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Protein

F-box only protein 9

Gene

FBXO9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.1 Publication

Miscellaneous

Overexpressed in multiple myeloma leading to constitutive activation of the PI3K/mTORC2/Akt pathway to promote survival.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 9
Alternative name(s):
Cross-immune reaction antigen 1
Renal carcinoma antigen NY-REN-57
Gene namesi
Name:FBXO9
Synonyms:FBX9, VCIA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112146.16
HGNCiHGNC:13588 FBXO9
MIMi609091 gene
neXtProtiNX_Q9UK97

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi26268
OpenTargetsiENSG00000112146
PharmGKBiPA28049

Polymorphism and mutation databases

BioMutaiFBXO9
DMDMi13124238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198861 – 447F-box only protein 9Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UK97
PaxDbiQ9UK97
PeptideAtlasiQ9UK97
PRIDEiQ9UK97
ProteomicsDBi84742
84743 [Q9UK97-2]
84744 [Q9UK97-3]

PTM databases

iPTMnetiQ9UK97
PhosphoSitePlusiQ9UK97

Expressioni

Gene expression databases

BgeeiENSG00000112146 Expressed in 234 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_FBXO9
ExpressionAtlasiQ9UK97 baseline and differential
GenevisibleiQ9UK97 HS

Organism-specific databases

HPAiHPA064246

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi117652, 10 interactors
DIPiDIP-60458N
IntActiQ9UK97, 11 interactors
STRINGi9606.ENSP00000244426

Structurei

3D structure databases

ProteinModelPortaliQ9UK97
SMRiQ9UK97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati94 – 127TPRAdd BLAST34
Domaini185 – 236F-boxPROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

TPR repeat

Phylogenomic databases

eggNOGiKOG2997 Eukaryota
ENOG410XPVI LUCA
GeneTreeiENSGT00390000014256
HOGENOMiHOG000047162
HOVERGENiHBG001041
InParanoidiQ9UK97
KOiK10295
OMAiSKTTYLR
OrthoDBiEOG091G0BDF
PhylomeDBiQ9UK97
TreeFamiTF324797

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR036181 MIT_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDIIWVFPP QAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW
60 70 80 90 100
MFELAPGVSS SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK
110 120 130 140 150
AVEEEQNGAL YEAIKFYRRA MQLVPDIEFK ITYTRSPDGD GVGNSYIEDN
160 170 180 190 200
DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE LESSQIHISV LPMEVLMYIF
210 220 230 240 250
RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV WGRSCIKLVP
260 270 280 290 300
YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI
310 320 330 340 350
RFFPDGHVMM LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK
360 370 380 390 400
VFAVITKKKE EKPLDYKYRY FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL
410 420 430 440
IWIHHSCHIT YKSTGETAVS AFEIDKMYTP LFFARVRSYT AFSERPL
Length:447
Mass (Da):52,329
Last modified:May 1, 2000 - v1
Checksum:i2A88163DAB898D69
GO
Isoform 2 (identifier: Q9UK97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MPDIIWVFPPQ → M

Show »
Length:437
Mass (Da):51,136
Checksum:iAF7DCF6AD4F4035E
GO
Isoform 3 (identifier: Q9UK97-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):47,361
Checksum:i1AAA1F46C31315BB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IY65C9IY65_HUMAN
F-box only protein 9
FBXO9
145Annotation score:
C9JDZ9C9JDZ9_HUMAN
F-box only protein 9
FBXO9
118Annotation score:
C9J4V1C9J4V1_HUMAN
F-box only protein 9
FBXO9
48Annotation score:
V9GZ74V9GZ74_HUMAN
F-box only protein 9
FBXO9
150Annotation score:
H7C4H6H7C4H6_HUMAN
F-box only protein 9
FBXO9
191Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0129801 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0129791 – 11MPDIIWVFPPQ → M in isoform 2. 4 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176704 mRNA Translation: AAF03704.1
AY858798 mRNA Translation: AAW51115.1
AL137520 mRNA Translation: CAB70786.2
AK021559 mRNA Translation: BAG51038.1
AB209833 mRNA Translation: BAD93070.1
AL031178 Genomic DNA No translation available.
BC000650 mRNA Translation: AAH00650.2
AF174597 mRNA Translation: AAF04518.1
CCDSiCCDS55022.1 [Q9UK97-2]
CCDS55023.1 [Q9UK97-1]
CCDS55024.1 [Q9UK97-3]
PIRiT46366
RefSeqiNP_036479.1, NM_012347.4 [Q9UK97-1]
NP_258441.1, NM_033480.2 [Q9UK97-2]
NP_258442.2, NM_033481.3 [Q9UK97-3]
XP_005249052.1, XM_005248995.4 [Q9UK97-3]
XP_005249053.1, XM_005248996.4 [Q9UK97-3]
UniGeneiHs.216653

Genome annotation databases

EnsembliENST00000244426; ENSP00000244426; ENSG00000112146 [Q9UK97-1]
ENST00000323557; ENSP00000326968; ENSG00000112146 [Q9UK97-2]
ENST00000370939; ENSP00000359977; ENSG00000112146 [Q9UK97-3]
GeneIDi26268
KEGGihsa:26268
UCSCiuc063pbc.1 human [Q9UK97-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176704 mRNA Translation: AAF03704.1
AY858798 mRNA Translation: AAW51115.1
AL137520 mRNA Translation: CAB70786.2
AK021559 mRNA Translation: BAG51038.1
AB209833 mRNA Translation: BAD93070.1
AL031178 Genomic DNA No translation available.
BC000650 mRNA Translation: AAH00650.2
AF174597 mRNA Translation: AAF04518.1
CCDSiCCDS55022.1 [Q9UK97-2]
CCDS55023.1 [Q9UK97-1]
CCDS55024.1 [Q9UK97-3]
PIRiT46366
RefSeqiNP_036479.1, NM_012347.4 [Q9UK97-1]
NP_258441.1, NM_033480.2 [Q9UK97-2]
NP_258442.2, NM_033481.3 [Q9UK97-3]
XP_005249052.1, XM_005248995.4 [Q9UK97-3]
XP_005249053.1, XM_005248996.4 [Q9UK97-3]
UniGeneiHs.216653

3D structure databases

ProteinModelPortaliQ9UK97
SMRiQ9UK97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117652, 10 interactors
DIPiDIP-60458N
IntActiQ9UK97, 11 interactors
STRINGi9606.ENSP00000244426

PTM databases

iPTMnetiQ9UK97
PhosphoSitePlusiQ9UK97

Polymorphism and mutation databases

BioMutaiFBXO9
DMDMi13124238

Proteomic databases

EPDiQ9UK97
PaxDbiQ9UK97
PeptideAtlasiQ9UK97
PRIDEiQ9UK97
ProteomicsDBi84742
84743 [Q9UK97-2]
84744 [Q9UK97-3]

Protocols and materials databases

DNASUi26268
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244426; ENSP00000244426; ENSG00000112146 [Q9UK97-1]
ENST00000323557; ENSP00000326968; ENSG00000112146 [Q9UK97-2]
ENST00000370939; ENSP00000359977; ENSG00000112146 [Q9UK97-3]
GeneIDi26268
KEGGihsa:26268
UCSCiuc063pbc.1 human [Q9UK97-1]

Organism-specific databases

CTDi26268
DisGeNETi26268
EuPathDBiHostDB:ENSG00000112146.16
GeneCardsiFBXO9
HGNCiHGNC:13588 FBXO9
HPAiHPA064246
MIMi609091 gene
neXtProtiNX_Q9UK97
OpenTargetsiENSG00000112146
PharmGKBiPA28049
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2997 Eukaryota
ENOG410XPVI LUCA
GeneTreeiENSGT00390000014256
HOGENOMiHOG000047162
HOVERGENiHBG001041
InParanoidiQ9UK97
KOiK10295
OMAiSKTTYLR
OrthoDBiEOG091G0BDF
PhylomeDBiQ9UK97
TreeFamiTF324797

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXO9 human
GeneWikiiFBXO9
GenomeRNAii26268
PROiPR:Q9UK97
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112146 Expressed in 234 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_FBXO9
ExpressionAtlasiQ9UK97 baseline and differential
GenevisibleiQ9UK97 HS

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR036181 MIT_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX9_HUMAN
AccessioniPrimary (citable) accession number: Q9UK97
Secondary accession number(s): A6NFW3
, B3KMM6, O75986, Q59EH8, Q6PKH7, Q9NT57, Q9Y593
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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