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Entry version 116 (05 Jun 2019)
Sequence version 3 (05 May 2009)
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Protein

Protein TASOR

Gene

TASOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TASORCurated
Alternative name(s):
CTCL tumor antigen se89-11 Publication
Retinoblastoma-associated protein RAP1401 Publication
Transgene activation suppressor protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TASOR1 PublicationImported
Synonyms:C3orf63Imported, FAM208AImported, KIAA11051 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30314 TASOR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616493 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UK61

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23272

Open Targets

More...
OpenTargetsi
ENSG00000163946

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128395774

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM208A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462994

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957282 – 1670Protein TASORAdd BLAST1669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei344PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei633PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Cross-linki823Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki832Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei843PhosphoserineBy similarity1
Cross-linki872Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei927PhosphoserineCombined sources1
Modified residuei971PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei982PhosphothreonineCombined sources1
Modified residuei1049PhosphothreonineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1552PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UK61

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UK61

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UK61

PeptideAtlas

More...
PeptideAtlasi
Q9UK61

PRoteomics IDEntifications database

More...
PRIDEi
Q9UK61

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84729
84730 [Q9UK61-2]
84731 [Q9UK61-3]
84732 [Q9UK61-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UK61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UK61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163946 Expressed in 235 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UK61 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UK61 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006735
HPA017142

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HUSH complex; at least composed of TASOR, PPHLN1 and MPHOSPH8 (PubMed:26022416). Interacts with MORC2; the interaction associateS MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (PubMed:28581500). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (PubMed:30487602).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MPHOSPH8Q995493EBI-308354,EBI-2653928

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116873, 56 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UK61

Database of interacting proteins

More...
DIPi
DIP-56150N

Protein interaction database and analysis system

More...
IntActi
Q9UK61, 21 interactors

Molecular INTeraction database

More...
MINTi
Q9UK61

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417509

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TASOR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4K Eukaryota
ENOG410XSS9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111372

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UK61

KEGG Orthology (KO)

More...
KOi
K21873

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCQMVSP

Database of Orthologous Groups

More...
OrthoDBi
57214at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UK61

TreeFam database of animal gene trees

More...
TreeFami
TF336055

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022188 DUF3715

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12509 DUF3715, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAVETEAC QPTDASWESG GGGDDEMKQA LPELESSQQN GGGGGLNIAE
60 70 80 90 100
PSGGAGREEN AGAEAAQSLS HEQPQDSSEA GAAALPRGPE EPERPVRRSF
110 120 130 140 150
QIPRKSREKK ALFQPLTPGS REFEDVVNIL HSSYLEPTSV TNFNYRRACL
160 170 180 190 200
VHNELLEKEF TEKRRELKFD GRLDKELSES YAFLMVDRYQ VQTICEKGLH
210 220 230 240 250
VGQSKITILG SPSMGVYLSR YADLLQANPL DTGAMGDVVI FKIMKGKIKS
260 270 280 290 300
IYDPMGVKSL ESMLNKSALD PTPKHECHVS KNANRITSLL AYRAYELTQY
310 320 330 340 350
YFYEYGFDEL RRRPRHVCPY AVVSFTYKDD IQTPKFVPSS RSNSFNTDRN
360 370 380 390 400
IDKYNYTLWK GQLLNKGKLL CYISLRSATR AFLPIKLPEK LDVETVMSID
410 420 430 440 450
HLKQKIPPAL FYKETYLGPN EVLKNGMYCS LYEVVEKTRI GSNMESLLQK
460 470 480 490 500
LDREKLVLVK PLGDRGYLFL LSPYQMVPPY EYQTAKSRVL HALFLFQEPR
510 520 530 540 550
SIVTSQKGST NAAPQERHES MPDVLKIAQF LQFSLIQCRK EFKNISAINF
560 570 580 590 600
HSVVEKYVSE FFKRGFGSGK REFIMFPYDS RLDDKKFLYS APRNKSHIDT
610 620 630 640 650
CLHAYIFRPE VYQLPICKLK ELFEENRKLQ QFSPLSDYEG QEEEMNGTKM
660 670 680 690 700
KFGKRNNSRG EAIISGKQRS SHSLDYDKDR VKELINLIQC RKKSVGGDSD
710 720 730 740 750
TEDMRSKTVL KRKLEDLPEN MRKLAKTSNL SENCHLYEES PQPIGSLGHD
760 770 780 790 800
ADLRRQQQDT CNSGIADIHR LFNWLSETLA NARHSDASLT DTVNKALGLS
810 820 830 840 850
TDDAYEELRQ KHEYELNSTP DKKDYEQPTC AKVENAQFKG TQSLLLEVDA
860 870 880 890 900
TSKYSVAIST SEVGTDHKLH LKEDPNLISV NNFEDCSLCP SVPIEHGFRR
910 920 930 940 950
QQSKSNNVEE TEIHWKLIPI TGGNARSPED QLGKHGEKQT PGMKSPEEQL
960 970 980 990 1000
VCVPPQEAFP NDPRVINRQR SSDYQFPSSP FTDTLKGTTE DDVLTGQVEE
1010 1020 1030 1040 1050
QCVPAAEAEP PAVSETTERT VLGEYNLFSR KIEEILKQKN VSYVSTVSTP
1060 1070 1080 1090 1100
IFSTQEKMKR LSEFIYSKTS KAGVQEFVDG LHEKLNTIII KASAKGGNLP
1110 1120 1130 1140 1150
PVSPNDSGAK IASNPLERHV IPVSSSDFNN KHLLEPLCSD PLKDTNSDEQ
1160 1170 1180 1190 1200
HSTSALTEVE MNQPQHATEL MVTSDHIVPG DMAREPVEET TKSPSDVNIS
1210 1220 1230 1240 1250
AQPALSNFIS QLEPEVFNSL VKIMKDVQKN TVKFYIHEEE ESVLCKEIKE
1260 1270 1280 1290 1300
YLIKLGNTEC HPEQFLERRS KLDKLLIIIQ NEDIAGFIHK IPGLVTLKKL
1310 1320 1330 1340 1350
PCVSFAGVDS LDDVKNHTYN ELFVSGGFIV SDESILNPEV VTVENLKNFL
1360 1370 1380 1390 1400
TFLEELSTPE GKWQWKVHCK FQKKLKELGR LNAKALSLLT LLNVYQKKHL
1410 1420 1430 1440 1450
VEILSYHNCD SQTRNAPELD CLIRLQAQNI QQRHIVFLTE KNIKMLSSYT
1460 1470 1480 1490 1500
DNGIVVATAE DFMQNFKNLV GYHNSITEEN LPQLGANENL ESQSALLEND
1510 1520 1530 1540 1550
EKDEEDMSLD SGDEISHIEV CSNFHSEIWE KETKGSRGTD QKKNTQIELQ
1560 1570 1580 1590 1600
SSPDVQNSLL EDKTYLDSEE RTSIDIVCSE GENSNSTEQD SYSNFQVYHS
1610 1620 1630 1640 1650
QLNMSHQFSH FNVLTHQTFL GTPYALSSSQ SQENENYFLS AYTESLDRDK
1660 1670
SPPPLSWGKS DSSRPYSQEK
Note: No experimental confirmation available. Gene prediction based on partial mRNA data.Curated
Length:1,670
Mass (Da):189,032
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8BE5ED05A96C897
GO
Isoform 2 (identifier: Q9UK61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-396: Missing.
     942-982: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,233
Mass (Da):139,998
Checksum:iD1A00958B3FA184B
GO
Isoform 3 (identifier: Q9UK61-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1495-1512: ALLENDEKDEEDMSLDSG → DAVLTLTPLELGVGISQH
     1513-1670: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,512
Mass (Da):170,815
Checksum:i95836C9CD088E80C
GO
Isoform 4 (identifier: Q9UK61-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     921-981: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,609
Mass (Da):182,281
Checksum:iFFA47C216944929C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0F1A0A087X0F1_HUMAN
Protein TASOR
TASOR
1,035Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG34913 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI29988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti941P → I in BAA83057 (PubMed:10470851).Curated1
Sequence conflicti1129N → S in AAD55098 (PubMed:18726359).Curated1
Sequence conflicti1135E → G in AAD55098 (PubMed:18726359).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05959538Q → P. Corresponds to variant dbSNP:rs958755Ensembl.1
Natural variantiVAR_033350831A → G. Corresponds to variant dbSNP:rs17056999Ensembl.1
Natural variantiVAR_055092998V → I. Corresponds to variant dbSNP:rs2291498Ensembl.1
Natural variantiVAR_0333511046T → R3 PublicationsCorresponds to variant dbSNP:rs9835332Ensembl.1
Natural variantiVAR_0333521435I → V1 PublicationCorresponds to variant dbSNP:rs2291498Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0270301 – 396Missing in isoform 2. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_027031921 – 981Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_027032942 – 982Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0270331495 – 1512ALLEN…SLDSG → DAVLTLTPLELGVGISQH in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0270341513 – 1670Missing in isoform 3. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF180425 mRNA Translation: AAD55098.1
AC099781 Genomic DNA No translation available.
AK094486 mRNA No translation available.
BC129987 mRNA Translation: AAI29988.1 Different initiation.
AF273053 mRNA Translation: AAG34913.1 Different initiation.
AB029028 mRNA Translation: BAA83057.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2877.1 [Q9UK61-2]
CCDS46853.1 [Q9UK61-3]
CCDS87094.1 [Q9UK61-4]

NCBI Reference Sequences

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RefSeqi
NP_001106207.1, NM_001112736.1 [Q9UK61-3]
NP_056039.2, NM_015224.3 [Q9UK61-2]
XP_005265056.1, XM_005264999.1
XP_011531854.1, XM_011533552.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355628; ENSP00000347845; ENSG00000163946 [Q9UK61-4]
ENST00000431842; ENSP00000399410; ENSG00000163946 [Q9UK61-2]
ENST00000493960; ENSP00000417509; ENSG00000163946 [Q9UK61-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23272

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23272

UCSC genome browser

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UCSCi
uc003dic.5 human [Q9UK61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180425 mRNA Translation: AAD55098.1
AC099781 Genomic DNA No translation available.
AK094486 mRNA No translation available.
BC129987 mRNA Translation: AAI29988.1 Different initiation.
AF273053 mRNA Translation: AAG34913.1 Different initiation.
AB029028 mRNA Translation: BAA83057.1
CCDSiCCDS2877.1 [Q9UK61-2]
CCDS46853.1 [Q9UK61-3]
CCDS87094.1 [Q9UK61-4]
RefSeqiNP_001106207.1, NM_001112736.1 [Q9UK61-3]
NP_056039.2, NM_015224.3 [Q9UK61-2]
XP_005265056.1, XM_005264999.1
XP_011531854.1, XM_011533552.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116873, 56 interactors
CORUMiQ9UK61
DIPiDIP-56150N
IntActiQ9UK61, 21 interactors
MINTiQ9UK61
STRINGi9606.ENSP00000417509

PTM databases

iPTMnetiQ9UK61
PhosphoSitePlusiQ9UK61

Polymorphism and mutation databases

BioMutaiFAM208A
DMDMi229462994

Proteomic databases

EPDiQ9UK61
jPOSTiQ9UK61
PaxDbiQ9UK61
PeptideAtlasiQ9UK61
PRIDEiQ9UK61
ProteomicsDBi84729
84730 [Q9UK61-2]
84731 [Q9UK61-3]
84732 [Q9UK61-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355628; ENSP00000347845; ENSG00000163946 [Q9UK61-4]
ENST00000431842; ENSP00000399410; ENSG00000163946 [Q9UK61-2]
ENST00000493960; ENSP00000417509; ENSG00000163946 [Q9UK61-3]
GeneIDi23272
KEGGihsa:23272
UCSCiuc003dic.5 human [Q9UK61-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23272
DisGeNETi23272

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM208A
HGNCiHGNC:30314 TASOR
HPAiHPA006735
HPA017142
MIMi616493 gene
neXtProtiNX_Q9UK61
OpenTargetsiENSG00000163946
PharmGKBiPA128395774

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF4K Eukaryota
ENOG410XSS9 LUCA
GeneTreeiENSGT00530000063735
HOGENOMiHOG000111372
InParanoidiQ9UK61
KOiK21873
OMAiPCQMVSP
OrthoDBi57214at2759
PhylomeDBiQ9UK61
TreeFamiTF336055

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM208A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23272

Protein Ontology

More...
PROi
PR:Q9UK61

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163946 Expressed in 235 organ(s), highest expression level in brain
ExpressionAtlasiQ9UK61 baseline and differential
GenevisibleiQ9UK61 HS

Family and domain databases

InterProiView protein in InterPro
IPR022188 DUF3715
PfamiView protein in Pfam
PF12509 DUF3715, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTASOR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK61
Secondary accession number(s): A1L3A4
, B5ME28, Q9H2F7, Q9UPP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 5, 2009
Last modified: June 5, 2019
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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