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Entry version 145 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Calcipressin-3

Gene

RCAN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcipressin-3
Alternative name(s):
Down syndrome candidate region 1-like protein 2
Myocyte-enriched calcineurin-interacting protein 3
Short name:
MCIP3
Regulator of calcineurin 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCAN3
Synonyms:DSCR1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117602.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3042 RCAN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11123

Open Targets

More...
OpenTargetsi
ENSG00000117602

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400972

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UKA8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RCAN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
15213951

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114201 – 241Calcipressin-3Add BLAST241

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKA8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UKA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UKA8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKA8

PeptideAtlas

More...
PeptideAtlasi
Q9UKA8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKA8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17228
18826
676
84752 [Q9UKA8-1]
84753 [Q9UKA8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117602 Expressed in bronchial epithelial cell and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UKA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000117602 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with protein phosphatase PPP3CA/calcineurin A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116297, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UKA8, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363516

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UKA8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UKA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 203Calcineurin-binding1 PublicationAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4019 Eukaryota
ENOG4111I50 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159501

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1577930_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKA8

KEGG Orthology (KO)

More...
KOi
K17905

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDNQVTF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKA8

TreeFam database of animal gene trees

More...
TreeFami
TF313579

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034923 RCAN3

The PANTHER Classification System

More...
PANTHERi
PTHR10300 PTHR10300, 1 hit
PTHR10300:SF6 PTHR10300:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04847 Calcipressin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UKA8-1) [UniParc]FASTAAdd to basket
Also known as: RCAN3-1a,2,3,4,5

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF
60 70 80 90 100
ACSVHEAVFE AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA
110 120 130 140 150
ARARIELHET DFNGQKLKLY FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP
160 170 180 190 200
ASPPVGWKQS EDAMPVINYD LLCAVSKLGP GEKYELHAGT ESTPSVVVHV
210 220 230 240
CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA L
Length:241
Mass (Da):27,492
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91AB619F5E443FBD
GO
Isoform 2 (identifier: Q9UKA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-133: Missing.

Show »
Length:231
Mass (Da):26,361
Checksum:i346DE2B3E62C9A66
GO
Isoform 3 (identifier: Q9UKA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-173: VQMSGEVRDK...MPVINYDLLC → ERNMNFTREQ...RGAPTLRPQR
     174-241: Missing.

Show »
Length:173
Mass (Da):20,747
Checksum:i323CC883395F2C63
GO
Isoform 4 (identifier: Q9UKA8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-115: FEALFTIYDD...ELHETDFNGQ → NMNFTREQSR...RGAPTLRPQR
     116-241: Missing.

Show »
Length:115
Mass (Da):13,764
Checksum:i09FA31CAE7A64D21
GO
Isoform 5 (identifier: Q9UKA8-5) [UniParc]FASTAAdd to basket
Also known as: RCAN3-2,4,5, RCAN3-1c,2,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     66-123: Missing.

Show »
Length:183
Mass (Da):20,508
Checksum:i9F5DDAECF807B489
GO
Isoform 6 (identifier: Q9UKA8-6) [UniParc]FASTAAdd to basket
Also known as: RCAN3-1,3,4,5, RCAN3-1a,3,4,5, RCAN3-1c,3,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:116
Mass (Da):12,745
Checksum:iE2D8F424C595539D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YF64H0YF64_HUMAN
Calcipressin-3
RCAN3
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 4 (identifier: Q9UKA8-4)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106R → Q in AAW83514 (PubMed:16516408).Curated1
Isoform 3 (identifier: Q9UKA8-3)
Sequence conflicti164R → Q in ABO46010 (PubMed:16516408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033727236T → N. Corresponds to variant dbSNP:rs16829813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548551 – 125Missing in isoform 6. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_04751066 – 123Missing in isoform 5. 2 PublicationsAdd BLAST58
Alternative sequenceiVSP_04596868 – 115FEALF…DFNGQ → NMNFTREQSRHPAWWFMSVK VKLKRKKRQKTPNRKLPRRG APTLRPQR in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_045969116 – 241Missing in isoform 4. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_045970124 – 173VQMSG…YDLLC → ERNMNFTREQSRHPAWWFMS VKVKLKRKKRQKTPNRKLPR RGAPTLRPQR in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_001319124 – 133Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_045971174 – 241Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF176116 mRNA Translation: AAF01684.1
AF176117 mRNA Translation: AAF01685.1
AY906854 mRNA Translation: AAW83514.1
EF467309 mRNA Translation: ABO46010.1
EF431960 mRNA Translation: ABO27184.1
EF529733 mRNA Translation: ABP88933.1
JN228252 mRNA Translation: AEL88283.1
JN203053 mRNA Translation: AEL12453.1
HQ287726 mRNA Translation: ADO15700.1
HQ317421 mRNA Translation: ADR51177.1
HQ317422 mRNA Translation: ADR51178.1
HQ317423 mRNA Translation: ADR51179.1
HQ317426 mRNA Translation: ADR51182.1
HQ317427 mRNA Translation: ADR51183.1
HQ317445 mRNA Translation: ADR02808.1
HQ317446 mRNA Translation: ADR02809.1
AL034582 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95133.1
BC035854 mRNA Translation: AAH35854.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS254.1 [Q9UKA8-1]
CCDS57979.1 [Q9UKA8-2]
CCDS57980.1 [Q9UKA8-3]
CCDS57981.1 [Q9UKA8-5]
CCDS57982.1 [Q9UKA8-4]
CCDS72730.1 [Q9UKA8-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001238906.1, NM_001251977.1 [Q9UKA8-1]
NP_001238907.1, NM_001251978.1 [Q9UKA8-1]
NP_001238908.1, NM_001251979.1 [Q9UKA8-1]
NP_001238909.1, NM_001251980.1 [Q9UKA8-2]
NP_001238910.1, NM_001251981.1 [Q9UKA8-5]
NP_001238911.1, NM_001251982.1 [Q9UKA8-3]
NP_001238912.1, NM_001251983.1 [Q9UKA8-6]
NP_001238913.1, NM_001251984.1 [Q9UKA8-6]
NP_001238914.1, NM_001251985.1 [Q9UKA8-4]
NP_038469.1, NM_013441.3 [Q9UKA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374393; ENSP00000363514; ENSG00000117602 [Q9UKA8-4]
ENST00000374395; ENSP00000363516; ENSG00000117602 [Q9UKA8-1]
ENST00000412742; ENSP00000391912; ENSG00000117602 [Q9UKA8-3]
ENST00000425530; ENSP00000409540; ENSG00000117602 [Q9UKA8-2]
ENST00000436717; ENSP00000414447; ENSG00000117602 [Q9UKA8-5]
ENST00000538532; ENSP00000445401; ENSG00000117602 [Q9UKA8-1]
ENST00000610732; ENSP00000479300; ENSG00000117602 [Q9UKA8-1]
ENST00000616511; ENSP00000478174; ENSG00000117602 [Q9UKA8-6]
ENST00000618490; ENSP00000484519; ENSG00000117602 [Q9UKA8-6]
ENST00000630217; ENSP00000486836; ENSG00000117602 [Q9UKA8-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11123

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11123

UCSC genome browser

More...
UCSCi
uc001bjj.4 human [Q9UKA8-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176116 mRNA Translation: AAF01684.1
AF176117 mRNA Translation: AAF01685.1
AY906854 mRNA Translation: AAW83514.1
EF467309 mRNA Translation: ABO46010.1
EF431960 mRNA Translation: ABO27184.1
EF529733 mRNA Translation: ABP88933.1
JN228252 mRNA Translation: AEL88283.1
JN203053 mRNA Translation: AEL12453.1
HQ287726 mRNA Translation: ADO15700.1
HQ317421 mRNA Translation: ADR51177.1
HQ317422 mRNA Translation: ADR51178.1
HQ317423 mRNA Translation: ADR51179.1
HQ317426 mRNA Translation: ADR51182.1
HQ317427 mRNA Translation: ADR51183.1
HQ317445 mRNA Translation: ADR02808.1
HQ317446 mRNA Translation: ADR02809.1
AL034582 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95133.1
BC035854 mRNA Translation: AAH35854.1
CCDSiCCDS254.1 [Q9UKA8-1]
CCDS57979.1 [Q9UKA8-2]
CCDS57980.1 [Q9UKA8-3]
CCDS57981.1 [Q9UKA8-5]
CCDS57982.1 [Q9UKA8-4]
CCDS72730.1 [Q9UKA8-6]
RefSeqiNP_001238906.1, NM_001251977.1 [Q9UKA8-1]
NP_001238907.1, NM_001251978.1 [Q9UKA8-1]
NP_001238908.1, NM_001251979.1 [Q9UKA8-1]
NP_001238909.1, NM_001251980.1 [Q9UKA8-2]
NP_001238910.1, NM_001251981.1 [Q9UKA8-5]
NP_001238911.1, NM_001251982.1 [Q9UKA8-3]
NP_001238912.1, NM_001251983.1 [Q9UKA8-6]
NP_001238913.1, NM_001251984.1 [Q9UKA8-6]
NP_001238914.1, NM_001251985.1 [Q9UKA8-4]
NP_038469.1, NM_013441.3 [Q9UKA8-1]

3D structure databases

SMRiQ9UKA8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116297, 14 interactors
IntActiQ9UKA8, 16 interactors
STRINGi9606.ENSP00000363516

PTM databases

iPTMnetiQ9UKA8
PhosphoSitePlusiQ9UKA8

Polymorphism and mutation databases

BioMutaiRCAN3
DMDMi15213951

Proteomic databases

EPDiQ9UKA8
jPOSTiQ9UKA8
MassIVEiQ9UKA8
PaxDbiQ9UKA8
PeptideAtlasiQ9UKA8
PRIDEiQ9UKA8
ProteomicsDBi17228
18826
676
84752 [Q9UKA8-1]
84753 [Q9UKA8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30319 245 antibodies

The DNASU plasmid repository

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DNASUi
11123

Genome annotation databases

EnsembliENST00000374393; ENSP00000363514; ENSG00000117602 [Q9UKA8-4]
ENST00000374395; ENSP00000363516; ENSG00000117602 [Q9UKA8-1]
ENST00000412742; ENSP00000391912; ENSG00000117602 [Q9UKA8-3]
ENST00000425530; ENSP00000409540; ENSG00000117602 [Q9UKA8-2]
ENST00000436717; ENSP00000414447; ENSG00000117602 [Q9UKA8-5]
ENST00000538532; ENSP00000445401; ENSG00000117602 [Q9UKA8-1]
ENST00000610732; ENSP00000479300; ENSG00000117602 [Q9UKA8-1]
ENST00000616511; ENSP00000478174; ENSG00000117602 [Q9UKA8-6]
ENST00000618490; ENSP00000484519; ENSG00000117602 [Q9UKA8-6]
ENST00000630217; ENSP00000486836; ENSG00000117602 [Q9UKA8-5]
GeneIDi11123
KEGGihsa:11123
UCSCiuc001bjj.4 human [Q9UKA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11123
DisGeNETi11123
EuPathDBiHostDB:ENSG00000117602.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RCAN3
HGNCiHGNC:3042 RCAN3
HPAiENSG00000117602 Tissue enhanced (brain)
MIMi605860 gene
neXtProtiNX_Q9UKA8
OpenTargetsiENSG00000117602
PharmGKBiPA162400972

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00940000159501
HOGENOMiCLU_1577930_0_0_1
InParanoidiQ9UKA8
KOiK17905
OMAiYDNQVTF
PhylomeDBiQ9UKA8
TreeFamiTF313579

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11123 1 hit in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RCAN3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RCAN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11123
PharosiQ9UKA8 Tbio

Protein Ontology

More...
PROi
PR:Q9UKA8
RNActiQ9UKA8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117602 Expressed in bronchial epithelial cell and 200 other tissues
ExpressionAtlasiQ9UKA8 baseline and differential
GenevisibleiQ9UKA8 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034923 RCAN3
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF6 PTHR10300:SF6, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCAN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKA8
Secondary accession number(s): A4GU14
, A4LA69, E3VWE2, E5L4P0, E5L4P7, E7ENV1, E7EWD8, G1FI66, G1FLF0, Q5ECL3, Q5TGC6, Q9NUC8, Q9UKA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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