CCNL1

Functionⁱ

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).4 Publications

Miscellaneous

CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
positive regulation of phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
positive regulation of transcription by RNA polymerase II Source: GO_Central
RNA processing Source: InterPro
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkⁱ	Q9UK58

SignaLinkⁱ

Q9UK58

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-L1 Short name: Cyclin-L
Gene namesⁱ	Name:CCNL1 ORF Names:BM-001, UNQ530/PRO1073
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163660.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20569 CCNL1
MIMⁱ	613384 gene
neXtProtⁱ	NX_Q9UK58

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57018
Open Targets More...OpenTargetsⁱ	ENSG00000163660
PharmGKBⁱ	PA134980948

Polymorphism and mutation databases

BioMutaⁱ	CCNL1
DMDMⁱ	74753368

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080480	1 – 526	Cyclin-L1Add BLAST		526

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	325	PhosphothreonineCombined sources	1
Modified residueⁱ	335	PhosphoserineCombined sources	1
Modified residueⁱ	338	PhosphoserineCombined sources	1
Cross-linkⁱ	339	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	347	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	352	PhosphoserineCombined sources	1
Modified residueⁱ	355	PhosphoserineCombined sources	1
Cross-linkⁱ	362	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	374	PhosphoserineCombined sources	1
Modified residueⁱ	445	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UK58
PaxDbⁱ	Q9UK58
PeptideAtlas More...PeptideAtlasⁱ	Q9UK58
PRIDEⁱ	Q9UK58
ProteomicsDBⁱ	84724 84725 [Q9UK58-4] 84726 [Q9UK58-5]

PTM databases

iPTMnetⁱ	Q9UK58
PhosphoSitePlusⁱ	Q9UK58

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000163660 Expressed in 224 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_CCNL1
ExpressionAtlasⁱ	Q9UK58 baseline and differential
Genevisibleⁱ	Q9UK58 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057911

HPAⁱ

HPA057911

Interactionⁱ

Subunit structureⁱ

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13 (PubMed:11980906, PubMed:18216018). Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:11980906, PubMed:18216018).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
APPBP2	Q92624	3	EBI-2836773,EBI-743771
NKAPD1	Q6ZUT1	4	EBI-2836773,EBI-3920396
RNPS1	Q15287	3	EBI-2836773,EBI-395959
SAP30BP	Q9UHR5	4	EBI-2836773,EBI-751683
TFIP11	Q9UBB9	3	EBI-2836773,EBI-1105213

Protein-protein interaction databases

BioGridⁱ	121327, 11 interactors
ComplexPortalⁱ	CPX-341 Cyclin L1-CDK11A(p110) complex CPX-344 Cyclin L1-CDK11A(p58) complex CPX-346 Cyclin L1-CDK11B(p58) complex CPX-348 Cyclin L1-CDK11B(p110) complex
IntActⁱ	Q9UK58, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q9UK58
STRINGⁱ	9606.ENSP00000295926

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UK58
SMRⁱ	Q9UK58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	88 – 190	Cyclin-like 1Add BLAST	103
Regionⁱ	203 – 287	Cyclin-like 2Add BLAST	85
Regionⁱ	390 – 432	RSAdd BLAST	43

Domainⁱ

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.1 Publication

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0835 Eukaryota COG5333 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000231292
HOVERGENⁱ	HBG056044
InParanoidⁱ	Q9UK58
OMAⁱ	MSCVCLA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BW9
PhylomeDBⁱ	Q9UK58
TreeFamⁱ	TF101011

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015431 Cyclin_L1 IPR006671 Cyclin_N
PANTHERⁱ	PTHR10026:SF64 PTHR10026:SF64, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Ccnl1 is an immediate-early gene with independently regulated isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UK58-1) [UniParc]FASTA Add to basket

Also known as: Cyclin L alpha, cyclin L1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV 
        60         70         80         90        100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP 
       110        120        130        140        150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI 
       160        170        180        190        200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH 
       210        220        230        240        250
PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI 
       260        270        280        290        300
YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE 
       310        320        330        340        350
KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE 
       360        370        380        390        400
KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR 
       410        420        430        440        450
SRSRSHTPRR HYNNRRSRSG TYSSRSRSRS RSHSESPRRH HNHGSPHLKA 
       460        470        480        490        500
KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD HSDAAKKHRH ERGHHRDRRE 
       510        520 
RSRSFERSHK SKHHGGSRSG HGRHRR

Length:526

Mass (Da):59,634

Last modified:May 1, 2000 - v1

Checksum:ⁱ64C0CAEF54A3E9F9

GO

Isoform 2 (identifier: Q9UK58-4) [UniParc]FASTA Add to basket

Also known as: Cyclin L beta, cyclin L1beta

The sequence of this isoform differs from the canonical sequence as follows:
226-232: NYMNDSL → VVHDGKS
233-526: Missing.

« Hide

        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV 
        60         70         80         90        100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP 
       110        120        130        140        150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI 
       160        170        180        190        200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH 
       210        220        230 
PHKIIVMYLQ VLECERNQTL VQTAWVVHDG KS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:232

Mass (Da):25,408

Checksum:ⁱACD35FB41FF67306

GO

Isoform 3 (identifier: Q9UK58-5) [UniParc]FASTA Add to basket

Also known as: Cyclin L gamma, cyclin L1gamma

The sequence of this isoform differs from the canonical sequence as follows:
163-172: RTPSPLILDQ → SDQLHLPKPG
173-526: Missing.

« Hide

        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV 
        60         70         80         90        100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP 
       110        120        130        140        150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI 
       160        170 
NVFHHLRQLR GKSDQLHLPK PG

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:172

Mass (Da):18,322

Checksum:ⁱ972B0E52D25720E1

GO

Isoform 4 (identifier: Q9UK58-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
411-428: HYNNRRSRSGTYSSRSRS → QDEVLLRCPGRSRTPGLK
429-526: Missing.

« Hide

        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV 
        60         70         80         90        100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP 
       110        120        130        140        150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI 
       160        170        180        190        200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH 
       210        220        230        240        250
PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI 
       260        270        280        290        300
YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE 
       310        320        330        340        350
KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE 
       360        370        380        390        400
KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR 
       410        420 
SRSRSHTPRR QDEVLLRCPG RSRTPGLK

Note: No experimental confirmation.

Show »

Length:428

Mass (Da):47,789

Checksum:ⁱBBB4FEAE8731FAD0

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C4G1	H7C4G1_HUMAN		Cyclin-L1 Cyclin-L1	CCNL1	59	Annotation score:

Sequence cautionⁱ

The sequence AAF64257 differs from that shown. Probable cloning artifact.Curated

The sequence AAQ89026 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	149	V → L in AAH67812 (PubMed:15489334).Curated		1
Sequence conflictⁱ	507 – 508	RS → SP in AAF64257 (PubMed:11042152).Curated		2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016120	163 – 172	RTPSPLILDQ → SDQLHLPKPG in isoform 3. 1 Publication	10
Alternative sequenceⁱVSP_016121	173 – 526	Missing in isoform 3. 1 PublicationAdd BLAST	354
Alternative sequenceⁱVSP_016122	226 – 232	NYMNDSL → VVHDGKS in isoform 2. 1 Publication	7
Alternative sequenceⁱVSP_016123	233 – 526	Missing in isoform 2. 1 PublicationAdd BLAST	294
Alternative sequenceⁱVSP_058299	411 – 428	HYNNR…SRSRS → QDEVLLRCPGRSRTPGLK in isoform 4. Add BLAST	18
Alternative sequenceⁱVSP_058300	429 – 526	Missing in isoform 4. Add BLAST	98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF180920 mRNA Translation: AAD53184.1 AF367476 mRNA Translation: AAM21204.1 AF367477 mRNA Translation: AAM21205.1 AY034790 mRNA Translation: AAK61551.1 AK022974 mRNA Translation: BAG51145.1 AK122738 mRNA No translation available. AC104411 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78712.1 BC007081 mRNA Translation: AAH07081.1 BC038394 mRNA Translation: AAH38394.1 BC067812 mRNA Translation: AAH67812.1 AF208843 mRNA Translation: AAF64257.1 Sequence problems. AY358663 mRNA Translation: AAQ89026.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3178.1 [Q9UK58-1] CCDS77847.1 [Q9UK58-6]
NCBI Reference Sequences More...RefSeqⁱ	NP_001295114.1, NM_001308185.1 [Q9UK58-6] NP_064703.1, NM_020307.3 [Q9UK58-1] XP_016862381.1, XM_017006892.1 XP_016862382.1, XM_017006893.1 XP_016862383.1, XM_017006894.1 XP_016862384.1, XM_017006895.1 XP_016862385.1, XM_017006896.1
UniGeneⁱ	Hs.4859

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK58	CCNL1 isoform 3		PANTR		526	UniRef100_Q9UK58
Cyclin-L1		MACMU		526
Cyclin L1		MACFA		526
Uncharacterized protein		COLAP		526
Uncharacterized protein		CERAT		526
+9
Q9UK58-4	CCNL1 isoform 9		PONAB		232	UniRef100_A0A2J8WTE7
CCNL1 isoform 11		PANTR		232
Q9UK58-5	Cyclin-L1		PONAB		172	UniRef100_Q5RD50
CCNL1 isoform 12		PANTR		172
Uncharacterized protein		MACMU		172
Uncharacterized protein		COLAP		172
Uncharacterized protein		CERAT		172
+9
Q9UK58-6	CCNL1 isoform 1		PANTR		428	UniRef100_A0A2I3RC39
Uncharacterized protein		COLAP		428
Uncharacterized protein		CERAT		428
Uncharacterized protein		PAPAN		428
Uncharacterized protein		MANLE		428
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9UK58	CCNL1 isoform 3		PANTR		526	UniRef90_Q9UK58
Cyclin-L1		MACMU		526
Cyclin L1		MACFA		526
Uncharacterized protein		COLAP		526
Uncharacterized protein		CERAT		526
+75
Q9UK58-4	cyclin-L1 isoform X2		MESAU		290	UniRef90_A0A1U8C4S9
cyclin-L1 isoform X2		NEOSC		232
CCNL1 isoform 9		PONAB		232
CCNL1 isoform 11		PANTR		232
cyclin-L1 isoform X2		PHYCD		232
+26
Q9UK58-5	Isoform 2 of Cyclin-L1		RAT		173	UniRef90_Q9R1Q2-2
Cyclin-L1		PONAB		172
Cyclin-L1		MOUSE		178
Cyclin L1		CALJA		174
Uncharacterized protein		Cebus capucinus imitator		173
+24
Q9UK58-6	CCNL1 isoform 1		PANTR		428	UniRef90_A0A2I3RC39
Uncharacterized protein		COLAP		428
Uncharacterized protein		CERAT		428
Uncharacterized protein		PAPAN		428
Uncharacterized protein		MANLE		428
+23

Protein	Similar proteins		Species	Score	Length	Source
Q9UK58	Cyclin-L2		HUMAN		520	UniRef50_Q9UK58
CCNL1 isoform 3		PANTR		526
Cyclin-L1		MACMU		526
Cyclin L1		MACFA		526
Uncharacterized protein		COLAP		526
+163
Q9UK58-4	Isoform 2 of Cyclin-L2		HUMAN		227	UniRef50_Q96S94-2
Uncharacterized protein		RHIBE		234
Uncharacterized protein		RHIRO		187
cyclin-L2 isoform X2		ERIEU		231
Uncharacterized protein		FELCA		230
+142
Q9UK58-5	Isoform 2 of Cyclin-L1		RAT		173	UniRef50_Q9R1Q2-2
Cyclin-L1		PONAB		172
Cyclin-L1		MOUSE		178
Cyclin L1		CALJA		174
Uncharacterized protein		AOTNA		173
+30
Q9UK58-6	Uncharacterized protein		STRPU		456	UniRef50_W4YGU9
Uncharacterized protein		ATTCE		424
Cyclin-L2		Habropoda laboriosa		415
Cyclin-L2		APICC		415
Uncharacterized protein (Fragment)		SOLIN		341
+74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF180920 mRNA Translation: AAD53184.1 AF367476 mRNA Translation: AAM21204.1 AF367477 mRNA Translation: AAM21205.1 AY034790 mRNA Translation: AAK61551.1 AK022974 mRNA Translation: BAG51145.1 AK122738 mRNA No translation available. AC104411 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78712.1 BC007081 mRNA Translation: AAH07081.1 BC038394 mRNA Translation: AAH38394.1 BC067812 mRNA Translation: AAH67812.1 AF208843 mRNA Translation: AAF64257.1 Sequence problems. AY358663 mRNA Translation: AAQ89026.1 Sequence problems.
CCDSⁱ	CCDS3178.1 [Q9UK58-1] CCDS77847.1 [Q9UK58-6]
RefSeqⁱ	NP_001295114.1, NM_001308185.1 [Q9UK58-6] NP_064703.1, NM_020307.3 [Q9UK58-1] XP_016862381.1, XM_017006892.1 XP_016862382.1, XM_017006893.1 XP_016862383.1, XM_017006894.1 XP_016862384.1, XM_017006895.1 XP_016862385.1, XM_017006896.1
UniGeneⁱ	Hs.4859

3D structure databases

ProteinModelPortalⁱ	Q9UK58
SMRⁱ	Q9UK58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121327, 11 interactors
ComplexPortalⁱ	CPX-341 Cyclin L1-CDK11A(p110) complex CPX-344 Cyclin L1-CDK11A(p58) complex CPX-346 Cyclin L1-CDK11B(p58) complex CPX-348 Cyclin L1-CDK11B(p110) complex
IntActⁱ	Q9UK58, 37 interactors
MINTⁱ	Q9UK58
STRINGⁱ	9606.ENSP00000295926

PTM databases

iPTMnetⁱ	Q9UK58
PhosphoSitePlusⁱ	Q9UK58

Polymorphism and mutation databases

BioMutaⁱ	CCNL1
DMDMⁱ	74753368

Proteomic databases

EPDⁱ	Q9UK58
PaxDbⁱ	Q9UK58
PeptideAtlasⁱ	Q9UK58
PRIDEⁱ	Q9UK58
ProteomicsDBⁱ	84724 84725 [Q9UK58-4] 84726 [Q9UK58-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000295925; ENSP00000295925; ENSG00000163660 [Q9UK58-5] ENST00000295926; ENSP00000295926; ENSG00000163660 [Q9UK58-1] ENST00000461804; ENSP00000420277; ENSG00000163660 [Q9UK58-6] ENST00000465947; ENSP00000418094; ENSG00000163660 [Q9UK58-5] ENST00000470121; ENSP00000417237; ENSG00000163660 [Q9UK58-4] ENST00000475298; ENSP00000417343; ENSG00000163660 [Q9UK58-5] ENST00000477127; ENSP00000418449; ENSG00000163660 [Q9UK58-5] ENST00000631619; ENSP00000487951; ENSG00000163660 [Q9UK58-5]
GeneIDⁱ	57018
KEGGⁱ	hsa:57018
UCSCⁱ	uc003fbd.2 human uc003fbf.4 human [Q9UK58-1]

Organism-specific databases

CTDⁱ	57018
DisGeNETⁱ	57018
EuPathDBⁱ	HostDB:ENSG00000163660.11
GeneCardsⁱ	CCNL1
HGNCⁱ	HGNC:20569 CCNL1
HPAⁱ	HPA057911
MIMⁱ	613384 gene
neXtProtⁱ	NX_Q9UK58
OpenTargetsⁱ	ENSG00000163660
PharmGKBⁱ	PA134980948
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0835 Eukaryota COG5333 LUCA
GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000231292
HOVERGENⁱ	HBG056044
InParanoidⁱ	Q9UK58
OMAⁱ	MSCVCLA
OrthoDBⁱ	EOG091G0BW9
PhylomeDBⁱ	Q9UK58
TreeFamⁱ	TF101011

Enzyme and pathway databases

SignaLinkⁱ	Q9UK58

SignaLinkⁱ

Q9UK58

Miscellaneous databases

ChiTaRSⁱ	CCNL1 human
GeneWikiⁱ	CCNL1
GenomeRNAiⁱ	57018
Protein Ontology More...PROⁱ	PR:Q9UK58
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163660 Expressed in 224 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_CCNL1
ExpressionAtlasⁱ	Q9UK58 baseline and differential
Genevisibleⁱ	Q9UK58 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015431 Cyclin_L1 IPR006671 Cyclin_N
PANTHERⁱ	PTHR10026:SF64 PTHR10026:SF64, 1 hit
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNL1_HUMAN
Accessionⁱ	Q9UK58Primary (citable) accession number: Q9UK58 Secondary accession number(s): B3KMY3 Q9NZF3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	May 1, 2000
	Last modified:	October 10, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UK58 (CCNL1_HUMAN)

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Cyclin-L1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ