translation available.
AC137517 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78484.1
CH471052 Genomic DNA Translation: EAW78489.1
CH471052 Genomic DNA Translation: EAW78492.1
CH471052 Genomic DNA Translation: EAW78493.1
BC019081 mRNA Translation: AAH19081.2
BC150256 mRNA Translation: AAI50257.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46956.1 [Q9UKE5-1]
CCDS54673.1 [Q9UKE5-8]
CCDS54674.1 [Q9UKE5-5]
CCDS54675.1 [Q9UKE5-6]
CCDS54676.1 [Q9UKE5-2]
CCDS54677.1 [Q9UKE5-7]
CCDS54678.1 [Q9UKE5-3]
CCDS54679.1 [Q9UKE5-4]

NCBI Reference Sequences

More...RefSeqi		NP_001155032.1, NM_001161560.2 [Q9UKE5-4]
NP_001155033.1, NM_001161561.2 [Q9UKE5-2]
NP_001155034.1, NM_001161562.2 [Q9UKE5-6]
NP_001155035.1, NM_001161563.2 [Q9UKE5-3]
NP_001155036.1, NM_001161564.2 [Q9UKE5-7]
NP_001155037.1, NM_001161565.2 [Q9UKE5-5]
NP_001155038.1, NM_001161566.2 [Q9UKE5-8]
NP_055843.1, NM_015028.3 [Q9UKE5-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23043

UCSC genome browser

More...UCSCi		uc003fhh.3, human [Q9UKE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172264 mRNA Translation: AAF03782.1
AF172268 mRNA Translation: AAF03786.1
AF172267 mRNA Translation: AAF03785.1
AF172266 mRNA Translation: AAF03784.1
AF172265 mRNA Translation: AAF03783.1
AF172270 mRNA Translation: AAF03788.1
AF172271 mRNA Translation: AAF03789.1
AF172269 mRNA Translation: AAF03787.1
AB011123 mRNA Translation: BAA25477.2 Different initiation.
AK291056 mRNA Translation: BAF83745.1
AC026315 Genomic DNA No translation available.
AC078793 Genomic DNA No translation available.
AC092919 Genomic DNA No translation available.
AC137517 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78484.1
CH471052 Genomic DNA Translation: EAW78489.1
CH471052 Genomic DNA Translation: EAW78492.1
CH471052 Genomic DNA Translation: EAW78493.1
BC019081 mRNA Translation: AAH19081.2
BC150256 mRNA Translation: AAI50257.1
CCDSiCCDS46956.1 [Q9UKE5-1]
CCDS54673.1 [Q9UKE5-8]
CCDS54674.1 [Q9UKE5-5]
CCDS54675.1 [Q9UKE5-6]
CCDS54676.1 [Q9UKE5-2]
CCDS54677.1 [Q9UKE5-7]
CCDS54678.1 [Q9UKE5-3]
CCDS54679.1 [Q9UKE5-4]
RefSeqiNP_001155032.1, NM_001161560.2 [Q9UKE5-4]
NP_001155033.1, NM_001161561.2 [Q9UKE5-2]
NP_001155034.1, NM_001161562.2 [Q9UKE5-6]
NP_001155035.1, NM_001161563.2 [Q9UKE5-3]
NP_001155036.1, NM_001161564.2 [Q9UKE5-7]
NP_001155037.1, NM_001161565.2 [Q9UKE5-5]
NP_001155038.1, NM_001161566.2 [Q9UKE5-8]
NP_055843.1, NM_015028.3 [Q9UKE5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X7FX-ray2.80A/B/C/D/E1-325[»]
5AX9X-ray2.40A/B/C11-314[»]
5CWZX-ray2.90A/B/C11-314[»]
5D7AX-ray2.90A/B/C11-314[»]
6RA5X-ray2.90A/B11-314[»]
6RA7X-ray1.20A11-314[»]
SMRiQ9UKE5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116682, 63 interactors
DIPiDIP-37562N
IntActiQ9UKE5, 120 interactors
MINTiQ9UKE5
STRINGi9606.ENSP00000399511

Chemistry databases

BindingDBiQ9UKE5
ChEMBLiCHEMBL4527
DrugBankiDB12010, Fostamatinib
DrugCentraliQ9UKE5
GuidetoPHARMACOLOGYi2244

PTM databases

iPTMnetiQ9UKE5
PhosphoSitePlusiQ9UKE5
SwissPalmiQ9UKE5

Polymorphism and mutation databases

BioMutaiTNIK
DMDMi29840818

Proteomic databases

EPDiQ9UKE5
jPOSTiQ9UKE5
MassIVEiQ9UKE5
PaxDbiQ9UKE5
PeptideAtlasiQ9UKE5
PRIDEiQ9UKE5
ProteomicsDBi84769 [Q9UKE5-1]
84770 [Q9UKE5-2]
84771 [Q9UKE5-3]
84772 [Q9UKE5-4]
84773 [Q9UKE5-5]
84774 [Q9UKE5-6]
84775 [Q9UKE5-7]
84776 [Q9UKE5-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2086, 542 antibodies

Genome annotation databases

GeneIDi23043
KEGGihsa:23043
UCSCiuc003fhh.3, human [Q9UKE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23043
DisGeNETi23043
EuPathDBiHostDB:ENSG00000154310.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNIK
HGNCiHGNC:30765, TNIK
HPAiENSG00000154310, Tissue enhanced (brain)
MalaCardsiTNIK
MIMi610005, gene
617028, phenotype
neXtProtiNX_Q9UKE5
OpenTargetsiENSG00000154310
Orphaneti88616, Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA134893180

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0587, Eukaryota
GeneTreeiENSGT00950000183196
InParanoidiQ9UKE5
KOiK08840
OMAiFKIVRYE
OrthoDBi533537at2759
PhylomeDBiQ9UKE5
TreeFamiTF105138

Enzyme and pathway databases

PathwayCommonsiQ9UKE5
ReactomeiR-HSA-2559580, Oxidative Stress Induced Senescence
SignaLinkiQ9UKE5
SIGNORiQ9UKE5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23043, 7 hits in 902 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNIK, human
EvolutionaryTraceiQ9UKE5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TNIK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23043
PharosiQ9UKE5, Tchem

Protein Ontology

More...PROi		PR:Q9UKE5
RNActiQ9UKE5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154310, Expressed in corpus callosum and 223 other tissues
ExpressionAtlasiQ9UKE5, baseline and differential
GenevisibleiQ9UKE5, HS

Family and domain databases

InterProiView protein in InterPro
IPR001180, CNH_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00036, CNH, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219, CNH, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNIK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKE5
Secondary accession number(s): A7E2A3
, A8K4U1, D3DNQ6, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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