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Protein

Cyclin-L1

Gene

CCNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).4 Publications

Miscellaneous

CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9UK58

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L1
Short name:
Cyclin-L
Gene namesi
Name:CCNL1
ORF Names:BM-001, UNQ530/PRO1073
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163660.11
HGNCiHGNC:20569 CCNL1
MIMi613384 gene
neXtProtiNX_Q9UK58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi57018
OpenTargetsiENSG00000163660
PharmGKBiPA134980948

Polymorphism and mutation databases

BioMutaiCCNL1
DMDMi74753368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804801 – 526Cyclin-L1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei374PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UK58
PaxDbiQ9UK58
PeptideAtlasiQ9UK58
PRIDEiQ9UK58
ProteomicsDBi84724
84725 [Q9UK58-4]
84726 [Q9UK58-5]

PTM databases

iPTMnetiQ9UK58
PhosphoSitePlusiQ9UK58

Expressioni

Tissue specificityi

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).4 Publications

Gene expression databases

BgeeiENSG00000163660 Expressed in 224 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CCNL1
ExpressionAtlasiQ9UK58 baseline and differential
GenevisibleiQ9UK58 HS

Organism-specific databases

HPAiHPA057911

Interactioni

Subunit structurei

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13 (PubMed:11980906, PubMed:18216018). Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:11980906, PubMed:18216018).By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121327, 11 interactors
ComplexPortaliCPX-341 Cyclin L1-CDK11A(p110) complex
CPX-344 Cyclin L1-CDK11A(p58) complex
CPX-346 Cyclin L1-CDK11B(p58) complex
CPX-348 Cyclin L1-CDK11B(p110) complex
IntActiQ9UK58, 37 interactors
MINTiQ9UK58
STRINGi9606.ENSP00000295926

Structurei

3D structure databases

ProteinModelPortaliQ9UK58
SMRiQ9UK58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 190Cyclin-like 1Add BLAST103
Regioni203 – 287Cyclin-like 2Add BLAST85
Regioni390 – 432RSAdd BLAST43

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.1 Publication

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000231292
HOVERGENiHBG056044
InParanoidiQ9UK58
OMAiMSCVCLA
OrthoDBiEOG091G0BW9
PhylomeDBiQ9UK58
TreeFamiTF101011

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015431 Cyclin_L1
IPR006671 Cyclin_N
PANTHERiPTHR10026:SF64 PTHR10026:SF64, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Ccnl1 is an immediate-early gene with independently regulated isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK58-1) [UniParc]FASTAAdd to basket
Also known as: Cyclin L alpha, cyclin L1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV
60 70 80 90 100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP
110 120 130 140 150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI
160 170 180 190 200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH
210 220 230 240 250
PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI
260 270 280 290 300
YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE
310 320 330 340 350
KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE
360 370 380 390 400
KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR
410 420 430 440 450
SRSRSHTPRR HYNNRRSRSG TYSSRSRSRS RSHSESPRRH HNHGSPHLKA
460 470 480 490 500
KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD HSDAAKKHRH ERGHHRDRRE
510 520
RSRSFERSHK SKHHGGSRSG HGRHRR
Length:526
Mass (Da):59,634
Last modified:May 1, 2000 - v1
Checksum:i64C0CAEF54A3E9F9
GO
Isoform 2 (identifier: Q9UK58-4) [UniParc]FASTAAdd to basket
Also known as: Cyclin L beta, cyclin L1beta

The sequence of this isoform differs from the canonical sequence as follows:
     226-232: NYMNDSL → VVHDGKS
     233-526: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:232
Mass (Da):25,408
Checksum:iACD35FB41FF67306
GO
Isoform 3 (identifier: Q9UK58-5) [UniParc]FASTAAdd to basket
Also known as: Cyclin L gamma, cyclin L1gamma

The sequence of this isoform differs from the canonical sequence as follows:
     163-172: RTPSPLILDQ → SDQLHLPKPG
     173-526: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:172
Mass (Da):18,322
Checksum:i972B0E52D25720E1
GO
Isoform 4 (identifier: Q9UK58-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-428: HYNNRRSRSGTYSSRSRS → QDEVLLRCPGRSRTPGLK
     429-526: Missing.

Note: No experimental confirmation.
Show »
Length:428
Mass (Da):47,789
Checksum:iBBB4FEAE8731FAD0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4G1H7C4G1_HUMAN
Cyclin-L1
CCNL1
59Annotation score:

Sequence cautioni

The sequence AAF64257 differs from that shown. Probable cloning artifact.Curated
The sequence AAQ89026 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149V → L in AAH67812 (PubMed:15489334).Curated1
Sequence conflicti507 – 508RS → SP in AAF64257 (PubMed:11042152).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016120163 – 172RTPSPLILDQ → SDQLHLPKPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_016121173 – 526Missing in isoform 3. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_016122226 – 232NYMNDSL → VVHDGKS in isoform 2. 1 Publication7
Alternative sequenceiVSP_016123233 – 526Missing in isoform 2. 1 PublicationAdd BLAST294
Alternative sequenceiVSP_058299411 – 428HYNNR…SRSRS → QDEVLLRCPGRSRTPGLK in isoform 4. Add BLAST18
Alternative sequenceiVSP_058300429 – 526Missing in isoform 4. Add BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180920 mRNA Translation: AAD53184.1
AF367476 mRNA Translation: AAM21204.1
AF367477 mRNA Translation: AAM21205.1
AY034790 mRNA Translation: AAK61551.1
AK022974 mRNA Translation: BAG51145.1
AK122738 mRNA No translation available.
AC104411 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78712.1
BC007081 mRNA Translation: AAH07081.1
BC038394 mRNA Translation: AAH38394.1
BC067812 mRNA Translation: AAH67812.1
AF208843 mRNA Translation: AAF64257.1 Sequence problems.
AY358663 mRNA Translation: AAQ89026.1 Sequence problems.
CCDSiCCDS3178.1 [Q9UK58-1]
CCDS77847.1 [Q9UK58-6]
RefSeqiNP_001295114.1, NM_001308185.1 [Q9UK58-6]
NP_064703.1, NM_020307.3 [Q9UK58-1]
XP_016862381.1, XM_017006892.1
XP_016862382.1, XM_017006893.1
XP_016862383.1, XM_017006894.1
XP_016862384.1, XM_017006895.1
XP_016862385.1, XM_017006896.1
UniGeneiHs.4859

Genome annotation databases

EnsembliENST00000295925; ENSP00000295925; ENSG00000163660 [Q9UK58-5]
ENST00000295926; ENSP00000295926; ENSG00000163660 [Q9UK58-1]
ENST00000461804; ENSP00000420277; ENSG00000163660 [Q9UK58-6]
ENST00000465947; ENSP00000418094; ENSG00000163660 [Q9UK58-5]
ENST00000470121; ENSP00000417237; ENSG00000163660 [Q9UK58-4]
ENST00000475298; ENSP00000417343; ENSG00000163660 [Q9UK58-5]
ENST00000477127; ENSP00000418449; ENSG00000163660 [Q9UK58-5]
ENST00000631619; ENSP00000487951; ENSG00000163660 [Q9UK58-5]
GeneIDi57018
KEGGihsa:57018
UCSCiuc003fbd.2 human
uc003fbf.4 human [Q9UK58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180920 mRNA Translation: AAD53184.1
AF367476 mRNA Translation: AAM21204.1
AF367477 mRNA Translation: AAM21205.1
AY034790 mRNA Translation: AAK61551.1
AK022974 mRNA Translation: BAG51145.1
AK122738 mRNA No translation available.
AC104411 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78712.1
BC007081 mRNA Translation: AAH07081.1
BC038394 mRNA Translation: AAH38394.1
BC067812 mRNA Translation: AAH67812.1
AF208843 mRNA Translation: AAF64257.1 Sequence problems.
AY358663 mRNA Translation: AAQ89026.1 Sequence problems.
CCDSiCCDS3178.1 [Q9UK58-1]
CCDS77847.1 [Q9UK58-6]
RefSeqiNP_001295114.1, NM_001308185.1 [Q9UK58-6]
NP_064703.1, NM_020307.3 [Q9UK58-1]
XP_016862381.1, XM_017006892.1
XP_016862382.1, XM_017006893.1
XP_016862383.1, XM_017006894.1
XP_016862384.1, XM_017006895.1
XP_016862385.1, XM_017006896.1
UniGeneiHs.4859

3D structure databases

ProteinModelPortaliQ9UK58
SMRiQ9UK58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121327, 11 interactors
ComplexPortaliCPX-341 Cyclin L1-CDK11A(p110) complex
CPX-344 Cyclin L1-CDK11A(p58) complex
CPX-346 Cyclin L1-CDK11B(p58) complex
CPX-348 Cyclin L1-CDK11B(p110) complex
IntActiQ9UK58, 37 interactors
MINTiQ9UK58
STRINGi9606.ENSP00000295926

PTM databases

iPTMnetiQ9UK58
PhosphoSitePlusiQ9UK58

Polymorphism and mutation databases

BioMutaiCCNL1
DMDMi74753368

Proteomic databases

EPDiQ9UK58
PaxDbiQ9UK58
PeptideAtlasiQ9UK58
PRIDEiQ9UK58
ProteomicsDBi84724
84725 [Q9UK58-4]
84726 [Q9UK58-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295925; ENSP00000295925; ENSG00000163660 [Q9UK58-5]
ENST00000295926; ENSP00000295926; ENSG00000163660 [Q9UK58-1]
ENST00000461804; ENSP00000420277; ENSG00000163660 [Q9UK58-6]
ENST00000465947; ENSP00000418094; ENSG00000163660 [Q9UK58-5]
ENST00000470121; ENSP00000417237; ENSG00000163660 [Q9UK58-4]
ENST00000475298; ENSP00000417343; ENSG00000163660 [Q9UK58-5]
ENST00000477127; ENSP00000418449; ENSG00000163660 [Q9UK58-5]
ENST00000631619; ENSP00000487951; ENSG00000163660 [Q9UK58-5]
GeneIDi57018
KEGGihsa:57018
UCSCiuc003fbd.2 human
uc003fbf.4 human [Q9UK58-1]

Organism-specific databases

CTDi57018
DisGeNETi57018
EuPathDBiHostDB:ENSG00000163660.11
GeneCardsiCCNL1
HGNCiHGNC:20569 CCNL1
HPAiHPA057911
MIMi613384 gene
neXtProtiNX_Q9UK58
OpenTargetsiENSG00000163660
PharmGKBiPA134980948
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000231292
HOVERGENiHBG056044
InParanoidiQ9UK58
OMAiMSCVCLA
OrthoDBiEOG091G0BW9
PhylomeDBiQ9UK58
TreeFamiTF101011

Enzyme and pathway databases

SignaLinkiQ9UK58

Miscellaneous databases

ChiTaRSiCCNL1 human
GeneWikiiCCNL1
GenomeRNAii57018
PROiPR:Q9UK58
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163660 Expressed in 224 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CCNL1
ExpressionAtlasiQ9UK58 baseline and differential
GenevisibleiQ9UK58 HS

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015431 Cyclin_L1
IPR006671 Cyclin_N
PANTHERiPTHR10026:SF64 PTHR10026:SF64, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCCNL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK58
Secondary accession number(s): B3KMY3
, C9JPL0, Q6NVY9, Q6UWS7, Q8NI48, Q96QT0, Q9NZF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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