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UniProtKB - Q9UK58 (CCNL1_HUMAN)

Entry version 174 (10 Feb 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Cyclin-L1

Gene

CCNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).4 Publications

Miscellaneous

CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UK58

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UK58

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-L1
Short name:
Cyclin-L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNL1
ORF Names:BM-001, UNQ530/PRO1073
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20569, CCNL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613384, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UK58

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163660.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		57018

Open Targets

More...OpenTargetsi		ENSG00000163660

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134980948

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UK58, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCNL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74753368

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804801 – 526Cyclin-L1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei325PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei374PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UK58

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UK58

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UK58

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UK58

PeptideAtlas

More...PeptideAtlasi		Q9UK58

PRoteomics IDEntifications database

More...PRIDEi		Q9UK58

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		11129
84724 [Q9UK58-1]
84725 [Q9UK58-4]
84726 [Q9UK58-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UK58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UK58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163660, Expressed in bone marrow and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UK58, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UK58, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163660, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity).

Interacts with CDK11A, CDK12 and CDK13 (PubMed:11980906, PubMed:18216018). Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018).

Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:11980906, PubMed:18216018).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121327, 32 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-341, Cyclin L1-CDK11A(p110) complex
CPX-344, Cyclin L1-CDK11A(p58) complex
CPX-346, Cyclin L1-CDK11B(p58) complex
CPX-348, Cyclin L1-CDK11B(p110) complex

Protein interaction database and analysis system

More...IntActi		Q9UK58, 44 interactors

Molecular INTeraction database

More...MINTi		Q9UK58

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UK58, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UK58

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni88 – 190Cyclin-like 1Add BLAST103
Regioni203 – 287Cyclin-like 2Add BLAST85
Regioni390 – 432RSAdd BLAST43

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0835, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159135

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_107641_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UK58

Identification of Orthologs from Complete Genome Data

More...OMAi		INFIYQA

Database of Orthologous Groups

More...OrthoDBi		1519153at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UK58

TreeFam database of animal gene trees

More...TreeFami		TF101011

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR004367, Cyclin_C-dom
IPR015431, Cyclin_L1
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10026, PTHR10026, 1 hit
PTHR10026:SF64, PTHR10026:SF64, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Ccnl1 is an immediate-early gene with independently regulated isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK58-1) [UniParc]FASTAAdd to basket
Also known as: Cyclin L alpha, cyclin L1alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV 
        60         70         80         90        100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP 
       110        120        130        140        150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI 
       160        170        180        190        200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH 
       210        220        230        240        250
PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI 
       260        270        280        290        300
YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE 
       310        320        330        340        350
KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE 
       360        370        380        390        400
KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR 
       410        420        430        440        450
SRSRSHTPRR HYNNRRSRSG TYSSRSRSRS RSHSESPRRH HNHGSPHLKA 
       460        470        480        490        500
KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD HSDAAKKHRH ERGHHRDRRE 
       510        520 
RSRSFERSHK SKHHGGSRSG HGRHRR
Length:526
Mass (Da):59,634
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64C0CAEF54A3E9F9
GO
Isoform 2 (identifier: Q9UK58-4) [UniParc]FASTAAdd to basket
Also known as: Cyclin L beta, cyclin L1beta

The sequence of this isoform differs from the canonical sequence as follows:
     226-232: NYMNDSL → VVHDGKS
     233-526: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:232
Mass (Da):25,408
Checksum:iACD35FB41FF67306
GO
Isoform 3 (identifier: Q9UK58-5) [UniParc]FASTAAdd to basket
Also known as: Cyclin L gamma, cyclin L1gamma

The sequence of this isoform differs from the canonical sequence as follows:
     163-172: RTPSPLILDQ → SDQLHLPKPG
     173-526: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:172
Mass (Da):18,322
Checksum:i972B0E52D25720E1
GO
Isoform 4 (identifier: Q9UK58-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-428: HYNNRRSRSGTYSSRSRS → QDEVLLRCPGRSRTPGLK
     429-526: Missing.

Show »
Length:428
Mass (Da):47,789
Checksum:iBBB4FEAE8731FAD0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4G1H7C4G1_HUMAN
Cyclin-L1
CCNL1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64257 differs from that shown. Probable cloning artifact.Curated
The sequence AAQ89026 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149V → L in AAH67812 (PubMed:15489334).Curated1
Sequence conflicti507 – 508RS → SP in AAF64257 (PubMed:11042152).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016120163 – 172RTPSPLILDQ → SDQLHLPKPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_016121173 – 526Missing in isoform 3. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_016122226 – 232NYMNDSL → VVHDGKS in isoform 2. 1 Publication7
Alternative sequenceiVSP_016123233 – 526Missing in isoform 2. 1 PublicationAdd BLAST294
Alternative sequenceiVSP_058299411 – 428HYNNR…SRSRS → QDEVLLRCPGRSRTPGLK in isoform 4. Add BLAST18
Alternative sequenceiVSP_058300429 – 526Missing in isoform 4. Add BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF180920 mRNA Translation: AAD53184.1
AF367476 mRNA Translation: AAM21204.1
AF367477 mRNA Translation: AAM21205.1
AY034790 mRNA Translation: AAK61551.1
AK022974 mRNA Translation: BAG51145.1
AK122738 mRNA No translation available.
AC104411 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78712.1
BC007081 mRNA Translation: AAH07081.1
BC038394 mRNA Translation: AAH38394.1
BC067812 mRNA Translation: AAH67812.1
AF208843 mRNA Translation: AAF64257.1 Sequence problems.
AY358663 mRNA Translation: AAQ89026.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3178.1 [Q9UK58-1]
CCDS77847.1 [Q9UK58-6]

NCBI Reference Sequences

More...RefSeqi		NP_001295114.1, NM_001308185.1 [Q9UK58-6]
NP_064703.1, NM_020307.3 [Q9UK58-1]
XP_016862381.1, XM_017006892.1
XP_016862382.1, XM_017006893.1
XP_016862383.1, XM_017006894.1
XP_016862384.1, XM_017006895.1
XP_016862385.1, XM_017006896.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295925; ENSP00000295925; ENSG00000163660 [Q9UK58-5]
ENST00000295926; ENSP00000295926; ENSG00000163660 [Q9UK58-1]
ENST00000461804; ENSP00000420277; ENSG00000163660 [Q9UK58-6]
ENST00000465947; ENSP00000418094; ENSG00000163660 [Q9UK58-5]
ENST00000470121; ENSP00000417237; ENSG00000163660 [Q9UK58-4]
ENST00000475298; ENSP00000417343; ENSG00000163660 [Q9UK58-5]
ENST00000477127; ENSP00000418449; ENSG00000163660 [Q9UK58-5]
ENST00000631619; ENSP00000487951; ENSG00000163660 [Q9UK58-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57018

UCSC genome browser

More...UCSCi		uc003fbd.2, human
uc003fbf.4, human [Q9UK58-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180920 mRNA Translation: AAD53184.1
AF367476 mRNA Translation: AAM21204.1
AF367477 mRNA Translation: AAM21205.1
AY034790 mRNA Translation: AAK61551.1
AK022974 mRNA Translation: BAG51145.1
AK122738 mRNA No translation available.
AC104411 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78712.1
BC007081 mRNA Translation: AAH07081.1
BC038394 mRNA Translation: AAH38394.1
BC067812 mRNA Translation: AAH67812.1
AF208843 mRNA Translation: AAF64257.1 Sequence problems.
AY358663 mRNA Translation: AAQ89026.1 Sequence problems.
CCDSiCCDS3178.1 [Q9UK58-1]
CCDS77847.1 [Q9UK58-6]
RefSeqiNP_001295114.1, NM_001308185.1 [Q9UK58-6]
NP_064703.1, NM_020307.3 [Q9UK58-1]
XP_016862381.1, XM_017006892.1
XP_016862382.1, XM_017006893.1
XP_016862383.1, XM_017006894.1
XP_016862384.1, XM_017006895.1
XP_016862385.1, XM_017006896.1

3D structure databases

SMRiQ9UK58
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121327, 32 interactors
ComplexPortaliCPX-341, Cyclin L1-CDK11A(p110) complex
CPX-344, Cyclin L1-CDK11A(p58) complex
CPX-346, Cyclin L1-CDK11B(p58) complex
CPX-348, Cyclin L1-CDK11B(p110) complex
IntActiQ9UK58, 44 interactors
MINTiQ9UK58
STRINGi9606.ENSP00000295926

PTM databases

iPTMnetiQ9UK58
PhosphoSitePlusiQ9UK58

Genetic variation databases

BioMutaiCCNL1
DMDMi74753368

Proteomic databases

EPDiQ9UK58
jPOSTiQ9UK58
MassIVEiQ9UK58
PaxDbiQ9UK58
PeptideAtlasiQ9UK58
PRIDEiQ9UK58
ProteomicsDBi11129
84724 [Q9UK58-1]
84725 [Q9UK58-4]
84726 [Q9UK58-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18411, 215 antibodies

Genome annotation databases

EnsembliENST00000295925; ENSP00000295925; ENSG00000163660 [Q9UK58-5]
ENST00000295926; ENSP00000295926; ENSG00000163660 [Q9UK58-1]
ENST00000461804; ENSP00000420277; ENSG00000163660 [Q9UK58-6]
ENST00000465947; ENSP00000418094; ENSG00000163660 [Q9UK58-5]
ENST00000470121; ENSP00000417237; ENSG00000163660 [Q9UK58-4]
ENST00000475298; ENSP00000417343; ENSG00000163660 [Q9UK58-5]
ENST00000477127; ENSP00000418449; ENSG00000163660 [Q9UK58-5]
ENST00000631619; ENSP00000487951; ENSG00000163660 [Q9UK58-5]
GeneIDi57018
KEGGihsa:57018
UCSCiuc003fbd.2, human
uc003fbf.4, human [Q9UK58-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57018
DisGeNETi57018

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCNL1
HGNCiHGNC:20569, CCNL1
HPAiENSG00000163660, Low tissue specificity
MIMi613384, gene
neXtProtiNX_Q9UK58
OpenTargetsiENSG00000163660
PharmGKBiPA134980948
VEuPathDBiHostDB:ENSG00000163660.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0835, Eukaryota
GeneTreeiENSGT00940000159135
HOGENOMiCLU_107641_0_0_1
InParanoidiQ9UK58
OMAiINFIYQA
OrthoDBi1519153at2759
PhylomeDBiQ9UK58
TreeFamiTF101011

Enzyme and pathway databases

PathwayCommonsiQ9UK58
SignaLinkiQ9UK58

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57018, 321 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCNL1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CCNL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57018
PharosiQ9UK58, Tbio

Protein Ontology

More...PROi		PR:Q9UK58
RNActiQ9UK58, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163660, Expressed in bone marrow and 234 other tissues
ExpressionAtlasiQ9UK58, baseline and differential
GenevisibleiQ9UK58, HS

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR004367, Cyclin_C-dom
IPR015431, Cyclin_L1
IPR006671, Cyclin_N
PANTHERiPTHR10026, PTHR10026, 1 hit
PTHR10026:SF64, PTHR10026:SF64, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK58
Secondary accession number(s): B3KMY3
, C9JPL0, Q6NVY9, Q6UWS7, Q8NI48, Q96QT0, Q9NZF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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