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UniProtKB - Q9UKA4 (AKA11_HUMAN)
Protein
A-kinase anchor protein 11
Gene
AKAP11
Organism
Homo sapiens (Human)
Status
Functioni
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
GO - Molecular functioni
- protein kinase A binding Source: GO_Central
- protein kinase A regulatory subunit binding Source: Ensembl
- protein phosphatase 1 binding Source: ProtInc
GO - Biological processi
- cortical actin cytoskeleton organization Source: Ensembl
- intracellular signal transduction Source: ProtInc
- protein localization Source: GO_Central
- protein localization to endosome Source: Ensembl
- renal water homeostasis Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9UKA4 |
SignaLinki | Q9UKA4 |
SIGNORi | Q9UKA4 |
Names & Taxonomyi
Protein namesi | Recommended name: A-kinase anchor protein 11Short name: AKAP-11 Alternative name(s): A-kinase anchor protein 220 kDa Short name: AKAP 220 Short name: hAKAP220 Protein kinase A-anchoring protein 11 Short name: PRKA11 |
Gene namesi | Name:AKAP11 Synonyms:AKAP220, KIAA0629 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:369, AKAP11 |
MIMi | 604696, gene |
neXtProti | NX_Q9UKA4 |
VEuPathDBi | HostDB:ENSG00000023516 |
Subcellular locationi
Cytoplasm and Cytosol
Cytoskeleton
Note: Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 11215 |
OpenTargetsi | ENSG00000023516 |
PharmGKBi | PA24663 |
Miscellaneous databases
Pharosi | Q9UKA4, Tbio |
Genetic variation databases
BioMutai | AKAP11 |
DMDMi | 13431310 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064517 | 1 – 1901 | A-kinase anchor protein 11Add BLAST | 1901 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 422 | PhosphoserineCombined sources | 1 | |
Modified residuei | 433 | PhosphoserineCombined sources | 1 | |
Modified residuei | 444 | PhosphoserineCombined sources | 1 | |
Modified residuei | 448 | PhosphoserineCombined sources | 1 | |
Modified residuei | 981 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1100 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1171 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1176 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1177 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1242 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1337 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1485 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1580 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UKA4 |
jPOSTi | Q9UKA4 |
MassIVEi | Q9UKA4 |
MaxQBi | Q9UKA4 |
PaxDbi | Q9UKA4 |
PeptideAtlasi | Q9UKA4 |
PRIDEi | Q9UKA4 |
ProteomicsDBi | 84751 |
PTM databases
GlyConnecti | 999, 1 N-Linked glycan (1 site) |
GlyGeni | Q9UKA4, 20 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (19 sites) |
iPTMneti | Q9UKA4 |
PhosphoSitePlusi | Q9UKA4 |
Expressioni
Tissue specificityi
Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.
Gene expression databases
Bgeei | ENSG00000023516, Expressed in caudate nucleus and 254 other tissues |
Genevisiblei | Q9UKA4, HS |
Organism-specific databases
HPAi | ENSG00000023516, Low tissue specificity |
Interactioni
Binary interactionsi
Q9UKA4
With | #Exp. | IntAct |
---|---|---|
LITAF [Q99732] | 3 | EBI-1049491,EBI-725647 |
GO - Molecular functioni
- protein kinase A binding Source: GO_Central
- protein kinase A regulatory subunit binding Source: Ensembl
- protein phosphatase 1 binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 116384, 86 interactors |
IntActi | Q9UKA4, 43 interactors |
MINTi | Q9UKA4 |
STRINGi | 9606.ENSP00000025301 |
Miscellaneous databases
RNActi | Q9UKA4, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9UKA4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 407 – 443 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 843 – 864 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 971 – 993 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1131 – 1153 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1650 – 1663 | PKA-RII subunit binding domainAdd BLAST | 14 | |
Regioni | 1708 – 1805 | DisorderedSequence analysisAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 974 – 993 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1137 – 1153 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1708 – 1740 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1753 – 1769 | Polar residuesSequence analysisAdd BLAST | 17 |
Domaini
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Sequence similaritiesi
Belongs to the AKAP110 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRN4, Eukaryota |
GeneTreei | ENSGT00940000153313 |
HOGENOMi | CLU_002178_0_0_1 |
InParanoidi | Q9UKA4 |
OMAi | KFKFDCP |
OrthoDBi | 43913at2759 |
PhylomeDBi | Q9UKA4 |
TreeFami | TF343800 |
Family and domain databases
InterProi | View protein in InterPro IPR008382, SPHK1-interactor_AKAP_110 |
PANTHERi | PTHR10226, PTHR10226, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UKA4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATFRNNHMK TKASVRKSFS EDVFQSVKSL LQSQKELCSV TAEDCLQQDE
60 70 80 90 100
HANLTEVTFL GFNEETDAAH IQDLAAVSLE LPDILNSLHF CSLNENEIIC
110 120 130 140 150
MKNINKPLDI SSDPLNQSHP SGMLCVMRVS PTSPRLRIDF IFSLLSKYAT
160 170 180 190 200
GIRYTLDTFL HQKHQLETTD EDDDDTNQSV SSIEDDFVTA FEHLEEEETS
210 220 230 240 250
KPYNDGMNIT VLRSQCDAAS QTVTGHHLET HDLKILISSG QQKSLAKPST
260 270 280 290 300
SSVNVLGHKE LPSVKTSVTT SISEPWTQRS FYRSSNASDK DSDLQKTFFS
310 320 330 340 350
SSPAYSSESE CSSPSPVIFL DEEGYQKSLK AKLELPKIPV MKDDIEDSDS
360 370 380 390 400
EVSEFFDSFD QFDELEQTLE TCLFNKDPVI GKSSQRKGHK HGKSCMNPQK
410 420 430 440 450
FKFDRPALPA NVRKPTPRKP ESPYGNLCDA PDSPRPVKAS REDSGLFSPI
460 470 480 490 500
RSSAFSPLGG CTPAECFCQT DIGGDRIHEN HDSVYYTYED YAKSISCEVL
510 520 530 540 550
GSVLRTHHTN TLSNINSIKH GENKTVTFKH GNLDQKNKSK NKSLMIKDSI
560 570 580 590 600
QKFAADLVEK SFGSAFKDLQ KGVSSCTNAL YHLAIKLTSS VLQMAFDELR
610 620 630 640 650
RQRAFSLKER AISGLANFLV SEALSNALKD LQYVKKQIFT NTVARFAADL
660 670 680 690 700
AEELVFEGIM EVCQFSYPQT PASPQCGSFD FEDKVVKLYA KDLSESVIQE
710 720 730 740 750
AFIELSQVDV TFTTKAAVSV STDNIKYVSA ESVVPSTQAV TFSPSFHNQA
760 770 780 790 800
IMVTKPVQEY KKEYTVQQAL FCTSGIVTSI PVPLAGSALL PYHISSTACQ
810 820 830 840 850
AKAHLSSDDS NSNGDSAQVH IATKNREEKA ACLRNICLPS EHNPGNQNDF
860 870 880 890 900
KPTNDDIEMQ SSSKLPNDPA IISNFSAAVV HTIVNETLES MTSLEVTKMV
910 920 930 940 950
DERTDYLTKS LKEKTPPFSH CDQAVLQCSE ASSNKDMFAD RLSKSIIKHS
960 970 980 990 1000
IDKSKSVIPN IDKNAVYKES LPVSGEESQL TPEKSPKFPD SQNQLTHCSL
1010 1020 1030 1040 1050
SAAKDCVPEC KVSMVHGSSL ETLPSCPAVT GQKSDLKESA KDQPLKKHNL
1060 1070 1080 1090 1100
NSTSLEALSF GQENPFPHSH TFSSTALTCV DGLHVEDKQK VRDRNVIPDT
1110 1120 1130 1140 1150
PPSTPLVPSR ASSEWDIKKL TKKLKGELAK EFAPATPPST PHNSSVGSLS
1160 1170 1180 1190 1200
ENEQNTIEKE EFMLKLMRSL SEEVESSESG ELPEVDVKSE HSGKKVQFAE
1210 1220 1230 1240 1250
ALATHILSLA TEMAASHLDN KIIQEPKVKN PCLNVQSQRS VSPTFLNPSD
1260 1270 1280 1290 1300
ENLKTLCNFA GDLAAEVITE AEKIAKVRNC MLFKQKKNSC YADGDEDYKV
1310 1320 1330 1340 1350
EEKLDIEAVV HPREVDPFIL SLPPSSCMSG LMYKYPSCES VTDEYAGHLI
1360 1370 1380 1390 1400
QILKQEGGNS ELIMDQYANR LAYRSVKSGL QEAAKTTKVQ CNSRMFPVPS
1410 1420 1430 1440 1450
SQVKTNKELL MFSNKEHHQE ADKKRQSKRN EGYFCKNQTC ERTLDPYRNE
1460 1470 1480 1490 1500
VSQLYSFSTS LVHSITKDAK EELTASLVGL PKSLTDSCLF EKSGYEEDNE
1510 1520 1530 1540 1550
CHVTPELPKS LQPSSQNHRF YHSTGSLNGY GCGDNVVQAV EQYAKKVVDD
1560 1570 1580 1590 1600
TLELTLGSTV FRVSETTKSA DRVTYAEKLS PLTGQACRYC DLKELHNCTG
1610 1620 1630 1640 1650
NSSQHFFRQG SLASSKPASN PKFSSRYQKS RIFHLSVPQI HVNLDKKAVL
1660 1670 1680 1690 1700
AEKIVAEAIE KAERELSSTS LAADSGIGQE GASFAESLAT ETMTAAVTNV
1710 1720 1730 1740 1750
GHAVSSSKEI EDFQSTESVS SQQMNLSIGD DSTGSWSNLS FEDEHQDESS
1760 1770 1780 1790 1800
SFHHLSESNG NSSSWSSLGL EGDLYEDNLS FPTSDSDGPD DKDEEHEDEV
1810 1820 1830 1840 1850
EGLGQDGKTL LITNIDMEPC TVDPQLRIIL QWLIASEAEV AELYFHDSAN
1860 1870 1880 1890 1900
KEFMLLSKQL QEKGWKVGDL LQAVLQYYEV MEKASSEERC KSLFDWLLEN
A
Sequence cautioni
The sequence BAA92117 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1303 | K → R in BAA92117 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1444 – 1469 | LDPYR…ITKDA → CGPSVELSPWKWQTRCGREG NSWKRE in BAA92117 (PubMed:14702039).CuratedAdd BLAST | 26 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020131 | 721 | S → C. Corresponds to variant dbSNP:rs2236364Ensembl. | 1 | |
Natural variantiVAR_048207 | 1070 | H → R. Corresponds to variant dbSNP:rs17063163EnsemblClinVar. | 1 | |
Natural variantiVAR_048208 | 1410 | L → F. Corresponds to variant dbSNP:rs17063167Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176555 mRNA Translation: AAF07045.1 AL136527 Genomic DNA No translation available. AB014529 mRNA Translation: BAA31604.2 AK002166 mRNA Translation: BAA92117.1 Different initiation. |
CCDSi | CCDS9383.1 |
PIRi | T00384 |
RefSeqi | NP_057332.1, NM_016248.3 XP_011533205.1, XM_011534903.2 XP_011533206.1, XM_011534904.1 XP_011533207.1, XM_011534905.1 XP_011533208.1, XM_011534906.2 XP_016875870.1, XM_017020381.1 |
Genome annotation databases
Ensembli | ENST00000025301.4; ENSP00000025301.2; ENSG00000023516.9 |
GeneIDi | 11215 |
KEGGi | hsa:11215 |
MANE-Selecti | ENST00000025301.4; ENSP00000025301.2; NM_016248.4; NP_057332.1 |
UCSCi | uc001uys.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF176555 mRNA Translation: AAF07045.1 AL136527 Genomic DNA No translation available. AB014529 mRNA Translation: BAA31604.2 AK002166 mRNA Translation: BAA92117.1 Different initiation. |
CCDSi | CCDS9383.1 |
PIRi | T00384 |
RefSeqi | NP_057332.1, NM_016248.3 XP_011533205.1, XM_011534903.2 XP_011533206.1, XM_011534904.1 XP_011533207.1, XM_011534905.1 XP_011533208.1, XM_011534906.2 XP_016875870.1, XM_017020381.1 |
3D structure databases
AlphaFoldDBi | Q9UKA4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116384, 86 interactors |
IntActi | Q9UKA4, 43 interactors |
MINTi | Q9UKA4 |
STRINGi | 9606.ENSP00000025301 |
PTM databases
GlyConnecti | 999, 1 N-Linked glycan (1 site) |
GlyGeni | Q9UKA4, 20 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (19 sites) |
iPTMneti | Q9UKA4 |
PhosphoSitePlusi | Q9UKA4 |
Genetic variation databases
BioMutai | AKAP11 |
DMDMi | 13431310 |
Proteomic databases
EPDi | Q9UKA4 |
jPOSTi | Q9UKA4 |
MassIVEi | Q9UKA4 |
MaxQBi | Q9UKA4 |
PaxDbi | Q9UKA4 |
PeptideAtlasi | Q9UKA4 |
PRIDEi | Q9UKA4 |
ProteomicsDBi | 84751 |
Protocols and materials databases
Antibodypediai | 23478, 58 antibodies from 19 providers |
DNASUi | 11215 |
Genome annotation databases
Ensembli | ENST00000025301.4; ENSP00000025301.2; ENSG00000023516.9 |
GeneIDi | 11215 |
KEGGi | hsa:11215 |
MANE-Selecti | ENST00000025301.4; ENSP00000025301.2; NM_016248.4; NP_057332.1 |
UCSCi | uc001uys.2, human |
Organism-specific databases
CTDi | 11215 |
DisGeNETi | 11215 |
GeneCardsi | AKAP11 |
HGNCi | HGNC:369, AKAP11 |
HPAi | ENSG00000023516, Low tissue specificity |
MIMi | 604696, gene |
neXtProti | NX_Q9UKA4 |
OpenTargetsi | ENSG00000023516 |
PharmGKBi | PA24663 |
VEuPathDBi | HostDB:ENSG00000023516 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRN4, Eukaryota |
GeneTreei | ENSGT00940000153313 |
HOGENOMi | CLU_002178_0_0_1 |
InParanoidi | Q9UKA4 |
OMAi | KFKFDCP |
OrthoDBi | 43913at2759 |
PhylomeDBi | Q9UKA4 |
TreeFami | TF343800 |
Enzyme and pathway databases
PathwayCommonsi | Q9UKA4 |
SignaLinki | Q9UKA4 |
SIGNORi | Q9UKA4 |
Miscellaneous databases
BioGRID-ORCSi | 11215, 4 hits in 1087 CRISPR screens |
ChiTaRSi | AKAP11, human |
GeneWikii | AKAP11 |
GenomeRNAii | 11215 |
Pharosi | Q9UKA4, Tbio |
PROi | PR:Q9UKA4 |
RNActi | Q9UKA4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000023516, Expressed in caudate nucleus and 254 other tissues |
Genevisiblei | Q9UKA4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008382, SPHK1-interactor_AKAP_110 |
PANTHERi | PTHR10226, PTHR10226, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AKA11_HUMAN | |
Accessioni | Q9UKA4Primary (citable) accession number: Q9UKA4 Secondary accession number(s): O75124, Q9NUK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families