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UniProtKB - Q9UKA4 (AKA11_HUMAN)

Entry version 177 (25 May 2022)
Sequence version 1 (01 May 2000)
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Protein

A-kinase anchor protein 11

Gene

AKAP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UKA4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UKA4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UKA4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 11
Short name:
AKAP-11
Alternative name(s):
A-kinase anchor protein 220 kDa
Short name:
AKAP 220
Short name:
hAKAP220
Protein kinase A-anchoring protein 11
Short name:
PRKA11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP11
Synonyms:AKAP220, KIAA0629
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:369, AKAP11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604696, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UKA4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000023516

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11215

Open Targets

More...OpenTargetsi		ENSG00000023516

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24663

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UKA4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AKAP11

Domain mapping of disease mutations (DMDM)

More...DMDMi		13431310

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645171 – 1901A-kinase anchor protein 11Add BLAST1901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei981PhosphothreonineCombined sources1
Modified residuei1100PhosphothreonineCombined sources1
Modified residuei1171PhosphoserineCombined sources1
Modified residuei1176PhosphoserineBy similarity1
Modified residuei1177PhosphoserineBy similarity1
Modified residuei1242PhosphoserineCombined sources1
Modified residuei1337PhosphoserineCombined sources1
Modified residuei1485PhosphothreonineCombined sources1
Modified residuei1580PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UKA4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UKA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UKA4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UKA4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UKA4

PeptideAtlas

More...PeptideAtlasi		Q9UKA4

PRoteomics IDEntifications database

More...PRIDEi		Q9UKA4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84751

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		999, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UKA4, 20 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (19 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UKA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UKA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000023516, Expressed in caudate nucleus and 254 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UKA4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000023516, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116384, 86 interactors

Protein interaction database and analysis system

More...IntActi		Q9UKA4, 43 interactors

Molecular INTeraction database

More...MINTi		Q9UKA4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000025301

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UKA4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UKA4

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni407 – 443DisorderedSequence analysisAdd BLAST37
Regioni843 – 864DisorderedSequence analysisAdd BLAST22
Regioni971 – 993DisorderedSequence analysisAdd BLAST23
Regioni1131 – 1153DisorderedSequence analysisAdd BLAST23
Regioni1650 – 1663PKA-RII subunit binding domainAdd BLAST14
Regioni1708 – 1805DisorderedSequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi974 – 993Polar residuesSequence analysisAdd BLAST20
Compositional biasi1137 – 1153Polar residuesSequence analysisAdd BLAST17
Compositional biasi1708 – 1740Polar residuesSequence analysisAdd BLAST33
Compositional biasi1753 – 1769Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRN4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002178_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UKA4

Identification of Orthologs from Complete Genome Data

More...OMAi		KFKFDCP

Database of Orthologous Groups

More...OrthoDBi		43913at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UKA4

TreeFam database of animal gene trees

More...TreeFami		TF343800

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008382, SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...PANTHERi		PTHR10226, PTHR10226, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UKA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATFRNNHMK TKASVRKSFS EDVFQSVKSL LQSQKELCSV TAEDCLQQDE 
        60         70         80         90        100
HANLTEVTFL GFNEETDAAH IQDLAAVSLE LPDILNSLHF CSLNENEIIC 
       110        120        130        140        150
MKNINKPLDI SSDPLNQSHP SGMLCVMRVS PTSPRLRIDF IFSLLSKYAT 
       160        170        180        190        200
GIRYTLDTFL HQKHQLETTD EDDDDTNQSV SSIEDDFVTA FEHLEEEETS 
       210        220        230        240        250
KPYNDGMNIT VLRSQCDAAS QTVTGHHLET HDLKILISSG QQKSLAKPST 
       260        270        280        290        300
SSVNVLGHKE LPSVKTSVTT SISEPWTQRS FYRSSNASDK DSDLQKTFFS 
       310        320        330        340        350
SSPAYSSESE CSSPSPVIFL DEEGYQKSLK AKLELPKIPV MKDDIEDSDS 
       360        370        380        390        400
EVSEFFDSFD QFDELEQTLE TCLFNKDPVI GKSSQRKGHK HGKSCMNPQK 
       410        420        430        440        450
FKFDRPALPA NVRKPTPRKP ESPYGNLCDA PDSPRPVKAS REDSGLFSPI 
       460        470        480        490        500
RSSAFSPLGG CTPAECFCQT DIGGDRIHEN HDSVYYTYED YAKSISCEVL 
       510        520        530        540        550
GSVLRTHHTN TLSNINSIKH GENKTVTFKH GNLDQKNKSK NKSLMIKDSI 
       560        570        580        590        600
QKFAADLVEK SFGSAFKDLQ KGVSSCTNAL YHLAIKLTSS VLQMAFDELR 
       610        620        630        640        650
RQRAFSLKER AISGLANFLV SEALSNALKD LQYVKKQIFT NTVARFAADL 
       660        670        680        690        700
AEELVFEGIM EVCQFSYPQT PASPQCGSFD FEDKVVKLYA KDLSESVIQE 
       710        720        730        740        750
AFIELSQVDV TFTTKAAVSV STDNIKYVSA ESVVPSTQAV TFSPSFHNQA 
       760        770        780        790        800
IMVTKPVQEY KKEYTVQQAL FCTSGIVTSI PVPLAGSALL PYHISSTACQ 
       810        820        830        840        850
AKAHLSSDDS NSNGDSAQVH IATKNREEKA ACLRNICLPS EHNPGNQNDF 
       860        870        880        890        900
KPTNDDIEMQ SSSKLPNDPA IISNFSAAVV HTIVNETLES MTSLEVTKMV 
       910        920        930        940        950
DERTDYLTKS LKEKTPPFSH CDQAVLQCSE ASSNKDMFAD RLSKSIIKHS 
       960        970        980        990       1000
IDKSKSVIPN IDKNAVYKES LPVSGEESQL TPEKSPKFPD SQNQLTHCSL 
      1010       1020       1030       1040       1050
SAAKDCVPEC KVSMVHGSSL ETLPSCPAVT GQKSDLKESA KDQPLKKHNL 
      1060       1070       1080       1090       1100
NSTSLEALSF GQENPFPHSH TFSSTALTCV DGLHVEDKQK VRDRNVIPDT 
      1110       1120       1130       1140       1150
PPSTPLVPSR ASSEWDIKKL TKKLKGELAK EFAPATPPST PHNSSVGSLS 
      1160       1170       1180       1190       1200
ENEQNTIEKE EFMLKLMRSL SEEVESSESG ELPEVDVKSE HSGKKVQFAE 
      1210       1220       1230       1240       1250
ALATHILSLA TEMAASHLDN KIIQEPKVKN PCLNVQSQRS VSPTFLNPSD 
      1260       1270       1280       1290       1300
ENLKTLCNFA GDLAAEVITE AEKIAKVRNC MLFKQKKNSC YADGDEDYKV 
      1310       1320       1330       1340       1350
EEKLDIEAVV HPREVDPFIL SLPPSSCMSG LMYKYPSCES VTDEYAGHLI 
      1360       1370       1380       1390       1400
QILKQEGGNS ELIMDQYANR LAYRSVKSGL QEAAKTTKVQ CNSRMFPVPS 
      1410       1420       1430       1440       1450
SQVKTNKELL MFSNKEHHQE ADKKRQSKRN EGYFCKNQTC ERTLDPYRNE 
      1460       1470       1480       1490       1500
VSQLYSFSTS LVHSITKDAK EELTASLVGL PKSLTDSCLF EKSGYEEDNE 
      1510       1520       1530       1540       1550
CHVTPELPKS LQPSSQNHRF YHSTGSLNGY GCGDNVVQAV EQYAKKVVDD 
      1560       1570       1580       1590       1600
TLELTLGSTV FRVSETTKSA DRVTYAEKLS PLTGQACRYC DLKELHNCTG 
      1610       1620       1630       1640       1650
NSSQHFFRQG SLASSKPASN PKFSSRYQKS RIFHLSVPQI HVNLDKKAVL 
      1660       1670       1680       1690       1700
AEKIVAEAIE KAERELSSTS LAADSGIGQE GASFAESLAT ETMTAAVTNV 
      1710       1720       1730       1740       1750
GHAVSSSKEI EDFQSTESVS SQQMNLSIGD DSTGSWSNLS FEDEHQDESS 
      1760       1770       1780       1790       1800
SFHHLSESNG NSSSWSSLGL EGDLYEDNLS FPTSDSDGPD DKDEEHEDEV 
      1810       1820       1830       1840       1850
EGLGQDGKTL LITNIDMEPC TVDPQLRIIL QWLIASEAEV AELYFHDSAN 
      1860       1870       1880       1890       1900
KEFMLLSKQL QEKGWKVGDL LQAVLQYYEV MEKASSEERC KSLFDWLLEN 

A
Length:1,901
Mass (Da):210,512
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0893316C46A75672
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92117 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1303K → R in BAA92117 (PubMed:14702039).Curated1
Sequence conflicti1444 – 1469LDPYR…ITKDA → CGPSVELSPWKWQTRCGREG NSWKRE in BAA92117 (PubMed:14702039).CuratedAdd BLAST26

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020131721S → C. Corresponds to variant dbSNP:rs2236364Ensembl.1
Natural variantiVAR_0482071070H → R. Corresponds to variant dbSNP:rs17063163EnsemblClinVar.1
Natural variantiVAR_0482081410L → F. Corresponds to variant dbSNP:rs17063167Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF176555 mRNA Translation: AAF07045.1
AL136527 Genomic DNA No translation available.
AB014529 mRNA Translation: BAA31604.2
AK002166 mRNA Translation: BAA92117.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9383.1

Protein sequence database of the Protein Information Resource

More...PIRi		T00384

NCBI Reference Sequences

More...RefSeqi		NP_057332.1, NM_016248.3
XP_011533205.1, XM_011534903.2
XP_011533206.1, XM_011534904.1
XP_011533207.1, XM_011534905.1
XP_011533208.1, XM_011534906.2
XP_016875870.1, XM_017020381.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000025301.4; ENSP00000025301.2; ENSG00000023516.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11215

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11215

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000025301.4; ENSP00000025301.2; NM_016248.4; NP_057332.1

UCSC genome browser

More...UCSCi		uc001uys.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176555 mRNA Translation: AAF07045.1
AL136527 Genomic DNA No translation available.
AB014529 mRNA Translation: BAA31604.2
AK002166 mRNA Translation: BAA92117.1 Different initiation.
CCDSiCCDS9383.1
PIRiT00384
RefSeqiNP_057332.1, NM_016248.3
XP_011533205.1, XM_011534903.2
XP_011533206.1, XM_011534904.1
XP_011533207.1, XM_011534905.1
XP_011533208.1, XM_011534906.2
XP_016875870.1, XM_017020381.1

3D structure databases

AlphaFoldDBiQ9UKA4
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi116384, 86 interactors
IntActiQ9UKA4, 43 interactors
MINTiQ9UKA4
STRINGi9606.ENSP00000025301

PTM databases

GlyConnecti999, 1 N-Linked glycan (1 site)
GlyGeniQ9UKA4, 20 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (19 sites)
iPTMnetiQ9UKA4
PhosphoSitePlusiQ9UKA4

Genetic variation databases

BioMutaiAKAP11
DMDMi13431310

Proteomic databases

EPDiQ9UKA4
jPOSTiQ9UKA4
MassIVEiQ9UKA4
MaxQBiQ9UKA4
PaxDbiQ9UKA4
PeptideAtlasiQ9UKA4
PRIDEiQ9UKA4
ProteomicsDBi84751

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23478, 58 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		11215

Genome annotation databases

EnsembliENST00000025301.4; ENSP00000025301.2; ENSG00000023516.9
GeneIDi11215
KEGGihsa:11215
MANE-SelectiENST00000025301.4; ENSP00000025301.2; NM_016248.4; NP_057332.1
UCSCiuc001uys.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11215
DisGeNETi11215

GeneCards: human genes, protein and diseases

More...GeneCardsi		AKAP11
HGNCiHGNC:369, AKAP11
HPAiENSG00000023516, Low tissue specificity
MIMi604696, gene
neXtProtiNX_Q9UKA4
OpenTargetsiENSG00000023516
PharmGKBiPA24663
VEuPathDBiHostDB:ENSG00000023516

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRN4, Eukaryota
GeneTreeiENSGT00940000153313
HOGENOMiCLU_002178_0_0_1
InParanoidiQ9UKA4
OMAiKFKFDCP
OrthoDBi43913at2759
PhylomeDBiQ9UKA4
TreeFamiTF343800

Enzyme and pathway databases

PathwayCommonsiQ9UKA4
SignaLinkiQ9UKA4
SIGNORiQ9UKA4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11215, 4 hits in 1087 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AKAP11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AKAP11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11215
PharosiQ9UKA4, Tbio

Protein Ontology

More...PROi		PR:Q9UKA4
RNActiQ9UKA4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000023516, Expressed in caudate nucleus and 254 other tissues
GenevisibleiQ9UKA4, HS

Family and domain databases

InterProiView protein in InterPro
IPR008382, SPHK1-interactor_AKAP_110
PANTHERiPTHR10226, PTHR10226, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKA11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKA4
Secondary accession number(s): O75124, Q9NUK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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