UniProtKB - Q9UK58 (CCNL1_HUMAN)
Cyclin-L1
CCNL1
Functioni
Miscellaneous
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- RNA processing Source: InterPro
Keywordsi
Molecular function | Cyclin |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9UK58 |
SignaLinki | Q9UK58 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-L1Short name: Cyclin-L |
Gene namesi | Name:CCNL1 ORF Names:BM-001, UNQ530/PRO1073 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20569, CCNL1 |
MIMi | 613384, gene |
neXtProti | NX_Q9UK58 |
VEuPathDBi | HostDB:ENSG00000163660.11 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
- nucleoplasm 1 Publication
Note: Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.By similarity
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 57018 |
OpenTargetsi | ENSG00000163660 |
PharmGKBi | PA134980948 |
Miscellaneous databases
Pharosi | Q9UK58, Tbio |
Genetic variation databases
BioMutai | CCNL1 |
DMDMi | 74753368 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080480 | 1 – 526 | Cyclin-L1Add BLAST | 526 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 325 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 338 | PhosphoserineCombined sources | 1 | |
Cross-linki | 339 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 347 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 352 | PhosphoserineCombined sources | 1 | |
Modified residuei | 355 | PhosphoserineCombined sources | 1 | |
Cross-linki | 362 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 374 | PhosphoserineCombined sources | 1 | |
Modified residuei | 445 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UK58 |
jPOSTi | Q9UK58 |
MassIVEi | Q9UK58 |
PaxDbi | Q9UK58 |
PeptideAtlasi | Q9UK58 |
PRIDEi | Q9UK58 |
ProteomicsDBi | 11129 84724 [Q9UK58-1] 84725 [Q9UK58-4] 84726 [Q9UK58-5] |
PTM databases
iPTMneti | Q9UK58 |
PhosphoSitePlusi | Q9UK58 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163660, Expressed in bone marrow and 234 other tissues |
ExpressionAtlasi | Q9UK58, baseline and differential |
Genevisiblei | Q9UK58, HS |
Organism-specific databases
HPAi | ENSG00000163660, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity).
Interacts with CDK11A, CDK12 and CDK13 (PubMed:11980906, PubMed:18216018). Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018).
Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:11980906, PubMed:18216018).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ9UK58
Isoform 3 [Q9UK58-5]
Protein-protein interaction databases
BioGRIDi | 121327, 32 interactors |
ComplexPortali | CPX-341, Cyclin L1-CDK11A(p110) complex CPX-344, Cyclin L1-CDK11A(p58) complex CPX-346, Cyclin L1-CDK11B(p58) complex CPX-348, Cyclin L1-CDK11B(p110) complex |
IntActi | Q9UK58, 44 interactors |
MINTi | Q9UK58 |
STRINGi | 9606.ENSP00000295926 |
Miscellaneous databases
RNActi | Q9UK58, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 88 – 190 | Cyclin-like 1Add BLAST | 103 | |
Regioni | 203 – 287 | Cyclin-like 2Add BLAST | 85 | |
Regioni | 390 – 432 | RSAdd BLAST | 43 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0835, Eukaryota |
GeneTreei | ENSGT00940000159135 |
HOGENOMi | CLU_107641_0_0_1 |
InParanoidi | Q9UK58 |
OMAi | INFIYQA |
OrthoDBi | 1519153at2759 |
PhylomeDBi | Q9UK58 |
TreeFami | TF101011 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR004367, Cyclin_C-dom IPR015431, Cyclin_L1 IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF64, PTHR10026:SF64, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV
60 70 80 90 100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP
110 120 130 140 150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI
160 170 180 190 200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH
210 220 230 240 250
PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI
260 270 280 290 300
YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE
310 320 330 340 350
KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE
360 370 380 390 400
KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR
410 420 430 440 450
SRSRSHTPRR HYNNRRSRSG TYSSRSRSRS RSHSESPRRH HNHGSPHLKA
460 470 480 490 500
KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD HSDAAKKHRH ERGHHRDRRE
510 520
RSRSFERSHK SKHHGGSRSG HGRHRR
The sequence of this isoform differs from the canonical sequence as follows:
226-232: NYMNDSL → VVHDGKS
233-526: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
163-172: RTPSPLILDQ → SDQLHLPKPG
173-526: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C4G1 | H7C4G1_HUMAN | Cyclin-L1 | CCNL1 | 59 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 | V → L in AAH67812 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 507 – 508 | RS → SP in AAF64257 (PubMed:11042152).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016120 | 163 – 172 | RTPSPLILDQ → SDQLHLPKPG in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_016121 | 173 – 526 | Missing in isoform 3. 1 PublicationAdd BLAST | 354 | |
Alternative sequenceiVSP_016122 | 226 – 232 | NYMNDSL → VVHDGKS in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_016123 | 233 – 526 | Missing in isoform 2. 1 PublicationAdd BLAST | 294 | |
Alternative sequenceiVSP_058299 | 411 – 428 | HYNNR…SRSRS → QDEVLLRCPGRSRTPGLK in isoform 4. Add BLAST | 18 | |
Alternative sequenceiVSP_058300 | 429 – 526 | Missing in isoform 4. Add BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF180920 mRNA Translation: AAD53184.1 AF367476 mRNA Translation: AAM21204.1 AF367477 mRNA Translation: AAM21205.1 AY034790 mRNA Translation: AAK61551.1 AK022974 mRNA Translation: BAG51145.1 AK122738 mRNA No translation available. AC104411 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78712.1 BC007081 mRNA Translation: AAH07081.1 BC038394 mRNA Translation: AAH38394.1 BC067812 mRNA Translation: AAH67812.1 AF208843 mRNA Translation: AAF64257.1 Sequence problems. AY358663 mRNA Translation: AAQ89026.1 Sequence problems. |
CCDSi | CCDS3178.1 [Q9UK58-1] CCDS77847.1 [Q9UK58-6] |
RefSeqi | NP_001295114.1, NM_001308185.1 [Q9UK58-6] NP_064703.1, NM_020307.3 [Q9UK58-1] XP_016862381.1, XM_017006892.1 XP_016862382.1, XM_017006893.1 XP_016862383.1, XM_017006894.1 XP_016862384.1, XM_017006895.1 XP_016862385.1, XM_017006896.1 |
Genome annotation databases
Ensembli | ENST00000295925; ENSP00000295925; ENSG00000163660 [Q9UK58-5] ENST00000295926; ENSP00000295926; ENSG00000163660 [Q9UK58-1] ENST00000461804; ENSP00000420277; ENSG00000163660 [Q9UK58-6] ENST00000465947; ENSP00000418094; ENSG00000163660 [Q9UK58-5] ENST00000470121; ENSP00000417237; ENSG00000163660 [Q9UK58-4] ENST00000475298; ENSP00000417343; ENSG00000163660 [Q9UK58-5] ENST00000477127; ENSP00000418449; ENSG00000163660 [Q9UK58-5] ENST00000631619; ENSP00000487951; ENSG00000163660 [Q9UK58-5] |
GeneIDi | 57018 |
KEGGi | hsa:57018 |
UCSCi | uc003fbd.2, human uc003fbf.4, human [Q9UK58-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF180920 mRNA Translation: AAD53184.1 AF367476 mRNA Translation: AAM21204.1 AF367477 mRNA Translation: AAM21205.1 AY034790 mRNA Translation: AAK61551.1 AK022974 mRNA Translation: BAG51145.1 AK122738 mRNA No translation available. AC104411 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78712.1 BC007081 mRNA Translation: AAH07081.1 BC038394 mRNA Translation: AAH38394.1 BC067812 mRNA Translation: AAH67812.1 AF208843 mRNA Translation: AAF64257.1 Sequence problems. AY358663 mRNA Translation: AAQ89026.1 Sequence problems. |
CCDSi | CCDS3178.1 [Q9UK58-1] CCDS77847.1 [Q9UK58-6] |
RefSeqi | NP_001295114.1, NM_001308185.1 [Q9UK58-6] NP_064703.1, NM_020307.3 [Q9UK58-1] XP_016862381.1, XM_017006892.1 XP_016862382.1, XM_017006893.1 XP_016862383.1, XM_017006894.1 XP_016862384.1, XM_017006895.1 XP_016862385.1, XM_017006896.1 |
3D structure databases
SMRi | Q9UK58 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121327, 32 interactors |
ComplexPortali | CPX-341, Cyclin L1-CDK11A(p110) complex CPX-344, Cyclin L1-CDK11A(p58) complex CPX-346, Cyclin L1-CDK11B(p58) complex CPX-348, Cyclin L1-CDK11B(p110) complex |
IntActi | Q9UK58, 44 interactors |
MINTi | Q9UK58 |
STRINGi | 9606.ENSP00000295926 |
PTM databases
iPTMneti | Q9UK58 |
PhosphoSitePlusi | Q9UK58 |
Genetic variation databases
BioMutai | CCNL1 |
DMDMi | 74753368 |
Proteomic databases
EPDi | Q9UK58 |
jPOSTi | Q9UK58 |
MassIVEi | Q9UK58 |
PaxDbi | Q9UK58 |
PeptideAtlasi | Q9UK58 |
PRIDEi | Q9UK58 |
ProteomicsDBi | 11129 84724 [Q9UK58-1] 84725 [Q9UK58-4] 84726 [Q9UK58-5] |
Protocols and materials databases
Antibodypediai | 18411, 215 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 57018 |
DisGeNETi | 57018 |
GeneCardsi | CCNL1 |
HGNCi | HGNC:20569, CCNL1 |
HPAi | ENSG00000163660, Low tissue specificity |
MIMi | 613384, gene |
neXtProti | NX_Q9UK58 |
OpenTargetsi | ENSG00000163660 |
PharmGKBi | PA134980948 |
VEuPathDBi | HostDB:ENSG00000163660.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0835, Eukaryota |
GeneTreei | ENSGT00940000159135 |
HOGENOMi | CLU_107641_0_0_1 |
InParanoidi | Q9UK58 |
OMAi | INFIYQA |
OrthoDBi | 1519153at2759 |
PhylomeDBi | Q9UK58 |
TreeFami | TF101011 |
Enzyme and pathway databases
PathwayCommonsi | Q9UK58 |
SignaLinki | Q9UK58 |
Miscellaneous databases
BioGRID-ORCSi | 57018, 321 hits in 881 CRISPR screens |
ChiTaRSi | CCNL1, human |
GeneWikii | CCNL1 |
GenomeRNAii | 57018 |
Pharosi | Q9UK58, Tbio |
PROi | PR:Q9UK58 |
RNActi | Q9UK58, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163660, Expressed in bone marrow and 234 other tissues |
ExpressionAtlasi | Q9UK58, baseline and differential |
Genevisiblei | Q9UK58, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR004367, Cyclin_C-dom IPR015431, Cyclin_L1 IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF64, PTHR10026:SF64, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNL1_HUMAN | |
Accessioni | Q9UK58Primary (citable) accession number: Q9UK58 Secondary accession number(s): B3KMY3 Q9NZF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM