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Entry version 169 (13 Nov 2019)
Sequence version 1 (01 May 2000)
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Protein

Polypyrimidine tract-binding protein 2

Gene

PTBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polypyrimidine tract-binding protein 2
Alternative name(s):
Neural polypyrimidine tract-binding protein
Neurally-enriched homolog of PTB
PTB-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTBP2
Synonyms:NPTB, PTB, PTBLP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17662 PTBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608449 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
58155

Open Targets

More...
OpenTargetsi
ENSG00000117569

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33935

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKA9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761983

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002329281 – 531Polypyrimidine tract-binding protein 2Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei308PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKA9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UKA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKA9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKA9

PeptideAtlas

More...
PeptideAtlasi
Q9UKA9

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKA9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84754 [Q9UKA9-1]
84755 [Q9UKA9-2]
84756 [Q9UKA9-3]
84757 [Q9UKA9-4]
84758 [Q9UKA9-5]
84759 [Q9UKA9-6]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00647067

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2061

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKA9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UKA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117569 Expressed in 223 organ(s), highest expression level in corpus callosum

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UKA9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047420

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with NOVA1; the interaction is direct.

Interacts with NOVA2; the interaction is direct (By similarity).

Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.

Part of a ternary complex containing KHSRP and HNRPH1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P981753EBI-12255608,EBI-721525

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121796, 25 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UKA9

Protein interaction database and analysis system

More...
IntActi
Q9UKA9, 26 interactors

Molecular INTeraction database

More...
MINTi
Q9UKA9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359216

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UKA9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UKA9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 133RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini181 – 257RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini338 – 412RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini455 – 529RRM 4PROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi315 – 324Poly-Ala10

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1190 Eukaryota
ENOG410XPMZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182683

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKA9

KEGG Orthology (KO)

More...
KOi
K14948

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQQAKLX

Database of Orthologous Groups

More...
OrthoDBi
1545178at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKA9

TreeFam database of animal gene trees

More...
TreeFami
TF319824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12778 RRM1_PTBP2, 1 hit
cd12693 RRM2_PTBP1_like, 1 hit
cd12696 RRM3_PTBP2, 1 hit
cd12702 RRM4_PTBP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006536 HnRNP-L/PTB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034798 PTBP1/2/3_RRM2
IPR021790 PTBP1_RRM
IPR035002 PTBP2_RRM1
IPR034799 PTBP2_RRM3
IPR034800 PTBP2_RRM4
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit
PF11835 RRM_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 4 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01649 hnRNP-L_PTB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UKA9-1) [UniParc]FASTAAdd to basket
Also known as: nPTB1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE
60 70 80 90 100
DKMDGAPSRV LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE
110 120 130 140 150
LATEEAAITM VNYYSAVTPH LRNQPIYIQY SNHKELKTDN TLNQRAQAVL
160 170 180 190 200
QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV LRIIIDNMYY PVTLDVLHQI
210 220 230 240 250
FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG QNIYNACCTL
260 270 280 290 300
RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL
310 320 330 340 350
LAVPGALSPL AIPNAAAAAA AAAAGRVGMP GVSAGGNTVL LVSNLNEEMV
360 370 380 390 400
TPQSLFTLFG VYGDVQRVKI LYNKKDSALI QMADGNQSQL AMNHLNGQKM
410 420 430 440 450
YGKIIRVTLS KHQTVQLPRE GLDDQGLTKD FGNSPLHRFK KPGSKNFQNI
460 470 480 490 500
FPPSATLHLS NIPPSVAEED LRTLFANTGG TVKAFKFFQD HKMALLQMAT
510 520 530
VEEAIQALID LHNYNLGENH HLRVSFSKST I
Length:531
Mass (Da):57,491
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57ADA23F422AE02A
GO
Isoform 2 (identifier: Q9UKA9-2) [UniParc]FASTAAdd to basket
Also known as: nPTB2, PTBPLP-L

The sequence of this isoform differs from the canonical sequence as follows:
     489-489: Q → QR

Show »
Length:532
Mass (Da):57,647
Checksum:iA77702A0B7A84298
GO
Isoform 3 (identifier: Q9UKA9-3) [UniParc]FASTAAdd to basket
Also known as: nPTB3, PTBPLP-L'

The sequence of this isoform differs from the canonical sequence as follows:
     302-302: A → GLPVAA
     489-489: Q → QR

Show »
Length:537
Mass (Da):58,084
Checksum:i35F5BFD2614647B3
GO
Isoform 4 (identifier: Q9UKA9-4) [UniParc]FASTAAdd to basket
Also known as: nPTB4

The sequence of this isoform differs from the canonical sequence as follows:
     302-302: A → GLPVAA

Show »
Length:536
Mass (Da):57,928
Checksum:i9510D0E9AC2FCBD6
GO
Isoform 5 (identifier: Q9UKA9-5) [UniParc]FASTAAdd to basket
Also known as: nPTB5, nPTB7, PTBPLP-S

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: MVTPQSLF → VFMEMCSV
     357-531: Missing.

Show »
Length:356
Mass (Da):37,898
Checksum:iC1D3D2E104207E27
GO
Isoform 6 (identifier: Q9UKA9-6) [UniParc]FASTAAdd to basket
Also known as: nPTB6, nPTB8, PTBPLP-S'

The sequence of this isoform differs from the canonical sequence as follows:
     302-302: A → GLPVAA
     349-356: MVTPQSLF → VFMEMCSV
     357-531: Missing.

Show »
Length:361
Mass (Da):38,336
Checksum:iC47DB1BA2B404A03
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018015302A → GLPVAA in isoform 3, isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_018016349 – 356MVTPQSLF → VFMEMCSV in isoform 5 and isoform 6. 2 Publications8
Alternative sequenceiVSP_018017357 – 531Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST175
Alternative sequenceiVSP_018018489Q → QR in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF176085 mRNA Translation: AAF14284.1
AB051232 mRNA Translation: BAB71742.1
AB051233 mRNA Translation: BAB71743.1
AF530580 mRNA Translation: AAM94624.1
AF530581 mRNA Translation: AAM94625.1
AF530582 mRNA Translation: AAM94626.1
AF530583 mRNA Translation: AAM94627.1
BK000526 mRNA Translation: DAA00060.1
AL357150 Genomic DNA No translation available.
BC016582 mRNA Translation: AAH16582.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72828.1 [Q9UKA9-3]
CCDS72829.1 [Q9UKA9-4]
CCDS72830.1 [Q9UKA9-2]
CCDS754.1 [Q9UKA9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001287914.1, NM_001300985.1 [Q9UKA9-3]
NP_001287915.1, NM_001300986.1
NP_001287916.1, NM_001300987.1
NP_001287917.1, NM_001300988.1 [Q9UKA9-4]
NP_001287918.1, NM_001300989.1 [Q9UKA9-2]
NP_001287919.1, NM_001300990.1
NP_067013.1, NM_021190.3 [Q9UKA9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370197; ENSP00000359216; ENSG00000117569 [Q9UKA9-3]
ENST00000370198; ENSP00000359217; ENSG00000117569 [Q9UKA9-4]
ENST00000426398; ENSP00000412788; ENSG00000117569 [Q9UKA9-1]
ENST00000609116; ENSP00000477024; ENSG00000117569 [Q9UKA9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:58155

UCSC genome browser

More...
UCSCi
uc001drn.3 human [Q9UKA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176085 mRNA Translation: AAF14284.1
AB051232 mRNA Translation: BAB71742.1
AB051233 mRNA Translation: BAB71743.1
AF530580 mRNA Translation: AAM94624.1
AF530581 mRNA Translation: AAM94625.1
AF530582 mRNA Translation: AAM94626.1
AF530583 mRNA Translation: AAM94627.1
BK000526 mRNA Translation: DAA00060.1
AL357150 Genomic DNA No translation available.
BC016582 mRNA Translation: AAH16582.1
CCDSiCCDS72828.1 [Q9UKA9-3]
CCDS72829.1 [Q9UKA9-4]
CCDS72830.1 [Q9UKA9-2]
CCDS754.1 [Q9UKA9-1]
RefSeqiNP_001287914.1, NM_001300985.1 [Q9UKA9-3]
NP_001287915.1, NM_001300986.1
NP_001287916.1, NM_001300987.1
NP_001287917.1, NM_001300988.1 [Q9UKA9-4]
NP_001287918.1, NM_001300989.1 [Q9UKA9-2]
NP_001287919.1, NM_001300990.1
NP_067013.1, NM_021190.3 [Q9UKA9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQ1NMR-A51-138[»]
2MJUNMR-A325-531[»]
4CQ1X-ray1.69A/B/C/D/E/F/G/H336-531[»]
SMRiQ9UKA9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121796, 25 interactors
CORUMiQ9UKA9
IntActiQ9UKA9, 26 interactors
MINTiQ9UKA9
STRINGi9606.ENSP00000359216

PTM databases

GlyConnecti2061
iPTMnetiQ9UKA9
PhosphoSitePlusiQ9UKA9
SwissPalmiQ9UKA9

Polymorphism and mutation databases

BioMutaiPTBP2
DMDMi74761983

2D gel databases

REPRODUCTION-2DPAGEiIPI00647067

Proteomic databases

EPDiQ9UKA9
jPOSTiQ9UKA9
MassIVEiQ9UKA9
PaxDbiQ9UKA9
PeptideAtlasiQ9UKA9
PRIDEiQ9UKA9
ProteomicsDBi84754 [Q9UKA9-1]
84755 [Q9UKA9-2]
84756 [Q9UKA9-3]
84757 [Q9UKA9-4]
84758 [Q9UKA9-5]
84759 [Q9UKA9-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
58155

Genome annotation databases

EnsembliENST00000370197; ENSP00000359216; ENSG00000117569 [Q9UKA9-3]
ENST00000370198; ENSP00000359217; ENSG00000117569 [Q9UKA9-4]
ENST00000426398; ENSP00000412788; ENSG00000117569 [Q9UKA9-1]
ENST00000609116; ENSP00000477024; ENSG00000117569 [Q9UKA9-2]
GeneIDi58155
KEGGihsa:58155
UCSCiuc001drn.3 human [Q9UKA9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58155
DisGeNETi58155

GeneCards: human genes, protein and diseases

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GeneCardsi
PTBP2
HGNCiHGNC:17662 PTBP2
HPAiHPA047420
MIMi608449 gene
neXtProtiNX_Q9UKA9
OpenTargetsiENSG00000117569
PharmGKBiPA33935

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1190 Eukaryota
ENOG410XPMZ LUCA
GeneTreeiENSGT00950000182683
InParanoidiQ9UKA9
KOiK14948
OMAiAQQAKLX
OrthoDBi1545178at2759
PhylomeDBiQ9UKA9
TreeFamiTF319824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTBP2 human
EvolutionaryTraceiQ9UKA9

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58155
PharosiQ9UKA9

Protein Ontology

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PROi
PR:Q9UKA9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117569 Expressed in 223 organ(s), highest expression level in corpus callosum
GenevisibleiQ9UKA9 HS

Family and domain databases

CDDicd12778 RRM1_PTBP2, 1 hit
cd12693 RRM2_PTBP1_like, 1 hit
cd12696 RRM3_PTBP2, 1 hit
cd12702 RRM4_PTBP2, 1 hit
Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR006536 HnRNP-L/PTB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034798 PTBP1/2/3_RRM2
IPR021790 PTBP1_RRM
IPR035002 PTBP2_RRM1
IPR034799 PTBP2_RRM3
IPR034800 PTBP2_RRM4
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF11835 RRM_8, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF54928 SSF54928, 4 hits
TIGRFAMsiTIGR01649 hnRNP-L_PTB, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKA9
Secondary accession number(s): Q8N0Z1
, Q8N160, Q8NFB0, Q8NFB1, Q969N9, Q96Q76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 1, 2000
Last modified: November 13, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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