Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 3

Gene

FBXO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO3
Synonyms:FBX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110429.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13582 FBXO3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609089 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UK99

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26273

Open Targets

More...
OpenTargetsi
ENSG00000110429

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28040

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXO3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198771 – 471F-box only protein 3Add BLAST471

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UK99

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UK99

PeptideAtlas

More...
PeptideAtlasi
Q9UK99

PRoteomics IDEntifications database

More...
PRIDEi
Q9UK99

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84745
84746 [Q9UK99-2]
84747 [Q9UK99-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UK99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UK99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110429 Expressed in 227 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

CleanEx database of gene expression profiles

More...
CleanExi
HS_FBXO3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UK99 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UK99 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002467

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117657, 38 interactors

Database of interacting proteins

More...
DIPi
DIP-53688N

Protein interaction database and analysis system

More...
IntActi
Q9UK99, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9UK99

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265651

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UK99

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UK99

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 56F-boxPROSITE-ProRule annotationAdd BLAST47
Domaini278 – 408ApaGPROSITE-ProRule annotationAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi418 – 452Asp/Glu-rich (highly acidic)Add BLAST35
Compositional biasi453 – 456Poly-Arg4
Compositional biasi463 – 466Poly-Arg4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4408 Eukaryota
COG2967 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232174

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005647

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UK99

KEGG Orthology (KO)

More...
KOi
K10290

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLGRYIQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08GB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UK99

TreeFam database of animal gene trees

More...
TreeFami
TF329795

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1470, 1 hit
3.40.1580.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007474 ApaG_domain
IPR036767 ApaG_sf
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR018958 Knr4/Smi1-like_dom
IPR037883 Knr4/Smi1-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04379 DUF525, 1 hit
PF12937 F-box-like, 1 hit
PF09346 SMI1_KNR4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00256 FBOX, 1 hit
SM00860 SMI1_KNR4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110069 SSF110069, 1 hit
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51087 APAG, 1 hit
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK99-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAMETETAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD
60 70 80 90 100
PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW
110 120 130 140 150
DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN
160 170 180 190 200
GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KYCLPLTFCI
210 220 230 240 250
HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT
260 270 280 290 300
SYVKNVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH
310 320 330 340 350
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG
360 370 380 390 400
EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH
410 420 430 440 450
MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDEDDDSA DMDESDEDDE
460 470
EERRRRVFDV PIRRRRCSRL F
Length:471
Mass (Da):54,561
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FDA81669264E0AD
GO
Isoform 2 (identifier: Q9UK99-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-415: EM → VS
     416-471: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):47,530
Checksum:i9CA7AC918B28FCB0
GO
Isoform 3 (identifier: Q9UK99-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-40: Missing.
     414-415: EM → VS
     416-471: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):46,975
Checksum:i221BD13D1AB4236E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1E0G3V1E0_HUMAN
F-box only protein 3
FBXO3 hCG_27567
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJM3E9PJM3_HUMAN
F-box only protein 3
FBXO3
430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q49AF1Q49AF1_HUMAN
F-box only protein 3
FBXO3
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E3U2B4E3U2_HUMAN
cDNA FLJ59154, highly similar to F-...
FBXO3
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL46E9PL46_HUMAN
F-box only protein 3
FBXO3
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28L → M in CAB66560 (PubMed:11230166).Curated1
Sequence conflicti96 – 98IKK → VKR in CAB66560 (PubMed:11230166).Curated3
Sequence conflicti164A → T in BAA91991 (PubMed:14702039).Curated1
Sequence conflicti227D → G in CAB66560 (PubMed:11230166).Curated1
Sequence conflicti239F → L in CAB66560 (PubMed:11230166).Curated1
Sequence conflicti378G → E in CAB66560 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049037221V → I. Corresponds to variant dbSNP:rs1402954Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03961436 – 40Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_024395414 – 415EM → VS in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_024396416 – 471Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001943 mRNA Translation: BAA91991.1
AK128454 mRNA Translation: BAG54678.1
AL136625 mRNA Translation: CAB66560.1
AC113192 Genomic DNA No translation available.
AL049629 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68186.1
CH471064 Genomic DNA Translation: EAW68188.1
CH471064 Genomic DNA Translation: EAW68189.1
BC046110 mRNA Translation: AAH46110.1
AF176702 mRNA Translation: AAF03702.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44566.1 [Q9UK99-2]
CCDS7887.1 [Q9UK99-1]

NCBI Reference Sequences

More...
RefSeqi
NP_036307.2, NM_012175.3 [Q9UK99-1]
NP_208385.1, NM_033406.2 [Q9UK99-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.406787

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265651; ENSP00000265651; ENSG00000110429 [Q9UK99-1]
ENST00000448981; ENSP00000408836; ENSG00000110429 [Q9UK99-2]
ENST00000530401; ENSP00000433781; ENSG00000110429 [Q9UK99-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26273

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26273

UCSC genome browser

More...
UCSCi
uc001muz.4 human [Q9UK99-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001943 mRNA Translation: BAA91991.1
AK128454 mRNA Translation: BAG54678.1
AL136625 mRNA Translation: CAB66560.1
AC113192 Genomic DNA No translation available.
AL049629 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68186.1
CH471064 Genomic DNA Translation: EAW68188.1
CH471064 Genomic DNA Translation: EAW68189.1
BC046110 mRNA Translation: AAH46110.1
AF176702 mRNA Translation: AAF03702.1
CCDSiCCDS44566.1 [Q9UK99-2]
CCDS7887.1 [Q9UK99-1]
RefSeqiNP_036307.2, NM_012175.3 [Q9UK99-1]
NP_208385.1, NM_033406.2 [Q9UK99-2]
UniGeneiHs.406787

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HDWX-ray2.00A278-407[»]
ProteinModelPortaliQ9UK99
SMRiQ9UK99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117657, 38 interactors
DIPiDIP-53688N
IntActiQ9UK99, 8 interactors
MINTiQ9UK99
STRINGi9606.ENSP00000265651

PTM databases

iPTMnetiQ9UK99
PhosphoSitePlusiQ9UK99

Polymorphism and mutation databases

BioMutaiFBXO3
DMDMi145559474

Proteomic databases

EPDiQ9UK99
PaxDbiQ9UK99
PeptideAtlasiQ9UK99
PRIDEiQ9UK99
ProteomicsDBi84745
84746 [Q9UK99-2]
84747 [Q9UK99-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26273
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265651; ENSP00000265651; ENSG00000110429 [Q9UK99-1]
ENST00000448981; ENSP00000408836; ENSG00000110429 [Q9UK99-2]
ENST00000530401; ENSP00000433781; ENSG00000110429 [Q9UK99-3]
GeneIDi26273
KEGGihsa:26273
UCSCiuc001muz.4 human [Q9UK99-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26273
DisGeNETi26273
EuPathDBiHostDB:ENSG00000110429.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXO3
HGNCiHGNC:13582 FBXO3
HPAiHPA002467
MIMi609089 gene
neXtProtiNX_Q9UK99
OpenTargetsiENSG00000110429
PharmGKBiPA28040

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4408 Eukaryota
COG2967 LUCA
GeneTreeiENSGT00940000153571
HOGENOMiHOG000232174
HOVERGENiHBG005647
InParanoidiQ9UK99
KOiK10290
OMAiDLGRYIQ
OrthoDBiEOG091G08GB
PhylomeDBiQ9UK99
TreeFamiTF329795

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26273

Protein Ontology

More...
PROi
PR:Q9UK99

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110429 Expressed in 227 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_FBXO3
ExpressionAtlasiQ9UK99 baseline and differential
GenevisibleiQ9UK99 HS

Family and domain databases

Gene3Di2.60.40.1470, 1 hit
3.40.1580.10, 1 hit
InterProiView protein in InterPro
IPR007474 ApaG_domain
IPR036767 ApaG_sf
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR018958 Knr4/Smi1-like_dom
IPR037883 Knr4/Smi1-like_sf
PfamiView protein in Pfam
PF04379 DUF525, 1 hit
PF12937 F-box-like, 1 hit
PF09346 SMI1_KNR4, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00860 SMI1_KNR4, 1 hit
SUPFAMiSSF110069 SSF110069, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51087 APAG, 1 hit
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK99
Secondary accession number(s): B3KY16
, D3DR05, Q86X90, Q9H0V2, Q9NUX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 17, 2007
Last modified: December 5, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again