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Protein

F-box/LRR-repeat protein 4

Gene

FBXL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box/LRR-repeat protein 4
Alternative name(s):
F-box and leucine-rich repeat protein 4
F-box protein FBL4/FBL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXL4
Synonyms:FBL4, FBL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112234.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13601 FBXL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605654 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UKA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial DNA depletion syndrome 13 (MTDPS13)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by early infantile onset of encephalopathy, hypotonia, lactic acidosis, and severe global developmental delay. Cells derived from patient tissues show defects in mitochondrial oxidative phosphorylation and decreased mtDNA content.
See also OMIM:615471
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070858205I → T in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs1350566881Ensembl.1
Natural variantiVAR_076547481L → P in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs772037717EnsemblClinVar.1
Natural variantiVAR_070859482R → W in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs398123061EnsemblClinVar.1
Natural variantiVAR_070860551I → N in MTDPS13. 1 Publication1
Natural variantiVAR_070861565D → G in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs398123062EnsemblClinVar.1
Natural variantiVAR_070862568G → A in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs398123060EnsemblClinVar.1
Natural variantiVAR_070863597Q → P in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs201989042EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
26235

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
FBXL4

MalaCards human disease database

More...
MalaCardsi
FBXL4
MIMi615471 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112234

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
369897 Mitochondrial DNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28024

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21263631

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198441 – 621F-box/LRR-repeat protein 4Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UKA2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UKA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UKA2

PeptideAtlas

More...
PeptideAtlasi
Q9UKA2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UKA2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84750

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UKA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UKA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112234 Expressed in 205 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_FBXL4

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UKA2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033362
HPA029140

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117626, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UKA2, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UKA2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 332F-boxPROSITE-ProRule annotationAdd BLAST56
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati376 – 397LRR 1Add BLAST22
Repeati402 – 421LRR 2Add BLAST20
Repeati427 – 448LRR 3Add BLAST22
Repeati452 – 474LRR 4Add BLAST23
Repeati480 – 501LRR 5Add BLAST22
Repeati504 – 524LRR 6Add BLAST21
Repeati532 – 558LRR 7Add BLAST27
Repeati559 – 583LRR 8Add BLAST25
Repeati584 – 609LRR 9Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1947 Eukaryota
ENOG410XQ54 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006948

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051588

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UKA2

KEGG Orthology (KO)

More...
KOi
K10270

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLYRTKI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06EZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UKA2

TreeFam database of animal gene trees

More...
TreeFami
TF323721

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646 F-box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00367 LRR_CC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UKA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPVFPMLTV LTMFYYICLR RRARTATRGE MMNTHRAIES NSQTSPLNAE
60 70 80 90 100
VVQYAKEVVD FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY
110 120 130 140 150
GTWWDQCPSA SLPFKRTPPN FQSQDYVELT FEQQVYPTAV HVLETYHPGA
160 170 180 190 200
VIRILACSAN PYSPNPPAEV RWEILWSERP TKVNASQARQ FKPCIKQINF
210 220 230 240 250
PTNLIRLEVN SSLLEYYTEL DAVVLHGVKD KPVLSLKTSL IDMNDIEDDA
260 270 280 290 300
YAEKDGCGMD SLNKKFSSAV LGEGPNNGYF DKLPYELIQL ILNHLTLPDL
310 320 330 340 350
CRLAQTCKLL SQHCCDPLQY IHLNLQPYWA KLDDTSLEFL QSRCTLVQWL
360 370 380 390 400
NLSWTGNRGF ISVAGFSRFL KVCGSELVRL ELSCSHFLNE TCLEVISEMC
410 420 430 440 450
PNLQALNLSS CDKLPPQAFN HIAKLCSLKR LVLYRTKVEQ TALLSILNFC
460 470 480 490 500
SELQHLSLGS CVMIEDYDVI ASMIGAKCKK LRTLDLWRCK NITENGIAEL
510 520 530 540 550
ASGCPLLEEL DLGWCPTLQS STGCFTRLAH QLPNLQKLFL TANRSVCDTD
560 570 580 590 600
IDELACNCTR LQQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN
610 620
RAVLELNASF PKVFIKKSFT Q
Length:621
Mass (Da):70,097
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8FD51A5C4F922D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5F → Y in AAF03699 (PubMed:10531037).Curated1
Sequence conflicti42S → G in AAF09247 (PubMed:10945468).Curated1
Sequence conflicti122Q → K in AAF03699 (PubMed:10531037).Curated1
Sequence conflicti126Y → I in AAF03699 (PubMed:10531037).Curated1
Sequence conflicti219E → G in AAF03699 (PubMed:10531037).Curated1
Sequence conflicti232P → A in AAF03699 (PubMed:10531037).Curated1
Sequence conflicti533P → L in BAG35902 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070858205I → T in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs1350566881Ensembl.1
Natural variantiVAR_076547481L → P in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs772037717EnsemblClinVar.1
Natural variantiVAR_070859482R → W in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs398123061EnsemblClinVar.1
Natural variantiVAR_070860551I → N in MTDPS13. 1 Publication1
Natural variantiVAR_070861565D → G in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs398123062EnsemblClinVar.1
Natural variantiVAR_070862568G → A in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs398123060EnsemblClinVar.1
Natural variantiVAR_070863597Q → P in MTDPS13. 1 PublicationCorresponds to variant dbSNP:rs201989042EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF176699 mRNA Translation: AAF03699.1
AF174590 mRNA Translation: AAF04511.1
AF199355 mRNA Translation: AAF09247.1
AK313076 mRNA Translation: BAG35902.1
AL022395 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48489.1
CH471051 Genomic DNA Translation: EAW48490.1
BC055010 mRNA Translation: AAH55010.1
BC091484 mRNA Translation: AAH91484.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5041.1

NCBI Reference Sequences

More...
RefSeqi
NP_001265645.1, NM_001278716.1
NP_036292.2, NM_012160.4
XP_016866215.1, XM_017010726.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.536850
Hs.714504

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229971; ENSP00000229971; ENSG00000112234
ENST00000369244; ENSP00000358247; ENSG00000112234

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26235

UCSC genome browser

More...
UCSCi
uc003ppf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176699 mRNA Translation: AAF03699.1
AF174590 mRNA Translation: AAF04511.1
AF199355 mRNA Translation: AAF09247.1
AK313076 mRNA Translation: BAG35902.1
AL022395 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48489.1
CH471051 Genomic DNA Translation: EAW48490.1
BC055010 mRNA Translation: AAH55010.1
BC091484 mRNA Translation: AAH91484.1
CCDSiCCDS5041.1
RefSeqiNP_001265645.1, NM_001278716.1
NP_036292.2, NM_012160.4
XP_016866215.1, XM_017010726.1
UniGeneiHs.536850
Hs.714504

3D structure databases

ProteinModelPortaliQ9UKA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117626, 43 interactors
IntActiQ9UKA2, 6 interactors
STRINGi9606.ENSP00000229971

PTM databases

iPTMnetiQ9UKA2
PhosphoSitePlusiQ9UKA2

Polymorphism and mutation databases

DMDMi21263631

Proteomic databases

EPDiQ9UKA2
MaxQBiQ9UKA2
PaxDbiQ9UKA2
PeptideAtlasiQ9UKA2
PRIDEiQ9UKA2
ProteomicsDBi84750

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229971; ENSP00000229971; ENSG00000112234
ENST00000369244; ENSP00000358247; ENSG00000112234
GeneIDi26235
KEGGihsa:26235
UCSCiuc003ppf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26235
DisGeNETi26235
EuPathDBiHostDB:ENSG00000112234.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXL4
GeneReviewsiFBXL4
HGNCiHGNC:13601 FBXL4
HPAiCAB033362
HPA029140
MalaCardsiFBXL4
MIMi605654 gene
615471 phenotype
neXtProtiNX_Q9UKA2
OpenTargetsiENSG00000112234
Orphaneti369897 Mitochondrial DNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies
PharmGKBiPA28024

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00940000155184
HOGENOMiHOG000006948
HOVERGENiHBG051588
InParanoidiQ9UKA2
KOiK10270
OMAiVLYRTKI
OrthoDBiEOG091G06EZ
PhylomeDBiQ9UKA2
TreeFamiTF323721

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FBXL4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26235

Protein Ontology

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PROi
PR:Q9UKA2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112234 Expressed in 205 organ(s), highest expression level in kidney
CleanExiHS_FBXL4
GenevisibleiQ9UKA2 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SMARTiView protein in SMART
SM00367 LRR_CC, 7 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBXL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UKA2
Secondary accession number(s): B2R7Q5
, E1P530, O95919, Q5BJH0, Q9UJU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: December 5, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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