UniProtKB - Q9UKD1 (GMEB2_HUMAN)
Protein
Glucocorticoid modulatory element-binding protein 2
Gene
GMEB2
Organism
Homo sapiens (Human)
Status
Functioni
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 110 | ZincBy similarity | 1 | |
Binding sitei | 136 | DNABy similarity | 1 | |
Binding sitei | 140 | DNABy similarity | 1 | |
Binding sitei | 143 | DNABy similarity | 1 | |
Binding sitei | 154 | DNABy similarity | 1 | |
Metal bindingi | 167 | ZincBy similarity | 1 | |
Metal bindingi | 171 | ZincBy similarity | 1 | |
Metal bindingi | 175 | ZincBy similarity | 1 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: InterPro
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UKD1 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucocorticoid modulatory element-binding protein 2Short name: GMEB-2 Alternative name(s): DNA-binding protein p79PIF Parvovirus initiation factor p79 Short name: PIF p79 |
Gene namesi | Name:GMEB2 Synonyms:KIAA1269 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101216.10 |
HGNCi | HGNC:4371, GMEB2 |
MIMi | 607451, gene |
neXtProti | NX_Q9UKD1 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000101216 |
PharmGKBi | PA28756 |
Miscellaneous databases
Pharosi | Q9UKD1, Tdark |
Polymorphism and mutation databases
BioMutai | GMEB2 |
DMDMi | 22001626 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074092 | 1 – 530 | Glucocorticoid modulatory element-binding protein 2Add BLAST | 530 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 155 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 155 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 373 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UKD1 |
jPOSTi | Q9UKD1 |
MassIVEi | Q9UKD1 |
MaxQBi | Q9UKD1 |
PaxDbi | Q9UKD1 |
PeptideAtlasi | Q9UKD1 |
PRIDEi | Q9UKD1 |
ProteomicsDBi | 84767 |
PTM databases
GlyConnecti | 2845, 1 O-Linked glycan (1 site) |
GlyGeni | Q9UKD1, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q9UKD1 |
PhosphoSitePlusi | Q9UKD1 |
Expressioni
Tissue specificityi
Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.
Gene expression databases
Bgeei | ENSG00000101216, Expressed in parotid gland and 234 other tissues |
ExpressionAtlasi | Q9UKD1, baseline and differential |
Genevisiblei | Q9UKD1, HS |
Organism-specific databases
HPAi | ENSG00000101216, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF).
Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP).
Binary interactionsi
Hide detailsQ9UKD1
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 117605, 30 interactors |
IntActi | Q9UKD1, 20 interactors |
STRINGi | 9606.ENSP00000266068 |
Miscellaneous databases
RNActi | Q9UKD1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 163 | SANDPROSITE-ProRule annotationAdd BLAST | 83 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 304 – 348 | Sequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 57 – 64 | Poly-Ala | 8 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4333, Eukaryota |
GeneTreei | ENSGT00410000025596 |
InParanoidi | Q9UKD1 |
OMAi | DDTFSFW |
OrthoDBi | 692814at2759 |
PhylomeDBi | Q9UKD1 |
TreeFami | TF317090 |
Family and domain databases
Gene3Di | 3.10.390.10, 1 hit |
InterProi | View protein in InterPro IPR024830, GMEB1/2 IPR010919, SAND-like_dom_sf IPR000770, SAND_dom |
PANTHERi | PTHR10417, PTHR10417, 1 hit |
Pfami | View protein in Pfam PF01342, SAND, 1 hit |
SMARTi | View protein in SMART SM00258, SAND, 1 hit |
SUPFAMi | SSF63763, SSF63763, 1 hit |
PROSITEi | View protein in PROSITE PS50864, SAND, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UKD1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATPDVSVHM EEVVVVTTPD TAVDGSGVEG VKTVLVTTNL APHGGDLTED
60 70 80 90 100
NMETENAAAA AAAAFTASSQ LKEAVLVKMA EEGENLEAEI VYPITCGDSR
110 120 130 140 150
ANLIWRKFVC PGINVKCVQY DEHVISPKEF VHLAGKSTLK DWKRAIRMNG
160 170 180 190 200
IMLRKIMDSG ELDFYQHDKV CSNTCRSTKI DLSGARVSLS SPTSAEYIPL
210 220 230 240 250
TPAAADVNGS PATITIETCE DPGDWTAAIG DDTFTFWRGL KDAGLLDEVI
260 270 280 290 300
QEFHQELVET MRGLQQRVQD PPLQLRDAVL LNNIVQNFGM LDLVKKVLAS
310 320 330 340 350
HKCQMDRSRE QYARDLAALE QQCDEHRRRA KELKHKSQHL SNVLMTLTPV
360 370 380 390 400
SLPPPVKRPR LARATSGPAA MASQVLTQSA QLALGPGVPV PQLTSVPLGK
410 420 430 440 450
VVSTLPSTVL GKGSLQAPPA SSPASPLLGG YTVLASSGST YPSTVEIHPD
460 470 480 490 500
ASSLTVLSTA AVQDGSTVFK VVSPLQLLTL PGLGPTLQNV AQASPGSSTI
510 520 530
VTVPAGAAPG PEEHTATIEV AAMAEDHERK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JTV1 | Q5JTV1_HUMAN | Glucocorticoid modulatory element b... | GMEB2 hCG_23414 | 479 | Annotation score: |
Sequence cautioni
The sequence BAA86583 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 – 44 | DGSGV…LAPHG → CPAGCALRDPDSILSSLHFT R (PubMed:17974005).CuratedAdd BLAST | 21 | |
Sequence conflicti | 77 – 78 | Missing (PubMed:17974005).Curated | 2 | |
Sequence conflicti | 381 – 382 | QL → PV in BAA86583 (PubMed:10574462).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF173867 mRNA Translation: AAD51351.1 AB033095 mRNA Translation: BAA86583.1 Different initiation. AL121907 Genomic DNA No translation available. AL353715 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75253.1 CH471077 Genomic DNA Translation: EAW75254.1 BC036305 mRNA Translation: AAH36305.1 AL133646 mRNA Translation: CAB63765.1 |
CCDSi | CCDS13528.1 |
RefSeqi | NP_036516.1, NM_012384.4 XP_005260259.1, XM_005260202.4 |
Genome annotation databases
Ensembli | ENST00000266068; ENSP00000266068; ENSG00000101216 ENST00000370077; ENSP00000359094; ENSG00000101216 |
GeneIDi | 26205 |
KEGGi | hsa:26205 |
UCSCi | uc002yfp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF173867 mRNA Translation: AAD51351.1 AB033095 mRNA Translation: BAA86583.1 Different initiation. AL121907 Genomic DNA No translation available. AL353715 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75253.1 CH471077 Genomic DNA Translation: EAW75254.1 BC036305 mRNA Translation: AAH36305.1 AL133646 mRNA Translation: CAB63765.1 |
CCDSi | CCDS13528.1 |
RefSeqi | NP_036516.1, NM_012384.4 XP_005260259.1, XM_005260202.4 |
3D structure databases
SMRi | Q9UKD1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117605, 30 interactors |
IntActi | Q9UKD1, 20 interactors |
STRINGi | 9606.ENSP00000266068 |
PTM databases
GlyConnecti | 2845, 1 O-Linked glycan (1 site) |
GlyGeni | Q9UKD1, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q9UKD1 |
PhosphoSitePlusi | Q9UKD1 |
Polymorphism and mutation databases
BioMutai | GMEB2 |
DMDMi | 22001626 |
Proteomic databases
EPDi | Q9UKD1 |
jPOSTi | Q9UKD1 |
MassIVEi | Q9UKD1 |
MaxQBi | Q9UKD1 |
PaxDbi | Q9UKD1 |
PeptideAtlasi | Q9UKD1 |
PRIDEi | Q9UKD1 |
ProteomicsDBi | 84767 |
Protocols and materials databases
ABCDi | Q9UKD1, 1 sequenced antibody |
Antibodypediai | 1759, 98 antibodies |
DNASUi | 26205 |
Genome annotation databases
Ensembli | ENST00000266068; ENSP00000266068; ENSG00000101216 ENST00000370077; ENSP00000359094; ENSG00000101216 |
GeneIDi | 26205 |
KEGGi | hsa:26205 |
UCSCi | uc002yfp.1, human |
Organism-specific databases
CTDi | 26205 |
EuPathDBi | HostDB:ENSG00000101216.10 |
GeneCardsi | GMEB2 |
HGNCi | HGNC:4371, GMEB2 |
HPAi | ENSG00000101216, Low tissue specificity |
MIMi | 607451, gene |
neXtProti | NX_Q9UKD1 |
OpenTargetsi | ENSG00000101216 |
PharmGKBi | PA28756 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4333, Eukaryota |
GeneTreei | ENSGT00410000025596 |
InParanoidi | Q9UKD1 |
OMAi | DDTFSFW |
OrthoDBi | 692814at2759 |
PhylomeDBi | Q9UKD1 |
TreeFami | TF317090 |
Enzyme and pathway databases
PathwayCommonsi | Q9UKD1 |
Miscellaneous databases
BioGRID-ORCSi | 26205, 21 hits in 867 CRISPR screens |
ChiTaRSi | GMEB2, human |
GeneWikii | GMEB2 |
GenomeRNAii | 26205 |
Pharosi | Q9UKD1, Tdark |
PROi | PR:Q9UKD1 |
RNActi | Q9UKD1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101216, Expressed in parotid gland and 234 other tissues |
ExpressionAtlasi | Q9UKD1, baseline and differential |
Genevisiblei | Q9UKD1, HS |
Family and domain databases
Gene3Di | 3.10.390.10, 1 hit |
InterProi | View protein in InterPro IPR024830, GMEB1/2 IPR010919, SAND-like_dom_sf IPR000770, SAND_dom |
PANTHERi | PTHR10417, PTHR10417, 1 hit |
Pfami | View protein in Pfam PF01342, SAND, 1 hit |
SMARTi | View protein in SMART SM00258, SAND, 1 hit |
SUPFAMi | SSF63763, SSF63763, 1 hit |
PROSITEi | View protein in PROSITE PS50864, SAND, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GMEB2_HUMAN | |
Accessioni | Q9UKD1Primary (citable) accession number: Q9UKD1 Secondary accession number(s): E1P5J3 Q9ULF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 26, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM