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Protein

Protein TASOR

Gene

FAM208A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TASORCurated
Alternative name(s):
CTCL tumor antigen se89-11 Publication
Retinoblastoma-associated protein RAP1401 Publication
Transgene activation suppressor protein1 Publication
Gene namesi
Name:FAM208AImported
Synonyms:C3orf63Imported, KIAA11051 Publication, TASOR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163946.13
HGNCiHGNC:30314 FAM208A
MIMi616493 gene
neXtProtiNX_Q9UK61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23272
OpenTargetsiENSG00000163946
PharmGKBiPA128395774

Polymorphism and mutation databases

BioMutaiFAM208A
DMDMi229462994

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002957282 – 1670Protein TASORAdd BLAST1669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei633PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Cross-linki823Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki832Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei843PhosphoserineBy similarity1
Cross-linki872Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei927PhosphoserineCombined sources1
Modified residuei971PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei982PhosphothreonineCombined sources1
Modified residuei1049PhosphothreonineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1552PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UK61
PaxDbiQ9UK61
PeptideAtlasiQ9UK61
PRIDEiQ9UK61
ProteomicsDBi84729
84730 [Q9UK61-2]
84731 [Q9UK61-3]
84732 [Q9UK61-4]

PTM databases

iPTMnetiQ9UK61
PhosphoSitePlusiQ9UK61

Expressioni

Gene expression databases

BgeeiENSG00000163946 Expressed in 235 organ(s), highest expression level in brain
CleanExiHS_C3orf63
ExpressionAtlasiQ9UK61 baseline and differential
GenevisibleiQ9UK61 HS

Organism-specific databases

HPAiHPA006735
HPA017142

Interactioni

Subunit structurei

Component of the HUSH complex; at least composed of FAM208A/TASOR, PPHLN1 and MPHOSPH8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MPHOSPH8Q995493EBI-308354,EBI-2653928

Protein-protein interaction databases

BioGridi116873, 55 interactors
DIPiDIP-56150N
IntActiQ9UK61, 18 interactors
STRINGi9606.ENSP00000417509

Structurei

3D structure databases

ProteinModelPortaliQ9UK61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM208 family.Curated

Phylogenomic databases

eggNOGiENOG410IF4K Eukaryota
ENOG410XSS9 LUCA
GeneTreeiENSGT00530000063735
HOGENOMiHOG000111372
HOVERGENiHBG061247
InParanoidiQ9UK61
KOiK21873
OMAiKEYEQPT
OrthoDBiEOG091G00B8
PhylomeDBiQ9UK61
TreeFamiTF336055

Family and domain databases

InterProiView protein in InterPro
IPR022188 DUF3715
PfamiView protein in Pfam
PF12509 DUF3715, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAVETEAC QPTDASWESG GGGDDEMKQA LPELESSQQN GGGGGLNIAE
60 70 80 90 100
PSGGAGREEN AGAEAAQSLS HEQPQDSSEA GAAALPRGPE EPERPVRRSF
110 120 130 140 150
QIPRKSREKK ALFQPLTPGS REFEDVVNIL HSSYLEPTSV TNFNYRRACL
160 170 180 190 200
VHNELLEKEF TEKRRELKFD GRLDKELSES YAFLMVDRYQ VQTICEKGLH
210 220 230 240 250
VGQSKITILG SPSMGVYLSR YADLLQANPL DTGAMGDVVI FKIMKGKIKS
260 270 280 290 300
IYDPMGVKSL ESMLNKSALD PTPKHECHVS KNANRITSLL AYRAYELTQY
310 320 330 340 350
YFYEYGFDEL RRRPRHVCPY AVVSFTYKDD IQTPKFVPSS RSNSFNTDRN
360 370 380 390 400
IDKYNYTLWK GQLLNKGKLL CYISLRSATR AFLPIKLPEK LDVETVMSID
410 420 430 440 450
HLKQKIPPAL FYKETYLGPN EVLKNGMYCS LYEVVEKTRI GSNMESLLQK
460 470 480 490 500
LDREKLVLVK PLGDRGYLFL LSPYQMVPPY EYQTAKSRVL HALFLFQEPR
510 520 530 540 550
SIVTSQKGST NAAPQERHES MPDVLKIAQF LQFSLIQCRK EFKNISAINF
560 570 580 590 600
HSVVEKYVSE FFKRGFGSGK REFIMFPYDS RLDDKKFLYS APRNKSHIDT
610 620 630 640 650
CLHAYIFRPE VYQLPICKLK ELFEENRKLQ QFSPLSDYEG QEEEMNGTKM
660 670 680 690 700
KFGKRNNSRG EAIISGKQRS SHSLDYDKDR VKELINLIQC RKKSVGGDSD
710 720 730 740 750
TEDMRSKTVL KRKLEDLPEN MRKLAKTSNL SENCHLYEES PQPIGSLGHD
760 770 780 790 800
ADLRRQQQDT CNSGIADIHR LFNWLSETLA NARHSDASLT DTVNKALGLS
810 820 830 840 850
TDDAYEELRQ KHEYELNSTP DKKDYEQPTC AKVENAQFKG TQSLLLEVDA
860 870 880 890 900
TSKYSVAIST SEVGTDHKLH LKEDPNLISV NNFEDCSLCP SVPIEHGFRR
910 920 930 940 950
QQSKSNNVEE TEIHWKLIPI TGGNARSPED QLGKHGEKQT PGMKSPEEQL
960 970 980 990 1000
VCVPPQEAFP NDPRVINRQR SSDYQFPSSP FTDTLKGTTE DDVLTGQVEE
1010 1020 1030 1040 1050
QCVPAAEAEP PAVSETTERT VLGEYNLFSR KIEEILKQKN VSYVSTVSTP
1060 1070 1080 1090 1100
IFSTQEKMKR LSEFIYSKTS KAGVQEFVDG LHEKLNTIII KASAKGGNLP
1110 1120 1130 1140 1150
PVSPNDSGAK IASNPLERHV IPVSSSDFNN KHLLEPLCSD PLKDTNSDEQ
1160 1170 1180 1190 1200
HSTSALTEVE MNQPQHATEL MVTSDHIVPG DMAREPVEET TKSPSDVNIS
1210 1220 1230 1240 1250
AQPALSNFIS QLEPEVFNSL VKIMKDVQKN TVKFYIHEEE ESVLCKEIKE
1260 1270 1280 1290 1300
YLIKLGNTEC HPEQFLERRS KLDKLLIIIQ NEDIAGFIHK IPGLVTLKKL
1310 1320 1330 1340 1350
PCVSFAGVDS LDDVKNHTYN ELFVSGGFIV SDESILNPEV VTVENLKNFL
1360 1370 1380 1390 1400
TFLEELSTPE GKWQWKVHCK FQKKLKELGR LNAKALSLLT LLNVYQKKHL
1410 1420 1430 1440 1450
VEILSYHNCD SQTRNAPELD CLIRLQAQNI QQRHIVFLTE KNIKMLSSYT
1460 1470 1480 1490 1500
DNGIVVATAE DFMQNFKNLV GYHNSITEEN LPQLGANENL ESQSALLEND
1510 1520 1530 1540 1550
EKDEEDMSLD SGDEISHIEV CSNFHSEIWE KETKGSRGTD QKKNTQIELQ
1560 1570 1580 1590 1600
SSPDVQNSLL EDKTYLDSEE RTSIDIVCSE GENSNSTEQD SYSNFQVYHS
1610 1620 1630 1640 1650
QLNMSHQFSH FNVLTHQTFL GTPYALSSSQ SQENENYFLS AYTESLDRDK
1660 1670
SPPPLSWGKS DSSRPYSQEK
Note: No experimental confirmation available. Gene prediction based on partial mRNA data.Curated
Length:1,670
Mass (Da):189,032
Last modified:May 5, 2009 - v3
Checksum:iA8BE5ED05A96C897
GO
Isoform 2 (identifier: Q9UK61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-396: Missing.
     942-982: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,233
Mass (Da):139,998
Checksum:iD1A00958B3FA184B
GO
Isoform 3 (identifier: Q9UK61-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1495-1512: ALLENDEKDEEDMSLDSG → DAVLTLTPLELGVGISQH
     1513-1670: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,512
Mass (Da):170,815
Checksum:i95836C9CD088E80C
GO
Isoform 4 (identifier: Q9UK61-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     921-981: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,609
Mass (Da):182,281
Checksum:iFFA47C216944929C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0F1A0A087X0F1_HUMAN
Protein TASOR
FAM208A
1,035Annotation score:

Sequence cautioni

The sequence AAG34913 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI29988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti941P → I in BAA83057 (PubMed:10470851).Curated1
Sequence conflicti1129N → S in AAD55098 (PubMed:18726359).Curated1
Sequence conflicti1135E → G in AAD55098 (PubMed:18726359).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05959538Q → P. Corresponds to variant dbSNP:rs958755Ensembl.1
Natural variantiVAR_033350831A → G. Corresponds to variant dbSNP:rs17056999Ensembl.1
Natural variantiVAR_055092998V → I. Corresponds to variant dbSNP:rs2291498Ensembl.1
Natural variantiVAR_0333511046T → R3 PublicationsCorresponds to variant dbSNP:rs9835332Ensembl.1
Natural variantiVAR_0333521435I → V1 PublicationCorresponds to variant dbSNP:rs2291498Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0270301 – 396Missing in isoform 2. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_027031921 – 981Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_027032942 – 982Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0270331495 – 1512ALLEN…SLDSG → DAVLTLTPLELGVGISQH in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0270341513 – 1670Missing in isoform 3. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180425 mRNA Translation: AAD55098.1
AC099781 Genomic DNA No translation available.
AK094486 mRNA No translation available.
BC129987 mRNA Translation: AAI29988.1 Different initiation.
AF273053 mRNA Translation: AAG34913.1 Different initiation.
AB029028 mRNA Translation: BAA83057.1
CCDSiCCDS2877.1 [Q9UK61-2]
CCDS46853.1 [Q9UK61-3]
CCDS87094.1 [Q9UK61-4]
RefSeqiNP_001106207.1, NM_001112736.1 [Q9UK61-3]
NP_056039.2, NM_015224.3 [Q9UK61-2]
XP_005265056.1, XM_005264999.1 [Q9UK61-1]
XP_011531854.1, XM_011533552.2
UniGeneiHs.116877

Genome annotation databases

EnsembliENST00000355628; ENSP00000347845; ENSG00000163946 [Q9UK61-4]
ENST00000431842; ENSP00000399410; ENSG00000163946 [Q9UK61-2]
ENST00000493960; ENSP00000417509; ENSG00000163946 [Q9UK61-3]
GeneIDi23272
KEGGihsa:23272
UCSCiuc003dic.5 human [Q9UK61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180425 mRNA Translation: AAD55098.1
AC099781 Genomic DNA No translation available.
AK094486 mRNA No translation available.
BC129987 mRNA Translation: AAI29988.1 Different initiation.
AF273053 mRNA Translation: AAG34913.1 Different initiation.
AB029028 mRNA Translation: BAA83057.1
CCDSiCCDS2877.1 [Q9UK61-2]
CCDS46853.1 [Q9UK61-3]
CCDS87094.1 [Q9UK61-4]
RefSeqiNP_001106207.1, NM_001112736.1 [Q9UK61-3]
NP_056039.2, NM_015224.3 [Q9UK61-2]
XP_005265056.1, XM_005264999.1 [Q9UK61-1]
XP_011531854.1, XM_011533552.2
UniGeneiHs.116877

3D structure databases

ProteinModelPortaliQ9UK61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116873, 55 interactors
DIPiDIP-56150N
IntActiQ9UK61, 18 interactors
STRINGi9606.ENSP00000417509

PTM databases

iPTMnetiQ9UK61
PhosphoSitePlusiQ9UK61

Polymorphism and mutation databases

BioMutaiFAM208A
DMDMi229462994

Proteomic databases

EPDiQ9UK61
PaxDbiQ9UK61
PeptideAtlasiQ9UK61
PRIDEiQ9UK61
ProteomicsDBi84729
84730 [Q9UK61-2]
84731 [Q9UK61-3]
84732 [Q9UK61-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355628; ENSP00000347845; ENSG00000163946 [Q9UK61-4]
ENST00000431842; ENSP00000399410; ENSG00000163946 [Q9UK61-2]
ENST00000493960; ENSP00000417509; ENSG00000163946 [Q9UK61-3]
GeneIDi23272
KEGGihsa:23272
UCSCiuc003dic.5 human [Q9UK61-1]

Organism-specific databases

CTDi23272
DisGeNETi23272
EuPathDBiHostDB:ENSG00000163946.13
GeneCardsiFAM208A
HGNCiHGNC:30314 FAM208A
HPAiHPA006735
HPA017142
MIMi616493 gene
neXtProtiNX_Q9UK61
OpenTargetsiENSG00000163946
PharmGKBiPA128395774
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4K Eukaryota
ENOG410XSS9 LUCA
GeneTreeiENSGT00530000063735
HOGENOMiHOG000111372
HOVERGENiHBG061247
InParanoidiQ9UK61
KOiK21873
OMAiKEYEQPT
OrthoDBiEOG091G00B8
PhylomeDBiQ9UK61
TreeFamiTF336055

Miscellaneous databases

ChiTaRSiFAM208A human
GenomeRNAii23272
PROiPR:Q9UK61
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163946 Expressed in 235 organ(s), highest expression level in brain
CleanExiHS_C3orf63
ExpressionAtlasiQ9UK61 baseline and differential
GenevisibleiQ9UK61 HS

Family and domain databases

InterProiView protein in InterPro
IPR022188 DUF3715
PfamiView protein in Pfam
PF12509 DUF3715, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTASOR_HUMAN
AccessioniPrimary (citable) accession number: Q9UK61
Secondary accession number(s): A1L3A4
, B5ME28, Q9H2F7, Q9UPP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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