Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 138 (18 Sep 2019)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Jupiter microtubule associated homolog 1

Gene

JPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).4 Publications

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Jupiter microtubule associated homolog 1Imported
Alternative name(s):
Androgen-regulated protein 2
Hematological and neurological expressed 1 protein
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JPT1Imported
Synonyms:ARM2, HN11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14569 JPT1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UK76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51155

Open Targets

More...
OpenTargetsi
ENSG00000189159

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29347

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
JPT1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004244871 – 154Jupiter microtubule associated homolog 1Add BLAST154
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00000549182 – 154Jupiter microtubule associated homolog 1, N-terminally processedAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in Hematological and neurological expressed 1 protein, N-terminally processedCombined sources1 Publication1
Modified residuei28PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei54PhosphothreonineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1 Publication1
Modified residuei88PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei148N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UK76

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UK76

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UK76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UK76

PeptideAtlas

More...
PeptideAtlasi
Q9UK76

PRoteomics IDEntifications database

More...
PRIDEi
Q9UK76

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84734 [Q9UK76-1]
84735 [Q9UK76-2]
84736 [Q9UK76-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9UK76-1 [Q9UK76-1]
Q9UK76-2 [Q9UK76-2]
Q9UK76-3 [Q9UK76-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UK76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UK76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by EGF growth factor at mRNA and protein levels (PubMed:21323578). Induced by androgens (PubMed:22155408). Negatively regulated by the microRNA miR-132 (PubMed:25450365).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189159 Expressed in 220 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UK76 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UK76 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059729

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the complex composed, at least, of APC, CTNNB1 and GSK3B; the interaction takes place with the inactive form of GSK3B (phosphorylated at 'Ser-9').

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119338, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UK76, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348316

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JUPITER family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J50B Eukaryota
ENOG410YZCR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231170

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UK76

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFVCFLH

Database of Orthologous Groups

More...
OrthoDBi
1279488at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UK76

TreeFam database of animal gene trees

More...
TreeFami
TF327169

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033335 JUPITER

The PANTHER Classification System

More...
PANTHERi
PTHR34930 PTHR34930, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17054 JUPITER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK76-1) [UniParc]FASTAAdd to basket
Also known as: HN1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPTEQ PVRKNKMASN
60 70 80 90 100
IFGTPEENQA SWAKSAGAKS SGGREDLESS GLQRRNSSEA SSGDFLDLKG
110 120 130 140 150
EGDIHENVDT DLPGSLGQSE EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS

LVLG
Length:154
Mass (Da):16,015
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B443E4C7A28F093
GO
Isoform 2 (identifier: Q9UK76-2) [UniParc]FASTAAdd to basket
Also known as: HN1B

The sequence of this isoform differs from the canonical sequence as follows:
     100-154: GEGDIHENVD...PGGKSSLVLG → KMWTQTCQAA...LTVHLLDLFH

Show »
Length:181
Mass (Da):19,916
Checksum:iFF644A114DE28850
GO
Isoform 3 (identifier: Q9UK76-3) [UniParc]FASTAAdd to basket
Also known as: HN1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Show »
Length:108
Mass (Da):11,023
Checksum:iC9E266E6180AB723
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT51J3KT51_HUMAN
Jupiter microtubule-associated homo...
JPT1
104Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSH8J3KSH8_HUMAN
Jupiter microtubule-associated homo...
JPT1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3M5F2Z3M5_HUMAN
Jupiter microtubule-associated homo...
JPT1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85R → G in BAD97041 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0171321 – 46Missing in isoform 3. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_017133100 – 154GEGDI…SLVLG → KMWTQTCQAAWGRVKRSPCL LRLCPARWPRPQCHPEEIPL AASPASSWVSSDCPERCRSV CFLHACELHNLSLTVHLLDL FH in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF086910 mRNA Translation: AAP97140.1
AY322169 mRNA Translation: AAP83838.1
AY322170 mRNA Translation: AAP83839.1
AF348672 Genomic DNA Translation: AAL83903.1
AF348672 Genomic DNA Translation: AAP83962.1
AF348672 Genomic DNA Translation: AAP83963.1
AF177862 mRNA Translation: AAD53312.1
AF266846 mRNA Translation: AAQ14298.1
AF266847 Genomic DNA Translation: AAQ14299.1
AK223321 mRNA Translation: BAD97041.1
AK312613 mRNA Translation: BAG35500.1
CH471099 Genomic DNA Translation: EAW89244.1
BC001420 mRNA Translation: AAH01420.1
BC039343 mRNA Translation: AAH39343.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32729.1 [Q9UK76-2]
CCDS45771.1 [Q9UK76-1]
CCDS45772.1 [Q9UK76-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001002032.1, NM_001002032.2 [Q9UK76-2]
NP_001002033.1, NM_001002033.2 [Q9UK76-3]
NP_001275538.1, NM_001288609.1 [Q9UK76-3]
NP_001275539.1, NM_001288610.1 [Q9UK76-3]
NP_001275540.1, NM_001288611.1
NP_057269.1, NM_016185.3 [Q9UK76-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356033; ENSP00000348316; ENSG00000189159 [Q9UK76-2]
ENST00000409753; ENSP00000387059; ENSG00000189159 [Q9UK76-1]
ENST00000470924; ENSP00000462784; ENSG00000189159 [Q9UK76-3]
ENST00000476258; ENSP00000464266; ENSG00000189159 [Q9UK76-3]
ENST00000481647; ENSP00000462478; ENSG00000189159 [Q9UK76-3]
ENST00000482348; ENSP00000462834; ENSG00000189159 [Q9UK76-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51155

UCSC genome browser

More...
UCSCi
uc002jna.3 human [Q9UK76-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086910 mRNA Translation: AAP97140.1
AY322169 mRNA Translation: AAP83838.1
AY322170 mRNA Translation: AAP83839.1
AF348672 Genomic DNA Translation: AAL83903.1
AF348672 Genomic DNA Translation: AAP83962.1
AF348672 Genomic DNA Translation: AAP83963.1
AF177862 mRNA Translation: AAD53312.1
AF266846 mRNA Translation: AAQ14298.1
AF266847 Genomic DNA Translation: AAQ14299.1
AK223321 mRNA Translation: BAD97041.1
AK312613 mRNA Translation: BAG35500.1
CH471099 Genomic DNA Translation: EAW89244.1
BC001420 mRNA Translation: AAH01420.1
BC039343 mRNA Translation: AAH39343.1
CCDSiCCDS32729.1 [Q9UK76-2]
CCDS45771.1 [Q9UK76-1]
CCDS45772.1 [Q9UK76-3]
RefSeqiNP_001002032.1, NM_001002032.2 [Q9UK76-2]
NP_001002033.1, NM_001002033.2 [Q9UK76-3]
NP_001275538.1, NM_001288609.1 [Q9UK76-3]
NP_001275539.1, NM_001288610.1 [Q9UK76-3]
NP_001275540.1, NM_001288611.1
NP_057269.1, NM_016185.3 [Q9UK76-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119338, 17 interactors
IntActiQ9UK76, 5 interactors
STRINGi9606.ENSP00000348316

PTM databases

iPTMnetiQ9UK76
PhosphoSitePlusiQ9UK76

Polymorphism and mutation databases

BioMutaiJPT1

Proteomic databases

EPDiQ9UK76
jPOSTiQ9UK76
MassIVEiQ9UK76
PaxDbiQ9UK76
PeptideAtlasiQ9UK76
PRIDEiQ9UK76
ProteomicsDBi84734 [Q9UK76-1]
84735 [Q9UK76-2]
84736 [Q9UK76-3]
TopDownProteomicsiQ9UK76-1 [Q9UK76-1]
Q9UK76-2 [Q9UK76-2]
Q9UK76-3 [Q9UK76-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51155
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356033; ENSP00000348316; ENSG00000189159 [Q9UK76-2]
ENST00000409753; ENSP00000387059; ENSG00000189159 [Q9UK76-1]
ENST00000470924; ENSP00000462784; ENSG00000189159 [Q9UK76-3]
ENST00000476258; ENSP00000464266; ENSG00000189159 [Q9UK76-3]
ENST00000481647; ENSP00000462478; ENSG00000189159 [Q9UK76-3]
ENST00000482348; ENSP00000462834; ENSG00000189159 [Q9UK76-3]
GeneIDi51155
KEGGihsa:51155
UCSCiuc002jna.3 human [Q9UK76-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51155
DisGeNETi51155

GeneCards: human genes, protein and diseases

More...
GeneCardsi
JPT1
HGNCiHGNC:14569 JPT1
HPAiHPA059729
neXtProtiNX_Q9UK76
OpenTargetsiENSG00000189159
PharmGKBiPA29347

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J50B Eukaryota
ENOG410YZCR LUCA
GeneTreeiENSGT00940000164037
HOGENOMiHOG000231170
InParanoidiQ9UK76
OMAiRFVCFLH
OrthoDBi1279488at2759
PhylomeDBiQ9UK76
TreeFamiTF327169

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HN1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HN1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51155

Pharos

More...
Pharosi
Q9UK76

Protein Ontology

More...
PROi
PR:Q9UK76

Gene expression databases

BgeeiENSG00000189159 Expressed in 220 organ(s), highest expression level in forebrain
ExpressionAtlasiQ9UK76 baseline and differential
GenevisibleiQ9UK76 HS

Family and domain databases

InterProiView protein in InterPro
IPR033335 JUPITER
PANTHERiPTHR34930 PTHR34930, 1 hit
PfamiView protein in Pfam
PF17054 JUPITER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJUPI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK76
Secondary accession number(s): B2R6K3
, Q53FG7, Q7Z2D2, Q7Z2F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again